MethylInsecticidesDiazinonMetaboliteInsecticideIntoxicationAtrazinePolymorphismsCytochromeLiverGenesParaquatPesticidesHepaticProteinsExposureAbsorptionDoseNerveChemicalsSarinVivoConcentrationExposures2019SkinMolecularTissuesExperimentalNIEHSMonkeyEffectsApplicationsPopulationDepartment of HealtConsistentCellsResearchDevelopmentDaysAheadDataResult
Methyl12
- For many pesticides, including methyl parathion (MP), there is software. (nih.gov)
- 1979. Separation of methyl parathion and fenitrothion metabolites by liquid chromatography. (cdc.gov)
- 2000. Placental transfer and pharmacokinetics of a single dermal dose of [14C] methyl parathion in rats. (cdc.gov)
- Studies on adsorption and desorption of methyl parathion on humic substances. (cdc.gov)
- Stability of commercial formulation of fenitrothion, methyl parathion, and parathion in anaerobic soils. (cdc.gov)
- 2000. Monitoring methyl parathion residues in milk and yogurt, and fate of [14C] methyl parathion during milk processing. (cdc.gov)
- Movement of methyl parathion, lindane and atrazine through lysimeters in field conditions. (cdc.gov)
- The influence of fly ash on hydrolysis, degradation and adsorption of methyl parathion in aqueous soil suspensions. (cdc.gov)
- 1975. [Effect of methyl parathion or zineb administration on the activity of some hepatic enzymes in rats]. (cdc.gov)
- The specific organophosphorus insecticides with urinary metabolites measured are chlorpyrifos and chlorpyrifos-methyl (3,5,6-trichloro-2-pyridinol or TCPy), diazinon (2,-isopropyl-4-methyl-6-hydroxypyrimidine or IMPY), malathion (malathion dicarboxylic acid or MDA), and methyl and ethyl parathion (para-nitrophenol or PNP). (cdc.gov)
- Methyl parathion has extremely limited agricultural use, and ethyl parathion is no longer registered for use in the U.S. Each of these measured urinary metabolites can also result from environmental degradation of the parent organophosphorus insecticide. (cdc.gov)
- PM, pirimiphos-methyl-oxon (PMO), and phosphorylated tyrosine (Tyr) adducts derived from human serum albumin were analyzed in vivo. (inrae.fr)
Insecticides4
- Because pyrethroid insecticides are widely used in the U.S. population, measuring urinary pyrethroid metabolites is important to evaluate human exposure and potential for health effects. (cdc.gov)
- Human metabolism of these organophosphorus insecticides results in the specific metabolites named above, dialkylphosphate metabolites, and other metabolites, all which are eliminated in urine over a few days. (cdc.gov)
- 1999 In case of a human contact with foodstuffs or aerosols of OP insecticides the salivary glands will be a most likely target within the oral cavity. (tam-receptor.com)
- Parathion is an ingredient of organic phosphate insecticides widely used in this country. (e-cep.org)
Diazinon1
Metabolite2
- 12. Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. (nih.gov)
- 2012 Paraoxon (PX) may be the oxidative metabolite of parathion (System 1) an inhibitor of AChE and it has been used being a model OP substance to research and recognize toxicologically relevant goals in cell lines of neuronal origins (Bharate et al. (tam-receptor.com)
Insecticide1
- Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. (antibodies-online.com)
Intoxication2
Atrazine1
- have demonstrated that isolated LDs from rapeseed were capable of effective extraction of some hydrophobic pollutants such as atrazine, carbaryl, parathion, naphthalene, and 2-phenylethanol from aqueous environments. (frontiersin.org)
Polymorphisms1
- Polymorphisms in metabolism and repair genes affects DNA damage caused by open-cast coal mining exposure. (cdc.gov)
Cytochrome9
- Inactivation of rat liver cytochrome P-450 by the suicide substrates parathion and chloramphenicol. (nih.gov)
- 1. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. (nih.gov)
- 3. Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies. (nih.gov)
- 5. In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). (nih.gov)
- 7. Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. (nih.gov)
- 8. Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9. (nih.gov)
- 11. In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. (nih.gov)
- 15. Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole. (nih.gov)
- 19. Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. (nih.gov)
Liver6
- Arginine and Proline metabolism by the liver. (nih.gov)
- 2. Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. (nih.gov)
- 6. Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. (nih.gov)
- 14. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. (nih.gov)
- 16. Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver. (nih.gov)
- 17. Characterization of dextromethorphan N-demethylation by human liver microsomes. (nih.gov)
Genes3
- The EGP catalogues single nucleotide variation (also called SNPs) in environmentally-responsive genes in the human genome and carries out research on the biological implications of such genetic variation. (nih.gov)
- The second phase of resequencing will include genes regulating metabolism, signal transduction and apoptosis. (nih.gov)
- These interactions involved parathion and terbufos use and three vitamin D genes (VDR, RXRB, and GC). (nih.gov)
Paraquat1
- Thus, hers was the first study to show that a combination of maneb and paraquat exposures in this human population increased Parkinson's risk. (nih.gov)
Pesticides3
- Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. (nih.gov)
- This method can be used to assess human exposure to select non-persistent pesticides by measuring their metabolites in urine. (cdc.gov)
- They include traditional chemical warfare nerve agents such as sarin and VX, and toxic industrial chemicals and pesticides such as cyanide, chlorine, parathion, and sodium fluoroacetate. (nih.gov)
Hepatic1
- 4. Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype. (nih.gov)
Proteins1
- A previously developed method employing the use of a dialysis membrane in series with human dermis tissue mounted in side-by-side diffusion cells was utilized to observe the effects of the presence of soluble proteins in the donor compartment on the measured transport parameters of parathion. (cdc.gov)
Exposure5
- Lys degradation molecular toxicological consequences of exposure in humans. (nih.gov)
- 18. Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium. (nih.gov)
- Health Sciences (NIEHS) in 1998 to improve understanding of human genetic susceptibility to environmental exposure. (nih.gov)
- Two determinations must be made when a physician responds to a patient's concerns about a specific exposure: (1) whether any quantity of the toxicant has known adverse effects on reproduction in humans and (2) whether the substance is present in sufficient quantity to affect the patient or population exposed. (medscape.com)
- Adjustments to the POD are made to account for uncertainties and to protect the most sensitive human population at risk of exposure to the chemical(s). (cdc.gov)
Absorption1
- A panel of experts in physiologically based pharmacokinetic dependent on rates of absorption, distribution, metabolism, and (PBPK) modeling and relevant quantitative methods was convened excretion (ADME). (cdc.gov)
Dose2
- Human health risk assessments (HHRAs) use the dose- at Stephen B. Thacker CDC Library on August 19, 2014 models and the supporting computer code is necessary for their response relationship to characterize and quantify potential health consideration for use in HHRAs. (cdc.gov)
- Two specific case study examples are animal-to-human extrapolation of dose-response information. (cdc.gov)
Nerve1
- Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. (nih.gov)
Chemicals2
- The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. (inchem.org)
- These chemicals adversely affect human health, especially for vulnerable population such as the elderly, pregnant women, fetuses, and children. (ommegaonline.org)
Sarin1
- Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radić Z. (2015) Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. (nih.gov)
Vivo1
- The scope of research supported by this FOA includes development of appropriate human-relevant animal models and generation of in vivo efficacy data consistent with the intended use of the product in humans. (nih.gov)
Concentration2
- D-Arginine and D-Ornithine metabolism highest concentration tested. (nih.gov)
- These results: a) demonstrate that CoMet is a valuable method to identify potential compounds for experimental validation, b) indicate that cancer cell metabolism may be regulated to reduce the intracellular concentration of certain antiproliferative metabolites, leading to uninhibited cellular growth and c) suggest that many other endogenous metabolites with important roles in carcinogenesis are awaiting discovery. (biomedcentral.com)
Exposures2
- NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
- Human health effects from dimethoate or omethoate at low environmental doses or at biomonitored levels from low environmental exposures are unknown. (cdc.gov)
20192
Skin1
- Scientists with CPSC , FDA , and NIEHS and collaborators compiled such a data set for human skin sensitization potential by collecting data from the scientific literature for human predictive patch tests that used the human maximization or human repeated insult patch test protocols. (nih.gov)
Molecular1
- The results are discussed in the context of a predictive model for partitioning and transport of low molecular weight solutes in human dermis. (cdc.gov)
Tissues1
- Dioxins are highly lipophilic and bioaccumulate in fatty tissues of marine organisms used for seafood where they constitute a potential risk for human health. (frontiersin.org)
Experimental1
- This article will facilitate the anatomical identification and comparison of experimental data involving the human vmPFC. (cdk-receptor.com)
NIEHS1
- The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
Monkey1
- Find PON1 ELISA Kits for a variety of species such as anti-Human PON1, anti-Mouse PON1, anti-Monkey PON1. (antibodies-online.com)
Effects2
- Arginine and Proline metabolism midobutanoic acid, cis-4-hydroxy- documented effects reported are from epidemiological studies in adult humans the formula. (nih.gov)
- This issue is complicated in humans by the high natural spontaneous abortion rate of 15-30%, which makes determining the specific reproductive effects in humans difficult without studying large groups. (medscape.com)
Applications2
- Jorde pointed out that knowledge of human genetic variation is important because it has applications in medicine and forensics, and because it can be informative about the evolutionary history of the human population. (nih.gov)
- The issue also includes ToxSpotlight articles on how cryopreserved human precision-cut lung slices can be a relevant model for use in regulatory applications and how lipid dysregulation may be associated with progression of silica-induced pulmonary fibrosis. (toxicology.org)
Population1
- In addition, the African population has the highest level of diversity, suggesting it is more ancient than other human populations. (nih.gov)
Department of Healt2
- There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. (nih.gov)
- As part of the Department of Health and Human Services' implementation of e-Government the NIH will gradually transition each research grant mechanism to electronic submission through Grants.gov and the use of the SF 424 Research and Related (R&R) forms. (nih.gov)
Consistent1
- This is consistent with the idea that the human race evolved first on the African continent and then spread to other continents. (nih.gov)
Cells1
- Pyruvate metabolism stem cells. (nih.gov)
Research1
- In April 2003, the National Human Genome Research Institute (NHGRI) and the National Institutes of Health (NIH) celebrated the 50th anniversary of Watson and Crick's Nobel Prize-winning work on the double-helical structure of DNA and the completion of a final version of the sequence of the human genome. (nih.gov)
Development1
- The development of the human blood-CSF-brain barrier. (cdc.gov)
Days1
- Human metabolism of pyrethroids occurs rapidly, and metabolites are eliminated in urine and bile over several days. (cdc.gov)
Ahead1
- steer contact with OP oxons might occur ahead of metabolism Therefore. (tam-receptor.com)
Data1
- Because humans are the primary subject of interest for regulatory safety testing, it is advantageous to have human reference data available for evaluation of NAMs for assessing chemical safety. (nih.gov)
Result1
- Some people have variations, or alleles, of that gene that result in slower OP metabolism. (nih.gov)