• mammalian
  • The information obtained from yeast studies can then be used to inform more directed studies in mammalian models, such as mice or human cell lines. (omrf.org)
  • mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • We recently provided evidence from immunofluorescence and electron microscopy studies that merotelic kinetochore orientation is a major mechanism for lagging chromosomes during mitosis in PtK1 cells. (biologists.org)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • development
  • The findings suggest that the number of sex chromosomes influences the development of brain asymmetry not simply to modify the torque but in a complex pattern along the antero-posterior axis. (ox.ac.uk)
  • thought
  • The evolution of sex chromosome dimorphism (SCD) is generally thought to follow a repeatable pattern. (royalsocietypublishing.org)
  • In addition to the PAR1 and PAR2, there is a human-specific X-transposed region that was duplicated from the X to the Y. The X-transposed region is often not excluded from X-specific analyses, unlike the PARs, because it is not thought to routinely recombine. (genetics.org)
  • male
  • However, in a ZW system one can separate the effect of the hemizygous chromosome from the male-biased mutations, providing an excellent system for understanding the evolution of SCD. (royalsocietypublishing.org)
  • A counting process senses the X chromosome/autosome ratio and ensures that X chromosome inactivation (XCI) initiates in the female (XX) but not in the male (XY) mouse embryo. (embopress.org)
  • process
  • In addition, we have recently determined that the spindle checkpoint is especially important for the segregation of error-prone meiotic chromosomes and that the human spindle checkpoint protein, BubR1, can participate in this process in yeast. (omrf.org)
  • pair
  • They then compared the number of mutations between the X form and the Y form of a pair of X-Y genes to come up with rough estimates of when they were last alike, giving them a 'geologic' snapshot of sex chromosomes. (abc.net.au)
  • move
  • In the 'extrusion-capture' model, replication through an anchored replisome provides the force to move daughter chromosomes to the poles ( Lemon and Grossman, 2001 ). (wiley.com)
  • appear
  • Most likely this suppression was the result of a series of chromosomal inversions on the Y chromosome, which would also explain why the genes appear to be in order on the X but scrambled on the Y," Page explains. (abc.net.au)
  • studies
  • We use yeast as a model for our studies, as yeast and humans use the same basic machinery, but the yeast system allows us to obtain data much more quickly. (omrf.org)
  • research
  • Research published in this week's Science reveals that the Y chromosome developed from an X-like ancestor around 300 million years ago. (abc.net.au)