• MSCs undergoing chondrogenesis are preferentially responsive to an electromagnetic efficacy window defined by field amplitude, duration and frequency of exposure. (nature.com)
  • Hyaluronic acid (HA) hydrogels formed via photocrosslinking provide stable 3D hydrogel environments that support the chondrogenesis of mesenchymal stem cells (MSCs). (umn.edu)
  • MSCs can easily be obtained from various human tissue sources such as the bone marrow, cord blood, placenta, and adipose [ 2 - 5 ]. (hindawi.com)
  • Additionally, Abedin and King showed that FGF-2 suppresses the cellular senescence of human MSCs [ 17 ]. (hindawi.com)
  • While one of the criteria for human mesenchymal stem cells (MSCs) has been in vitro plastic adherence, such 2D culture conditions are not representative of in vivo cell-cell and cell-extracellular matrix (ECM) interactions, which may be especially important for this progenitor/stem cell of skeletal and connective tissues. (ntu.edu.tw)
  • In this study, the authors examined combinations of growth factors that induce effective chondrogenesis from adipose tissue-derived mesenchymal stem cells (MSCs). (cellsurgicalnetwork.com)
  • Human MSCs were isolated from bone marrow (BMMSCs) and adipose tissue (ATMSCs) and characterized according to flow cytometry for CD34, CD45, CD73, and CD166. (cellsurgicalnetwork.com)
  • FGFR1, FGFR2, and FGFR3 are crucial for both chondrogenesis and osteogenesis. (nih.gov)
  • Chapter 5 utilizes a series of CG scaffolds that were inspired by elements of distinct components of orthopedic interfaces (cartilage, tendon/ligament, and bone) to examine the role of biomaterial physical properties (relative density, mineral content) on biasing MSC phenotype in the presence of mixed soluble signals to drive osteogenesis or chondrogenesis. (illinois.edu)
  • Chapter 4 uses selective modification of our standard CG scaffold to probe the combined influences of structural and biochemical instructive cues to drive human bone marrow-derived mesenchymal stem cell (MSC) differentiation down tenogenic, osteogenic, and chondrogenic lineages respectively. (illinois.edu)
  • In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. (wikipedia.org)
  • The ability to understand and regulate human vasculature development and differentiation has the potential to benefit patients suffering from a variety of ailments, including cardiovascular disease, peripheral. (biomedcentral.com)
  • We show that LNA043 promotes chondrogenesis and cartilage matrix synthesis in vitro and regenerates hyaline articular cartilage in preclinical OA and cartilage injury models in vivo. (nih.gov)
  • The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
  • Rich JT, Rosová I, Nolta JA, Myckatyn TM, Sandell LJ, McAlinden A. Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. (wustl.edu)
  • After 4 weeks of in vitro culture, glycosaminoglycan assays, real-time reverse transcriptase polymerase chain reaction, and histological findings demonstrated that the combination of 5 ng/mL of TGF-beta(2) and 100 ng/mL of BMP-7 most effectively induced chondrogenesis from ATMSCs. (cellsurgicalnetwork.com)
  • We target the development of 3D in vitro systems capable of modelling the constitutive tissues of the human Bone Organ. (bourginelab.com)
  • We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
  • In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
  • We explore the relations existing between cysteamine-driven inflammation versus cytoprotection in vivo and in human pathologies. (univ-mrs.fr)
  • This pilot study aimed to investigate the effect of characterized MSC-EVs on chondrogenesis in a 3D chondrocyte inflammation model with the pro-inflammatory cytokine TNFα. (bvsalud.org)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • In preliminary studies, our µRB-based scaffolds markedly enhanced the survival of human stem cells and accelerated bone repair in vivo. (ca.gov)
  • Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
  • Fgf18 is generally known to activate the IIIc splice variants of FgfR2 and FgfR3, and both of these receptors are known to be expressed in chondrocytes of human and murine articular cartilage. (cusabio.com)
  • Our lab's mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. (stanford.edu)
  • We have developed new tools to explore VNN1 expression in human tissues and completed a first global analysis of VNN expression and function in tissues from patients. (univ-mrs.fr)
  • These studies integrate both basic scientists and clinicians to more effectively translate these basic science findings into new, innovative human health care protocols of using tissue engineering to repair skeletal tissues as in this accompanying figure. (case.edu)
  • Biomimicking approaches can be implemented toward reconstitution of the constitutive elements of the human skeletal or hematopoietic tissues. (bourginelab.com)
  • Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells. (nih.gov)
  • We discovered LNA043-a derivative of angiopoietin-like 3 (ANGPTL3)-as a potent chondrogenesis inducer using a phenotypic screen with human mesenchymal stem cells. (nih.gov)
  • This study highlights the intricacies of calcium homeostasis during early chondrogenesis and the constraints that are placed on PEMF-based therapeutic strategies aimed at promoting MSC chondrogenesis. (nature.com)
  • Comparative gene expression profile analysis between native human odontoblasts and pulp tissue. (nih.gov)
  • This mechanism might account for the extent of tissue damage upon stress but also contributes to normal chondrogenesis by regulating chondroblast expansion. (univ-mrs.fr)
  • The immune landscape of human thymic epithelial tumors. (abcam.com)
  • MA5-17177 targets SOX9 in indirect ELISA, ICC, IF and WB applications and shows reactivity with Human samples. (thermofisher.com)
  • Purified recombinant fragment of human SOX9 expressed in E. Coli. (thermofisher.com)
  • The MA5-17177 immunogen is purified recombinant fragment of human SOX9 expressed in E. Coli. (thermofisher.com)
  • The N-terminal 6xHis tag sequence was appended to the gene coding for the E.coli of the human FGF18 protein to form the recombinant DNA. (cusabio.com)
  • The recombinant human FGF18 was expressed as N-terminal 6xHis-tagged fusion. (cusabio.com)
  • Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. (nih.gov)
  • By means of a recently developed non-invasive ex vivo minimal model based on the interaction of the human enterocyte-like HT29 cell line and fecal slurries, we explored the enterocyte-associated microbiome of 21 Hadza hunter-gatherers and nine urban living Italians. (frontiersin.org)
  • Quantitative real-time gene profiling of human alveolar osteoblasts. (otago.ac.nz)
  • According to these previous findings, the structural and functional configuration of the Hadza gut microbiota is well aligned with the dietary and environmental factors characteristic of their foraging lifestyle, supporting the importance of microbiota as an evolutionary legacy that provides specific adaptive versatility to disparate human subsistence and environmental occupation. (frontiersin.org)
  • Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. (novusbio.com)
  • King's College London) fuelled her interest in vascular cellular signalling and her subsequent post-doctoral position with Professor Jeremy Pearson at King's College London (KCL) allowed her to pursue this interest in human endothelial cells. (rvc.ac.uk)
  • Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
  • Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control PerCP-eFluor® 710 (Product # 46-4714-82) (blue histogram) or Anti-Human CD14 PerCP-eFluor® 710 (purple histogram). (thermofisher.com)
  • Applications Tested: This 61D3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • TNFα, human MSC-EV preparations (MSC-EV batches 41.5-EVi1 and 84-EVi), EVs from human platelet lysate (hPL4-EV), or the combination of TNFα and EVs were supplemented. (bvsalud.org)
  • Description: The 61D3 monoclonal antibody reacts with human CD14, a 53-55 kDa GPI-linked glycoprotein. (thermofisher.com)
  • Expression of matrilin-2 and -4 in human dental pulps during dentin-pulp complex wound healing. (nih.gov)
  • It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. (thermofisher.com)
  • The knowledge gained from animal models will be directly applied to the study of human MSC, as our preliminary studies have already proven to be successful. (case.edu)
  • The last aspect of our work is to document involvement of Vanin molecules in human inflammatory diseases with a specific emphasis on inflammatory bowel diseases. (univ-mrs.fr)
  • The current literature evidences a high ratio of preclinical to clinical studies on this topic, suggesting that we are in a transition phase to clinical application in human. (springer.com)
  • Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. (nih.gov)
  • In order to be human-readable, please install an RSS reader. (mdpi.com)