Human cartilage articular. Medical search. Frequent questions

Rabbit articular chondrocytes were then seeded on three different HAM substrates: the epithelial side of intact HAM (IHE), basement side of denuded HAM (DHB), and stromal side of denuded HAM (DHS). (nih.gov)
CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFbeta and BMP through SMAD signaling. (ca.gov)
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. (ca.gov)
Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. (ca.gov)
Co-culture of mesenchymal stromal cells (MSCs) with articular chondrocytes (ACs) has been reported to improve the efficiency of utilization of a small number of ACs for the engineering of implantable cartilaginous tissues. (unibas.ch)
This study aimed to optimise methods of cryopreserving human articular cartilage (AC) tissue for the isolation of late chondrocytes. (ox.ac.uk)
In conclusion, modification of appropriate factors, such as the size of the tissue, cryoprotective agent, and isolation protocol, can allow successful isolation of viable chondrocytes with high proliferative capacity from cryopreserved human articular cartilage tissue. (ox.ac.uk)
Further studies are required to determine whether these cells may retain cartilage differentiation capacity and provide sufficient chondrocytes for use as implants in clinical applications. (ox.ac.uk)
The results of the study confirmed the ability of chondrocytes to migrate outside of the cadaveric cartilage explant tissue and into the porous structure of the Agili-C™ scaffold and fill its entire volume with newly formed extracellular matrix (ECM) enriched in hyaline cartilage components, such as collagen type II and aggrecan, and lacking collagen type I. (cartiheal.com)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Furthermore, ADSCs differentiated into chondrocytes, both in vitro and in vivo, and enhanced the regeneration of articular cartilage in NOD/ SCID mice as compared with the control. (vinastemcelllab.com)
This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
Viscosupplementation in association with the appropriate cytokine environment is being studied to determine whether articular cartilage chondrocytes can be reactivated and programmed to regenerate in order to cover defects within the knee joint. (medscape.com)

To retrospectively correlate radiographic findings of osteoarthritis of the tibiofemoral joint with arthroscopic findings of articular cartilage degeneration within the tibiofemoral joint in patients with chronic knee pain. (nih.gov)
The sensitivity and specificity of the radiographic features of osteoarthritis for the detection of articular cartilage degeneration within the medial and lateral compartments of the tibiofemoral joint were determined. (nih.gov)
Human AC specimens from osteoarthritis patients who had undergone total knee replacement were used to optimise the chondrocyte isolation process and the choice of cryoprotective agent (CPA). (ox.ac.uk)
Paker, N., Tekdos, D., Kesiktas, N., and Soy, D. Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study. (webmd.com)
Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. (cabi.org)
Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. (cabi.org)
All common treatment options aim to reduce the clinical consequences of osteoarthritis (OA) characterized by persistent synovitis and progressive degradation of articular. (cabi.org)
Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. (cabi.org)
Evaluating the safety of intra-articular mitotherapy in the equine model: a potential novel treatment for osteoarthritis. (cabi.org)
No current treatments available halt osteoarthritis progression in horses or humans. (cabi.org)
[ 70 ] No single biomarker has proved reliable for diagnosis and monitoring, but combinations of cartilage-derived and bone-derived biomarkers have been used to identify osteoarthritis subtypes, with possible impact on treatment. (medscape.com)
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage loss, subchondral bone remodeling, and synovial inflammation. (frontiersin.org)
Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). (karger.com)
Loss of this fluid, called synovial fluid, results in a gradual decrease in cartilage thickness and increase in friction, which is related to the degradation and joint pain of osteoarthritis. (sciencedaily.com)
Future work for Burris and his colleagues includes exploring the implications for osteoarthritis (OA), which is associated with the degradation of cartilage. (sciencedaily.com)
McDevitt CA, Muir H. Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog. (lievers.net)
Osteoarthritis (OA) is a disease that affects the integrity of the articular cartilage which leads to serious health issues for many individuals. (umontreal.ca)
In osteoarthritis, the cartilage in the joints breaks down. (medlineplus.gov)
Both of these factors increase contact stresses, which can lead to articular cartilage damage and subsequent osteoarthritis. (medscape.com)
However, the current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)

The pathologic changes in OA joints include degradation of the articular cartilage, especially at the superficial zones, thickening of the subchondral bone, osteophyte formation, and variable degrees of synovial inflammation 11 . (nature.com)
The earliest report of osteochondritis dissecans (OCD) was published in 1888 by Konig, who characterized a loose-body formation associated with articular cartilage and subchondral bone fracture. (medscape.com)
Both Konig and Kappis believed that lesions due to OCD were the result of ischemic necrosis of the underlying subchondral bone that eventually led to separation of the fragment and its overlying articular cartilage. (medscape.com)
Pure cartilage graft implantation appears to be a simple option, but it has not been applied widely as cartilage will not reattach easily to the subchondral bone. (unboundmedicine.com)
This disease impacts all joint tissues and is characterized by progressive cartilage degradation, synovitis, abnormal subchondral bone remodeling, and osteophyte formation [ 2 ]. (aging-us.com)

Untreated cartilage defects often lead to joint pain and degeneration over time, often requiring joint replacement. (ca.gov)
The proposed candidate is a universal cell therapy designed to generate new articular cartilage in these defects and interrupt the cycle of degeneration. (ca.gov)
The proposed treatment may be of major public benefit, as it would represent the first curative strategy for cartilage injury and subsequent degeneration, likely decreasing economic burden on the state and its people. (ca.gov)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
However, it is being investigated as a tool for monitoring cartilage degeneration, and it can be used for guided injections of joints not easily accessed without imaging. (medscape.com)
gagCEST is a promising MRI method that has the potential to directly reflect the glycosaminoglycan (GAG) depletion within early degeneration of articular cartilage. (lu.se)
The methods evaluated in this thesis have the potential to detect and follow tissue degeneration in articular cartilage and meniscus and could become valuable tools in future studies to increase our knowledge of disease progression in OA. (lu.se)
[ 17 ] performed similar studies in which a varus stress was placed across the knee, and each study documented degeneration of the articular cartilage in the medial compartment. (medscape.com)

We have measured the relationship between tissue swelling stress and consolidation for bovine articular cartilage and corneal stroma in uniaxial confined compression as a function of bath ionic strength. (lievers.net)
When bovine articular cartilage specimens were immerged in solutions with different salt concentration, a 50 MHz focused ultrasound beam was used to monitor the dynamic swelling or shrinkage process. (who.int)

The purpose of this study is to evaluate the feasibility of human amniotic membrane (HAM) as a chondrocyte carrier by assessing cell proliferation and maintenance of phenotype in vitro and cartilage regeneration in vivo. (nih.gov)
In conclusion, our findings suggest that denuded HAM could be one of the ideal cell carrier matrices for cartilage regeneration. (nih.gov)
They explain that the significance of this cartilage regeneration protocol is that it is successful in patients with historically difficult-to-treat grade IV bipolar or bone-on-bone osteochondral lesions. (wikipedia.org)
This thesis reports a novel tissue engineering strategy using a facile, very low cost-based microfluidic technique to produce visible light crosslinked microgels composed of protein-based material for human articular cartilage tissue regeneration. (monash.edu)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)

The main target groups are patients with very small defects of the articular cartilage. (wikipedia.org)
KFAR SABA, Israel, Nov. 6, 2018 /PRNewswire/ - CartiHeal, developer of Agili-C™, a proprietary implant for the treatment of joint surface lesions, announced today the publication of a study demonstrating that the Agili-C™ implant promotes the regenerative capacity of articular cartilage defects in human cadaveric ex-vivo model. (cartiheal.com)
The goal of the study was to investigate the ex-vivo Mechanism Of Action of the Agili-C™ implant in the repair of full-thickness cartilage defects. (cartiheal.com)
CartiHeal, a privately-held medical device company with headquarters in Israel, develops proprietary implants for the treatment of cartilage and osteochondral defects in traumatic and osteoarthritic joints. (cartiheal.com)
Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity. (nature.com)

Lavage focuses on removing degenerative articular cartilage flaps and fibrous tissue. (wikipedia.org)
These results confirm that expanded ADSCs are safe and effective for the treatment of injured articular cartilage and offer a promising therapy for degenerative cartilaginous diseases. (vinastemcelllab.com)
[ 1 ] It can be thought of as a degenerative disorder arising from the biochemical breakdown of articular (hyaline) cartilage in the synovial joints. (medscape.com)

It protects the repair site from infiltration of undesired fibrous tissue while providing the appropriate environment for hyaline cartilage matrix formation. (wikipedia.org)
In particular, it was intended to validate whether the Agili-C™ implant has the potential to stimulate cartilage in-growth through chondrocyte migration into the 3D interconnected porous structure of the scaffold, along with maintaining their viability and phenotype and the deposition of hyaline cartilage matrix. (cartiheal.com)

In the study, human articular cartilage cadaveric knee and ankle specimens were collected within 24 hours from death from 14 donors, male and female. (cartiheal.com)
Mechanical and biochemical properties of human articular cartilage in osteoarthritic femoral heads and in autopsy specimens. (ox.ac.uk)
The associated free swelling behavior of cartilage and cornea specimens is computed from these results and is found to compare favorably with data from the literature. (lievers.net)

Researchers have investigated the use of monoclonal antibodies, synovial fluid markers, and urinary pyridinium cross-links (ie, breakdown products of cartilage) as osteoarthritic indicators. (medscape.com)
In 2008, Ateshian's group demonstrated this phenomenon for the first time using a small sphere articulated against a cartilage plug, showing that interstitial pressure was maintained indefinitely if the contact area moved faster than the diffusive speed of the synovial fluid. (sciencedaily.com)

Here we investigated the in vitro and in vivo chondrogenic capacities of scaffold-based constructs generated by combining primary human ACs with human bone marrow MSCs (BM-MSCs). (unibas.ch)
For AC tissue cryopreservation, intact cored cartilage discs (5 mm diameter) and diced cartilage (0.2-1 mm cubes) from the same sized discs were step cooled and stored in liquid nitrogen for up to 48 h before chondrocyte isolation and in vitro assay of cell viability and proliferative potential. (ox.ac.uk)
ADSC efficacy was determined by assessing their chondrocytic differentiative potential in vitro in cartilage-inducing medium as well as in vivo via injection into a NOD/ SCID mice joint failure model. (vinastemcelllab.com)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
Work currently is being performed to generate articular cartilage in vitro with the ultimate goal of resurfacing a femoral condyle or tibial plateau. (medscape.com)

The medial and lateral articular facets of the talus articulate with the medial and lateral malleoli. (medscape.com)

In conclusion, the analysis of samples taken from knee and ankle joints of human donors confirmed that the Agili-C™implant induces deposition of new extracellular matrix with similar characteristics to the native hyaline cartilage inside the entire volume of the scaffold. (cartiheal.com)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
500kDa) found in the extracellular matrix of articular, nasal and tracheal cartilage. (prospecbio.com)

We hypothesized that pure cartilage graft with augmented osteochondral fusion capacity may be used for cartilage repair and we compared this method with other repair techniques. (unboundmedicine.com)
Processed chondrograft demonstrated good osteochondral integration, and the resulting tissue appeared to be hyaline cartilage. (unboundmedicine.com)
The applied cartilage surface processing method allows acceptable osteochondral integration, and the repair tissue appears to have good macroscopic and histologic characteristics. (unboundmedicine.com)

Each articular surface of the tibiofemoral joint was graded at arthroscopy. (nih.gov)

Stabilize collagen aldimine reducible cross-links to reinforce the strength and elasticity of connective tissues such as cartilage, synovium, ligaments, tendons, fascia, bone, blood vessel walls and the dermis of the skin. (life-enthusiast.com)

The project objective was to investigate the impact of prolonged standing on in vivo changes in articular cartilage deformation within the knee joint and lower extremity muscle characteristics. (cdc.gov)

We studied the mechanical and biochemical properties of articular cartilage from 22 osteoarthritic femoral heads obtained at operation and 97 femoral heads obtained at autopsy. (ox.ac.uk)

In this thesis the focus is on articular cartilage and meniscus and methods to study these tissues. (lu.se)
Magnetic resonance imaging (MRI) is suitable for imaging of cartilage and meniscus, and quantitative imaging methods have the potential to probe the molecular composition and microstructure. (lu.se)
With removal of approximately one third of the meniscus, increased force is transferred directly to the tibial articular surface. (medscape.com)

Our group of scientists and clinicians has been continuously funded by the California Institute of Regenerative Medicine (CIRM) to develop a first-in class pluripotent stem cell-based therapy for focal articular cartilage lesions. (ca.gov)
The work described in this proposal is designed to produce a universal treatment for articular cartilage lesions. (ca.gov)
dubious - discuss] A 2011 study reports histologically confirmed hyaline cartilage regrowth in a 5 patient case-series, 2 with grade IV bipolar or kissing lesions in the knee. (wikipedia.org)
One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)

Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. (cabi.org)
We extract intrinsic layered material parameters of the articular cartilage using a triphasic model. (who.int)

But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
COMP is not only cartilage-derived but is common in other tissues, such as synovium and tendon. (prospecbio.com)

Intra-articular injection of mitochondria is a novel treatment that has the potential to improve cell metabolism and decrease inflammation, but safety of this treatment has yet to be established in the horse. (cabi.org)
There are two main options for medication therapies, which are the drugs for treating symptomatic pain and intra-articular (IA) injection. (frontiersin.org)

The knee cartilage samples were collected from gender- and age-matched KBD (n = 9) and OA (n = 9) patients. (nature.com)

A hydrogel implant to help the body regrow cartilage in the knee is currently being studied in U.S. and European clinical trials. (wikipedia.org)
This study demonstrates the superiority compared to conventional bulk hydrogel with encouraging potential of this system to be applied in the further cartilage tissue clinical translate studies, with additional potential for a broad range of regenerative medicine. (monash.edu)
In OA, while it has been shown to reduce the severity of the disease in the murine model [ 8 , 16 ], the senolytic UBX0101 failed to demonstrate clinical efficacy in humans. (aging-us.com)

Infected Bite Wounds of the Hand A small puncture wound, particularly from a human or cat bite, may involve significant injury to the tendon, joint capsule, or articular cartilage. (msdmanuals.com)

A typical distinction of KBD from OA or other bone and joint diseases is the damage of epiphyseal cartilage and hyaline cartilage in the deep zones of cartilage 11 , 14 . (nature.com)

Autologous chondrocyte implantation produced hyalinelike cartilage, although its cellular organization was distinguishable from the surrounding articular cartilage. (unboundmedicine.com)

Articular cartilage repair treatment involves the repair of the surface of the articular joint's hyaline cartilage. (wikipedia.org)
It is characterized by the breakdown of articular cartilage but involves all parts of the joint. (lu.se)

The defect area was successfully regenerated with hyaline cartilage in the Safranin-O stain and International Cartilage Repair Society (ICRS) scoring after 8 weeks of implantation. (nih.gov)
Studies, however, have shown that marrow stimulation techniques often have insufficiently filled the chondral defect and the repair material is often fibrocartilage (which is not as good mechanically as hyaline cartilage). (wikipedia.org)
citation needed] During the standard microfracture procedure, the implant is applied to the cartilage defect as a liquid. (wikipedia.org)
It is then exposed to UVA light for 90 seconds, turning it into a solid, soft implant that completely occupies the space of the cartilage defect. (wikipedia.org)
To model a chondral defect, donut-shaped cartilage explants were prepared from each tissue specimen. (cartiheal.com)

Maroudas A. Balance between swelling pressure and collagen tension in normal and degenerate cartilage. (lievers.net)

They result from a combination of inversion, plantarflexion, and external rotation forces that cause the posteromedial talar dome to impact the tibial articular surface with a relatively more perpendicular force vector. (medscape.com)
the tibial cartilage is 18-37% stiffer than the corresponding sites on the talus. (medscape.com)

Elmore SM, Sokoloff L, Norris G, Carmeci P. Nature of "imperfect" elasticity of articular cartilage. (lievers.net)
Sokoloff L. Elasticity of articular cartilage: effect of ions and viscous solutions. (lievers.net)
Elasticity imaging at these frequencies can provide strain maps with a resolution in the order of millimeters, but this is not sufficient for applications to skin, articular cartilage, or other fine structures. (who.int)

Broadly taken, there are five major types of articular cartilage repair:[citation needed] Arthroscopic lavage is a "cleaning up" procedure of the knee joint. (wikipedia.org)
Marrow stimulating techniques attempt to solve articular cartilage damage through an arthroscopic procedure. (wikipedia.org)

Microfracture techniques show new potential, as animal studies indicate that microfracture-activated skeletal stem-cells form articular cartilage, instead of fibrous tissue, when co-delivered with a combination of BMP2 and VEGF receptor antagonist. (wikipedia.org)
The data for adverse health effects of stable strontium in humans are sparse, but indicate a possibility of skeletal effects under special circumstances: an epidemiological study of strontium-related rickets in Turkish children and a few studies of hemodialysis patients who developed osteomalacia because of strontium in dialysis water. (cdc.gov)

We used a multiple-incision technique (processed chondrograft) to increase cartilage graft surface. (unboundmedicine.com)

A focal cartilage lesion has limited capacity to heal, and the repair modalities used at present are still unable to provide a universal solution. (unboundmedicine.com)

He is the Director of the University of Connecticut Human Soft Tissue Research Laboratory (integrated Translational Labs incorporating cell and molecular biology, histology, biomechanics and outcomes research). (isakos.com)

Water content, swelling ability and proteoglycan content were measured, the cartilage was examined histologically and the density of the underlying bone was assessed. (ox.ac.uk)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)

Over the last few decades, surgeons and researchers have made progress in elaborating surgical cartilage repair interventions. (wikipedia.org)
Though the different articular cartilage repair procedures differ in the technologies and surgical techniques used, they all share the same aim to repair articular cartilage whilst keeping options open for alternative treatments in the future. (wikipedia.org)
This short-term solution is not considered as an articular cartilage repair procedure but rather a palliative treatment to reduce pain, mechanical restriction and inflammation. (wikipedia.org)
citation needed] Further on, chances are high that after only 1 or 2 years of the surgery symptoms start to return as the fibrocartilage wears away, forcing the patient to reengage in articular cartilage repair. (wikipedia.org)
The proposed co-culture strategy is directly relevant towards a single-stage surgical procedure for cartilage repair. (unibas.ch)
Compared with other methods, processed chondrograft was found to be similarly effective in cartilage repair. (unboundmedicine.com)
Cucchiarini, M., Madry, H. Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair. (uniklinikum-saarland.de)

Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)

Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)
The important question is why cartilage doesn't deflate over the course of days, months or years in our joints," said David Burris, an assistant professor in the Mechanical Engineering Department at the University of Delaware. (sciencedaily.com)
Parsons JR, Black J. Mechanical behavior of articular cartilage: quantitative changes with alteration of ionic environment. (lievers.net)

Depending upon the severity of articular cartilage damage and joint deformity, one or more of these measures may ameliorate symptoms such that no further intervention is required. (medscape.com)

Cartilage explants with or without the Agili-C™ implant inside were cultured for 60 days. (cartiheal.com)
Human skin explants from post-bariatric surgery are imaged in a micro-computed tomography scanner, with optimised parameters to reach one 3D image every 5 min during 3 h of 1UI/h infusion. (bvsalud.org)

In summary, human cartilage grafts were successfully generated, culturing BM-MSCs with a relatively low fraction of non-expanded ACs in porous scaffolds. (unibas.ch)

Trang chủ Công trình KHCN Sách/Chương sách Expanded Adipose Tissue-Derived Stem Cells for Articular Cartilage Injury Treatment: A Safety. (vinastemcelllab.com)

When these fractures result from punching someone in the mouth, human oral flora may contaminate the wound, sometimes causing infection. (msdmanuals.com)

The problem facing the orthopedist in unicompartmental arthritis is addressing single-compartment articular cartilage wear and biomechanical overload while preserving the integrity of the remaining knee joint. (medscape.com)

Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)

Since cartilage is porous, fluid is readily squeezed out of the holes over time. (sciencedaily.com)
As you sit and read this at your desk, fluid is slowly leaking out of the porous cartilage in your knee into a membrane-walled cavity between your upper and lower leg bones. (sciencedaily.com)

Anatomy49

Organisms7

Diseases23

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes20

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Health Care1

Chondrocytes14

Osteoarthritis20

Subchondral bone5

Degeneration8

Bovine articular cartilage2

Regeneration6

Defects5

Degenerative3

Hyaline cartilage matrix2

Specimens3

Synovial2

Vitro5

Medial and lateral1

Extracellular3

Osteochondral3

Arthroscopy1

Connective tissues1

Vivo1

Biochemical1

Meniscus3

Lesions5

Intrinsic2

Tissues2

Injection2

Knee cartilage1

Clinical3

Tendon1

Epiphyseal1

Chondrocyte implantation1

Involves2

Defect5

Collagen1

Tibial2

Elasticity3

Arthroscopic2

Skeletal2

Graft1

Capacity1

Translational1

Histologically1

Cellular1

Repair7

Differentiation1

Mechanical3

Deformity1

Explants2

Successfully1

Treatment1

Fractures1

Arthritis1

Stem-cells1

Porous2