Human gamma 14 3 3 proteins. Medical search. Frequent questions

It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. (wikipedia.org)
Evidence indicates 14-3-3 is required for Raf-1 kinase activity and phosphorylation amoung many other functions. (icbinhibitor.com)
We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. (cdc.gov)
DNA-dependent protein kinase catalytic subunit (DNAPKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. (cdc.gov)
The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase. (umassmed.edu)
14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide. (prospecbio.com)
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. (dogcancerblog.com)
Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells. (researchmap.jp)
Phosphatidylinositol 3-kinase-independent signal transduction pathway for PDGF-induced chemotaxis. (researchmap.jp)
Protein tyrosines and protein kinase C are required for gene expression of monocyte chemoattractant protein-1 in human monocytes. (researchmap.jp)
Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells. (researchmap.jp)
Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation : The isoform that may mediate G1/S inhibition. (researchmap.jp)
Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. (researchmap.jp)
CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. (thermofisher.com)

This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. (wikipedia.org)
Background: Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. (icbinhibitor.com)
14-3-3 proteins are highly conserved and ubiquitously expressed. (prospecbio.com)

With over 35 years of providing the best recombinant proteins to the scientific community, R&D Systems continues to lead the industry in quality, activity, and purity. (rndsystems.com)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene. (wikipedia.org)
This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. (wikipedia.org)
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. (antikoerper-online.de)
CUSABIO is a leading biotechnology company specialized in production of high quality products for gene, protein, antibody, ELISA kit. (cusabio.com)
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. (dogcancerblog.com)
Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. (dogcancerblog.com)
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)
Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 finger. (researchmap.jp)
Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells, 12 upregulated distinct genes including 5 cell growth-related, 3 thrombosis-related. (researchmap.jp)
Genes that encode the proteins of complement components or their isotypes are distributed throughout different chromosomes, with 19 genes comprising 3 significant complement gene clusters in the human genome. (medscape.com)

Specificity: Recognizes human beta, gamma, sigma and zeta isoforms of 14-3-3. (icbinhibitor.com)

Also, this recombinant protein promoted the release of NO and cell apoptosis, and inhibited the proliferation and migration of goat PBMCs and suppressed monocyte phagocytosis. (biomedcentral.com)
GO enrichment analysis of the interacting proteins identified terms related to apoptosis, protein binding, locomotion, hippo signalling and leukocyte and lymphocyte differentiation, supporting the experimental findings. (biomedcentral.com)
Oxidized low density lipoprotein induces apoptosis in cultured human umbilicalvein endothelial cells by common and unique mechanisms. (researchmap.jp)

14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. (icbinhibitor.com)
Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. (icbinhibitor.com)
The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. (prospecbio.com)
The complement cascade consists of 3 separate pathways that converge in a final common pathway. (medscape.com)
These 3 pathways converge at the component C3. (medscape.com)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1-3). (rndsystems.com)
Description: The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. (thermofisher.com)
Applications Tested: This RPA-T4 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
The classical pathway is triggered by interaction of the Fc portion of an antibody (immunoglobulin [Ig] M, IgG1, IgG2, IgG3) or C-reactive protein with C1q. (medscape.com)

Western blot and immunofluorescence assay (IFA) were used to examine the reactivity of rFg14-3-3e protein to anti- F. gigantica and anti-rFg14-3-3e antibodies, respectively. (biomedcentral.com)

Nature Communications , Vol. 14, no.1 (2023). (uclouvain.be)

Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsui M: Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. (hmdb.ca)

Fc gamma Rs that deliver an activating signal either have an intrinsic immunoreceptor tyrosine-based activation motif (ITAM) within their cytoplasmic domains or associate with one of the ITAM-bearing adapter subunits, FcR gamma or zeta (3, 5). (novusbio.com)

YWHAG Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 247 amino acids (1-247) and having a molecular mass of 28 kDa. (prospecbio.com)

The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. (cdc.gov)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

Can Commun Dis Rep 2021;47(3):128-31. (canada.ca)
Frontiers in Neuroscience , Vol. 14, p. 586108 (2021). (uclouvain.be)

Western blot analysis showed that rFg14-3-3e protein is recognized by sera from goats experimentally infected with F. gigantica and immunofluorescence staining using rat anti-rFg14-3-3e antibodies demonstrated the specific binding of rFg14-3-3e protein to the surface of goat PBMCs. (biomedcentral.com)
Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S). MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. (frontiersin.org)
All enzymes, antibodies, many hormones, hemoglobin and fibrogin (the body converts fibrogin into non-soluble, fibrin, a blood clotting agent) are globular proteins. (ljseedco.com)
The body uses globulin proteins to make antibodies which attack infecting agents (antigens) that invade the body. (ljseedco.com)

Towards non-parametric diffusion-T1 characterization of crossing fibers in the human brain. (lu.se)

Fig. 1: Serum mitogen-induced phosphorylation of PI3KC2-β induces complex formation with 14-3-3 proteins. (nature.com)
Fig. 5: mTORC2 signalling triggers PKN2 activation to control PI3KC2-β phosphorylation and sequestration with 14-3-3 proteins. (nature.com)
The transfer RNAs associated with progressive external ophthalmoplegia are present in mitochondria and help assemble the proteins that carry out the steps of oxidative phosphorylation. (medlineplus.gov)

CD4 + T cells play an important role in conferring protective immunity towards the liver stages of the malaria parasite [ 3 ]. (omicsonline.org)

Transfer RNAs help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
The method adopts amino acid composition (AAC), conjoint triad (CT), and auto covariance (AC) to extract global and local features of protein sequences, and leverages self-attention to enhance DNN feature extraction to more effectively accomplish the prediction of PPIs. (biomedcentral.com)
Proteins are organic macromolecules made up of amino acids, which are essential components of cells and sustain life activities. (biomedcentral.com)
There are eight amino acids the human body cannot make and two more the body cannot make in sufficient quantity, which are essential to healthy living. (ljseedco.com)
These essential amino acids, along with eleven others the body can make, are chained together in accordance to genetic guidelines, via RNA formats from DNA blueprints, into structural proteins that give body to life, and into enzymes (globular proteins) that carry out the mechanics of living. (ljseedco.com)
The best way to insure the body has enough amino acid material to make the globulins is to eat foods high in globulin proteins. (ljseedco.com)
Eating hemp gives the body all the essential amino acids required to maintain health, and provides the necessary kinds and amounts of amino acids the body needs to make human serum albumin and serum globulins like the immune enhancing gamma globulins. (ljseedco.com)
Scalar light instructions are able to assemble and maintain molecules of amino acids and proteins crucial to human and animal quantum health. (scalarlight.com)
In practice, the Scalar Light Amino Acid & Protein Program administers scalar light instructions in order to assemble and maintain amino acids and proteins inside the quantum body or scalar light force field. (scalarlight.com)
Below are the lists of amino acids and proteins that are assembled by way of the Scalar Light Amino Acid and Protein Program. (scalarlight.com)
Additionally, enzymes and micro-nutrients are likewise assembled as these nutrients serve to abet and catalyze the assembling of amino acids and proteins. (scalarlight.com)
The Scalar Light Amino Acid and Protein Program operates twenty-four (24) hours per day seven (7) days per week thereby assuring a constant creation and delivery of amino acids and proteins to the quantum, human body. (scalarlight.com)
The Scalar Light Amino Acid & Protein Program administers scalar light upon photographs of people, animals, plants, and objects. (scalarlight.com)

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data. (crg.eu)
It can also correctly predict the protein interaction of cell and tumor information contained in one-core network and crossover network.The SDNN-PPI proposed in this paper not only explores the mechanism of protein-protein interaction, but also provides new ideas for drug design and disease prevention. (biomedcentral.com)

The first evidence of R. sibirica mongolitimonae pathogenicity in humans was documented in France in 1996 ( 2 ). (cdc.gov)

LS-F33142 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human LAMC2 / Laminin Gamma 2 in samples of Plasma, Serum and Tissue Homogenates. (lsbio.com)
Source of all serum proteins is from USDA inspected abattoirs located in the United States. (bdbiosciences.com)
The level of serum albumin was significantly negatively correlated and the levels of serum aminotransferases, and serum gamma-glutamyl-transpeptidase were significantly positively correlated with urine nickel levels. (who.int)

22 ] utilized four categories of protein sequence information (AC, CT, LD, MAC) to encode proteins as feature vectors focusing on dimensionality reduction and proposed a new hierarchical PCA-EELM (principal component analysis-integrated extreme learning machine) model to predict protein interactions. (biomedcentral.com)

moreover, CYP4F3A mRNA and protein were induced by benzene metabolite phenol in HL-60 and K562 cells as well as ex vivo in human peripheral neutrophils. (cdc.gov)

The sarcomeres represent the contractile element, which is composed of actin, myosin, and Z-band proteins (see image below). (medscape.com)

Protein homeostasis is vital for organisms and requires chaperones like the conserved Bcl-2-associated athanogene (BAG) co-chaperones that bind to the heat shock protein 70 (HSP70) through their C-terminal BAG domain (BD). (bvsalud.org)

Responses to Env and regulatory proteins appeared to remain stable. (columbia.edu)
Deficiency of any of these regulatory proteins results in a state of overactivation of the complement system, with damaging inflammatory effects. (medscape.com)

Seder, R. A., Gazzinelli, R., Sher, A. & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. (nature.com)

We report on the cloning and expression of a recombinant F. gigantica 14-3-3 epsilon protein (rFg14-3-3e), and testing its effects on specific functions of goat peripheral blood mononuclear cells (PBMCs). (biomedcentral.com)
Using RNA expression profiling, we identified the membrane protein leucine-rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. (aacrjournals.org)
It has previously been reported that pro-inflammatory cytokine stimulation induces 12-lipoxygenase (12-LO) expression in human islets. (nih.gov)
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. (dogcancerblog.com)
Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release. (uclouvain.be)
These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)

We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)

CD4 is a receptor for the human immunodeficiency virus (HIV). (thermofisher.com)
The important components of this system are various cell membrane-associated proteins such as complement receptor 1 (CR1), complement receptor 2 (CR2), and decay accelerating factor (DAF). (medscape.com)

P = 0.019) showed a mean delay of 14 weeks after viral escape. (columbia.edu)
Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. (mdpi.com)
In the past few decades, there has been rapid spread of numerous severe viral infections, including human immunodeficiency virus (HIV), influenza A, severe acute respiratory syndrome (SARS), Ebola and Zika. (canada.ca)

We characterized the hierarchy of HIV-1-specific T-cell gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay responses during acute subtype C infection in 53 individuals and associated temporal patterns of responses with disease progression in the first 12 months. (columbia.edu)
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), causing coronavirus disease 2019 (COVID-19), entered the human population and rapidly spread around the world in the early months of 2020, causing a global pandemic. (canada.ca)
In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. (en-journal.org)

Protein-protein interactions (PPIs) dominate intracellular molecules to perform a series of tasks such as transcriptional regulation, information transduction, and drug signalling. (biomedcentral.com)
These radiation particles and rays carry enough energy to knock out electrons from atoms and molecules (such as water, protein, and DNA) that they hit or pass near. (cdc.gov)

Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? (wikipedia.org)
Deciphering immune events during early stages of human immunodeficiency virus type 1 (HIV-1) infection is critical for understanding the course of disease. (columbia.edu)
HA510 trade name] is indicated in combination with other antiretroviral medicines for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in children weighing 3-24.9 kg. (who.int)

Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)

Human leukemia frequently involves recurrent translocations. (bioone.org)
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. (rupress.org)
The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. (rupress.org)
The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations. (rupress.org)

However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. (en-journal.org)

Various assays were used to investigate the stimulatory effects of the purified rFg14-3-3e protein on specific functions of goat PBMCs, including cytokine secretion, proliferation, migration, nitric oxide (NO) production, phagocytosis, and apoptotic capabilities. (biomedcentral.com)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

20 ] proposed auto covariance (AC) to extract information from protein sequences and used support vector machine model to predict PPIs in the Saccharomyces cerevisiae dataset with 88.09% accuracy. (biomedcentral.com)
21 ] proposed local descriptors (LD) to represent protein sequences and successfully predicted potential PPIs on Saccharomyces cerevisiae (core subset) dataset by implementing K-neighbor model. (biomedcentral.com)
The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)

Indeed, there was no evidence that the benefits lasted longer than 3 months. (medscape.com)
Although the pathogenesis of CKD remains unclear, evidence indicates that early recognition and interventions may delay the progression to ESRD and cardiovascular disease [ 3 ]. (medsci.org)

Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. (en-journal.org)

these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). (rndsystems.com)
The CD64 proteins are high affinity receptors (~10 -8 -10 -9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10 -6 -10 -7 M) only recognizing IgG aggregates surrounding multivalent antigens (1, 4). (rndsystems.com)
Detects human Fc gamma RII/CD32 in direct ELISAs and Western blots. (novusbio.com)

Hemp seed protein is 65% globulin edistin! (ljseedco.com)
What is unique about hemp seed protein is that 65% of it is globulin edistin. (ljseedco.com)
Globulin is the third most abundant protein in the human body. (ljseedco.com)
Globulins like gamma globulin are absolutely essential to maintain a healthy immune system. (ljseedco.com)
Since hemp seed protein is 65% globulin edistin, and also includes quantities of albumin, its protein is readily available in a form quite similar to that found in blood plasma. (ljseedco.com)

In addition, disease caused by Fasciola infection (known as fasciolosis) in humans is included in the WHO top listed neglected tropical diseases [ 5 , 6 ], and it is estimated that at least 2.4 million people are infected worldwide and 180 million are at risk of infections [ 2 ]. (biomedcentral.com)
In addition, many of these viruses represent zoonoses (zoonotic diseases), increasing the risk of introducing a virus with completely new immunogenic properties into the human population. (canada.ca)
Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. (en-journal.org)
These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. (en-journal.org)
3] A registry of complement deficiencies has been established as a means to promote joint projects on treatment and prevention of diseases associated with defective complement function. (medscape.com)

In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. (nature.com)
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (nature.com)

Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission. (uclouvain.be)
Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation. (lu.se)

These proteins, like all others, are genetically coded and have a specific structure and distribution. (medscape.com)

Peripheral white blood cell (WBC) count aemias were caused by the organism [ 2,3 ]. (who.int)

Anatomy32

Organisms16

Diseases4

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes60

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science3

Health Care1

Kinase15

Highly conserved3

Recombinant Proteins2

Gene10

Isoforms1

Apoptosis3

Pathways6

Antibody4

Reactivity1

20231

Inhibitor1

Tyrosine1

YWHAG1

Centers for Diseas1

Structural Classifi1

20212

Antibodies4

Characterization1

Phosphorylation3

Liver1

Amino13

Interaction2

19961

Serum3

ENCODE1

Metabolite1

Actin1

Heat shock prot1

Regulatory proteins2

Interferon gamma production1

Expression6

Peptide2

Receptor2

Viral3

Acute3

Molecules2

Immunodeficiency virus type3

Metabolome Database1

Translocations4

Deficiency1

Apoptotic1

ELISA1

Sequences3

Evidence2

Deficient1

CD323

Globulin5

Diseases5

Tissues1

Cytokine2

Amyloid2

Genetically1

Peripheral1