• Organotypic 3-D corneal epithelial cultures approximate corneal epithelium, forming stratified layers approximately 60 μm thick and expressing corneal-specific keratins. (medscape.com)
  • 2. Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells. (nih.gov)
  • 16. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. (nih.gov)
  • Normal human bronchial epithelial cells (NHBE) were grown in culture and exposed to hog confinement dust extract. (cdc.gov)
  • In addition to their role as allergens, proteins from HDM attenuate the innate immune response to viral infection in respiratory epithelial cells. (nih.gov)
  • Our findings establish a reproducible, versatile three-dimensional framework for human epithelial disease modelling and regenerative medicine applications. (nature.com)
  • There is a significant need for genetically diverse cell culture platforms that accurately reconstitute tissue-specific epithelial function, particularly in humans where species-specific toxicology and disease pathophysiology is of significant biomedical relevance. (nature.com)
  • We have shown previously that galanin-1 receptors (Gal1-R) are expressed by epithelial cells lining the human GI tract, and upon activation cause Cl - secretion. (jci.org)
  • Human airway epithelial cells exposed to influenza virus induced several novel miRNAs that were identified using next generation sequencing (NGS) and their target genes by biochemical methods. (cdc.gov)
  • Expression patterns of these putative miRNAs were further confirmed using RT-PCR in human bronchial epithelial cells (HBEpC) exposed to H1N1, H9N1(1P10) and H9N1 (1WF10) strains of influenza virus. (cdc.gov)
  • Primary human bronchial epithelial cells HBEp cells. (cdc.gov)
  • Our laboratory uses a number of model systems, including traditional and inducible animal models, in vitro culture of differentiated mouse and human airway epithelial cells, and direct studies of human tissues. (unc.edu)
  • The 16HBE14o- human bronchial epithelial cell line ( SCC150 ) was isolated from the bronchus of a heart-lung patient and immortalized with pSVori-, an origin-of-replication-defective SV40 plasmid. (sigmaaldrich.com)
  • A complete collection of human lung epithelial cell lines licensed from the Gruenert Lab and housed at the NIH Cystic Fibrosis Research Center at the University of California, San Francisco is available at sigmaaldrich.com. (sigmaaldrich.com)
  • ALI culture of 16HBE14o- human bronchial epithelial cells. (sigmaaldrich.com)
  • Within these organoids, the retinal regions exhibited correct layering and contained all major retinal cell subtypes as well as retinal morphological cues, whereas the corneal regions closely resembled the transparent ocular-surface epithelium and contained of corneal, limbal, and conjunctival epithelial cells. (biomedcentral.com)
  • The airway surface liquid (ASL) covering pulmonary epithelial cells plays a pivotal role in MCC and infection control. (umontreal.ca)
  • To assess this hypothesis, we quantified the levels of VEGF in human respiratory epithelial lining fluid recovered by bronchoalveolar lavage from normal individuals. (nih.gov)
  • With the knowledge that proteins of molecular mass like VEGF (34 to 46 kDa) slowly diffuse across the alveolar epithelium, it is likely that this high level "reservoir" of VEGF protein on the respiratory epithelial surface plays a role in normal lung endothelial biology. (nih.gov)
  • Here we investigated gene expression and secretion of soluble factors elicited by GB004 treatment on immune cells and epithelial cells, human monolayer assays and immune co-culture studies to further explore its protective mechanism. (ecco-ibd.eu)
  • The protective role of GB004 on barrier integrity was further supported by immunostaining experiments demonstrating that GB004 treatment protected epithelial cells from TNFa-induced cell apoptosis, improving both epithelial cell number and tight junction protein ZO-1 staining. (ecco-ibd.eu)
  • MUC1, also referred to as mammary-type mucin, has a role in the maintenance of the lumina of ductal epithelial cells, and is thought to have an inhibitory role in cell-cell and cell-stroma interactions and in cytotoxic immunity. (bmj.com)
  • This suggests that CLU might have a specific role in maintaining mucosal epithelial differentiation, an idea that can now be tested using the mouse model for desiccating stress. (edu.au)
  • Knockdown of TNFAIP2 leads to reduced intracellular replication of L. pneumophila in human alveolar epithelial cells and to a vast number of differentially expressed genes, with some of them belonging e.g. to the immunsystem and cytoskeleton, respectively. (uni-marburg.de)
  • We were the first to implicate the UPR pathway mediated by the ubiquitous inositol requiring enzyme 1α (IRE1α) in cytokine production by human bronchial epithelia, using models relevant to CF. We also made the key discovery that the isoform IRE1β is only expressed in mucous cells, and required for allergic inflammation-induced airway epithelial mucin overproduction. (unc.edu)
  • Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. (endocrine-abstracts.org)
  • Background: Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. (endocrine-abstracts.org)
  • With the knowledge that VEGF can function to induce vascular leak, we hypothesized that to protect the lung from pulmonary edema, the VEGF produced in the lung must be compartmentalized from the pulmonary endothelium, and thus must be compartmentalized to the surface of the respiratory epithelium. (nih.gov)
  • Human papillomaviruses (HPVs) are etiologically associated with various benign and malignant neoplasms of cutaneous and mucosal epithelia. (mdpi.com)
  • Human papillomaviruses (HPVs) are DNA tumor viruses that infect cutaneous and mucosal epithelium. (iupui.edu)
  • Moreover, these durations far exceed those expected in human eyes, for which mean ocular surface residence times have been shown to be as low as 2.9 seconds. (medscape.com)
  • Using a preclinical mouse model for desiccating stress that mimics human dry eye disease, the authors recently demonstrated that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration in the tears. (edu.au)
  • CLU depletion from the ocular surface epithelia is seen in a variety of inflammatory conditions in humans and mice that lead to squamous metaplasia and a keratinized epithelium. (edu.au)
  • At the cellular level, HPV and HIV co-infection and microbiome dysbiosis can further lead to dysregulation of immune cells such as macrophages, natural killer cells, dendritic cells, mucosal associated invariant T cells and Th17 lymphocytes in mucosal epithelium. (nih.gov)
  • While most infections are self-limiting, a small subset that infects the mucosal epithelium progresses to cancer. (iupui.edu)
  • Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. (mcw.edu)
  • In the present study, we have identified another Ca2+-binding protein, hippocalcin, in the rat olfactory epithelium (OE). (mcw.edu)
  • This organ and the main olfactory epithelium, also in the nasal cavity, both contain sensory receptor cells able to detect pheromones. (nih.gov)
  • They also found that the MUP protein is recognized exclusively in the vomeronasal organ, not in the main olfactory epithelium, and activates a specific type of sensory receptor neuron. (nih.gov)
  • The NBC1 Na+/HCO3- cotransporter is expressed in many tissues, including kidney and intestinal epithelia. (nih.gov)
  • [ 20 ] Involucrin has been observed in suprabasal layers as is consistent with a role in differentiation. (medscape.com)
  • Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. (medlineplus.gov)
  • These can function to establish axes for differentiation in the embryo, or to perform barrier and transport roles in adult organs such as the kidney. (nature.com)
  • The scientific presentations emphasized developmental processes, encompassing such areas as: 1) the role of homeobox genes and growth factors in inner ear development and plasticity, 2) effects of altered gravitational loading on the development of the inner ear gravity receptor, 3) effects of altered gravitational loading on developing and mature neuromuscular systems and 4) molecular mechanisms that determine muscle fiber diversity and hypertrophic responses. (nih.gov)
  • In addition, such studies could facilitate targeted expression of potentially therapeutic genes to the vestibular system epithelium. (nih.gov)
  • Based on the knowledge that enhanced autophagy is linked to oxidative stress and the DNA damage response, both of which are linked to smoking, we used microarray analysis of the small airway epithelium to identify smoking up-regulated genes known to re-spond to oxidative stress and the DNA damage response. (refine.bio)
  • biotinylated histones are enriched in repeat regions in the human genome and appear to play a role in transcriptional repression of genes and genome stability. (researchgate.net)
  • We are using CRISPR/Cas9 to construct cell lines in which sequences encoding AIDs are inserted into both alleles of targeted genes of human tissue-culture cells that stably express the Transport Inhibitor Response 1 (TIR1) protein. (nih.gov)
  • The central goal of this study was to identify novel miRNAs and their target genes in response to influenza virus infections in airway epithelium. (cdc.gov)
  • Human genes, as well as those of most multicellular eukaryotes, are organized as mosaics of exons and introns. (jci.org)
  • Indeed, the number of protein-coding genes in humans is not radically different from that in the worm Caenorhabditis elegans (~20,000). (jci.org)
  • Bio-active components in human milk are speculated to colonize in human milk in several ways including secretion by the mammary gland, epithelium cells, and by milk cells. (wikipedia.org)
  • In intestinal and colonic epithelia, NBC1 localizes to basolateral membranes and is thought to function in anion secretion. (nih.gov)
  • To test the hypothesis that NBC1 plays a role in transepithelial HCO3- secretion in the intestinal tract, null mutant (NBC1-/-) mice were prepared by targeted disruption of its gene (Slc4a4). (nih.gov)
  • Extracellular nucleotides control MCC in airway epithelia by modulating ASL volume, ciliary beating and mucin secretion. (umontreal.ca)
  • Studies with A549 cells, a human alveolar type II cell model, have shown that mechanosensitive, Ca2+-dependent ATP secretion is strongly amplified by the synergistic autocrine/paracrine actions of released nucleotides. (umontreal.ca)
  • The neonatal type is characterized by a progressive inflammatory lesion, which suggests a role for infectious and/or toxic agents causing bile duct obliteration. (medscape.com)
  • Chronic bronchitis is characterized by inflammatory changes of the airway epithelium. (cdc.gov)
  • Immune factors in human milk are categorized mainly as anti-inflammatory primarily working without inducing inflammation or activating the complement system. (wikipedia.org)
  • Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium. (nih.gov)
  • Indeed, as its name implies, its aetiology remains elusive although a possible role for inflammatory mediators has been suggested. (open.ac.uk)
  • In the human Repligut intestinal epithelium assay, GB004 significantly reduced cell death and improved barrier integrity in response to pro-inflammatory cytokines. (ecco-ibd.eu)
  • GB004 modulates key anti-inflammatory and immunomodulatory activities in human co-culture systems. (ecco-ibd.eu)
  • The human alveolar epithelium and macrophages constitute the main cellular targets for inhaled microorganisms and play a key role in the initiation of the innate immune response and the defence against respiratory infection. (uni-marburg.de)
  • EGFR expression has been demonstrated in the basal layers of human corneal epithelium. (medscape.com)
  • Lentivirus-mediated enhanced expression of OSGIN1 in human primary basal/progenitor cells induced puncta-like staining of LC3B and up-regulation of LC3B mRNA and protein and P62 mRNA expression level in a dose and time-dependent manner. (refine.bio)
  • This led us to hypothesize that IL-6 may be a critical hog confinement dust mediator that stimulates TLR2 expression in the airway epithelium. (cdc.gov)
  • Characterization of Recombinant Human and Mouse Pigment Epithelium-derived Factor Receptor generated by Different Expression Systems. (nih.gov)
  • To determine the extracellular matrix proteins involved in the formation of human granular and lattice type I corneal stromal dystrophies, the expression patterns of fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 were compared in human corneal stromal dystrophy samples. (molvis.org)
  • MicroRNAs are essential regulators of gene expression in humans and can control pathogenesis and host-virus interactions. (cdc.gov)
  • NMBR expression in the olfactory and central thalamic regions of the brain plays a role in thermoregulation. (rndsystems.com)
  • Regulation of gene expression by transcription factors, role of receptor tyrosine kinases in cancer malignancies, aberrant gene expression in carcinogenesis, alterations in signal transduction pathways and gene translocations. (icgeb.org)
  • Briefly, TNFAIP2-mRNA and protein expression is induced by L. pneumophila Corby and Streptococcus pneumoniae in human and mouse cells, respectively. (uni-marburg.de)
  • In contrast, its expression cannot be induced by human (Pan/99 (H3N2)), nor by avian (Dk/Alb (H12N5)) influenza virus in A549 cells. (uni-marburg.de)
  • Immune factors and immune-modulating components in human milk include cytokines, growth factors, proteins, microbes, and human milk oligosaccharides. (wikipedia.org)
  • The T H 17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. (springer.com)
  • To further demonstrate the importance of IL-6 in the regulation of TLR2, NHBE were directly stimulated with recombinant human IL-6. (cdc.gov)
  • 5. Oxidative Stress Suppresses Cellular Autophagy in Corneal Epithelium. (nih.gov)
  • Together, these observations support the concept that smoking-induced up-regulation of OSGIN1 is at least one link between smoking-induced stress and enhanced-autophagy in the human airway epithelium. (refine.bio)
  • Overall design: Airway epithelium transcriptome analysis suggested that OSGIN, an oxidative response and cell death induction gene, was up-regulated by cigarette smoking and might be involved in autophagy regulation. (refine.bio)
  • 10. The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas. (nih.gov)
  • Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium. (cdc.gov)
  • Toll-like receptor 2 (TLR2), which recognizes peptidoglycan, lipoteichoic acid, and zymosan, is expressed in airway epithelium and is a key mediator in lung innate immunity. (cdc.gov)
  • I completed my Ph.D. in Neurological Sciences at McGill University in 2006, studying the role of the insulin-like growth factor-II (IGF-II/M6P) receptor in the regulation of cholinergic neurons. (open.ac.uk)
  • The infectious cycle is initiated once the infectious particles reach the basal layer of the epithelium, where they bind to and enter the cells. (srce.hr)
  • We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. (endocrine-abstracts.org)
  • It has been previously demonstrated that the atypical BC human cell line NCI-H720 is sensitive to everolimus (E), an m-TOR inhibitor, in terms of cell viability reduction, with a G0 cell-cycle arrest and a Cyclin D1 protein reduction. (endocrine-abstracts.org)
  • 3) and integrate with the host vasculature, or system of blood vessels, to support epithelium viability. (news-medical.net)
  • Therefore, this study aimed to explore the impact of Pm on primary human oral keratinocytes' transcriptome. (nih.gov)
  • The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. (jci.org)
  • We demonstrated that GADD45α and GADD45γ repression plays an unambiguous and universal role in the ability of tumors to escape programmed cell death. (icgeb.org)
  • [ 20 ] TG1 has been identified in the corneal epithelium, mostly in suprabasal cells and in the uppermost keratocyte layer, where it is found in association with fibrillin-containing microfibrils. (medscape.com)
  • Nicotinic acetylcholine receptors are best known for their role in chemical signaling between nerve cells, but they are also found in other tissues. (medlineplus.gov)
  • Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. (nature.com)
  • Both undifferentiated stem cells and terminally differentiated somatic cells form epithelia. (nature.com)
  • Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal and can differentiate into diverse somatic cell types and tissues. (nature.com)
  • One important role of these coenzymes is in the production of energy for cells. (nih.gov)
  • Primary cells and cell lines cultured at the air-liquid interface (ALI) closely represent native cells, preserving key characteristics of in vivo airway epithelium targeted by viruses. (sigmaaldrich.com)
  • however, upon irradiation, genetic inactivation of Setd2 in mouse intestinal epithelium facilitated the self-renewal of intestinal stem/progenitor cells as well as tissue regeneration. (jci.org)
  • A number of transcription factors are overactive in most human cancer cells, making these good targets for the development of anticancer drugs. (icgeb.org)
  • Recently, great efforts have been made to design protocols for obtaining ocular cells from human stem cells to model diseases or for regenerative purposes. (biomedcentral.com)
  • Here, the generation of more advanced in vitro multiocular organoids from human induced pluripotent stem cells (hiPSCs) is demonstrated. (biomedcentral.com)
  • The conjunctiva covers the sclera and is composed of 3-5 layers of epithelium with superficial scattered goblet cells that produce important mucins for the tear film. (biomedcentral.com)
  • GH is produced by normal and neoplastic endometrial cells and elevated levels have been observed in endometrial epithelium of patients with endometriosis and endometrial adenocarcinoma (EA). (endocrine-abstracts.org)
  • Introduction: Neuroendocrine tumours (NETs) are heterogeneous neoplasms arising from neuroendocrine cells spread in the respiratory and gastro-entero-pancreatic epithelium. (endocrine-abstracts.org)
  • However, in addition to the epithelium, there are more" legible "sensors of foreign molecules in the lung tissues -- macrophages and dendritic cells. (medindia.net)
  • The main role in this response is played by eosinophil cells, one of the white blood cells, or leukocytes. (medindia.net)
  • In the BioMAP human co-culture assay, cells were treated with GB004 one hour prior to stimulation and incubated for 24-168 hours. (ecco-ibd.eu)
  • hPSCs have therefore emerged as a powerful and reproducible source of diverse human tissues for disease modelling and regeneration. (nature.com)
  • But such research has focused largely on associations between traits of interest and variants that are common in the human population. (cdc.gov)
  • The role of HMT gene variants in prostate cancer remains unknown. (cancerindex.org)
  • As a result, the 3D structures that arise are relatively simple, and it has been challenging to perform controlled comparisons of different epithelia of the same genetic background, or the same epithelia with different genetic backgrounds. (nature.com)
  • Our understanding of the genetic mutations that affect complex human traits - such as height, smoking-related behaviour or the risk of diabetes - has been vastly broadened by genome-wide association studies (GWASs). (cdc.gov)
  • Almost half of the human genome is made up of mobile genetic elements, which includes endogenous proviruses and other sequences derived from retroviruses such as retrotransposons, retroposons, and processed pseudogenes. (virology.ws)
  • HPV infections are common in healthy women and only rarely cause cervical cancer, suggesting that individual genetic susceptibility may play a critical role in the establishment of persistent HPV infection and the development of cervical cancer. (unl.edu)
  • Although the importance of microenvironment in prostate cancer is widely recognized, the molecular and cellular processes leading from genetic changes in the prostatic epithelium to the establishment of a tumorigenic microenvironment for prostate cancer is unclear in most contexts. (dtic.mil)
  • The inner wall of the optic cup gives rise to the retina, while the outer wall gives rise to the pigment epithelium . (nih.gov)
  • Their presence in human milk may stimulate lymphocytes responsible for the development of the infant's specific immunity. (wikipedia.org)
  • These findings implied an important role for hRFT-2 in intestinal RF uptake, a conclusion that was further supported by findings of hRFT-2 gene-specific siRNA knockdown investigation. (nih.gov)
  • The purpose of this Notice of Funding Opportunity (NOFO) is to solicit research to better understand the mechanisms of persistent oral human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection as well as its role in the induction and pathogenesis of HPV-associated oropharyngeal cancers (HPV-OPC). (nih.gov)
  • Mutations of the murine papillomavirus conserved E2 C307 residue to serine and phenylalanine were used to investigate its role in E2 function. (iupui.edu)
  • A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveal" by Chunbo He, Xiangmin Lv et al. (unl.edu)
  • Zekan J, Skerlev M, Milić L, Karelović D. Human Papillomavirus-Related Diseases of the Female Lower Genital Tract: Oncogenic Aspects and Molecular Interaction. (srce.hr)
  • The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. (srce.hr)
  • The immune system uses innate and adaptive immunity to recognize and combat foreign agents that invade the body, but these methods are sometimes ineffective against human papillomavirus. (srce.hr)
  • Cloning and characterization of human MUC19 gene. (nih.gov)
  • [ 15 ] The 3-D cultures also have been shown to develop similar barrier properties to corneal epithelium as measured by transepithelial electrical resistance. (medscape.com)
  • Furthermore, GB004 demonstrates protective effects on human derived monolayer cultures by reducing cell death, promoting tight junction formation, and improving barrier integrity. (ecco-ibd.eu)
  • We investigated the role of TLR2 in pulmonary inflammation induced by hog confinement dust. (cdc.gov)
  • Its homeostatic activities in proteostasis, cytoprotection, and anti-inflammation have been well documented, however its roles in health and disease are still not well understood. (edu.au)
  • Notably, the role of specific miRNAs during influenza virus infections are still ill-defined. (cdc.gov)
  • NBC1 mutations cause proximal renal tubular acidosis in humans, consistent with its role in HCO3- absorption in the kidney. (nih.gov)
  • A positive and significant association between exposure to air pollution and goblet-cell hyperplasia in human conjunctiva was detected. (nih.gov)
  • CLU is prominent at fluid-tissue interfaces, and in 1996 it was demonstrated to be the most highly expressed transcript in the human cornea, the protein product being localized to the apical layers of the mucosal epithelia of the cornea and conjunctiva. (edu.au)
  • Studies show that HMOs also function as immune-modulators by blocking receptors that allow pathogenic bacteria to attach to the infant intestinal epithelium. (wikipedia.org)
  • Consistent with such a pathogenic role, high levels of lipofuscin fluorescence are found in the central area of the human RPE, and decline toward the periphery. (sens.org)
  • Pathogenic Escherichia coli , but not nonpathogenic E. coli , activate a p50/p65 NF-κB complex that binds to oligonucleotides corresponding to a recognition site located within the 5′ flanking region of the human GAL1R gene. (jci.org)
  • Anthrax occurs in humans when they are exposed to infected animals or tissue from infected animals or when they are directly exposed to B. anthracis spores ( 4--6 ). (cdc.gov)
  • Lactoferrin is an immune protein with strong anti-microbial function in human milk. (wikipedia.org)
  • Concomitant with the appearance of Karst in the somatic muscle precursors, the protein is also seen in the developing splanchnopleura, and can eventually be seen staining the mature visceral musculature around the midgut epithelium. (sdbonline.org)
  • CLU protein is also present in human tears. (edu.au)
  • In particular, we study the role of the Unfolded Protein Response (UPR) in these airway diseases. (unc.edu)
  • 4. SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium. (nih.gov)
  • 15. The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. (nih.gov)
  • These extensively-published human cell lines are valuable models for pulmonary diseases such as cystic fibrosis, asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. (sigmaaldrich.com)
  • Right now, the most common theory is that the disease could potentially be triggered by an initial injury to the lung epithelium which in turn induces an abnormal repair pathway, leading to d amage of the lung. (lu.se)
  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
  • First, the detailed study of the tumorigenic microenvironment and the correlation between NFATc1 and prostate cancer status in humans will help facilitate the development of clinically useful biomarkers for both diagnostic and prognostic purposes. (dtic.mil)
  • House dust mites (HDM) are ubiquitous arachnids that ingest shed human epithelium and reside in bedding and upholstered furniture. (nih.gov)
  • Just like humans, a mouse has regular contact with dust and dust mites living in it. (medindia.net)
  • Microorganisms may play an essential role in the pathogenesis of OLP. (nih.gov)
  • To identify the target(s) of these putative miRNAs, we screened 84 transcription factors that have a role in viral pathogenesis. (cdc.gov)
  • However, several theories including skin-to-skin contact, the entero-mammary pathway, and retrograde back-flow hypothesis have been put forth to explain the microbial composition of human milk. (wikipedia.org)
  • Ran is a Ras-family GTPase that plays critical roles in many cellular processes, including nucleo-cytoplasmic transport, nuclear envelope assembly, and mitotic spindle assembly. (nih.gov)
  • We found that hyperactivation of YAP1 in mouse cervical epithelium was sufficient to induce invasive cervical cancer. (unl.edu)
  • The role of the interleukin-6 molecule in the development of allergic asthma has been identified by the Russian Scientists, which can become a new target for the treatment of the disease. (medindia.net)
  • This allergen, is most often responsible for asthma in humans. (medindia.net)
  • Intracellular Ca2+ plays an important role in a variety of second messenger cascades. (mcw.edu)
  • and biotinidase, which plays a central role in the intestinal absorption of biotin, the transport of biotin in plasma and the regulation of histone biotinylation. (researchgate.net)
  • it also plays a critical role in the maintenance of photoreceptors, renewing photopigments and phagocytosing the photoreceptor disks, whose turnover at a high rate is essential to vision. (nih.gov)
  • a highly conserved cysteine residue in the DNA contact helix of E2 plays an unknown role. (iupui.edu)
  • The epithelium-specific Ets transcription factor, PDEF, plays a role in prostate and breast cancer, although its precise function has not been established. (icgeb.org)
  • Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. (abcam.com)
  • Plays a role in ciliogenesis and collective cell movements. (abcam.com)
  • Reports indicate that CD11c/CD18 plays a role as an adhesion molecule that mediates cellular binding to ligands expressed on stimulated epithelium and endothelium. (bdbiosciences.com)
  • Recent research has shown novel roles for vitamin B7 in cell signalling and epigenetic control and it must bind to specific lysine residues. (researchgate.net)
  • MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. (bmj.com)
  • MUCs are a heterogeneous group of glycoproteins with various roles both in homeostasis and carcinogenesis. (bmj.com)
  • This transparent layer is formed by a stratified epithelium in the outer section, a collagen-rich stroma that is maintained by keratocytes, and the endothelium in the inner part [ 5 ]. (biomedcentral.com)
  • Researchers at Scripps Research Institute and Harvard University, funded in part by NIH's National Institute on Deafness and Other Communication Disorders (NIDCD), set out to study the role of pheromones in male mouse aggression, a social behavior that's relatively easy to track. (nih.gov)
  • We are establishing proof-of-principle for human or mouse organoid transplantation, ultimately to effect phenotypic correction of diseases. (stanford.edu)