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  • STE20
  • MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al. (wikipedia.org)
  • regulation
  • Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. (uniprot.org)
  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. (rcsb.org)
  • Serine/threonine protein kinase that plays important roles in several processes including nuclear viral egress, viral replication or regulation of host cell cycle progression. (uniprot.org)
  • AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). (mybiosource.com)
  • The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (wikipedia.org)
  • phosphorylate
  • It is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. (wikipedia.org)
  • Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (wikipedia.org)
  • regulates
  • AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. (mybiosource.com)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. (uniprot.org)
  • regulate
  • By the late 1960s, cyclic AMP-dependent protein kinase had been purified, and most attention was centered on kinases and phosphatases that could regulate the activity of important enzymes. (wikipedia.org)
  • identification
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • nucleus
  • Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. (rcsb.org)
  • Daily oscillations in protein and mRNA transcription have been observed in many cells, including the mammalian master clock known as the suprachiasmatic nucleus (SCN). (wikipedia.org)
  • mitosis
  • The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. (wikipedia.org)
  • pathway
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • A hypoxia response pathway via mTOR (mammalian target of rapamycin) including inactivation of EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) and finally resulting in increased mRNA translation is known to be inhibited by DDIT4 . (nih.gov)
  • http://pathman.smpdb.ca/pathways/SMP00044/pathway Histidine Metabolism] (Serine/Threonine related? (openwetware.org)
  • Interaction of TLRs with their specific PAMP is mediated through either MyD88- dependent pathway and triggers the signaling through NF-κB and the MAP kinase pathway and therefore the secretion of pro-inflammatory cytokines and co-stimulatory molecules or TRIF - dependent signaling pathway. (wikipedia.org)
  • Moreover, there is also sufficient evidence which implicates ceramide to the activation of the kinase suppressor of Ras (KSR), PKCζ, and cathepsin D. Interestingly, cathepsin D has been proposed as the main target for ceramide formed in organelles called lysosomes, making lysosomal acidic SMase enzymes one of the key players in the mitochondrial pathway of apoptosis. (wikipedia.org)
  • binds
  • Furthermore, acetylation of a specific lysine residue binds to bromine-containing domains of certain transcription and chromatin regulatory proteins. (wikipedia.org)
  • A well-characterised example of this is the ribonuclease inhibitor, which binds to ribonucleases in one of the tightest known protein-protein interactions. (wikipedia.org)
  • isoforms
  • These variants, also called isoforms, are proteins that are structurally very similar to the regular histone H2B but feature some specific variations in their amino acid sequence. (wikipedia.org)
  • Histone H2B isoforms interact differently with other proteins, are found in specific regions of chromatin, have different types and numbers of post-translational modifications, and are more or less stable than regular histone H2B. (wikipedia.org)
  • bind
  • Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. (wikipedia.org)
  • The ability of these other NPFs to bind the Arp2/3 complex while cortactin is also bound could come from new interactions with cortactin's SH3 domain, which is in a different conformation when phosphorylated by Ser/Thr kinases and thus may be more open to interactions with other NPFs. (wikipedia.org)
  • Consistent with such multiple roles, ScCdc14 has been found to bind several proteins that regulate the cell cycle and DNA replication, or that associate with the spindle or kinetochore. (wikipedia.org)
  • receptor
  • black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7. (nih.gov)
  • We, therefore, investigated the effects of a lipophilic black cohosh rhizome extract and cycloartane-type triterpenoids on the estrogen receptor positive human breast cancer cell line MCF-7. (nih.gov)
  • In TNF-treated cells, TNFR1, TNFR-associated death domain protein (TRADD), Fas-associated death domain protein, and receptor-interacting protein kinase proteins form the signaling complex via modular interaction within their C-terminal death domains. (jimmunol.org)
  • Phospho-S215LKD and phospho-S296LAE motifs are also critical to TRADD for recruiting Fas-associated death domain protein and receptor-interacting protein kinase. (jimmunol.org)
  • TNF-bound TNFR1 recruits TNFR-associated death domain protein (TRADD), an adaptor protein that serves as the platform for additional recruitment of receptor-interacting protein kinase (RIP) and Fas-associated death domain protein (FADD), initiating both NF-κB activation and apoptosis induction ( 1 - 3 ). (jimmunol.org)
  • thus, cortactin must also be activated by receptor kinases that pick up a large variety of chemical signals. (wikipedia.org)
  • Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene. (wikipedia.org)
  • The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). (wikipedia.org)
  • mediate
  • AMPK)-related kinase, has been shown to mediate var- ious cellular functions, including proliferation, spliceo- Results some assembly, gene expression, carcinogenesis, MPK38 kinase activity is increased by Smads2/3/4 but 9-13 apoptosis, and metabolism , although its exact phy- decreased by Smad7 siological functions still remain to be determined. (deepdyve.com)
  • amino
  • The primary structure of a protein is the sequence of amino acid s in the polypeptide (s). (everything2.com)
  • These amino acids - or, for practical purposes, (since all amino acids have certain functional group s in common) their remainder groups - determine what elements make up the protein, and in what quantities. (everything2.com)
  • These structural type s are, in turn, due to the reactions between neighboring amino acids in the chain s, and so it is the primary structure of the protein that defines the secondary structure . (everything2.com)
  • These particular reactions between amino acids are hydrogen bonds , which create (relatively) small attractions between the "links" in the chain, which are nonetheless strong enough to determine if the protein will fold into sheets or twist into spirals . (everything2.com)
  • The primary and secondary structures of the proteins determine which amino acids react with each other, and so determine just what the tertiary structure will be. (everything2.com)
  • Proteins are polymer s whose molecules are made from many amino acid molecules linked together. (everything2.com)
  • There are twenty different, naturally occurring amino acid s. amino acid s can link to form poly peptide chains and these can associate with one another to form proteins. (everything2.com)
  • The twenty different amino acid s which exist in nature can be combined in any combination to make a protein. (everything2.com)
  • However, this order is of tremendous significance as a change in just one amino acid can drastically change the behaviour of the protein formed. (everything2.com)
  • Histone H2B is a lightweight structural protein made of 126 amino acids. (wikipedia.org)
  • These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. (wikipedia.org)
  • The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. (wikipedia.org)
  • Yeast
  • Many early studies, especially in the budding yeast Saccharomyces cerevisiae, demonstrated that the protein plays a key role in regulating late mitotic processes. (wikipedia.org)
  • Pathways
  • Additional stu- Smad7 inhibits these signaling pathways through differ- dies are required to investigate the effect of Smad proteins ential regulation of MPK38 activity. (deepdyve.com)
  • regulator
  • However, an opposite effect was observed on complex formation between MPK38 and its positive regulator zinc-finger-like protein 9 (ZPR9). (deepdyve.com)
  • Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. (wikipedia.org)
  • apoptosis
  • Smads2/3/4 increased, but Smad7 decreased, MPK38-mediated apoptosis signal-regulating kinase-1 (ASK1)/transforming growth factor-β (TGF-β)/p53 signaling. (deepdyve.com)
  • interactions
  • The C terminals of TNFR1, TRADD, FADD, and RIP all carry a discrete region termed the "death domain," which is composed of six continuous α-helical bundles and responsible for homotypic interactions among these four proteins. (jimmunol.org)
  • Similar to other histone proteins, histone H2B has a distinct histone fold that is optimized for histone-histone as well as histone-DNA interactions. (wikipedia.org)
  • Hyperacetylation of histone tails helps DNA-binding proteins access chromatin by weakening histone-DNA and nucleosome-nucleosome interactions. (wikipedia.org)
  • variants
  • There are sixteen variants of histone H2B found in humans, thirteen of which are expressed in regular body cells and three of which are only expressed in the testes. (wikipedia.org)
  • Two transcript variants encoding the same protein have been identified for this gene. (wikipedia.org)
  • mRNA
  • MicroRNA-101 targets DNA-PKcs via binding to the 3'- UTR of DNA-PKcs mRNA and efficiently reduces protein levels of DNA-PKcs. (wikipedia.org)
  • gene expression
  • Bio-Rad collaborated with Biogazelle, leaders in real-time PCR research, to design and experimentally validate PCR primers for gene expression assays across the human and mouse transcriptomes. (bio-rad.com)
  • complex
  • When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. (wikipedia.org)
  • Serum
  • Anti-PINK1 truncated antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Term portion of human PINK1 conjugated to Keyhole Limpet Hemocyanin (KLH). (rockland-inc.com)
  • As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum. (wikipedia.org)
  • mice
  • These findings suggest that Smad proteins have class-specific impacts on obesity-associated metabolism by differentially regulating MPK38 activity in diet-induced obese mice. (deepdyve.com)
  • parameters by differentially regulating MPK38 activity in MPK38/MELK, an AMP‐activated protein kinase HFD-induced obese mice. (deepdyve.com)
  • Studies have been conducted on TLR11 as well, and it has been shown that it recognizes flagellin and profilin-like proteins in mice. (wikipedia.org)
  • An experiment with genetically-altered mice that could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior, and several other abnormalities characteristic of schizophrenia. (wikipedia.org)