EnzymesGamma Glutamyl TrGSTsGlutathione TransferasesErythrocyte glutathionePolymorphismsProteinAntibodyTissuesSynthaseGenes2023SubstrateImmunodeficiency virusCentreReductaseMetabolome DatabaseReactivitySynthesisModulatesTumorEnzymeTerminalOmegaDiseaseSuppressionCellsSerumSpeciesAminotransferaseProteinsGeneticGeneCatalyzeAntigenActivityExpressionCellularInfectionIsoformRelationCancer
Enzymes6
- We previously showed that miRNA 3' additions are regulated by multiple nucleotidyl transferase enzymes. (nih.gov)
- In the present study, the oxidative bioactivation of MFA was studied using human liver microsomes (HLM) and recombinant human P450 enzymes. (unboundmedicine.com)
- Glutathione S-transferase P1 (GSTP1) is one of the xenobiotic-metabolizing and antioxidant enzymes, identified in the peripheral lungs. (thestemcellfoundation.com)
- Pol lambda and pol micro are ubiquitous enzymes, possess both DNA polymerase and terminal deoxyribonucleotidyl transferase activities and belong to pol X family, together with pol beta and TdT. (ox.ac.uk)
- Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. (thermofisher.com)
- Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (hmdb.ca)
Gamma Glutamyl Tr1
- A gamma-glutamyl transferase (GGT) test measures the amount of GGT in the blood. (medlineplus.gov)
GSTs1
- The super family of glutathione S -transferases (GSTs) is composed of multiple isozymes with significant evidence of functional polymorphic variation. (nature.com)
Glutathione Transferases1
- Three years after the initial discovery, they found that another protein structurally related to glutathione transferases, a chloride intracellular ion channel, CLIC-2, could also dampen the activity of the ryanodine receptor in the heart. (the-scientist.com)
Erythrocyte glutathione1
- Human erythrocyte glutathione S-transferase: a possible marker of chemical exposure. (cdc.gov)
Polymorphisms2
- To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
- Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. (cdc.gov)
Protein7
- AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. (edu.au)
- Immunohistochemical analysis of human specimens (n = 1987) established that OGT is upregulated at the protein level and that its expression correlates with high Gleason score, pT and pN stages, and biochemical recurrence. (ox.ac.uk)
- The human multidrug resistance protein 1 (MRP1) is a primary active transporter of reduced (GSH) and oxidized glutathione, as well as GSH-, glucuronate-, and sulfate-conjugated organic anions. (aspetjournals.org)
- 2002. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. . (oregonstate.edu)
- This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
- Full length human recombinant protein of human GSTP1 produced in E.coli. (thermofisher.com)
- Western blot: Recognizes a diffuse band at approximately 70-85 kDa on western blots of extracts (20 ug total protein) from human caudate, putamen, and nucleus accumbens. (sigmaaldrich.com)
Antibody7
- The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human GSTα1. (caslab.com)
- Then a biotinylated detection antibody specific for Human GSTα1 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
- Only those wells that contain Human GSTα1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutathione S Transferase Alpha 4 (GSTa4) in serum, plasma and other biological fluids. (envite.org)
- Human papillomavirus (HPV) proteins may elicit antibody responses in the process towards HPV-related malignancy. (who.int)
- Antibody response was evaluated using a glutathione S-transferase-based multiplex serology assay. (who.int)
- 12. Positive result of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab), human immunodeficiency virus (HIV) antibody, or syphilis at screening. (who.int)
Tissues2
- Phenol sulfur transferase, in short PST or SULT1, is a subfamily of the enzyme cytosolic sulfotransferases (SULTs) consisting of at least 8 isoforms in humans that catalyze the transfer of sulfuryl group from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to phenolic compounds, resulting in more hydrophilic products that can be more easily expelled from tissues for excretion. (wikipedia.org)
- This enzyme subfamily, which exists in nearly all human tissues, is important for the detoxification of phenol-containing xenobiotics or endogenous compounds, including the biotransformation of neurotransmitters and drugs. (wikipedia.org)
Synthase1
- FASN is a multienzyme, exhibiting the catalytic properties required for palmitate synthesis including synthase, transferase, dehydrase, reductase and thioesterase activity, in addition to NADPH binding. (tocris.com)
Genes4
- Its expression is controlled by the PST genes located on chromosomes 2, 4, and 16 depending on the isoform, for example the genes for the predominant isoform throughout the body of human adults, SULT1A1, which is highly heritable and variable between individuals, and the most important one in the nervous system, SULT1A3, are located on chromosome 16 at the position of 16p11.2 to 16p12.1. (wikipedia.org)
- HBP genes were overexpressed in human prostate cancers and androgen regulated in cultured human cancer cell lines. (ox.ac.uk)
- A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
- Database of human genes associated with cellular senescence. (senescence.info)
20231
- ECSA Scientific Day 2023 (23 November 2023): Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a black South African population, according to HIV status. (who.int)
Substrate2
- A peptide substrate of O-linked GlcNAc transferase (OGT), a eukaryotic glycosyltransferase that uses UDP-GlcNAc as a glycosyl donor. (eurogentec.com)
- The hexosamine biosynthetic pathway (HBP) senses metabolic status and produces an essential substrate for O-linked β-N-acetylglucosamine transferase (OGT), which glycosylates and thereby modulates the function of its target proteins. (ox.ac.uk)
Immunodeficiency virus1
- However, HPV seroepidemiology in noncervical HPV-related cancers remains poorly understood, particularly in populations with a high prevalence of human immunodeficiency virus (HIV). (who.int)
Centre1
- Glutathione S-transferase (GST) is a search Centre (NRC), Cairo, Egypt from detoxification enzyme that catalyses the 2001 to 2004, in accordance with the ethical addition of glutathione to various xeno- principles of the NRC, in collaboration with biotics [ 4 ]. (who.int)
Reductase1
- ABSTRACT Serum levels of glutathione reductase (GR), glutathione S-transferase- (GST-) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. (who.int)
Metabolome Database1
- Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)
Reactivity2
- No significant cross-reactivity or interference between Human GSTα1 and analogues was observed. (caslab.com)
- It is not known whether natural exposure to Plasmodium falciparum stimulates HGXPRT T cell reactivity in humans. (ox.ac.uk)
Synthesis1
Modulates1
- Glutathione transferase Omega 1-1 (GSTO1-1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH-SY5Y. (expasy.org)
Tumor1
- Immunostaining for terminal deoxynucleotidyl transferase (TdT) was positive in tumor cells, supporting the diagnosis of cutaneous involvement by T-ALL. (karger.com)
Enzyme4
- Phenol sulfur transferase deficiency, in short PST deficiency, is the lack or the reduced activity of the functional enzyme phenol sulfur transferase, which is crucial in the detoxification of mainly phenolic compounds by catalysing the sulfate conjugation of the hydroxyl groups in the toxic phenolic compounds to result in more hydrophilic forms for more efficient excretion. (wikipedia.org)
- BACKGROUND: The Plasmodium purine salvage enzyme, hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) can protect mice against Plasmodium yoelii pRBC challenge in a T cell-dependent manner and has, therefore, been proposed as a novel vaccine candidate. (ox.ac.uk)
- The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
- On a whim, she decided to add the enzyme glutathione transferase to the muscle cells' medium, just because the chemical was sitting on the lab bench next to her. (the-scientist.com)
Terminal1
Omega1
- Within a few months, Dulhunty and her colleagues published their first paper on the role of the omega class glutathione S-transferase, GSTO1-1, in inhibiting the ryanodine receptor in cardiac muscle and in increasing the activity of the skeletal muscle ryanodine receptor. (the-scientist.com)
Disease3
- Recently, the authors reported the association between GSTP1 gene polymorphism and susceptibility to chronic obstructive pulmonary disease (COPD), and protective effect of GSTP1 against cigarette smoke in human lung fibroblasts in vitro. (thestemcellfoundation.com)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. (frontiersin.org)
Suppression2
- Here we examine the changes in abundance of miRNAs that exhibit altered 3' NTA following the suppression of a panel of nucleotidyl transferases in cancer cell lines. (nih.gov)
- We also observed that suppression of one nucleotidyl transferase, TUT1, resulted in a global decrease in miRNA levels of approximately 40% as measured by qRT-PCR-based miRNA profiling. (nih.gov)
Cells2
- In this study, the authors investigated that depletion of GSTP1 by itself could induce cell death, including apoptosis, in human lung fibroblast-derived HFL-1 cells. (thestemcellfoundation.com)
- O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells. (ox.ac.uk)
Serum3
- This ELISA kit applies to the in vitro quantitative determination of Human GSTα1 concentrations in Serum, plasma and other biological fluids. (caslab.com)
- Description: A sandwich ELISA kit for detection of Glutathione S Transferase Alpha 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutathione S Transferase Alpha 4 (GSTa4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (envite.org)
Species2
- arthropod-borne virus) applies to any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, chiefly insects (flies and mosquitoes) and arachnids (ticks). (msdmanuals.com)
- The oropouche virus is transmitted to humans by Culicoides paraensis , a species of biting midges (small flying insects) present in South and Central America and the Caribbean. (msdmanuals.com)
Aminotransferase1
- Human kynurenine aminotransferase II (hKAT-II) efficiently catalyzes the transamination of knunrenine to kynurenic acid (KYNA). (rcsb.org)
Proteins2
- In this study, these data have been analyzed to find all human proteins containing (or predicted to contain) the cytosolic glutathione transferase (cGST) fold. (edu.au)
- Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. (nature.com)
Genetic1
- Database of human genetic variants associated with longevity. (senescence.info)
Gene1
- ADH is a dimeric zinc metalloprotein and occurs as five different classes in humans, resulting from gene duplications during vertebrate evolution, the first one traced to ~500. (researchgate.net)
Catalyze1
- Additionally, the ability of seven human glutathione S-transferases (hGSTs) to catalyze the GSH conjugation of the quinoneimines formed by P450s was also investigated. (unboundmedicine.com)
Antigen1
- Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. (ox.ac.uk)
Activity2
- Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity. (nih.gov)
- I could see immediately that the glutathione transferase began to inhibit the cardiac muscle receptor's activity," she recalls. (the-scientist.com)
Expression2
- This review addresses how differences in the human GST isozyme expression patterns influence cancer susceptibility, prognosis and treatment. (nature.com)
- Supporting this relationship, expression of c-MYC and OGT was tightly correlated in human prostate cancer samples (n = 1306). (ox.ac.uk)
Cellular3
- CONCLUSION: The prevalence of acute proliferative and convalescent IFNgamma responses to HGXPRT demonstrates cellular immunogenicity in humans. (ox.ac.uk)
- We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
- We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
Infection1
- In the urban-epidemic cycle, humans are the principal reservoir, and the infection cycle is human to human via the midge vector. (msdmanuals.com)
Isoform1
- 2009. Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. . (oregonstate.edu)
Relation1
Cancer2
- 2007. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. . (oregonstate.edu)
- Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention. (cdc.gov)