Human gata1 mrna gata1 transcription factor. Medical search. Frequent questions

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. (wikipedia.org)

Our lab has previously identified the first non-ribosomal protein mutations in DBA in the erythroid transcription factor GATA1 (Sankaran et al. (simplyblood.org)
Previously, we observed that transcription factor RUNX1 mutations ( RUNX1 -MT) coexisted with ASXL1 -MT in CMML and at myeloid blast phase of chronic myeloid leukemia. (biomedcentral.com)
Both disorders are characterised by recurring truncating somatic mutations of the GATA1 gene, which are considered key pathogenetic events. (smj.org.sg)
We herein report, to our knowledge, the first observation on the frequency and nature of GATA1 gene mutations in a cohort of Malaysian children with DS-associated TAM (n = 9) and ML-DS (n = 24) encountered successively over a period of five years at a national referral centre. (smj.org.sg)
Of the 29 patients who underwent GATA1 analysis, GATA1 mutations were observed in 15 (51.7%) patients, including 6 (75.0%) out of 8 patients with TAM, and 9 (42.9%) of 21 patients with ML-DS. (smj.org.sg)
The low frequency of GATA1 mutations in ML-DS patients is unusual and potentially indicates distinctive genomic events in our patient cohort. (smj.org.sg)
8 ) An additional shared, critical pathogenetic event involves the acquisition of characteristic somatic mutations in the GATA1 gene. (smj.org.sg)
These mutations, involving exons 2 or 3 of the GATA1 gene, result in synthesis of an aberrant truncated isoform (termed short GATA1 or GATA1s ) that is putatively oncogenic. (smj.org.sg)
10 ) The mechanistic basis for somatic GATA1 mutations and the additional molecular events that determine progression from TAM to ML-DS are the focus of intense research. (smj.org.sg)
This observational study attempts to characterise, for the first time, to our knowledge, the frequency and nature of somatic GATA1 mutations in DS children with TAM and ML-DS, encountered consecutively over a period of five years at a national paediatric oncology referral centre in Malaysia. (smj.org.sg)
The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53's critical role in PDAC suppression. (uni-saarland.de)

9 ) The gene, located on chromosome X ( Xp11.23 ), encodes a key haematopoietic transcription factor involved in erythroid and megakaryocyte differentiation. (smj.org.sg)

GATA1 codes for two zinc finger structural motifs, C-ZnF and N-ZnF, that are present in both GATA1 and GATA1-S proteins. (wikipedia.org)
Based primarily on mouse studies, it is proposed that the GATA1-FOG1 complex promotes human erythropoiesis by recruiting and binding with at least two gene expression-regulating complexes, Mi-2/NuRD complex (a chromatin remodeler) and CTBP1 (a histone deacetylase) and three gene expression-regulating proteins, SET8 (a GATA1-inhibiting histone methyltransferase), BRG1 (a transcription activator), and Mediator (a transcription co-activator). (wikipedia.org)
While transcription factors bind and recruit chromatin-modifying and remodeling proteins, the relative contribution of individual cis elements residing within clusters of cis elements to the transcriptional control of endogenous loci is incompletely understood. (prolekarniky.cz)
Their studies centered on mice missing delicate mental retardation gene (FMR1), which is another proteins that affects translation mRNA. (researchensemble.com)
One of the unexpected findings of the Human Genome Project was that over 98% of the human genome does not encode for proteins. (pharmaceuticalintelligence.com)

The covalent modification of histones to yield specific histone marks promotes either the activation or repression of transcription [3] . (prolekarniky.cz)

Nature Medicine, 2014) and was subsequently able to show that ribosomal protein haploinsufficiency results in selective impairment of GATA1 mRNA translation (Ludwig et al. (simplyblood.org)
These pathways involve mTOR-dependent activation of the 70 kDa ribosomal protein S6 kinase (p70S6K) as well as the inactivation of the repressor of mRNA translation, eukaryotic initiation element 4E (eIF4E) binding protein (4EBP) [1,2]. (researchensemble.com)
In 2014, Dr. Crispino suggested that in MF abnormal TPO signaling induces a ribosomal deficiency hampering GATA1 mRNA translation in MK. (refine.bio)

GATA1 regulates the expression (i.e. formation of the genes' products) of an ensemble of genes that mediate the development of red blood cells and platelets. (wikipedia.org)
The mesenchymal phenotype is associated with high expression levels of Snai1, a zinc-finger transcription factor that regulates metastasis by down-regulating the expression of genes such as E-cadherin ( 17 ). (iiarjournals.org)
Considering that each microRNA regulates up to hundreds of different mRNAs, and that each mRNA is regulated by tens of microRNAs, this finding adds a new layer of complexity to the regulatory dynamics of the human transcriptome. (pharmaceuticalintelligence.com)

Lacking the first 83 amino acids and therefore one of the two activation domains of GATA1, GATA1-S has significantly less gene-regulating activity than GATA1. (wikipedia.org)
mRNA-Seq revealed 1,107 significantly differentially expressed genes, 73 of which were increased 15 DPP and 1,034 were increased 30 DPP. (biomedcentral.com)
Erythrocytic CHCHD2 mRNA was significantly reduced even at the early stages of the disease. (biomedcentral.com)

Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated with promoting the progression of myelofibrosis, i.e. a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e. the extension of blood cell-forming cells to sites outside of the bone marrow. (wikipedia.org)
Studies using mice depleted of their Gata1 gene during adulthood show that: 1) Gata1 is required for the stimulation of erythropoiesis (i.e. increase in red blood cell formation) in response to stress and 2) Gata1-deficient adult mice invariably develop a form of myelofibrosis. (wikipedia.org)
Support for MK GATA1 deficiency as phenotypic modifier in MF was provided by the observation that mice carrying the Gata1low mutation reducing Gata1 transcription in MK develop myelofibrosis. (refine.bio)

Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)
Furthermore, we analysed the 5'-flanking region of the human adipose differentiation-related protein ( adrp ) gene that responded to all subtypes of PPARs. (biomedcentral.com)
In development, lineage-restricted transcription factors simultaneously promote differentiation while repressing alternative fates. (prolekarniky.cz)
Here, we have analyzed cis element regulation of the critical hematopoietic factor Gata2 , which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation. (prolekarniky.cz)
Although Gata2 is normally repressed in late-stage erythroblasts, the −1.8 kb mutation unexpectedly resulted in reactivated Gata2 transcription, blocked differentiation, and an aberrant lineage-specific gene expression pattern. (prolekarniky.cz)

They found that limited availability of ribosomes differentially affects mRNA transcripts, and especially reduces translation of transcripts with short or unstructured 5' UTRs that are necessary for erythropoiesis. (simplyblood.org)
By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult-specific expression, these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. (biomedcentral.com)

Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa B-driven transactivation of the HIF1A gene. (cancerindex.org)

Transcription factors in these networks occupy specific cis elements at target gene loci where they modulate chromatin remodeling and modification, and thereby transcription. (prolekarniky.cz)
For example, GATA-1 directly represses Gata2 transcription via displacing GATA-2 from chromatin sites at its own locus, a process termed a "GATA Switch" [6] , [7] . (prolekarniky.cz)
The lncRNAs have a broader spectrum of functions [ 2 , 3 ] such as regulation of transcription, RNA processing, nuclear-cytoplasmic transport, translation control and modulation of chromatin structure and are, therefore, a potential new class of cancer therapeutic targets [ 4 ]. (biomedcentral.com)

These features are associated with efficient translation in unperturbed conditions and among hematopoietic master regulators relatively uniquely exhibited by GATA1, a key transcription factor of erythropoiesis. (simplyblood.org)

GATA-1 mRNA expression was checked by RT-qPCR in Sirt1 inhibited K562 cells. (magtechjournal.com)
GATA factor cross-regulation represents an instructive model system for investigating the contribution of individual cis elements to the initiation and maintenance of transcriptional repression. (prolekarniky.cz)
The GATA family of transcription factors plays diverse roles in multiple developmental contexts [5] . (prolekarniky.cz)
GATA factors are often expressed in an overlapping but reciprocal pattern, such that expression of one GATA factor increases as expression of another decreases. (prolekarniky.cz)
GATA factor function has been extensively studied in the context of hematopoiesis, where GATA-1, GATA-2, and GATA-3 are key regulators. (prolekarniky.cz)

Description: The AFS98 monoclonal antibody reacts with the mouse CD115 molecule, a receptor for macrophage colony stimulating factor (M-CSF) or colony stimulating factor-1 (CSF-1). (thermofisher.com)
These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)

METHODS: We conducted bioinformatics analysis of the differential expression of CLEC4G in various human organs, carcinomatous and adjacent tissues. (bvsalud.org)
The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)

In this study, we examined whether AdipoR mRNA expression in human myotubes correlates with in vivo measures of insulin sensitivity. (diabetesjournals.org)
AdipoR1 mRNA expression was positively correlated with in vivo insulin and C-peptide concentrations, first-phase insulin secretion, and plasma triglyceride and cholesterol concentrations before and after adjustment for sex, age, waist-to-hip ratio, and body fat. (diabetesjournals.org)
Expression of AdipoR2 mRNA clearly associated only with plasma triglyceride concentrations. (diabetesjournals.org)
In multivariate linear regression models, mRNA expression of AdipoR1, but not AdipoR2, was a determinant of first-phase insulin secretion independent of insulin sensitivity and body fat. (diabetesjournals.org)
Then, mRNA and protein expression levels of CD34 in hepatocellular carcinoma (HCC) samples were detected via real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemical (IHC), respectively. (bvsalud.org)
BRCA2 gene expression is tightly regulated during the cell cycle in human breast cells. (biomedcentral.com)
ZAR2 binds to BRCA2/ZAR2 bi-directional promoter in vivo and is responsible, at least in part, for the silencing of BRCA2 gene expression in the G0/G1 phase in human breast cells. (biomedcentral.com)
Multivariate analysis showed that VGLL3 expression status was an independent risk factor for prognosis. (researchgate.net)
However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. (biomedcentral.com)
Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed us to estimate the proportion of variation in gene expression that could be attributed to genetic and epigenetic variation, both crucial to understanding differences in drug response and the etiology of liver diseases. (biomedcentral.com)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
To identify human PPARs-responsive genes, we established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR and investigated the gene expression profiles of these cells. (biomedcentral.com)
A significant reduction in protein and/or mRNA expression of CHCHD2 was confirmed in PD brains collected at autopsy as well as in the brains of a PD animal model overexpressing α-synuclein, in addition to seeing a reduction of CHCHD2 in erythrocytes of the same animals. (biomedcentral.com)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
More recently, Co-workers and Cost have got implicated particular spine mRNA translation pathways in formalin-induced behavioural hypersensitivity [9]. (researchensemble.com)

By contrast, Hepatocyte growth factor (Hgf), a well-known promoter of epithelial-mesenchymal transitions and a prime target of Matriptase1 activity, plays no major role. (biologists.com)
For example, an individual miRNA may regulate multiple mRNAs, and in contrast, an individual gene may also be regulated by multiple miRNAs, thus representing a complex network of miRNA-mRNA interactions. (biomedcentral.com)

It is 7.74 kilobases in length, consists of 6 exons, and codes for a full-length protein, GATA1, of 414 amino acids as well as a shorter one, GATA1-S. GATA1-S lacks the first 83 amino acids of GATA1 and therefore consists of only 331 amino acids. (wikipedia.org)
The human GR protein is produced from 9 exons of the GR gene and is composed of 3 major subdomains, each of which has specific structural and functional properties. (brainimmune.com)

In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. (wikipedia.org)
Studies in Gata1-knockout mice, i.e. mice lacking the Gata1 gene, indicate that this gene is essential for the development and maintenance of blood-based and/or tissue-based hematological cells, particularly red blood cells and platelets but also eosinophils, basophils, mast cells, and dendritic cells. (wikipedia.org)
In Gata1low and wild-type mice, TPO mRNA was expressed by bone marrow (BM), spleen and liver. (refine.bio)

Given that CYP1A2 is an important drug-metabolizing enzyme, those factors that influence its epigenetic state may also contribute to the individual drug response. (biomedcentral.com)
So far it is not clear, to which extent such cancer-related or experimentally induced epigenetic alterations correspond to the natural epigenetic variability in human livers. (biomedcentral.com)

The human GATA1 gene is located on the short (i.e. "p") arm of the X chromosome at position 11.23. (wikipedia.org)
Fundamental to both disorders is the gene-dosage imbalance of the human chromosome 21. (smj.org.sg)

This has been a controversy for a long time especially in light of the emerging field of ribosome-mediated translation regulation and its relevance to human diseases. (simplyblood.org)
Summary We conclude that mTOR has a part in maintaining prolonged pain claims via mRNA translation and thus protein synthesis. (researchensemble.com)
This is attained by spinally administering the overall transcription inhibitor actinomycin D and the overall translation inhibitor anisomycin spinally, to formalin shot in to the hind paw prior. (researchensemble.com)

Molecular dissection of this process has been challenging as transcription factor loci are regulated by many trans -acting factors functioning through dispersed cis elements. (prolekarniky.cz)
Between 1993 and 2015, approximately 1,900 human genome loci were discovered to produce microRNAs and were added to miRBbase, the public database that catalogues and annotates microRNA molecules. (pharmaceuticalintelligence.com)
We wanted to know how many microRNA-producing loci really exist in humans," recalls Dr. Rigoutsos. (pharmaceuticalintelligence.com)

The laboratory of Dr. Vijay Sankaran at Boston Children's Hospital and the Broad Institute of MIT and Harvard recently reported a breakthrough discovery about the role of ribosome levels in human hematopoiesis and Diamond-Blackfan Anemia (DBA). (simplyblood.org)
Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)
We observe a marked increase in the levels of both the mature message and pre-mRNA in TAF1 depleted cells. (refine.bio)
Gata1low livers expressed TPO mRNA levels 6-fold greater than wild-type livers. (refine.bio)

These motifs are critical for both transcription factors' gene-regulating actions. (wikipedia.org)

While these studies led to a considerable insight into lineage commitment from HSPCs at the transcriptional level, the post-transcriptional regulation of these refined models of hematopoiesis and its relevance to human disease were largely unexplored. (simplyblood.org)

FOG1 powerfully promotes or suppresses the actions that the two transcription factors have on most of their target genes. (wikipedia.org)

Andersen, Thom and colleagues reveal the single-cell-resolution transcriptome of the midgestation human spinal cord and discover remarkable heterogeneity across and within cell types. (uni-saarland.de)

Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

We also identified 1,000 genes specific to fetal liver, which were enriched for GATA1, STAT5A, STAT5B and YY1 binding sites. (biomedcentral.com)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. (biomedcentral.com)

Nineteen candidate genes selected from mRNA-Seq results, were independently assessed by qRT-PCR in additional postpartum cows (5 animals) at both time points. (biomedcentral.com)
The results suggest that these cell lines are important tools used to identify the human PPARs-responsive genes. (biomedcentral.com)
These new results expand the selection of treatment strategies in PC, thus prompting the need to identify predictive factors to select ideal candidates for anticipated therapies. (oaepublish.com)

Arena-Idb provides a framework for network reconstruction of ncRNA heterogeneous interactions (i.e., with other type of molecules) and relationships with human diseases which guide the integration of data, extracted from different sources, via mapping of entities and minimization of ambiguity. (biomedcentral.com)
This means that the mouse models engineered to capture human disease cannot recapitulate the interactions mediated by these microRNAs. (pharmaceuticalintelligence.com)

Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and determined the consequences on metal induced transcription at an inducible gene, Metallothionein B (MtnB). (refine.bio)

We integrated high-resolution maps of transcriptional initiation and transcription to annotate a conservative set of intergenic lncRNAs expressed in mouse erythroblasts. (biomedcentral.com)

Together with mapping of disease-related genes, this transcriptomic mapping of the developing human spinal cord opens new avenues for interrogating the cellular basis of motor control in humans and guides human stem cell-based models of disease. (uni-saarland.de)

TFIID is a central player in activated transcription initiation. (refine.bio)

N-terminus zinc fingers) interacts with an essential transcription factor-regulating nuclear protein, FOG1. (wikipedia.org)

4. Finally, I think that this work is a good example of how rare diseases such as DBA can teach us a lot about human biology. (simplyblood.org)

At least 50,000 lncRNAs are expressed from intergenic regions of the human genome, more than twice the number of protein-coding genes [ 5 ]. (biomedcentral.com)
The current study generated a genome-wide transcriptomic profile of endometrial biopsies from these cows at both time points using mRNA-Seq. (biomedcentral.com)
The archetype is the Ion Torrent Personal Genome Machine (PGM), but with similar form factors are the 454 Jr and MiSeq. (blogspot.com)
We basically tripled the number of locations in the human genome that are now known to encode microRNAs," asserts Dr. Rigoutsos. (pharmaceuticalintelligence.com)

We also integrated our data with multiple existing datasets of the developing human spinal cord spanning 22 weeks of gestation to investigate the cell diversity over time. (uni-saarland.de)
In a comparative analysis between the human microRNA datasets and the chimpanzee, gorilla, orangutan, macaque, mouse, fruit fly, and mouse genomes, Dr. Rigoutsos and colleagues discovered that almost 95% of the newly unveiled microRNAs were primate-specific, and over 56% of them were found only in humans. (pharmaceuticalintelligence.com)

The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)
BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
Dynamic transcription factor activity profiling in 2D and 3D cell cultures. (chicagobiomedicalconsortium.org)

Similar to the knockout of Gata1, knockout of the mouse gene for FOG1, Zfpm1, causes total failure of red blood cell development and embryonic lethality by day 11.5. (wikipedia.org)
We are seeing many human microRNAs that do not exist in the mouse," states Dr. Rigoutsos. (pharmaceuticalintelligence.com)

The human spinal cord is exquisitely organized, and this complex organization contributes to the diversity and intricacy of motor behavior and sensory processing. (uni-saarland.de)

Single-cell transcriptomic landscape of the developing human spinal cord. (uni-saarland.de)
Here we transcriptomically profiled the midgestation human spinal cord with single-cell resolution and discovered remarkable heterogeneity across and within cell types. (uni-saarland.de)

Anatomy19

Organisms11

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes72

Disciplines and Occupations1

Information Science4

Termed Erythroid transcription factor1

Mutations11

Erythroid1

Proteins5

Histone1

Ribosomal3

Regulates3

Significantly3

Myelofibrosis3

Differentiation6

Differentially2

Signaling pathway1

Chromatin3

Erythropoiesis1

GATA5

Receptor2

Tissues2

Expression14

Pathways2

Contrast2

Exons2

Mice3

Epigenetic2

Chromosome2

Translation3

Loci3

Levels4

Motifs1

Hematopoiesis1

Promotes1

Transcriptome1

Tumor1

Progression1

Liver1

Pathology1

Regulation1

RESULTS3

Interactions2

Genes in human1

Cells2

Transcriptional1

Stem1

Initiation1

Zinc fingers1

Diseases1

Genome4

Datasets2

Activity3

Mouse2

Organization1

Cell2