• phosphorylate
  • It is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. (wikipedia.org)
  • Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • While the catalytic domain of these kinases is highly conserved, the sequence variation that is observed in the kinome (the subset of genes in the genome that encode kinases) provides for recognition of distinct substrates. (wikipedia.org)
  • The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. (wikipedia.org)
  • Chromosome
  • Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. (uniprot.org)
  • 1996
  • MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al. (wikipedia.org)
  • binds
  • CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (nih.gov)
  • Most kinases are inhibited by a pseudosubstrate that binds to the kinase like a real substrate but lacks the amino acid to be phosphorylated. (wikipedia.org)
  • expression
  • Expression of cyclin kinase subunit 2 in human breast cancer and its prognostic significance. (nih.gov)
  • Patients with positive-CKS2 protein expression had a poorer five year survival frequency than patients who did not express CKS2 protein. (nih.gov)
  • Of the latter, types include: Serine/threonine kinase (STK) expression is altered in many types of cancer. (wikipedia.org)
  • http://cancerres.aacrjournals.org/cgi/content/full/66/16/8147 "Frequent Alterations in the Expression of Serine/Threonine Kinases in Human Cancers" Capra et al. (wikipedia.org)
  • This oscillator, or "circadian clock," is made up of a transcription-translation negative feedback loop (TTNFL) in which several proteins work in tandem, each regulating the others' expression to generate a roughly 24-hour cycle of both mRNA and protein levels. (wikipedia.org)
  • This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. (wikipedia.org)
  • Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C". EMBO J. 9 (4): 1165-70. (wikipedia.org)
  • mitotic
  • Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. (uniprot.org)
  • In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. (wikipedia.org)
  • identification
  • p>This subsection of the 'Names and Taxonomy' section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)