Loading...


  • genomes
  • Human genomes include both protein-coding DNA genes and noncoding DNA . (wikipedia.org)
  • Haploid human genomes, which are contained in germ cells (the egg and sperm gamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote ) consist of three billion DNA base pairs , while diploid genomes (found in somatic cells ) have twice the DNA content. (wikipedia.org)
  • While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4% ) and bonobos . (wikipedia.org)
  • As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. (wikipedia.org)
  • Genes in well-studied cancer-associated signaling pathways also contain significantly more unstable repeats in tumor genomes. (biomedcentral.com)
  • Introduction Repetitive DNA sequence elements are widely abundant in the human and the other eukaryotic genomes. (cancer-basics.com)
  • Initially, we annotated the human and mouse genomes with STRs (see Figure 1 for an example and Methods for how STRs are identified). (biomedcentral.com)
  • proteins
  • Unexpectedly, we discovered that CAG expansion constructs express homopolymeric polyglutamine, polyalanine, and polyserine proteins in the absence of an ATG start codon. (jove.com)
  • Additionally, we show that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established SCA8 and DM1 mouse models and human tissue. (jove.com)
  • In contrast, in mutant strains carrying mutations in proteins involved in DNA replication or repair, expansions are frequently seen. (embopress.org)
  • Introns are found in the genes of most organisms and many viruses, and can be located in a wide range of genes, including those that generate proteins , ribosomal RNA (rRNA), and transfer RNA (tRNA). (wn.com)
  • When proteins are generated from intron-containing genes, RNA splicing takes place as part of the RNA processing pathway that follows transcription and precedes translation . (wn.com)
  • DM arises from the expansion of two similar non-coding microsatellites in the DMPK and CNBP genes which have been proposed to cause disease through a common mechanism, a toxic RNA gain-of-function which can either inhibit or activate specific proteins. (ufl.edu)
  • One of these candidates, the muscleblind-like (MBNL) family of proteins encoded by three genes, MBNL1, MBNL2, and MBNL3, are sequestered into discrete nuclear foci by RNA repeat expansions, preventing interactions with endogenous RNA targets and compromising their activity. (ufl.edu)
  • no method is currently available to correct the malfunctioning androgen receptor proteins produced by AR gene mutations. (wikipedia.org)
  • Genomic
  • These observations might impact ongoing tries to make use of LMD and MCMC simulations for TRS-related modeling of genomic DNA efficiency in elucidating the common denominators of the dynamic TRS expansion mutation with potential therapeutic applications. (cancer-basics.com)
  • genetic
  • The origin and migration of modern humans can be documented with reasonable certainty with archeological, linguistic, & molecular genetic analysis. (brainscape.com)
  • Genetic and fossil evidence confirms a sub-Saharan origin for anatomically modern humans (Box 6.8). (brainscape.com)
  • However, when used to refer to the number of repeating units of genetic information that are sufficient to encode the blueprint for something as complex as a human being, it never ceases to amaze me that this number is big enough! (bmj.com)
  • Although the transfer of a number of genes from these organelles to the nucleus prevents them from living independently, each still possesses genetic material in the form of double stranded DNA. (wikipedia.org)
  • They are also used in genetic linkage analysis to locate a gene or a mutation responsible for a given trait or disease. (wikipedia.org)
  • The increasing availability of DNA amplification by PCR at the beginning of the 1990s triggered a large number of studies using the amplification of microsatellites as genetic markers for forensic medicine, for paternity testing, and for positional cloning to find the gene underlying a trait or disease. (wikipedia.org)
  • specific genes
  • Category I includes Huntington's disease (HD) and the spinocerebellar ataxias that are caused by a CAG repeat expansion in protein-coding portions of specific genes. (wikipedia.org)
  • This and additional evidence supports the hypothesis that loss of MBNL1 function in DM causes defects in the alternative splicing of specific genes during postnatal development which leads to distinct pathological features in adult-onset disease, including myotonia and insulin insensitivity. (ufl.edu)
  • mediate
  • The mechanism by which trinucleotide secondary structures mediate expansions is not well understood. (embopress.org)
  • Thus the AR activates these genes to mediate the effects of androgens in the human body, including the development and maintenance of the male sexual phenotype and generalized anabolic effects. (wikipedia.org)
  • DMPK
  • Myotonic dystrophy type 1 (DM1) is a neuromuscular disease caused by the expansion of a CTG repeat in the DMPK gene and characterised by progressive skeletal muscle weakness and wasting. (jove.com)
  • STRs
  • We also demonstrate that STRs are significantly overrepresented in disease-related genes in both human and mouse. (biomedcentral.com)
  • These results are preserved when we limit the analysis to STRs outside known longer tandem repeats. (biomedcentral.com)
  • Long intergenic tandem repeats are well known targets for structural variation, and in this study we investigate whether exonic STRs share this property, and hence may serve as a probable target for exonic disease causing mutations. (biomedcentral.com)
  • We found a strong excess of validated indels in STR regions and demonstrated that exonic STRs are likely targets for disease causing mutations by showing that disease-related genes have a significantly higher STR content than non-disease-related genes. (biomedcentral.com)
  • disease
  • Taking advantage of a relevant transgenic mouse of a complex human disease, we found a novel connection between physiological phenotypes and synaptic protein dysregulation, indicative of synaptic dysfunction in myotonic dystrophy type 1 brain pathology. (jove.com)
  • Trinucleotide expansions cause disease by both protein- and RNA-mediated mechanisms. (jove.com)
  • The second, related DNA-triplet repeat disease, fragile X-E syndrome, was also identified on the X chromosome, but was found to be the result of an expanded CGG repeat. (wikipedia.org)
  • Three genes, SCA1 on 6p, SCA2 on 12q and MJD1 on 14q, have been isolated for SCA1, SCA2 and Machado-Joseph disease (MJD), respectively. (springer.com)
  • Myotonic dystrophy (DM) may be the most variable human disorder described, affecting every age group from newborns to the adult-onset form which can range from adolescent manifestations to late-onset disease. (ufl.edu)
  • Our working hypothesis is that MBNL genes show distinct temporal and spatial expression patterns that influence age-of-onset and disease-associated pathological changes. (ufl.edu)
  • Additionally, we show that MBNL1 interacts with DM1 pathogenic and non-pathogenic repeat RNAs, but inherent differences in these interactions contribute to the ability to promote disease associated changes in alternative splicing. (ufl.edu)
  • Your gift helps fund groundbreaking research aimed at understanding, treating and preventing human disease. (massgeneral.org)
  • In particular, we test whether they share the hypermutability of the longer tandem repeats and whether disease-related genes have a higher STR content than non-disease-related genes. (biomedcentral.com)
  • Here we focus on a class of very short tandem repeats and their contribution to disease risk. (biomedcentral.com)
  • codons
  • Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. (wikipedia.org)
  • Protein
  • Most (though probably not all) genes have been identified by a combination of high throughput experimental and bioinformatics approaches, yet much work still needs to be done to further elucidate the biological functions of their protein and RNA products. (wikipedia.org)
  • There are an estimated 19,000-20,000 human protein-coding genes. (wikipedia.org)
  • The human androgen receptor (AR) is a protein encoded by a gene located on the proximal long arm of the X chromosome (locus Xq11-Xq12). (wikipedia.org)
  • Chromosome
  • Mutations in 'reading disorder' genes include DCDC2 on chromosome 6 and ROBO1 on chromosome 3 together represent 20% of cases of dyslexia. (brainscape.com)
  • The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. (google.com)
  • The example shows an exonic STR region located in the nestin ( NES ) gene on chromosome 1. (biomedcentral.com)
  • relatively
  • Homo sapiens remained restricted to Africa and the Middle East until about 60,000 - 70,000 years ago, when a relatively small group of humans departed from eastern Africa across the mouth of the Red Sea and migrated into Asia and Europe. (brainscape.com)
  • phenotype
  • Thus, the phenotype of traits linked to genes found in either chloroplasts or mitochondria are determined exclusively by the maternal parent. (wikipedia.org)
  • base pairs
  • Four divergent domains consisted of microsatellite repeats biased in composition with purines on one strand and pyrimidines on the other, including mononucleotide repeats of C:G base pairs approximately 20 bp in length. (wikipedia.org)
  • AT in ATATATATAT) is repeated at least three times, (3) there are only few base pairs that do not match the periodic motif (see Methods). (biomedcentral.com)
  • chromosomes
  • These laws describe the inheritance of traits linked to single genes on chromosomes in the nucleus. (wikipedia.org)
  • The telomeres at the ends of the chromosomes, thought to be involved in ageing/senescence, consist of repetitive DNA, with the hexanucleotide repeat motif TTAGGG in vertebrates. (wikipedia.org)
  • disorder
  • Expanded SCA1 and CAG repeats were found to cosegregate with the disorder in six of the families tested and were also observed in one sporadic individual with a negative family history of SCA. (springer.com)
  • found
  • Overexpression of Mre11p or Rad50p suppresses the inhibition of DSB repair by CAG 98 and significantly increases the average size of expansions found at the recipient locus. (embopress.org)
  • We have found that the gain of novel LCRs is frequently associated with repeat expansion whereas the loss of LCRs is more often due to accumulation of amino acid substitutions as opposed to deletions. (biomedsearch.com)
  • foci
  • If the repeat is present in an intron it can cause toxic effects by forming spherical clusters called RNA foci in cell nuclei. (wikipedia.org)
  • intron
  • The word intron is derived from the term intragenic region , i.e. a region inside a gene. (wn.com)
  • Thus
  • The Mre11 complex thus appears to be directly involved in removing CAG or CTG hairpins that arise frequently during DNA synthesis accompanying gene conversion of these trinucleotide repeats. (embopress.org)
  • short repeats
  • Investigations of the relation between the AR polymorphism and breast cancer ( Table 1 ) have been conflicting, variably reporting that short repeats are associated with a decreased risk ( 14 - 18 ) or are not associated with risk ( 19 - 21 ) or are associated with decreased breast cancer survival ( 16 , 22 , 23 ). (aacrjournals.org)
  • loci
  • However, the origin and evolution of tandem repeat loci remain largely unknown. (biomedcentral.com)
  • Distinct CRM1TR sequence variants occupy the two CRM1TR loci, indicating that there is little or no movement of repeats between loci, even though they are separated by only ~1.4 Mb. (biomedcentral.com)
  • Analysis of monomers from two different CRM1TR loci shows that gene conversion is the major cause of sequence variation. (biomedcentral.com)
  • Through statistical analysis and enhanced tag cloud representation on defined functional related genes and cross-species clusters, the proposed system can correctly represent the patterns, loci, colors, and sizes of identified SSRs in accordance with gene functions, pattern qualities, and conserved characteristics among species. (hindawi.com)
  • In summary, I identified novel QTLs underlying NPC proliferation and these loci serve as starting points to identify genes (e.g. (ubc.ca)
  • Dienekes' Anthropology Blog: Decreased Rate of Evolution in Y Chromosome STR Loci of Increased Size of the Repeat Unit (Järve et al. (blogspot.com)
  • In order to study the evolutionary dynamics of STRs according to repeat unit size, we analysed variation at 24 Y chromosome repeat loci: 1 tri-, 14 tetra-, 7 penta-, and 2 hexanucleotide loci. (blogspot.com)
  • Whenever a conserved amount of base-pair mismatch ( 2 bps) was used in the do it again Arry-380 theme search, a complete of just one 1,451 microsatellite loci had been identified (which range from 15 - 132 bps) as well as the suggest microsatellite denseness was one per 8.07 kb. (ivachtin.com)
  • Thus, the mutation rate at microsatellite loci is expected to differ from other mutation rates, such as base substitution rates. (wikipedia.org)
  • SSRs
  • Simple sequence repeats (SSRs) are not only applied as genetic markers in evolutionary studies but they also play an important role in gene regulatory activities. (hindawi.com)
  • Efficient identification of conserved and exclusive SSRs through cross-species comparison is helpful for understanding the evolutionary mechanisms and associations between specific gene groups and SSR motifs. (hindawi.com)
  • Ultraconserved or exclusive SSRs among cross-species orthologous genes could be effectively retrieved and displayed through a friendly interface design. (hindawi.com)
  • Simple sequence repeats (SSRs) are nonrandom distributed nucleotides in genomes of different organisms with repeated basic patterns of lengths from mononucleotide to hexanucleotide [ 1 ]. (hindawi.com)
  • SSRs have been demonstrated as important motifs involved within various biological events including evolutionary processes, gene expression, genetic disease, chromatin organization, and DNA metabolic processes [ 2 - 4 ]. (hindawi.com)
  • Therefore, identifying highly conserved SSRs through cross-species comparison may provide an alternative approach to recognize significant biomarkers or discover putative gene regulatory SSR motifs from enormous gene candidates under the assumption of natural long-term evolutionary processes. (hindawi.com)
  • Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists, or as simple sequence repeats (SSRs) by plant geneticists. (wikipedia.org)
  • Abstract
  • Queen's University, 2003 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE STUDIES (Medical Genetics) THE UNIVERSITY OF BRITISH COLUMBIA November 2007  Sara Helen Alison Harbord, 2007 ii Abstract Skewed somatic X inactivation (XCI), X-linked gene overexpression and abnormal X content have been associated with breast and ovarian cancer. (ubc.ca)
  • Recombination
  • Gene conversion arises during DNA repair via DNA recombination, by which a piece of DNA sequence information is transferred from one DNA helix (which remains unchanged) to another DNA helix, whose sequence is altered. (wikipedia.org)
  • proteins
  • The search for these modifiers, much as the search for the HD gene did in the past, offers to open new entrées into the process of Huntington's disease pathogenesis by unlocking the biochemical changes that occur many years before diagnosis, and thereby providing validated target proteins and pathways for development of rational therapeutic interventions. (beds.ac.uk)
  • A supplementary 1,719 strikes were obtained, recommending that the mixed transcriptome of L. striatellus offers at least 14,080 proteins coding genes (12,361 from A. pisium plus 1,719 from D. melanogaster ). (ivachtin.com)
  • DM arises from the expansion of two similar non-coding microsatellites in the DMPK and CNBP genes which have been proposed to cause disease through a common mechanism, a toxic RNA gain-of-function which can either inhibit or activate specific proteins. (ufl.edu)
  • One of these candidates, the muscleblind-like (MBNL) family of proteins encoded by three genes, MBNL1, MBNL2, and MBNL3, are sequestered into discrete nuclear foci by RNA repeat expansions, preventing interactions with endogenous RNA targets and compromising their activity. (ufl.edu)
  • citation needed] Currently, nine neurologic disorders are known to be caused by an increased number of CAG repeats, typically in coding regions of otherwise unrelated proteins. (wikipedia.org)
  • Many are located in non-coding parts of the human genome and therefore do not produce proteins, but they can also be located in regulatory regions and coding regions. (wikipedia.org)
  • specific genes
  • This and additional evidence supports the hypothesis that loss of MBNL1 function in DM causes defects in the alternative splicing of specific genes during postnatal development which leads to distinct pathological features in adult-onset disease, including myotonia and insulin insensitivity. (ufl.edu)
  • Category I includes Huntington's disease (HD) and the spinocerebellar ataxias that are caused by a CAG repeat expansion in protein-coding portions of specific genes. (wikipedia.org)
  • Markers
  • HD , the Huntington's disease gene, was the first autosomal defect mapped using only DNA markers, a finding in 1983 that helped to spur similar studies in many other disorders and contributed to the concept of the human genome project. (beds.ac.uk)
  • Markers of an X reactivation event were examined: X gene dosage, expression, and methylation in 8 ovarian cancer cell lines. (ubc.ca)
  • Thus, STR markers with longer repeat units are more robust in distinguishing Y chromosome haplogroups and, in some cases, phylogenetic splits within established haplogroups. (blogspot.com)
  • Development of microsatellite markers from the conserved genomic regions are being worthwhile for reviewing the genetic diversity of closely related species or self-pollinated species. (beds.ac.uk)
  • Although several SSR markers have been reported, in tea, the trait-specific Simple Sequence Repeat (SSR) markers, leading to be useful in marker assisted breeding technique, are yet to be identified. (beds.ac.uk)
  • Among different markers used in crop improvement and molecular breeding technique, microsatellite markers are profoundly used for its reliability and time saving method. (beds.ac.uk)
  • The increasing availability of DNA amplification by PCR at the beginning of the 1990s triggered a large number of studies using the amplification of microsatellites as genetic markers for forensic medicine, for paternity testing, and for positional cloning to find the gene underlying a trait or disease. (wikipedia.org)
  • Thus
  • The Mre11 complex thus appears to be directly involved in removing CAG or CTG hairpins that arise frequently during DNA synthesis accompanying gene conversion of these trinucleotide repeats. (embopress.org)
  • Micro RNAs are short, non-coding RNA molecules, involved in post transcriptional mode of gene regulation and thus effects on related phenotype. (beds.ac.uk)
  • Thus, the phenotype of traits linked to genes found in either chloroplasts or mitochondria are determined exclusively by the maternal parent. (wikipedia.org)
  • myoglobin
  • Molecular characterization, phylogenetic analysis and expression profiling of myoglobin and cytoglobin genes in response to heat stress in channel catfish Ictalurus punctatus. (auburn.edu)
  • interspersed repetitive
  • The residual fifth is moderately to highly repetitive, and can be divided into two types, depending on whether the individual repeat units are dispersed singularly (interspersed repetitive DNA) or clustered together (satellite DNA). (bmj.com)
  • There are several families of interspersed repetitive DNA, although the two largest are known as short and long interspersed nuclear elements (SINEs and LINEs, respectively), 1 and it is to the SINE family that the frequently mentioned Alu repeat belongs. (bmj.com)
  • relatively
  • Homo sapiens remained restricted to Africa and the Middle East until about 60,000 - 70,000 years ago, when a relatively small group of humans departed from eastern Africa across the mouth of the Red Sea and migrated into Asia and Europe. (brainscape.com)
  • Huntington's
  • Another example of Huntington's disease (HD) was found as an irregular distribution of polyglutamine expansions (CAG repeats) located within the coding regions of Huntingtin (HTT) gene, and the excessive repeat number caused the symptoms of genetic neurological disease which appeared at an earlier stage [ 6 ]. (hindawi.com)
  • For almost three decades, Huntington's disease has been a prototype for the application of genetic strategies to human disease. (beds.ac.uk)
  • chromosomal
  • In fact "functional DNA", consisting of transcribed genes and regions involved either in transcriptional regulation or in maintaining chromosomal structure/integrity, is thought to comprise less than a sixth of the total human genome. (bmj.com)
  • genome
  • A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance. (auburn.edu)
  • My thesis aims to gain insights into the genes regulating NPC proliferation using a phenotypic-driven, genome-wide approach. (ubc.ca)
  • Sequential breakdown of the human genome into component DNA types. (bmj.com)
  • Microsatellites occur at thousands of locations within an organism's genome. (wikipedia.org)
  • Microsatellites are distributed throughout the genome. (wikipedia.org)
  • This was demonstrated in the land crab Gecarcinus lateralis, whose genome contains 3% of a GC-rich sequence consisting of repeats of a ~2100 base pair (bp) sequence called RU. (wikipedia.org)
  • disorder
  • Myotonic dystrophy (DM) may be the most variable human disorder described, affecting every age group from newborns to the adult-onset form which can range from adolescent manifestations to late-onset disease. (ufl.edu)
  • QTLs
  • These QTLs are hypothesized to harbor genes important for NPC proliferation and downstream experimentation is required to validate the function of these genes. (ubc.ca)
  • locus
  • We propose that successive intrastrand deletions generated the initial repeat structure, and gene conversions increased the size of each tandem repeat locus. (biomedcentral.com)
  • Overexpression of Mre11p or Rad50p suppresses the inhibition of DSB repair by CAG 98 and significantly increases the average size of expansions found at the recipient locus. (embopress.org)
  • regulatory
  • Complement regulatory protein genes in channel catfish and their involvement in disease defense response. (auburn.edu)
  • foci
  • If the repeat is present in an intron it can cause toxic effects by forming spherical clusters called RNA foci in cell nuclei. (wikipedia.org)
  • mechanism
  • Since that time, extensive investigations into the pathogenic mechanism have utilized the knowledge of the disease gene and its defect but, with notable exceptions, have rarely relied for guidance on the genetic findings in human patients to interpret the relevance of findings in non-human model systems. (beds.ac.uk)
  • overexpression
  • Partial or complete reactivation of the inactive X in females may be a step in breast and ovarian cancer progression, leading to overexpression of some tumour enhancing gene. (ubc.ca)
  • phenotype
  • However, the human patient still has much to teach us through a detailed analysis of genotype and phenotype. (beds.ac.uk)
  • androgen receptor
  • We investigated the association between polymorphism in the androgen receptor ( AR ) and vitamin D receptor ( VDR ) genes and breast cancer risk in a large population-based case-control study of genetically homogenous Swedish women. (aacrjournals.org)
  • base-pairs
  • AT in ATATATATAT) is repeated at least three times, (3) there are only few base pairs that do not match the periodic motif (see Methods). (biomedcentral.com)
  • Four divergent domains consisted of microsatellite repeats biased in composition with purines on one strand and pyrimidines on the other, including mononucleotide repeats of C:G base pairs approximately 20 bp in length. (wikipedia.org)
  • Between the strand-biased microsatellite repeats and G:C mononucleotide repeats, all sequence variations retained one or two base pairs with A (purine) interrupting the pyrimidine-rich strand and T (pyrimidine) interrupting the purine-rich strand. (wikipedia.org)
  • tumor
  • Expression of tumor suppressor genes in channel catfish after bacterial infections. (auburn.edu)
  • These data suggest a closer scrutiny of tumor suppressors with homopolymeric runs with proximal repeats as the potential drivers of oncogenesis in mismatch repair defective cells. (g3journal.org)
  • Identification
  • Channel catfish hemoglobin genes: Identification, phylogenetic and syntenic analysis, and specific induction in response to heat stress. (auburn.edu)
  • The search for the genetic defect itself pioneered many mapping and gene-finding technologies, and culminated in the identification of the HD gene, its mutation and its novel protein product in 1993. (beds.ac.uk)
  • adjacent
  • Interestingly, 5% of the single base pair substitutions might represent double-slippage events that occurred at the junction of immediately adjacent repeats, resulting in a shift in the repeat boundary. (g3journal.org)
  • In all RU variants examined, tandem repeats of the CGCAC:GTGCG sequence motif were also found adjacent to a C:G mononucleotide repeat within one of the repetitive pyrimidine:purine divergent domains. (wikipedia.org)
  • disorders
  • however, they are extremely useful in such fields as forensic DNA profiling and genetic linkage analysis, which can be used to search for genes involved in a wide range of disorders. (bmj.com)
  • These disorders are characterized by autosomal-dominant mode of inheritance (with the exception of spino-bulbar muscular atrophy, which shows X-linked inheritance), midlife onset, a progressive course, and a correlation of the number of CAG repeats with the severity of disease and the age at onset. (wikipedia.org)
  • Expression
  • Expression of nitric oxide synthase (NOS) genes in channel catfish is highly regulated and time dependent after bacterial challenges. (auburn.edu)
  • As proof of concept, a candidate gene called Galanin receptor 2 (Galr2) in the Chr 11 QTL was demonstrated to be a pro-proliferative regulator of NPCs using in vitro techniques manipulating Galr2 expression and Galr2 knockout mice. (ubc.ca)
  • Paracoccidioides gene expression during morphogenesis, and the events in hormone-mediated block, are under study with DNA microarray technology. (stanford.edu)
  • Expression levels of 8 X-linked genes were assessed by real-time PCR. (ubc.ca)
  • Expression was inconsistent between different genes and among cell lines, ranging from a 2 to 300-fold increase compared to a control. (ubc.ca)
  • Overall, expression was greatly increased for genes subject to inactivation but not increased in genes that escape inactivation for most ovarian cancer cell lines. (ubc.ca)
  • Nevertheless, several interesting hypotheses exist suggesting that certain microsatellites may exert subtle influences on the regulation of gene expression. (bmj.com)
  • Our working hypothesis is that MBNL genes show distinct temporal and spatial expression patterns that influence age-of-onset and disease-associated pathological changes. (ufl.edu)
  • We conclude that Mbnl3 null lines must be created to determine if expression of this Mbnl gene is essential for normal embryonic muscle development. (ufl.edu)
  • Overall, these results demonstrate that MBNL1 is an alternative splicing factor that regulates gene expression during postnatal life while MBNL3 expression is essential for normal myogenic differentiation in vitro and possibly in vivo. (ufl.edu)
  • This combination functions as a transcription complex to turn on androgen gene expression. (wikipedia.org)