Human apoptosis map kinase kinase kinase 1. Medical search. Frequent questions

The activation of this pathway stops the noncanonical one and simultaneously the apoptosis. (wikipedia.org)
A variety of extrinsic cues converge on the extracellular signal-regulated kinase/mitogen activated protein kinase (ERK/MAPK) pathway. (nature.com)
The mutation appears to have a direct role in activating the MAP kinase pathway, which controls processes such as cell proliferation, differentiation, survival and apoptosis (cell death). (gsk.com)
This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. (nih.gov)
c-Jun N-terminal kinase (JNK) signaling pathway by up-regulating the manifestation of its target growth arrest and DNA-damage-inducible protein GADD45 alpha (GADD45) and consequently activating mitogen-activated protein kinase kinase-4 (MKK4). (igesip.org)
Many pro-apoptotic genes, such as PUMA, Bax and NOXA, act as activators of the mitochondrial apoptotic pathway, and have p73 responsive elements in their promoter and may become up-regulated by p73 to induce apoptosis in response to chemotherapeutic medicines. (igesip.org)
In addition, p73-mediated up-regulation of the death receptor CD95, a mediator of the extrinsic apoptotic pathway, also contributes to p73-mediated apoptosis in malignancy cells under stress stimuli [8]. (igesip.org)
The JNK signaling pathway replies to various tension stimuli, through the transduction from the upstream MAPKKK including MEKKs, and eventually activation of JNK by phosphorylated at Thr and Tyr sites with the JNK immediate upstream kinases MKK4/MKK7. (igesip.org)
Furthermore, the JNK signaling pathway plays a part in cisplatin-dependent apoptosis in cancer cells [12]C[15] critically. (igesip.org)
2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Here we found that the germinal ablation of the MAPK c-Jun N-Terminal Kinase isoform 1 (JNK1) results in a significant reduction of myelin in the cerebral cortex and corpus callosum at both postnatal and adult stages. (nature.com)
The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways. (eurekaselect.com)
inhibited MST2 relationships with Raf-1 but improved binding to RASSF1A leading to higher activation of downstream tension signalling pathways (JNK FK866 and p38 MAPK) and apoptosis. (biomasswars.com)
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). (affbiotech.cn)
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. (affbiotech.cn)

This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. (thermofisher.com)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
29, 30, 37] FNIP1 then interacts with 5'-AMP (activated protein kinase), which interacts with mammalian target of rapamycin (mTOR) that is involved in cellular energy, cytokinesis, cell motility, cellular adhesion, and nutrient sensing. (medscape.com)

Whether SWCNT have the potential to induce apoptosis, BEAS-2B cells were exposed for different time points to SWCNT (50 mu g/cm2), and analyzed for PARP activation, as a molecular marker of apoptosis. (cdc.gov)
Recent research demonstrated that the potential to induce apoptosis through endoplasmic reticular (ER) stresses can be a target for cancer therapy. (hindawi.com)

Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)

Therefore, the aim of the present study was to investigate the gene expression patterns following siRNA‑mediated suppression of RUNX1‑RUNX1T1 and MAPK1 in Kasumi‑1 and SKNO‑1 cells and to determine the differentially expressed genes in enriched biological pathways. (prinsesmaximacentrum.nl)
RUNX1‑RUNX1T1 suppression exerted an anti‑apoptotic effect through the overexpression of BCL2, BIRC3 and CFLAR genes, while MAPK1 suppression induced apopotosis in t(8;21) cells by the apoptotic mitochondrial changes stimulated by the activity of upregulated TP53 and TNFSF10, and downregulated JUN gene. (prinsesmaximacentrum.nl)
Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. (thermofisher.com)
6) and activation from the Bax binding proteins MAP-1/MOAP-1(7 8 Therefore in mammalian cells MST kinases are real apoptosis inducers in response to tension and tumour suppressor genes. (biomasswars.com)
Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)

MAPKs are involved in directing cellular responses to a diverse array os stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines regulating cell functions including proliferation, gene expression, differentiation, mitosis, cell survival or apoptosis. (wikipedia.org)
HEMA reduces cell proliferation and induces apoptosis in vitro. (niom.no)
First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
Taken together, the current results demonstrate that MAPK1 promotes myeloid cell proliferation and differentiation simultaneously by cell cycle progression while suppresing apoptosis. (prinsesmaximacentrum.nl)
Our outcomes further show how the dissociation from the Raf-1-MST2 complicated can be section of mitogenic signalling therefore linking induction of proliferation with the chance of apoptosis. (biomasswars.com)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
These effects were diminished by PD98059, an inhibitor of MAP kinase. (cdc.gov)

GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
May 16, 2003 - Fri 12:30PM - Dr. Vilhelm Bohr, NIA - Human Premature Aging Proteins: Werner and Cockayne, Links Between DNA Repair and Aging 3. (bio.net)
The services include antibody microarrays, peptide arrays, kinase profiling, substrate profiling, mass spectrometry, bioinformatics analysis and standard screens that track the expression levels and phosphorylation states of hundreds of known cell signalling proteins within thematic families of protein kinases, phosphatases, stress/heat shock, cell cycle and apoptosis proteins. (hum-molgen.org)

By specifically binding to MEK 1 and 2, GSK'212 may result in an inhibition of cellular signalling and cellular growth in certain cancers. (gsk.com)
Akt can be a primary downstream effector of PI3K whose pleiotropic features are the inhibition of apoptosis (16-18). (biomasswars.com)
AEG was found to enhance glycogen synthesis through the inhibition of glycogen synthase kinase 3β. (wiley.com)
Inhibition of JNK activity by a specific inhibitor or small interfering RNA (siRNA) significantly abrogated TAp73-mediated apoptosis induced by cisplatin. (igesip.org)
Furthermore, inhibition of GADD45 by siRNA inactivated MKK4/JNK activities and also clogged TAp73-mediated apoptosis induction by cisplatin. (igesip.org)

Moreover, JNK1 KO and WT D-JNKI-1 treated OLs, while not showing overt alterations of differentiation in vitro, display a reduced surface compared to controls. (nature.com)
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. (thermofisher.com)

FOXA2 overexpression alleviated LPS‑induced inflammation, oxidative stress, apoptosis and ERS in WI‑38 cells. (spandidos-publications.com)
Furthermore, the inhibitory effects of FOXA2 on inflammation, oxidative stress and apoptosis, as well as ERS in LPS‑induced WI‑38 cells were partly weakened by additional treatment with U46619. (spandidos-publications.com)

Tyr14 phosphorylation by Src, Fyn or Abl tyrosine kinases, has been linked to various cellular phenomena including mechano-transduction, signal transduction, endocytosis, cell migration and focal adhesion dynamics. (diff.org)
Glucose transporter 4 translocation was confirmed by determining the uptake of glucose in the presence of insulin receptor tyrosine kinase and PI3K inhibitors. (wiley.com)

Furthermore, SWCNT induced time- and dose-dependent apoptosis and phosphorylation of histone gamma-H2A.X, a variant of histone H2A that is activated following DNA damage. (cdc.gov)
Akt-induced phosphorylation of MST2 (i) promotes MST2 discussion with Raf-1 (ii) blocks MST2 recruitment by RASSF1A and (iii) straight inhibits MST2 kinase activity. (biomasswars.com)

Dual Specificity Phosphatase 26 (DUSP26) inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. (prospecbio.com)
Ma C, Zhang D, Ma Q, Liu Y and Yang Y: Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1. (spandidos-publications.com)

Cell apoptosis was analyzed by Hoechst 33258 staining and annexin V-PI labeling. (molvis.org)

Unlike apoptosis, senescence is a state of which cells are still alive and metabolically active. (frontiersin.org)
Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. (cancerindex.org)

We also examined the ability of SWCNT to induce the transactivation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kB), transcription factors that are important members of signal transduction pathways. (cdc.gov)
These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
MEK 1 and 2 are thought to play a role in the activation of key signalling pathways that regulate cell growth.In BRAF mutant melanoma, MEK activation is a driver of the disease. (gsk.com)
Therefore MST2 serves mainly because a hub to integrate the natural outputs from the Akt and Raf-1 pathways. (biomasswars.com)
Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)

When a cell is tumorous it does not cease to proliferate inhibiting the apoptosis, as a result, in cancerous cells cIAP1 is rarely located in the cytoplasm. (wikipedia.org)
Activation of p38MAPK plays an important role in t BHP-induced apoptosis of iHTM cells. (molvis.org)
In this study, the anti-cancer effects of pentadecanoic acid were evaluated in human breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem cell properties compared to the parental MCF-7 cells. (mdpi.com)
A comparative study of effects of singlewall carbon nanotube s and crocidolite asbestos in human BEAS-2B cells. (cdc.gov)
In the present study, we investigated SWCNT effects on the human broncho-epithelial cells (BEAS-2B). (cdc.gov)
To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). (hindawi.com)
The first report in 2007, on SAA-stimulated human coronary artery endothelial cells (HCAEC), exhibited a substantial and significantly higher induction of released IL-6 protein and mRNA levels as compared to HUVEC [ 17 ], as well as increased responsiveness to IL-1 β [ 18 ]. (hindawi.com)
In this study, we established an model to compare the responses of type I (ATI) and type II (ATII) alveolar epithelial cells to infection by respiratory viruses used in murine models: mouse-adapted severe acute respiratory syndrome-associated coronavirus (SARS-CoV, v2163), murine coronavirus MHV-1, and influenza A (H1N1) virus, strain PR8. (cancercurehere.com)
In contrast, ATII cells that were cultured to trans-differentiate into an ATI-like cell phenotype were susceptible to MHV-1 and PR8, but not mouse-adapted SARS-CoV. (cancercurehere.com)
While MHV-1 and PR8 induced expression of a number of shared cytokines in ATI cells, there were several cytokines whose expression was induced uniquely by MHV-1 infection. (cancercurehere.com)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)
Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
24 25 This is a process catalysed by B-cell specific V(D)J recombinase activating enzymes RAG-1/2 which are expressed in both pre-B cells and GC B cells. (bmj.com)
1 What got scientists so interested was that the gene expression changes induced by resveratrol in yeast cells were similar to those thought to confer longer life in human beings. (lifeextension.com)
This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. (nih.gov)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
43] Additionally, knockdown of slingshot 2 (SSH2) serine phosphatase was demonstrated to induce caspase 3/7 activation that can trigger apoptosis in human carcinoma cells with a FLCN mutation. (medscape.com)

Mammalian sterile20-like kinases (MST1/2) are involved in stress-induced apoptosis signalling. (biomasswars.com)

In the past decade, induction of apoptosis has become the major strategy to combat cancer. (hindawi.com)
Therefore, a search for innovative strategies other than induction of apoptosis is urgently needed. (hindawi.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)

While many factors are involved in the etiology of cancer, it has been clearly established that diet significantly impacts risk of this disease [ 1 , 2 , 3 ]. (mdpi.com)
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide and the third most common type of cancer ( 1 ). (frontiersin.org)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)

However mitogenic stimulation and activated Ras also can disrupt the MST2-Raf-1 complex without FK866 causing MST2 activation (13 14 This suggests that MST2 release is part of normal mitogenic regulation and that mitogens must suppress the pro-apoptotic FK866 function of MST2. (biomasswars.com)

Among MAPKs, the c-Jun N-terminal kinases (JNKs) include three isoforms-JNK1, JNK2 and JNK3. (nature.com)
The JNK protein kinases consist of Jnk1, Jnk2 and Jnk3. (igesip.org)

cIAP1 is recruited to TNF receptor complexes where they support cell survival through NF-κB activation while suppressing apoptosis by preventing caspase activation. (wikipedia.org)
Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. (thermofisher.com)
Immunoblot analysis revealed an insulin-like glucose transporting mechanism of AEG by activating key markers involved in the insulin signaling cascade such as insulin receptor beta IRβ, insulin receptor substrate1, 85 phosphatidyl inositol 3′ kinase (PI3K) and PKB. (wiley.com)
HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)

Ubiquinated RIP1 associates with the prosurvival kinase TAK1. (wikipedia.org)

Mutations in SPAG8 were not encountered in 34 other unexplained ALS pedigrees, including 1 with linkage to chromosome 9p13.223.3. (cdk-receptor.com)
CAV -1 is an integral membrane protein found in caveolae, omega-shaped invaginations of the plasma membrane that form a subdomain of cholesterol- and sphingolipid-rich lipid rafts.Cav1 gene is localized to locus D7S522 of human chromosome 7q31.1In vivo, two isoforms of Cav1 are known to exist: α-caveolin that contains residues 1-178 and β-caveolin that contains residues 32-178. (diff.org)
MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. (thermofisher.com)

BTC binds and activates ErbB-1 and ErbB-4 homodimers and is further characterised by its unique ability to activate all possible heterodimeric ErbB receptors. (embl.de)

BRAF belongs to the RAF family of protein kinases. (gsk.com)

DUSP26 also induces activation of MAP kinase p38 and c-Jun N-terminal kinase. (prospecbio.com)
SWCNT induced greater activation of AP-1 and NF-kB at lower doses as compared to higher doses. (cdc.gov)
In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK. (niom.no)
Outcomes with Ras effector site mutants that selectively few to either PI3K or Raf-1 display that Akt activation is essential to abrogate MST2 activation in response to mitogenic excitement. (biomasswars.com)
Downregulation of Raf-1 can replacement FK866 for the loss of RASSF1A expression (6) suggesting that Raf-1 binding to MST2 is critical for preventing RASSF1A mediated MST2 activation and apoptosis. (biomasswars.com)

Notably, these latter phenotypes are recapitulated in pure cultures of JNK1 KO OPCs and of WT OPCs treated with the JNK inhibitor D-JNKI-1. (nature.com)

The contents of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) in serum and reactive oxygen species (ROS), nitric oxide (NO), superoxide dismutase (SOD), oxidized LDL lipoprotein (ox-LDL), endothelin-1 (ET-1), eNOS, malondialdehyde (MDA) in serum and abdominal aorta were determined by ELISA. (bvsalud.org)

Thus, it becomes crucial to understand the causal 'map' of the resistance conferred by RGF, so that its clinical potency can be amplified, resulting in enhanced efficacy with reduced adverse effects. (cancerindex.org)
However, resistance to apoptosis is considered to be a characteristic of several types of cancers. (hindawi.com)

The Raf-1 proto-oncogene binds to MST2 therefore inhibiting RASSF1A association and dimerisation (12). (biomasswars.com)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)

MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. (thermofisher.com)

Kinexus is a signal transduction company that utilizes innovative strategies to map and exploit intracellular communication systems involving protein kinases for drug discovery and development. (hum-molgen.org)

DUSP26 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (1-211a.a) and having a molecular mass of 26.3kDa. (prospecbio.com)
Yet, unlike p53, the molecular mechanisms implicating in p73-mediated cellular apoptosis are still not clearly recognized. (igesip.org)

However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated fatty acids in human health. (mdpi.com)
The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione. (niom.no)

Human recombinant apo-SAA was used to stimulate HCAEC at a final 1000 nM concentration for 24 hours. (hindawi.com)
Human being recombinant IGF-1 was from PromoCell. (biomasswars.com)

ARHGEF11 The Jnk3 is fixed to human brain generally, testis and heart [9]. (igesip.org)

Mutations on the gene that encodes cIAP1 are related to hemorrhage and vascular regression because of the defects it represents on the endothelial cell survival and the modification of apoptosis. (wikipedia.org)

38, 39, 40] The formation of pulmonary cysts may be related to the dysregulation of mTOR signaling, which facilitates S6-mediated protein synthesis and HIF-1-alpha-mediated angiogenesis. (medscape.com)

Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)

The JNK belongs to a superfamily of mitogen-activated protein (MAP) kinases. (igesip.org)

Anatomy19

Organisms8

Chemicals and Drugs168

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Pathway11

MAPK6

Protein kinase5

Induce apoptosis2

Mitogen-Activat1

Genes5

Proliferation6

Inhibitor of MAP kinase2

Proteins3

Inhibition5

Differentiation2

Oxidative stress2

Tyrosine2

Phosphorylation2

Inhibits2

Analyzed by Hoechst 332581

Senescence2

Pathways5

Cells22

Mammalian1

Induction3

Cancer7

Apoptotic1

JNK2 and JNK32

Receptor4

TAK11

Chromosome3

Receptors1

Family of protein1

Activation6

JNK11

Serum1

Resistance2

Binds1

Tumour1

Interacts1

Intracellular1

Molecular2

Role2

Recombinant2

JNK31

Encodes1

Facilitates1

Mechanisms1

Belongs1