Human enzyme gamma glutamyltransferase. Medical search. Frequent questions

EC 2.3.2.2) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). (wikipedia.org)
The activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase were assayed. (scialert.net)
The activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase in the non-drinkers were significantly lower than in moderate or heavy drinkers of alcohol in both males and females. (scialert.net)
These findings indicate that alcohol consumption either as chronic or moderate, elevated the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase in both males and females, but more pronounced in the females. (scialert.net)
Serum levels of aspartate aminotransferase, alanine transferase and alkaline phosphates in rats coadministered with both isoniazid (INH) 50 mg/kg and Salvia officinalis L. extract at 250 mg/kg showed significant reduction when compared to INH group, but administration of Salvia officinalis L. extract 250 mg/kg alone and with INH has alleviated gamma-glutamyl transferase comparing to INH receiving rats. (scirp.org)
A recent publication observed that 54% of patients hospitalized for COVID-19 at a single center in China had elevated gamma-glutamyl transferase (GGT). (medscape.com)
We illustrate the multi-pollutant approaches to predicting a marker of oxidative stress [gamma-glutamyl transferase (GGT)], a common disease pathway linking environmental exposure and numerous health endpoints. (cdc.gov)
Results: Overall AUROC values for Age Platelet Index (API), Aspartate to Alanine Ratio (AAR), AST-to-Platelet Ratio Index (APRI), Fibrosis Index based on 4 Factors (FIB-4) and Gamma glutamyl transferase to Platelet Ratio Index (GPR) were 0.52, 0.49, 0.55, 0.55 and 0.54 respectively. (bvsalud.org)
The gamma-glutamyl transferase -to platelet ratio (GPR) was developed and investigated as available test that is useful in predicting liver fibrosis stages in chronic HBV patients. (bvsalud.org)

Also changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphates (ALP), gamma-glutamyltransferase (GGT) levels were assessed. (scirp.org)

Pagani F, Panteghini M. Biological variation in serum activities of three hepatic enzymes. (medscape.com)

However, determination of high levels of total serum GGT activity is not specific to alcohol intoxication, and the measurement of selected serum forms of the enzyme offer more specific information. (wikipedia.org)
The effects of gender and alcohol consumption on serum enzymes, protein and bilirubin in heavy, moderate and non-drinkers were investigated. (scialert.net)
As this elevation can persist for up to 12 hours in the serum, the recommendation is to check the serum enzyme levels in a fasting state. (statpearls.com)
The enzyme was previously known as serum glutamate pyruvate transaminase (SGPT). (redcliffelabs.com)
The ALT enzyme is mainly found in the serum and organ tissues of the liver. (redcliffelabs.com)
It is an enzyme which is previously known as serum glutamate oxalate transaminase (SGOT) The AST enzyme is present in all tissues except bone, with the highest levels in the liver and skeletal muscles. (redcliffelabs.com)
Related tests include serum alkaline phosphatase and gamma-glutamyltransferase (GGT). (medscape.com)
Despite its widespread distribution in the human body, serum elevations of 5NT are medically useful in identifying hepatobiliary disease. (medscape.com)

Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively. (bvsalud.org)
We used an enzyme-linked immunosorbent assay which determines the concentration of copper/zinc superoxide dismutase independently from its enzymatic activity. (indexindex.com)
Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. (medsci.org)

As test cases to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). (uni-muenchen.de)
By tracing significant alterations of protein expression likely relevant for the observed phenotypic effects, the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. (uni-muenchen.de)
γ-Glutamyl transpeptidase was purified about 200-fold to a specific activity of 897 mU per mg protein from cultured human lens epithelium. (utmb.edu)
Transglutaminase 2 (TG2), encoded by the TGM2 gene, is also known as tissue transglutaminase (tTG), transgluytaminase C (TGC), and protein-glutamine-gamma-glutamyltransferase. (rndsystems.com)
Viral host receptor angiotensin-converting enzyme 2 (ACE2) and viral nucleocapsid protein stained positive in specimens, making gastrointestinal infection with COVID-19-and fecal-oral transmission-likely. (medscape.com)

A commutability confirmation test for the blood aldosterone measurement was performed on liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) as a designated comparison method (DCM) and four chemiluminescent enzyme immunoassay (CLEIA) measurement procedures based on metrological traceability. (jsce-ip.com)

This blood test is usually performed to evaluate the level of enzyme Aspartate Aminotransferase in the blood which is found in the liver. (redcliffelabs.com)

The name γ-glutamyltransferase is preferred by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. (wikipedia.org)

The TGM5 gene provides instructions for making an enzyme called transglutaminase 5. (medlineplus.gov)
This and other T GM5 gene variants reduce the activity of transglutaminase 5 or prevent cells from making any of this enzyme. (medlineplus.gov)

TGM2 has been implicated in a variety of human diseases including celiac disease, inclusion body myositis, atherosclerosis, and neurodegenerative diseases. (rndsystems.com)

The significant results in the Dutch sample indicate that genome-wide SNP platforms contain substantial information regarding the underlying genetic variation in the liver enzyme levels. (vu.nl)

By the breakdown of RBC about 0.5 to 2 grams of bilirubin is produced daily in the human body. (redcliffelabs.com)

At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. (unav.edu)

Alkaline phosphatase (or ALP) is another enzyme commonly measured when liver dysfunction is suspected. (aacc.org)

This enzyme is found in many of the body's tissues, although it seems to play a key role in the outer layer of skin (the epidermis). (medlineplus.gov)
It is an enzyme found in the cell membranes of several tissues, especially in the liver, kidney, and pancreas. (redcliffelabs.com)
Antibodies raised against an apparently homogeneous γ-glutamyl transpeptidase from human kidney precipitated the enzyme from ocular tissues and the enzyme purified from the cultured lens epithelial cells. (utmb.edu)
This indicates that the enzyme of the ocular tissues and the kidney are of similar genetic origin. (utmb.edu)

γ-Glutamyl transpeptidase was found to be in relatively much higher concentrations in human retina and iris than in the lens. (utmb.edu)
sCD26 concentrations in infection-triggered ME/CFS were found to be associated with activated T cells, liver enzymes, creatin kinase (CK) and lactate dehydrogenase (LDH) and inversely with Interleukin-1 beta (IL-1b). (frontiersin.org)

The older name is gamma-glutamyl transpeptidase (GGTP). (wikipedia.org)

268 GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. (wikipedia.org)
Gamma-glutamyltransferase (GGT), which is a key enzyme for the cellular glutathione (GSH) homeostasis, was shown to be overexpressed in human tumor cells selected for resistance to cisplatin and to influence the resistance of experimental tumors in vivo. (unipi.it)

We first established that cisplatin treatment of HeLa cells was accompanied by an early 3-fold induction of GGT synthesis, enhancing the possibility that this enzyme plays an important role in the cell defenses against this anticancer drug. (unipi.it)
Mirum will acquire Travere's rights to Cholbam®, indicated for the treatment of bile acid synthesis disorders due to single enzyme deficiencies and adjunctive treatment of peroxisomal disorders in patients who show signs or symptoms of liver disease, and Chenodal®, indicated for the treatment of radiolucent stones in the gallbladder, which is also under Phase 3 clinical evaluation for cerebrotendinous xanthomatosis (CTX). (kanerepublican.com)

Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73). (medscape.com)

Variation in the liver enzyme levels in humans is moderately heritable, as indicated by twin-family studies. (vu.nl)

Fenbendazole has been shown to reduce lung tumor growth in humans with lung cancer. (fenbenmed.com)

Isolated elevation or disproportionate elevation compared to other liver enzymes (such as ALT or alanine transaminase) can indicate harmful alcohol use or alcoholic liver disease, and can indicate excess alcohol consumption up to 3 or 4 weeks prior to the test. (wikipedia.org)

HA569 trade name] is indicated in combination with other antiretroviral medicines for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults, adolescents and children of any age (see section 4.4). (who.int)

1993). In addition, maternal alcohol consumption during gestation is known to cause fetal growth retardation in humans and laboratory animals (Lin, 1991), an effect persisting for a long period affect parturition (Oyama et al . (scialert.net)

Most other toxic effects of absorbed carbon tetrachloride are related to its metabolism by mixed function cytochrome P-450 oxygenases (in humans, primarily CYP2E1, but also CYP3A). (cdc.gov)
In healthy individuals, the circulating enzyme is primarily derived from the liver and bone. (statpearls.com)

Zinc and magnesium are important co-factors of this enzyme. (statpearls.com)
Magnesium had no significant effect on the enzyme activity, whereas, sodium and potassium inhibited the enzyme slightly. (utmb.edu)

20% bound to human plasma proteins. (nih.gov)

The liver is the second largest organ of the human body present in the right upper abdomen. (redcliffelabs.com)
The liver is one of the largest internal and most metabolic organ in human body. (planetayurveda.com)

Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding. (drugbank.com)

The human alkaline phosphatases (hALP) are found anchored on the cell membrane by glycosylphosphatidylinositol. (statpearls.com)
When this enzyme is blocked, cancer cells cannot grow and multiply by dividing into two new cells.The researchers found that Fenbendazole could kill lung cancer cells, prostate cancer cells, breast cancer cells, and melanoma cells with equal effectiveness. (fenbenmed.com)
The enzyme preparation was found to have a K m of about 0·7 mm for γ-glutamyl p-nitroanilide and a pH optimum of 8·2. (utmb.edu)

The animals were kept and handled in accordance to our University regulations that follows the Guidelines for the Human Use and Care of Laboratory Animals. (scirp.org)

Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). (unav.edu)

These findings provide evidence that the key enzyme sCD26 is linked to immunological alterations in infection-triggered ME/CFS and delineate a different pathomechanism in the non-infectious ME/CFS subset. (frontiersin.org)

Given that CYP1A2 is an important drug-metabolizing enzyme, those factors that influence its epigenetic state may also contribute to the individual drug response. (biomedcentral.com)

So far it is not clear, to which extent such cancer-related or experimentally induced epigenetic alterations correspond to the natural epigenetic variability in human livers. (biomedcentral.com)

5′-Nucleotidase (5NT) is an intrinsic membrane glycoprotein that is present as an enzyme in a wide variety of mammalian cells. (medscape.com)

an organelle, which plays several vital roles to human health and longevity. (mcisaachealthsystems.com)
OPCs are pesticides that are most actively used all over the world, therefore their residues and metabolites are widespread in the environmental objects, worsening total burden of the negative effect of chemical factors on human health and ecological systems [2, 4, 6, 8, 12, 13]. (kiev.ua)

In some individuals, this enzyme comes from the intestinal tract to a minimal extent. (statpearls.com)
In the lens, the enzyme was localized to a major extent in the epithelium plus capsule fraction. (utmb.edu)
The aminotransferase enzymes, ALT and AST, are indicators of liver cell death and can be used to answer the questions: What is the extent of hepatic damage or how many liver cells died in the last 24 hours? (aacc.org)

The enzyme was not inhibited by sulfhydryl blocking reagents up to a concentration of 1 mm indicating that the enzyme does not require the presence of sulfhydryl groups for its activity. (utmb.edu)

Therefore, under conditions of real global threat to human livelihood, active measures are required to minimise the risk of the action of hazardous chemical factors, which including among others OPCs [4, 8, 15]. (kiev.ua)

In addition the pathophysiological importance of this group of enzymes has increased significantly over the last decade with their involvement noted in a number of human diseases. (ucp.pt)

The lens cortex and nucleus had very little enzyme activity. (utmb.edu)
1(3) Other human derived activities such as improper sewage disposal, industrial activity (chemical/tannery/paint processes), and unregulated use of chemical fertilizers also contribute to As production and dissemination into populated regions. (mcisaachealthsystems.com)

Single site mutations at asparagine residues were shown to result in a functionally active yet slightly less thermally stable version of the enzyme in vitro, while knockout of all asparagine residues resulted in an accumulation of the uncleaved, propeptide form of the enzyme. (wikipedia.org)
Laboratory investigation showed slightly elevated liver enzymes. (cdc.gov)

The kidneys are also sensitive targets in humans and animals. (cdc.gov)

Fenbendazole may prevent carcinogenesis by reducing the proliferation of normal and cancer cells, decreasing the formation of related cancer oncogenes, and blocking the binding of cancer promoters to DNA.Fenbendazole is a safe and effective anticancer drug that has the ability to reduce cancer cells in humans. (fenbenmed.com)
Fenbendazole is best for reducing cancer cells in humans. (fenbenmed.com)
Medical studies have shown that fenbendazole reduced the number of cancer cells in patients who were suffering from cancer.Fenbendazole is one of the most frequently prescribed drugs for human Echinococcosis. (fenbenmed.com)
The drug blocks an enzyme called tyrosine kinase, which is essential to the survival of cancer cells. (fenbenmed.com)

Following isolation of the bacterium and the first establishment of a strain in 2000, a new serologic test allowed the identification of three additional human cases ( 5 ) . (cdc.gov)

Safety of an herbal capsule Asparagus falcatus L. in healthy human volunteers: A single-center, open-label, single arm phase 1 clinical trial. (who.int)

Transferase9

Alanine aminotransferase1

Hepatic enzymes1

Serum8

Immunosorbent3

Protein5

Immunoassay1

Aspartate1

Molecular Biology1

Transglutaminase2

TGM21

Genome-wide1

Bilirubin1

Mass spectrometry1

Alkaline Phosphatase1

Tissues4

Concentrations2

GGTP1

Glutathione2

Synthesis2

Cirrhosis1

Variation1

Tumor growth1

Liver disease1

Immunodeficiency1

Fetal1

Primarily2

Magnesium2

Plasma1

Organ2

Acute1

Found3

Laboratory animals1

Metabolic1

Infection1

Important1

Alterations1

Present1

Health2

Extent3

Concentration1

Factors1

Diseases1

Activity2

Slightly2

Targets1

Cells4

20001

Single1