Human interleukin 2. Medical search. Frequent questions

In a series of studies designed to extend our understanding of interleukin-2 (IL-2) and to study the effect of biologic response modifiers on bone marrow, we observed that administering recombinant human (rH) IL-2 to normal mice resulted in an increase in the frequency of colony-forming units-culture (CFU-C) in bone marrow. (nebraska.edu)
Quantitative binding studies and Scatchard plot analysis using radiolabeled recombinant human (rh) IL-2 indicated the presence of 12,000 +/- 4,700 low affinity IL-2 binding sites (kd = 66 nmol/L) per purified CGL basophil. (ashpublications.org)
Effect of targeted erythrocytes coated with recombinant human interleukin 2 on T-lymphocyte proliferation in vitro. (tamu.edu)
Mouse red blood cells (RBC) were incubated with recombinant human interleukin 2 (rIL 2) in protein-free media. (tamu.edu)
Tiago dos Reis Matos, MD, PhD, MSc , Amsterdam University Medical Centers, Amsterdam, the Netherlands, who was not involved in the study, told Medscape Medical News that "recombinant human interleukin-2 is an original therapy. (medscape.com)

HSB.2 subclones exhibited IL 1-dependent production of a variety of lymphokines other than IL 2, e.g., interferon-gamma (IFN-gamma), B cell growth factor (BCGF), and colony-stimulating factor (CSF). (aai.org)
Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. (cdc.gov)

PPD-induced expression of T cell IL-2 receptors was 5.9 times less in peripheral blood mononuclear cells of patients with tuberculosis as compared with healthy tuberculin reactors. (rupress.org)
Our results show that human blood basophils synthesize and express receptors for IL- 2. (ashpublications.org)
Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. (rndsystems.com)
2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)

Activated T-lymphocytes play an important role in asthma pathogenesis and release soluble interleukin-2 receptor (sIL-2R), which can be detected in the serum. (ersjournals.com)
sIL-2R, soluble interleukin 2 receptor. (cdc.gov)
Interleukin-1 alpha, soluble interleukin-2 receptor, and IgG concentrations in cystic fibrosis treated with prednisolone. (bmj.com)
In investigating T cell function, it was found that the administration of CMF led also to a similarly prolonged impairment of phytohemagglutinin (PHA-)stimulated soluble interleukin 2 receptor (sIL-2R) production and to a decrease in the proliferation of peripheral blood mononuclear cells following mitogenic stimulation with PHA. (curehunter.com)

Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. (wikipedia.org)
Immunoprecipitation experiments with lysates of purified CGL basophils and CD25 MoAbs showed a protein with a molecular weight of 60 Kd, equivalent to the Tac peptide on human T blasts. (ashpublications.org)
When rIL 2-coated RBC (RBC-IL2) were incubated in protein-containing media for 24 h to release the majority of bound rIL 2, and then were subsequently incubated in fresh media with an IL 2-dependent cytotoxic T cell line (CTLL), residual bound rIL 2 was still released as demonstrated by CTLL proliferation. (tamu.edu)
Interleukin-1 receptor-related protein 2. (invivogen.com)
The aim of the present study was to determine whether a relationship exists between the severity of early-onset overuse-related MSDs of the upper extremity and serum levels of IL-1beta (interleukin-1beta), TNF-alpha (tumour necrosis factor-alpha), IL-6 (interleukin-6) and CRP (C-reactive protein). (cdc.gov)
Detection of the Tau protein in human serum by a sensitive four-electrode electrochemical biosensor. (mdx.ac.uk)

Recombinant Interleukin-2 (IL-2) is expressed in E. coli and has been engineered to contain the serine for cysteine substitution found in Proleukin ® (aldesleukin). (rndsystems.com)

some mice were given dextran sodium sulfate to induce colitis, with or without a FFAR2 agonist or an antibody against interleukin 27 (IL27). (nih.gov)
The capture antibody is a monoclonal human IL-2 antibody pre-coated onto the 96-well strip plates provided in the kit. (biosensis.com)
Human test samples and standards of known IL-2 concentration are added to these wells and allowed to complex with the bound IL-2 antibody. (biosensis.com)
A biotinylated human IL-2 polyclonal antibody is then added. (biosensis.com)
RBC were covalently coupled to specific monoclonal antibody (mAb) towards the lymphocyte cell-surface marker Thyl.2, coated with rIL 2, subsequently exposed to the target CTLL cells, then evaluated for CTLL/RBC rosette formation. (tamu.edu)
The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-20. (caslab.com)
Then a biotinylated detection antibody specific for Human IL-20 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
Only those wells that contain Human IL-20, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
antigen test results, and antibody testing might be needed to The references were reviewed to identify additional relevant confirm previous SARS-CoV-2 infection. (cdc.gov)

PBMC stimulated with 1 μg/mL of aCD3 and 3 ug/ml of aCD28 for 2 days were treated with Tocris cell activation cocktail 500x (Catalog # 5476 ) and Brefeldin A (Catalog # 1231/5 ) for 3 hours or naïve PBMC lymphocytes. (rndsystems.com)
THP-1 cells can also restore the response of purified T lymphocytes to Concanavlin A, show increased CO 2 production on phagocytosis and can be differentiated into macrophage-like cells using for example DMSO. (sigmaaldrich.com)
Human recombinant interleukin-2 activated sheep lymphocytes lyse sheep pulmonary microvascular endothelial cells. (hopkinsmedicine.org)
To investigate whether carbamate pesticides also induce apoptosis in human T lymphocytes, in the present study Jurkat human T cells were treated in vitro with thiram, maneb, carbaryl or ziram. (researchgate.net)

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. (wikipedia.org)
Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2. (wikipedia.org)
CGL basophils were found to bind CD25 MoAbs (n = 4) directed against different epitopes of the 55- to 60-Kd subunit of the IL-2 receptor (= Tac peptide). (ashpublications.org)
Interleukin-2 receptor alpha chain precursor (IL-2 receptor alpha subunit) (P55) (TAC antigen) (CD25 antigen). (lu.se)

Detection of IL‑2 in PBMC cells by Flow Cytometry. (rndsystems.com)

The purpose of this kit is the in-vitro quantitative determination of human IL-2 in samples such as culture supernatant, serum, plasma (Heparin), plasma (EDTA) and plasma (Citrate). (biosensis.com)
For the quantification of Interleukin-2 (IL-2) in Culture Supernatant, Serum, Plasma (Heparin), Plasma (EDTA), Plasma (Citrate). (biosensis.com)
This ELISA kit applies to the in vitro quantitative determination of Human IL-20 concentrations in Serum, plasma and other biological fluids. (caslab.com)

A second group of patients with low IL-2 production did not have suppressor adherent cells and were clinically distinct, with more extensive disease on chest x ray. (rupress.org)
Interleukin (IL)-15, a major cytokine involved in cross-talk between accessory cells (dendritic cells and macrophages) and NK cells, is produced by epithelial renal cells. (nih.gov)
Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
rH IL-2 does not act only as an immunomodulatory agent in the presence or absence of suppressor T cells, but also accelerates host recovery from cytoreductive agents, resulting in decreased leukopenia and perhaps resistance to secondary infection. (nebraska.edu)
Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. (dadamo.com)
However, the in vivo validation of novel AAV constructs expressing products that act specifically on human cells and tissues is limited by a paucity of effective translatable models. (umassmed.edu)
Humanized mice that are engrafted with human cells, tissues, and immune systems offer strong potential to test the biological effectiveness of AAV vectors on human cells and tissues. (umassmed.edu)
Using the BLT (bone marrow, liver, thymus) humanized NOD-scid Il2rgnull (NSG) mouse model, which enables efficient development of HLA-restricted effector and regulatory T cells (Tregs), we have evaluated the delivery and function of human interleukin (IL)-2 by an AAV vector. (umassmed.edu)
Numbers of activated human natural killer cells were also increased significantly in humanized mice treated with the IL-2 vector. (umassmed.edu)
These data recapitulate observations in clinical trials of IL-2 therapy and collectively show that humanized mouse models offer a translational platform for testing the efficacy of AAV vectors targeting human immune cells. (umassmed.edu)
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. (watson-bio.cn)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Interleukin 2 (IL-2) promotes the proliferation of T cells. (fujifilm.com)
In vitro , Il-2 induces the proliferation and differentiation of CD4+ and CD8+ T cells, and acts as a proliferation factor of effector T cells. (fujifilm.com)
Dissociation of rIL 2 from RBC commenced when the carrier cells were transferred into fresh media. (tamu.edu)
At higher rIL 2 concentrations (1200-1500 i.u./10(8) cells), RBC-IL2 plus Thy1.2 mAb provided higher CTLL response than when RBC-IL2 plus non-specific mAb was used thus demonstrating enhancement by targeting. (tamu.edu)
However, the targeting effects were not seen with lower rIL 2 concentrations (80-110 i.u./10(8) cells). (tamu.edu)
Recombinant IL-2 is widely used in cell culture for the expansion of T cells. (rndsystems.com)
IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). (rndsystems.com)
IL-2 is best known for its autocrine and paracrine activity on T cells. (rndsystems.com)
It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis (1, 2). (rndsystems.com)
IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (9-11). (rndsystems.com)
NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
We previously found that ziram, a carbamate pesticide, significantly reduced perforin, granzyme A (GrA), granzyme B (GrB), granzyme 3/K (Gr3/K), and granulysin (GRN) levels in NK-92MI cells, a human natural killer (NK) cell line. (researchgate.net)
To investigate whether other carbamate pesticides also show similar toxicity on human NK cells, we conducted further exp. (researchgate.net)
We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. (researchgate.net)
In response to a viral infection, intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling, leading to different fates for two subsets of those cells - the one producing IL-2 and the one not producing IL-2. (uab.edu)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

IL12RB2 is its human gene. (wikipedia.org)
Recombinant adeno-associated viruses (rAAVs) serve as vectors for in vivo gene delivery in both mice and humans, and have broad applicability for the treatment of genetic diseases. (umassmed.edu)
But, it is unclear about signal transduction pathway and gene regulatory region of human betadefensin-2 (hBD-2). (ajou.ac.kr)
CONCLUSION: These results indicate there are two effective gene regions that regulate hBD-2 expression by IL-1a between 2.7kbp and 1.1kbp, and 500bp upstream of the translation starting point of hBD-2 in HMEEC-1. (ajou.ac.kr)
인체 중이점막 상피세포주 (HMEEC)에서 인터루킨-1알파 (interleukin-1α)에 의하여 인체 베타 디펜신-2 (hBD-2)의 발현이 증가되는 것과 이 현상에 Src-dependent Raf MEK1/2 ERK 신호전달경로가 관여하는 것은 보고되어있으므로, 신호전달경로 하위의 전사인자나 그 결합부위가 있는 유전자 조절부위(gene regulatory region)를 조사하여 향후 상위 신호전달물질과의 연계를 연구하는데 발판을 마련하고자 하였다. (ajou.ac.kr)
재료 및 방법: Human papilloma virus type16의 oncogene인 E6/E7 gene을 포함하여 만든 정상 인체 중이점막 상피세포주(HMEEC-1)를 이용하였다. (ajou.ac.kr)

Humanized mice treated with an AAV vector expressing human IL-2 showed a significant and sustained increase in the number of functional human FOXP3+CD4+ Tregs. (umassmed.edu)

IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. (prospecbio.com)

1. Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. (dadamo.com)

Disordered regulation of IL-2 metabolism may be a key feature in the depressed cellular immune response of tuberculosis. (rupress.org)
Thus, rH IL-2 plus chemotherapy may increase therapeutic activity against neoplastic disease, not only by adding immune stimulation to the direct antitumor effect of the drug but also by allowing delivery of higher, more effective doses of chemotherapy. (nebraska.edu)
IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. (watson-bio.cn)
Among the innate immunities beta-defensin-2 is known to play an important role in the immune function of middle ear. (ajou.ac.kr)
Graft rejection occurred 2 months after immune reconstitution, requiring readjustment of immunosuppressants. (bvsalud.org)

1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
The expression of human IL-2 did not significantly change the levels or activation status of conventional T-cell subsets. (umassmed.edu)
Cytokine and chemokine expression in humans infected with Sudan Ebola virus. (cdc.gov)
MATERIALS AND METHOD: The expression of hBD-2 by IL-1a in HMEEC (Human Middle Ear Epithelial Cell) was detected by RT-PCR. (ajou.ac.kr)

The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, and the WHO declared it a pandemic on March 11, 2020. (frontiersin.org)
As of December 27, 2020, the number of SARS-CoV-2 cases globally had eclipsed 8,06,78,170, mainly exceeding the total number of SARS cases during the 2003 epidemic and more than 17,63,106 people had now died. (frontiersin.org)
On October 2, 2020, this report was posted as an MMWR Early cases. (cdc.gov)
On 9 January 2020, WHO issued the absence of a vaccine, despite major efforts both a statement warning of the `risk' of human-to-human publicly and commercially, and no definitive treatment transmission, although China did not report such a meth- despite the use of antimalarial drugs, antibiotics, od of transmission ( 2 ). (who.int)

Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)

In addition, rH IL-2 was able to accelerate host recovery from cyclophosphamide (CTX)- or radiation-induced bone marrow depression and peripheral blood leukopenia. (nebraska.edu)

More than 40 patients were randomly assigned to receive one of two doses of a highly selective recombinant interleukin (IL)-2 conjugate, rezpegaldesleukin or placebo for 12 weeks, after which responders were observed out to 48 weeks. (medscape.com)

and 5) absence of severe respiratory illness (to concurrently received positive test results for SARS-CoV-2, exclude patients in which inflammation and organ dysfunc- the virus that causes COVID-19, by polymerase chain reaction tion might be attributable simply to tissue hypoxia). (cdc.gov)

The receptor for IL-2 consists of three subunits (55 kDa IL2Ralpha, 75 kDa IL2Rβ, 64 kDa common gamma chain gammac/IL2Rgamma) that are present on the cell surface in varying preformed complexes. (watson-bio.cn)
The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). (rndsystems.com)

Interleukin 1 (IL 1)-dependent lymphokine production by human leukemic T cell line HSB.2 subclones. (aai.org)
The HSB.2 subclones thus selected will provide a useful model for delineating the mechanism of IL 1-dependent lymphokine(s) production, and are a promising candidate for better lymphokine(s) producers. (aai.org)

None of the subclones that were obtained produced IL 2 constitutively, and only a low level of IL 2 was produced by the stimulation of these subclones with phytohemagglutinin (PHA) alone. (aai.org)

Abbott Nasal Self test 25 sterile nasal swabs a box Panbio™ COVID-19 Ag Home Test Device 41FK11/41FK21 In vitro diagnostic rapid test for qualitative detection of SARS-CoV-2 antigen. (gen9bio.com)

Cancer Research Communications (2022) 2 (8): 894-903. (aacrjournals.org)

The attachment of mAb to the RBCs surface did not markedly change the succeeding rIL 2 adsorption, and the bound rIL 2 did not impair antigen recognition by the mAb. (tamu.edu)

During the course of the coronavirus disease 2019 (COVID-19) ings, complications, laboratory test results including those pandemic, reports of a new multisystem inflammatory syn- from SARS-CoV-2 testing, imaging findings, treatments, drome in children (MIS-C) have been increasing in Europe and outcomes. (cdc.gov)

We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. (lu.se)

Mean PPD-induced IL-2 activity was 81.2% lower in patients as compared with healthy tuberculin reactors. (rupress.org)
Thus, multiple mechanisms are responsible for the synergistic therapeutic activity associated with rH IL-2 and CTX. (nebraska.edu)
Although several subclones were found to produce IFN-gamma and BCGF simultaneously with minimal IL 2 activity, no subclones with an exclusive BCGF production were obtained. (aai.org)
Furthermore, when supernatants from the stimulated A7-D9 subclone were applied to an Ultro-gel AcA54 gel chromatography, it was revealed that IL 2 activity (m.w. 17K to 18K) and IFN-gamma (40K to 45K) were clearly separated, whereas two peaks of BCGF activity coincided with each peak of IL 2 and IFN-gamma, respectively. (aai.org)
Human and mouse IL-2 exhibit cross-species activity. (watson-bio.cn)
and interleukin-2 (IL-2), which is important for retaining high T cell activity at the tumor. (nature.com)

Product Description google The human Interleukin 2 (IL-2) Kit is a sandwich ELISA. (biosensis.com)
Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
Detects human IL-2 in direct ELISA. (rndsystems.com)

It is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in patients weighing at least 35 kg. (who.int)
The patient had no history of human immunodeficiency virus infection. (bvsalud.org)

The clinical respiratory journal 2007 Dec 1 (2): 74-9. (cdc.gov)

In this study we present the biochemical characterization of the interleukin-2 (IL-2) receptor on the basophil surface membrane. (ashpublications.org)

Not only can rH IL-2 accelerate, in a dose-dependent manner, the return of bone marrow, peripheral blood cellularity, and CFU-C frequency to normal levels following cytoreduction by CTX or irradiation, but it also significantly increases CFU-C frequency to greater than normal levels. (nebraska.edu)
Cloning of a human T cell leukemic cell line, HSB.2, was performed by a limiting dilution method to obtain clones with high levels of IL 2 production. (aai.org)
High levels of IL 2 production (greater than 300 U/ml) were observed in several clones when stimulated with a cocktail of PHA and IL 1. (aai.org)
We observed that subclones with high IL 2-producing capacity tended to produce high levels of IFN-gamma or BCGF as well, while the capacity of CSF production was not parallel to these properties. (aai.org)
Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)

Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast. (mdx.ac.uk)

Patients with newly diagnosed, pulmonary tuberculosis had a tuberculin-specific defect in IL-2 production. (rupress.org)
Furthermore, purified IL-2 failed to correct PPD-induced blastogenesis in patients. (rupress.org)
Clinical characteristics and epidemiology features of patients infected with SARS-CoV-2 have been explored in the previous study. (frontiersin.org)
However, little is known about the combinative association of liver dysfunction and abnormal interleukins (ILs) in severe patients with COVID-19. (frontiersin.org)
This study integrated liver function data and ILs data in patients with COVID-19 and found that liver injury and two ILs, interleukin-2 receptor (IL-2R) and interleukin-6 (IL-6), were closely related to the prognosis of patients with COVID-19. (frontiersin.org)
Meanwhile, abnormal interleukins (ILs) were detected in patients with severe SARS-CoV-2 compared with those with milder infections ( 9 , 10 ). (frontiersin.org)
only 2 patients required surgical intervention for local progression or symptoms. (medscape.com)
Despite this aggressive treatment, median survival of glioblastoma patients is only about 15 months, and recurrence remains almost inevitable ( 1 , 2 ). (frontiersin.org)
These patients might not have positive SARS-CoV-2 PCR or when no abstract was available, the full paper was examined. (cdc.gov)

In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human. (dadamo.com)

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. (rupress.org)
adherent cell depletion increased their T cell production of IL-2 7.2-fold. (rupress.org)
The basis for low IL-2 production in such individuals is unknown. (rupress.org)
Among them, HSB.2-A7-D2, A7-D9, or C5-B2 subclones, which were selected after cloning twice, were most effective in IL 1-dependent IL 2 production. (aai.org)

The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. (rndsystems.com)

Anatomy43

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Protein7

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