Human biomedical research animals inbred strains. Medical search. Frequent questions

The simplified and known genetic background of captive mouse populations such as the Collaborative Cross, BXD recombinant inbred strain panel, the Diversity Outbred population, and collections of diverse inbred strains render them uniquely powerful resources for studying the mechanisms of short-term genome evolution and genomic inheritance. (jax.org)
Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
We now have been utilizing the Inbred Lengthy- and Quick-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to research the genetic underpinnings of acute ethanol tolerance which is taken into account to be a threat issue for alcohol use issues (AUDs). (eumorphia.org)

[3] I think the vast majority of the animals used in research are rodents, but it's hard to know for sure given the U.S.'s exclusion of rats and mice from reporting requirements. (erichgrunewald.com)
[4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)

The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, and contains data on 20 segmented structures, including variability of brain structures across the strain, and downloadable visualization tools. (sciencedaily.com)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
In addition, the standard reference genome in mouse was derived from the inbred C57BL/6 J strain, and the full set of genetic variants between CD-1 and C57BL/6 J are not known. (biomedcentral.com)

Although in vivo models of pathologic processes are useful only if they provide information that can be extrapolated to other species of interest, particularly to humans, and it is known that no model behaves ideally, it is also true that they allow not only to replicate but also, in some cases, to anticipate the genetic architecture of complex human phenotypes as is the case of cancer disease. (biomedcentral.com)
The genetic makeup of mice largely corresponds to that of humans, which is why they are irreplaceable model organisms in both the pharmaceutical industry and biomedical research. (ut.ee)
characterise several novel Rag1 −/− mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. (biologists.com)
Regulations state that every lab monkey must have detailed genetic and health records, and that only second-generation human-reared monkeys and their offspring can be used for experiments and research. (sixthtone.com)
At present, animals in research are essential not only in areas of neurological, infectious, digestive, genetic and chronic diseases, but also play a crucial role in the development of antibiotics, vaccines as well as in proper understanding of various diagnostics and prognostic tests. (ommegaonline.org)
Lawson HA , Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, and Semenkovich CF, Physiologic and genetic evidence link Hemopexin to triglycerides in mice and humans. (wustl.edu)
We also examined criteria and strategies for the conservation of animal genetic resources. (scirp.org)
The continuous increase in the human population coupled with rising incomes and urbanization necessitates the need to conserve the genetic potential of animals to avoid or lower the consequences of biodiversity loss. (scirp.org)
But clinical and genetic studies have a lot to teach us about dysferlinopathy and can inform research projects looking for new treatments. (jain-foundation.org)
Although inbred strains are typically better suited for such studies due to minimal genetic variability, outbred stocks confer practical advantages over inbred strains, such as improved breeding performance and low cost. (biomedcentral.com)
Knowledge of the full genetic variability of CD-1 would make it more useful in toxicology, pharmacology, and fundamental biomedical research. (biomedcentral.com)
Charles River lab uses a specific breeding program to minimize inbreeding and random genetic drift that could lead to divergence among colonies bred in different facilities worldwide. (biomedcentral.com)
Outbred stocks provide a good model for outbred human populations, but inbred mouse strains are typically preferred in toxicology, pharmacology, and fundamental biomedical research due to lower genetic and phenotypic variability. (biomedcentral.com)
However, the prior study only examined single nucleotide polymorphisms (SNPs) previously identified in other mouse strains, and to date, a full, genome-wide identification of genetic variants that exist between CD-1 mice has not been done. (biomedcentral.com)

Its main activity is the reproduction and maintenance of mice stocks either of inbred strains or genetically engineered mice, such as transgenic and knockout mouse lines, as well as chemically induced mutants developed by Fleming researchers. (wikipedia.org)
Mouse lines used in research laboratories are genetically homogeneous. (ut.ee)
Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains. (sciencedaily.com)
Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains," said project leader Helene Benveniste, who is a researcher in Brookhaven's medical department and a professor of anesthesiology at Stony Brook University. (sciencedaily.com)

Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)
Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3 tf /J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. (mdpi.com)

The Animal House has 6 different Facilities-Units of SPF status and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
My research leverages the power of the house mouse model system to address open questions in evolutionary genomics. (jax.org)
The classical laboratory inbred mouse strains derive from a small, ancestral population of wild mice that were selectively bred for traits of interest by mouse fanciers in the late 19th and early 20th centuries. (jax.org)
Our prior work has demonstrated that wild mouse populations harbor numerous predicted functional and disease-associated alleles, the majority of which are not present in classical inbred mouse strains and have therefore never been experimentally tested in the laboratory. (jax.org)
Thus, we contend that wild mice present an untapped opportunity for developing new mouse models of human disease and advancing new biomedical discoveries. (jax.org)
With the broad goal of elevating the profile of wild mice in biomedical research, my group is pursuing population genomic investigations in wild mice to understand the natural evolutionary forces that shape variation in wild mouse populations. (jax.org)
My work relied on wild-derived inbred mice as a model system, and I gained relevant practical experience with wild mouse husbandry, colony maintenance, and mouse reproductive phenotyping. (jax.org)
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
Choosing the right inbred strain for a particular experiment is an important consideration when working with laboratory mice and thus it is important to thoroughly map the functional differences between mouse lines. (ut.ee)
The work was done in parallel with an international collaboration, the Mouse Phenome Database (MPD) project, which was created to establish a collection of baseline phenotypic data from commonly used inbred mice. (sciencedaily.com)
We argue that new technologies will enable insights into how specific models align with human disease states and that this knowledge can be used to develop a diverse ecosystem of complementary mouse models of cancer. (biologists.com)
Thus, careful characterisation and judicious use of an array of mouse models provides an opportunity to address some of the issues surrounding both the reproducibility and translatability crises often referenced in pre-clinical cancer research. (biologists.com)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
BSRC Animal House provides mouse research models of the highest quality. (animalfacility.eu)
In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)
F or a human, herpes is usually no more than a painful inconvenience, but for a mouse, catching the sexually transmitted infection is akin to a kiss of death. (the-scientist.com)
University of Washington translational immunologist David Koelle , who didn't work on the study, agrees this is a fascinating study, but is "not sure how relevant [it] is to humans," because HSV-2 interacts with the mouse body differently than it does humans. (the-scientist.com)
Lawson HA , Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides. (wustl.edu)
Cheverud JM, Lawson HA , Funk R, Zhou J, Blakenhorn EP, Heber-Katz E, Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses. (wustl.edu)
An inbred strain of mouse. (ouhsc.edu)
CD-1 is an outbred mouse stock that is frequently used in toxicology, pharmacology, and fundamental biomedical research. (biomedcentral.com)
CD-1 is a commonly used outbred mouse, derived in Switzerland from two male and seven female albino mice from a non-inbred stock. (biomedcentral.com)
To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. (mdpi.com)
One approach involves the experimental transmission of disease by inoculating homogenized brain tissue from affected animals into transgenic mice that are overexpressing 1 of the 2 common polymorphic forms of the human PrP (either methionine or valine at residue 129) on a mouse PrP null background ( 16 ). (cdc.gov)

Guinea pigs are important animal models for human disease, and both outbred and inbred lines are utilized in biomedical research. (bvsalud.org)
Here, we investigated the effects of parental age, parity, and pairing approaches on mean total fetus count, percentage of female pups in the litter, and pup survival rate after 10 days in strain 13/N guinea pigs. (bvsalud.org)
These studies provide valuable information regarding the reproductive characteristics of strain 13/N guinea pigs, and support a variety of breeding approaches without significant effects on breeding success. (bvsalud.org)

Furthermore, careful re-introduction of biological variation, be that through outbred populations, environmental diversity or including animals of both sexes, can ensure that results are more broadly applicable and are less impacted by particular traits of homogeneous experimental populations. (biologists.com)

Jacques Derrida has explored the fundamental question of the "limit" that identifies and differentiates the human animal from the nonhuman animal. (erudit.org)
They can answer fundamental research questions that research on rodents has failed to address. (sixthtone.com)
A good example would be the brain, since there is still a lot we do not know about how it works and if we are to find answers to these important questions, fundamental research must continue.The information acquired by fundamental research often provides new insights into more applied medical research that ultimately leads to the developmentof new medicines. (ommegaonline.org)

Fleming's Animal house (certified with ISO 9001) provides husbandry of animals and services to the biomedical research community since 2001. (wikipedia.org)
Since 2001, the Animal House of BSRC 'Alexander Fleming' provides high quality breeding and experimental environment and animal models to the biomedical research community, promoting animal welfare, excellence and scientific interaction. (animalfacility.eu)
Sachser, N (2001): Rhythm of activity in closely related inbred strains of mice. (fu-berlin.de)
Sachser, N (2001): Circadian rhythm of three closely related inbred strains of mice differing in aggressive behaviour. (fu-berlin.de)

Here, we discuss the species-specific enrichment needs of ferrets, enrichmentconsiderations for ferrets housed in research settings, and the challenges and importance of providing appropriate enrichmentduring experimentation, including when ferrets are housed in high-containment facilities. (bvsalud.org)
I am on principle sympathetic with those who, it seems to me, are in the right and have good reasons to rise up against the way animals are treated: in industrial production, in slaughter, in consumption, in experimentation. (erudit.org)
This model is undoubtedly representing all aspects of human hookworm biology, and for elucidating activity of chemotherapy and planning control experimentation. (boffinaccess.com)
BSRC Animal House provides state of the art installation, phenotyping equipment, specialized personnel and animal models for research protocols, ensuring high standards of experimentation. (animalfacility.eu)
Undoubtedly, animal experimentation has played a central role in biomedical research throughout history, where animals were first used as models of anatomy and physiology. (ommegaonline.org)
It is our moral duty to ascertain that animal experimentation should cause as little suffering to animals, as possible and should only be performed where necessary. (ommegaonline.org)

A quantitative understanding of how the molecular transport systems at the human BBB are altered in diseases is essential not only to elucidate the pathophysiological roles of the BBB in human brain, but also to aid development of effective drugs and appropriate pharmacotherapies for CNS diseases. (aspetjournals.org)

The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)

Fields of excellence: Molecular mechanisms of disease (inflammation, cancer, metabolic syndrome, CNS disorders) Biomedical research The Fleming Museum of Contemporary Science, fleming.gr. (wikipedia.org)
There is a growing appreciation by the biomedical community that studying the impact of sex and gender on health, aging, and disease will lead to improvements in human health. (biomedcentral.com)
Sex- and gender-based comparisons can inform research on disease mechanisms and the development of new therapeutics as well as enhance scientific rigor and reproducibility. (biomedcentral.com)
While sex and gender differences in the etiology, age of disease onset, symptomology, diagnostics, response to treatment, and outcomes have long been known to exist for key health outcomes in medicine, insufficient biomedical research and reporting on the impact of sex and gender in health and disease still exists. (biomedcentral.com)
Although multiple animal models are available for mild to moderate clinical disease, models that develop severe disease are still needed. (bvsalud.org)
Mice are often used as model organisms for human diseases to understand the causes and nature of disease. (ut.ee)
No human disease due to anthrax caused by the Sterne strain has been reported. (cdc.gov)
Viral diseases have long been studied, but COVID-19 is a "new disease" that pushes the research community and the world more generally into "uncharted territories," says Casanova. (nature.com)
Animal models include a variety of inbred and outbred strains, as well as models for human disease. (animalfacility.eu)
Biomedical scientists have linked obesity in humans to higher risk of cardiovascular disease, as well as greater cancer risk and in some cases impaired immune systems . (the-scientist.com)
It became the first published book to advocate creating "induced animal models" for biomedical research, by proposing the use of chemical and physical induction of disease in animals. (ommegaonline.org)
The project allowed her to take full advantage of her early training in computer science, and it marked a turning point in her life: Though she still spent her free time doing community service and exploring the clinical side of neuropsychiatric disease, she found her attention turning ever more toward research. (rockefeller.edu)
These data are consistent with the conclusion that prion disease is less likely to develop in humans after exposure to naturally occurring prions of sheep than after exposure to epizootic BSE prions of ruminants. (cdc.gov)
The BSE prion is an epizootic agent and causes variant Creutzfeldt-Jakob disease (vCJD) in humans after dietary exposure ( 1 - 4 ). (cdc.gov)
This increase has rekindled speculation that atypical scrapie in small ruminants might be a source of human prion disease ( 11 ). (cdc.gov)
Although atypical scrapie has been discovered retrospectively in 2 UK sheep culled in 1987 and 1989 ( 14 , 15 ), the level and duration of human exposure to atypical scrapie prions are unknown, and this lack of knowledge confounds a cause-and-effect investigation of epidemiologic links between this animal disease and some form of CJD ( 11 ). (cdc.gov)

Currently, the Center hosts 14 research groups distributed in 4 Institutes (Immunology, Molecular Oncology, Molecular Biology and Genetics, Cellular & Developmental Biology). (wikipedia.org)
New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. (nih.gov)
Pam does research in Neuroscience, Physiology and Molecular Biology. (jain-foundation.org)

The enforcement of animal safety and welfare laws and regulations has led to stringent practices and prohibitions on use of animals for various purposes. (reportsanddata.com)
The data to support instillation or inoculation volumes are important both for optimal experimental design and to minimize or avoid effects of diluent alone, which may compromise both data interpretation and animal welfare. (bvsalud.org)
I got some (legitimate) pushback on this, stating essentially that while rodents aren't covered by the Animal Welfare Act, their use is now regulated by the NIH . (erichgrunewald.com)
Veterinarians act as spokespeople for laboratory animals, interpreting their behaviors to ensure both the quality of the research and the welfare of the animals. (sixthtone.com)
It is upon the researcher to ensure that research involving animals will contribute significantly to the health and welfare of either humans or animals. (ommegaonline.org)

Mice have been used as models of human biology and diseases, due to their phylogenetic and physiological similarities to humans, ease with which they can be maintained and bred in the laboratory, and existence of various inbred strains. (reportsanddata.com)
She studied creative writing, biology, and geology at Macalester College, where she honed her skills in journalism and podcast production and conducted research on dinosaur bones in Montana. (the-scientist.com)
Monkeys are also used for basic research into areas such as viruses, diseases, and neurology, as well as cutting-edge biology research into areas like stem cells and gene editing. (sixthtone.com)
There are seven major areas of medicine and biology, where animals are used, but majority of animal models is used to study the cause, nature and cure of diseases affecting both humans and animals. (ommegaonline.org)
Human biology is very much similar to that of many other animals. (ommegaonline.org)
At present, basic research in many areas of biology and medicine still needs to use animals. (ommegaonline.org)
Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)

In the past, animal research played a vital role in discoveries such as how the kidneys work, or how hormones control different parts of the body. (ommegaonline.org)

Most laboratory animals have the same set of organs - heart, lungs, liver, and so on which work in the same way as they do in human. (ommegaonline.org)

A survey of ten different disciplines including neuroscience, physiology, pharmacology, endocrinology, zoology, and behavioral science demonstrated that the majority of studies published in 2009 were conducted in male animals [ 2 ]. (biomedcentral.com)
Right here, we've got used RNA-seq to look at the transcriptome of complete mind in 40 of the LXS strains eight hours after a saline or ethanol "pretreatment" as in earlier behavioral research. (eumorphia.org)

We beforehand reported the era of a transgenic murine mannequin of progeria carrying a human BAC harboring the frequent mutation, G608G, which within the single-copy state develops options of HGPS which might be restricted to the vascular system. (eumorphia.org)
To investigate whether sheep infected with scrapie prions could be another source of infection, we inoculated transgenic mice that overexpressed human prion protein with brain tissue from sheep with natural field cases of classical and atypical scrapie, sheep with experimental BSE, and cattle with BSE. (cdc.gov)

This review will assist basic researchers, clinical investigators, as well as epidemiologists, population, and social scientists by providing an annotated bibliography of currently available resource tools on how to consider sex and gender as independent variables in research design and methodology. (biomedcentral.com)
The authors defined a resource as a broadly based tool that can be used to guide both novice and experienced researchers to consider the impact of sex and gender differences within research design and methodology. (biomedcentral.com)
The research team included seven academic researchers, both basic science and clinical science, from US universities. (biomedcentral.com)
You may have heard of the scandal where researchers from the University of Minnesota Twin Cities (UMN) intentionally tried to introduce bugs into the Linux kernel codebase as part of a research project. (erichgrunewald.com)
Using animals in scientific experiments seems like a clear case of using those animals as a mere means, just as the UMN researchers used those Linux kernel maintainers to further their own ends. (erichgrunewald.com)
In a study published November 8 in Cell Reports , researchers found that thanks to differences in their vaginal microbiomes compared with lean mice, obese mice fed a high-fat diet had stronger immune responses against HSV-2, which causes genital herpes in humans. (the-scientist.com)
Researchers at the Korea Advanced Institute of Science and Technology (KAIST) led by immunologist Heung Kyu Lee wanted to test obesity's effects on antiviral immunity, specifically against the common human sexually transmitted infection genital herpes. (the-scientist.com)
The turning of the century saw the development and use of animal models for infectious diseases and screening and the evaluation of new antibacterial drugs based upon the work of these three researchers. (ommegaonline.org)

The growth of the segment can be attributed to rising use of inbred mice in research of pharmacology and cardiovascular diseases, and to study responses of monoclonal antibodies. (reportsanddata.com)

The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)

The Biomedical Sciences Research Center "Alexander Fleming" is a non-profit research organisation based in Vari, Athens, Greece. (wikipedia.org)

However, different inbred lines carry different fixed alleles and therefore exhibit different phenotypic characteristics, which affects experimental results. (ut.ee)
Hookworms research has been greatly impeded by a lack of suitable animals for experimental work [3]. (boffinaccess.com)
This full development of N. Americanus in the experimental host initiated with human derived infective larvae (NaL3 ) is a great achievement indeed. (boffinaccess.com)
Sen & Seth [5] concluded that the hamsters are suitable experimental hosts for human hookworm infection. (boffinaccess.com)
Initially Sen [6] adapted human parasite, Necator americanus on injecting cortisone to experimental animals (up to 4 generations) and intensively made susceptible to Necator pathogen. (boffinaccess.com)
1 Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. (ommegaonline.org)
2* Department of Experimental Medicine and Biotechnology, Research Block-B, Postgraduate Institute of Medical Education and Research,India. (ommegaonline.org)
In 1865, Claude Bernard, a French physiologist published a book, An Introduction to the Study of Experimental Medicine, intended to provide guidance to physicians in experimental research[5]. (ommegaonline.org)
We used the called variants to construct a strain-specific CD-1 reference genome, which we show can improve mappability and reduce experimental biases from genome-wide sequencing data derived from CD-1 mice. (biomedcentral.com)

My research aims to understand the causes and consequences of variation in the mechanisms that govern DNA inheritance: chromosome segregation, recombination, and de novo mutation. (jax.org)
Theoretically, there are two mechanisms by which the Sterne strain may cause anthrax. (cdc.gov)
Animals can appear coloured due to two mechanisms, pigments and structural colours . (wikipedia.org)
Mechanisms and beneficial applications of resveratrol as feed additive in animal and poultry nutrition: A review. (scialert.net)

100M vertebrates are used for research and ancillary purposes annually. (erichgrunewald.com)
It's likely that well over 100 million vertebrates are used for research and ancillary purposes each year. (erichgrunewald.com)

Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T1 immunity to dietary antigen. (broadinstitute.org)

Similarly, even if animals being tested upon could consent to it, which they cannot, it seems highly unlikely that they would choose to do so, if for no other reason than that they are often euthanised after the experiment is over. (erichgrunewald.com)
One lab animal is generally used for only one experiment. (sixthtone.com)
Additionally, improved reporting of thedetailsmaximizes the availability andutility of the information gained fromevery animal experiment, also preventing the unnecessary animal use in thefuture. (ommegaonline.org)

These type of mice are being considered as an important tool in genetics studies of complex diseases, owing to which there is high demand for inbred mice. (reportsanddata.com)
In 2020, the veterinary segment accounted for the largest revenue share, due to rising prevalence of several animal disorders such as seizures and severe infectious diseases, resulting in increasing R&D to develop veterinary medicines. (reportsanddata.com)
Animal models are useful tools for studying diseases such as cancer. (biomedcentral.com)
2014. Strategies for combating and eradicating important infectious diseases of animals with particular reference to India: Present and future perspectives. (scialert.net)

[3] It is a common misconception that all albino animals have characteristic pink or red eyes (resulting from the lack of pigment in the iris allowing the blood vessels of the retina to be visible), however this is not the case for some forms of albinism. (wikipedia.org)

However, appropriate enrichmentdecisions vary greatly depending on the species involved and the research use of the animals. (bvsalud.org)
In other words, bioethics should examine the prejudices that are "based on species difference" and "species membership," and hence take up the central issue of "our obligations to nonhuman animals. (erudit.org)
These data are now in GeneNetwork (Species = Human, Group = Retina). (genenetwork.org)

A high-fat diet induced changes to the animals' vaginal microbiomes that boosted survival after exposure to the virus. (the-scientist.com)

Since the beginning of its operations in 1998, the Center develops basic as well as translational and applied research programs in biomedical sciences. (wikipedia.org)
One of the ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. (sciencedaily.com)
3 Department of Animal and Avian Sciences, University of Maryland, College Park, USA . (scirp.org)
Open Journal of Animal Sciences , 11 , 304-332. (scirp.org)
Dr Bradley Launikonis heads the muscle research lab at the School of Biomedical Sciences at the University of Queensland. (jain-foundation.org)

Animal models, specifically mice models, usually receive a large portion of research investment. (reportsanddata.com)
The global mice model market is expected to be primarily driven by use of mice models in cancer research. (reportsanddata.com)
Complying with required legislation for use of animal models can be time-consuming and inconvenient, and could restrain growth of the global mice model market. (reportsanddata.com)
Many published results either don't translate to human models or don't replicate. (erichgrunewald.com)
Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation. (tno.nl)
Since, new animal models are continually being characterized, identifying and selecting the most appropriate animal model is the single most essential element in animal-based research. (ommegaonline.org)
Humans have been using animals as models of their anatomy and physiology since the dawn of medicine. (ommegaonline.org)

We are also actively involved in the development of new strain and genomic resources derived from wild-caught animals. (jax.org)

One understands a philosopher only by heeding closely what he means to demonstrate, and in reality fails to demonstrate, concerning the limit between human and animal. (erudit.org)
Empathy deficit is closely related to antisocial and maltreatment behaviors [ 31 - 36 ], and recent animal studies revealed that emotion contagion or empathy and prosocial behavior occur in rodents [ 37 - 40 ]. (encephalitisjournal.org)

To address the underrepresentation of females in biomedical research, the National Institutes of Health (NIH) released a notice on June 9, 2015 entitled, Consideration of Sex as a Biological Variable in NIH-funded Biomedical Research that focuses on the "expectation that scientists will account for the possible role of sex as a biological variable in vertebrate animal and human studies" [ 5 ]. (biomedcentral.com)
Oct. 6, 2021 It takes billions of cells to make a human brain, and scientists have long struggled to map this complex network of neurons. (sciencedaily.com)

Compared with normal wild type strains which produce both the toxin and the capsule, the Sterne strain is relatively avirulent, however immunization using the Sterne strain is able to stimulate a protective immune response. (cdc.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs. (nih.gov)
For greater than a decade, aiming to assist biomedical analysis and stimulate worldwide collaboration, AMMRA has all the time been a pleasant and passionate ally of Asian and Australian member establishments dedicated to sharing information, exchanging sources, and selling biomedical analysis. (eumorphia.org)

A variety of brain-imaging techniques including magnetic resonance imaging are a direct outgrowth of DOE's support of basic physics research. (sciencedaily.com)
Studies in animals and humans have revealed that early-life stress affects brain development and social behavior in adulthood [ 7 , 28 , 30 , 41 - 43 ]. (encephalitisjournal.org)

The NIH has launched a research initiative focusing on the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), which currently has $1.15 billion in funding. (nature.com)

It is not used with animals that do not possess a cortex, i.e., it is used only with mammals. (lookformedical.com)

On the basis of use, the mice model market is segmented into human and veterinary. (reportsanddata.com)
however, most basic science research is conducted based on a male model. (biomedcentral.com)
An animal model that fully recapitulates severe COVID-19 presentation in humans has been a top priority since the discovery of SARS-CoV-2 in 2019. (bvsalud.org)
Syrian hamsters are a key animal model of SARS-CoV-2 and other respiratory viruses and are useful for the evaluation of associated medical countermeasures. (bvsalud.org)
Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. (tno.nl)
Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. (ouhsc.edu)

Oct. 2 Presentation by Brody Holohan, PhD, CIBM postdoctoral fellow (Center for Human Genetics, Marshfield Clinic Research Inst. (wisc.edu)

L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
Consequently, conservation of farm animal breeds had been for several reasons, for example, to retain potentially useful genes and gene combinations such as the Booroola fecundity gene in sheep [10], the exploitation of heterosis, and to overcome selection plateaus, in addition to cultural motivations, research, and food security. (scirp.org)

The Center also runs an Innovation and Enterprise Unit that facilitates the protection and exploitation of the Center's research and technologies. (wikipedia.org)

Dhawan,V. Animals in Research: Contemplating the Need (2019) J Vet Sci Ani Wel 3(1): 5012. (ommegaonline.org)

Chief Resident in Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, 1995-1995. (upenn.edu)

This research was initially funded by the National Institute on Drug Abuse and then by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). (sciencedaily.com)

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)

results from animal experimentations are applied to humans. (ommegaonline.org)

These resources will assist investigators applying for funding from the National Institutes of Health since all grant applicants will be required (as of January 25, 2016) to address the role of sex as a biological variable in vertebrate animal and human studies. (biomedcentral.com)
The development of the web-browser and database was supported by both NIBIB and the Office of Biological and Environmental Research within the U.S. Department of Energy's Office of Science. (sciencedaily.com)
Automatic detection and segmentation of biological objects in 2D and 3D image data is central for countless biomedical research questions to be answered. (mpi-cbg.de)
Animals may have both biological pigments and structural colours, for example, some butterflies with white wings. (wikipedia.org)

This article is organizedto support the easy availability of information that will facilitate the design and implementation of optimal environmentalenrichment for ferrets used in diverse research efforts in vivarium settings. (bvsalud.org)
The optimal maintenance of guinea pig colonies, commercially and in research settings, relies on robust informed breeding programs, however, breeding data on specialized inbred strains are limited. (bvsalud.org)

In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
We then used the identified variants to construct a strain-specific CD-1 reference genome, and associated annotation files, including genes and the full set of identified CD-1 variants. (biomedcentral.com)
Broad Genomics Platform sequences a whole human genome every four minutes. (broadinstitute.org)
In November 2022, Broad's Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. (broadinstitute.org)

A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)

For this reason, live vaccines have never been considered suitable for human use in the United States. (cdc.gov)
Dive into critical research updates from pioneers in the field with keynotes including: Carolyn Bertozzi, Ph.D. from Stanford University, Hans de Haard, Ph.D. from Argenx, Douglas Lauffenburger, Ph.D. from Massachusetts Institute of Technology, and Hanneke Schuitemaker, Ph.D. from Janssen Vaccines & Prevention. (cshlpress.com)
Trade restrictions and an increase in biomedical research, including into COVID-19 vaccines, have driven the price of animals used in experiments to new heights. (sixthtone.com)

In the natural image domain, spatial embedding-based instance segmentation methods are known to yield high-quality results, but their utility to biomedical data is largely unexplored. (mpi-cbg.de)

In mice, the attenuated strains possess a low degree of virulence, due to toxin production. (cdc.gov)

Because the time lag between exposure and development of vCJD may be decades, uncertainty about the extent of the pathogenicity of BSE for humans continues ( 5 ), and subclinical forms of infection may exist ( 6 , 7 ). (cdc.gov)

During selection, the lines were inbred by limiting the population size [ 9 ] until an average theoretical inbreeding coefficient of approximately 0.985 was reached. (biomedcentral.com)
From then on, a regular system of inbreeding involving full-sib (FS) mating was applied and maintained for more than 30 generations giving rise to CBi/L FS, CBi − FS and CBi FS lines. (biomedcentral.com)

It is probably not possible for humans to acquire a Sterne strain infection by the respiratory or oral route. (cdc.gov)
While it is highly unlikely that the Sterne strain will result in infection, cutaneous anthrax can be successfully treated with antimicrobial agents, making it improbable that a localized infection can become severe or fatal. (cdc.gov)

The research that makes up this database was published as a cover article in the October 2005 issue of the journal Neuroscience. (sciencedaily.com)
Dr. Lemckert is a senior research officer at The Children's Hospital at Westmead & The Children's Medical Research Institute, Kid's Neuroscience Centre. (jain-foundation.org)

Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)

To pursue this question, however, means that our movement in language should be more radical than what has been undertaken to date, in which case we may well have to rectify our language by eschewing the very concepts "human" and "nonhuman," as well as the more basic concept "animal," which has its provenance in the Latin renditions of classical Greek philosophical nomenclature. (erudit.org)

Anatomy3

Organisms22

Diseases7

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology10

Phenomena and Processes39

Disciplines and Occupations36

Anthropology, Education, Sociology and Social Phenomena26

Technology, Industry, Agriculture9

Humanities11

Information Science56

Named Groups4

Health Care51

Geographicals2

Recombinant inbred6

Rats2

C57BL3

Genetic14

Genetically4

Phenotypes2

Mouse26

Guinea pigs3

Populations1

Fundamental3

20014

Experimentation6

Quantitative1

Mammary2

Disease16

Molecular3

Welfare5

Biology7

Discoveries1

Laboratory animals1

Behavioral2

Transgenic2

Researchers8

Pharmacology1

Knockout1

Alexander Fleming1

Experimental9

Mechanisms4

Vertebrates2

Murine1

Experiment3

Diseases4

Albino1

Species3

Diet-induced1

Sciences5

Models7

Genomic1

Closely2

Scientists2

Stimulate3

Brain2

Acute1

Mammals1

Model6

Postdoctoral fellow1

Breeds2

Facilitates1

20191

Yale Universi1

National Insti1

Mice and humans1

Experimentations1

Biological4

Optimal2

Genome4

Outlook1

Vaccines3

Results1

Possess1

Development1

Lines2

Infection2

Neuroscience2

Journal2

Nonhuman1