Human antigens neoplasm. Medical search. Frequent questions

Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)

Poorly differentiated carcinomas near or at midline regions of the mediastinum or retroperitoneum in young or middle-aged males should be considered germ cell neoplasms-even in the absence of a testicular mass. (msdmanuals.com)

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) antibodies were the first of this class of immunotherapeutics to achieve US Food and Drug Administration (FDA) approval. (nih.gov)
Using immunohistochemistry, radiobinding, and indirect immunofluorescence assays, seven distinct cell surface antigens, detected by monoclonal antibodies, were analyzed for the degree of homogeneity or heterogeneity of antigen expression on A Panel of human small cell lung cancers. (elsevierpure.com)
The heterogeneity of antigen expression on lung cancer cells has significant implications for the use of these and other monoclonal antibodies in the study and therapy of lung cancer. (elsevierpure.com)
This antigen is an electrophoretically non-polymorphic glycoprotein of approximately 40,000 molecular weight, which is found in association with beta 2 microglobulin, and which is detected by monoclonal antibodies recognizing monomorphic determinants of HLA Class I. Elucidation of the nature and origin of this molecule may provide valuable information regarding the immune barrier that exists between mother and fetus. (ox.ac.uk)
Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
Active infection including Coronavirus disease 2019 (Polymerase chain reaction confirmed and or clinically suspected), tuberculosis, hepatitis B (known positive Hepatitis B virus (HBV) surface antigen result), hepatitis C, or Human immunodeficiency virus (HIV) (positive HIV 1 by 2 antibodies). (who.int)

Several CTAs, including NY-ESO-1, MAGE-A3, and MAGE-A4, have been or are being studied as target antigens in vaccine clinical trials for various types of tumors, including non-small-cell lung cancer, ovarian cancer, gastrointestinal carcinoma, and urothelial carcinoma ( 7, 9 - 13 ). (aacrjournals.org)
Many neoplasm proteins have been characterized and are used as tumor markers (TUMOR MARKERS, BIOLOGICAL) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (reference.md)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
Upon in vivo transfer, TCR-engineered iNKT (TCR-iNKT) cells showed the highest efficacy in restraining the progression of multiple tumors that expressed the cognate antigen compared with nontransduced iNKT cells or CD8+ T cells engineered with the same TCR. (unimib.it)
Our findings suggest that downregulation of antigen processing may be one of the strategies used by tumors to escape immune surveillance. (johnshopkins.edu)
With all assays, considerable heterogeneity of antigen expression between tumors from different Patients was observed. (elsevierpure.com)
In both fresh tumors and in cell lines, as well as in cell lines established from different metastatic sites in an individual Patient, we observed intratumor heterogeneity finding antigen Positive and negative cells and variation in antigenic density, by immunohistochemistry and indirect immunofluorescence assays. (elsevierpure.com)
Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors. (enzolifesciences.com)
Immunoperoxidase staining of tumor cells for alpha-fetoprotein or beta- human chorionic gonadotropin may suggest readily treatable germ cell tumors. (msdmanuals.com)

To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
Three cell lines, all human small cell lung carcinoma, consistently failed to process endogenously synthesized proteins for presentation to K d -restricted, Vac-specific T cells. (johnshopkins.edu)
Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma. (ox.ac.uk)
Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. (ox.ac.uk)
Thyroid neoplasms arising from follicular cells (adenoma, carcinoma, and follicular/papillary carcinoma) show a broad range of overlapping clinical and cytologic features. (medscape.com)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
IMPORTANCE: The American Joint Committee on Cancer (AJCC) has proposed the inclusion of pretreatment serum carcinoembryonic antigen (CEA) levels (C stage) into the conventional TNM staging system of colon cancer. (mcmaster.ca)

Bone marrow-derived dendritic cells (DCs) are the most potent antigen-presenting cells capable of activating naïve T cells. (nova.edu)
Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses. (ox.ac.uk)
This lentivector expressed a green fluorescent protein (GFP) transgene in mouse bone marrow-derived dendritic cell cultures and in human skin-derived Langerhans and dermal dendritic cells. (ox.ac.uk)
As immunization with the optimal dose of the dectin-2 lentivector was similar to that stimulated by a lentivector containing a strong constitutive viral promoter, targeting antigen expression to dendritic cells can provide a safe and effective vaccine. (ox.ac.uk)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)

CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? (cardiff.ac.uk)

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. (reference.md)
Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. (reference.md)
Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (reference.md)
These proteins are also known as human milk fat globulins (HMFG). (histoprime.com)

The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
Laboratory tests should include a complete blood count (CBC), urinalysis, stool examination for blood, and serum chemistries (including prostate-specific antigen assay in males). (msdmanuals.com)

Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. (aacrjournals.org)
Potential therapeutic applications of these findings include enhancing antigen processing at the level of the transcription of MHC-encoded proteasome and transporter genes. (johnshopkins.edu)

A dectin-2 lentivector encoding the human melanoma antigen NY-ESO-1 primed an NY-ESO-1-specific CD8(+) T-cell response in HLA-A2 transgenic mice and stimulated a CD4(+) T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b). (ox.ac.uk)
Human axillary lymph node tissue containing pigmented melanoma metastases. (enzolifesciences.com)
Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. (enzolifesciences.com)
Immunohistochemistry analysis of human melanoma skin tissue using Melanoma marker (human) mAb (HMB45) (Ready-To-Use), (Prod. (enzolifesciences.com)

Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
The monoclonal antibody was obtained by immunizing mice with human milk fat globulin and fusing the spleen cells with mouse myeloma cells. (histoprime.com)
A new monoclonal antibody to epithelial membrane antigen (EMA) - E29. (histoprime.com)

To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)

Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)

Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)

Tissue analysis for estrogen and progesterone receptors helps identify breast cancer, and immunoperoxidase staining for PSA (prostate-specific antigen) helps identify prostate cancer. (msdmanuals.com)

Metastases, invasion of lymph nodes, and coupling of cancer-associated antigens did not significantly modify marker sensitivity. (unisr.it)

As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)
The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)

and human chorionic gonadotropin (hCG), seen in choriocarcinoma testicular germ cell neoplasms. (doctorlib.info)

The MVX-ONCO-2 consists of two components: 1) biocompatible capsules, loaded with a genetically modified cell-line that secretes a strong immune-booster GM-CSF (granulocyte-macrophage stimulating factor) and 2) irradiated autologous patients' tumor cells, isolated from patients which serve as tumor antigens. (b3cnewswire.com)
In addition, when cell lines or Patient samples expressing antigen Positive and antigen negative tumor cells were cloned, heterogeneity of antigenic expression was still Present in the clonal lines. (elsevierpure.com)
This suggests that either the expression of the antigen was not heritable and/or the ability to regenerate antigenic heterogeneity is an intrinsic Property of the tumor cells. (elsevierpure.com)

Loading DCs ex vivo with tumor antigens can stimulate potent antitumor immunity in tumor-bearing mice. (nova.edu)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

We compared the recently proposed tumor markers CA195, CA242, and CAM43 with a widely used antigen, CA19.9, and a circulating marker of cellular proliferation, TPS, to define their specificity, sensitivity, and cost-benefit ratio. (unisr.it)

Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. (ox.ac.uk)
Expression of HLA-A, -B, and -C and beta 2-microglobulin antigens in human choriocarcinoma cell lines. (ox.ac.uk)

Cancer-testis antigens (CTA) are named after their pattern of expression, as they are found in various types of cancers but only in testicular germ cells of normal adult tissues ( 1 ). (aacrjournals.org)
The American Cancer Society estimates that infectious pathogens are associated with up to 20% of all human cancers worldwide. (cdc.gov)
This review describes the use of mRNA-encoded tumor antigens as a form of antigen loaded onto DCs, including our early experience from clinical trials in urological cancers. (nova.edu)
It is the most frequently mutated gene in human cancers. (doctorlib.info)

44 distinct CTA gene or antigen families such as MAGE, GAGE, BAGE, and NY-ESO-1 have been identified ( 7, 8 ). (aacrjournals.org)
To improve safety while retaining efficacy, we constructed a lentivector in which transgene expression was restricted to antigen-presenting cells using the mouse dectin-2 gene promoter. (ox.ac.uk)

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. (ox.ac.uk)

The antigen can also be detected in squamous cell carcinomas, even if the epithelium of origin (e.g. epidermis) itself is not reactive. (histoprime.com)

Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. (aacrjournals.org)
The identification of tumor antigens that are recognized by the immune system has allowed for the generation of vaccines for various malignancies. (unh.edu)
Lentivectors stimulate potent immune responses to antigen transgenes and are being developed as novel genetic vaccines. (ox.ac.uk)

It is now clear that tumours co-opt certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumour antigens. (nih.gov)
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
In this study, we explored the role of CD59 on human CD4+ T cells. (cardiff.ac.uk)
Here, we showed that harnessing iNKT cells with a second TCR specific for a tumor-associated peptide generated bispecific effectors for CD1d- and major histocompatibility complex (MHC)-restricted antigens in vitro. (unimib.it)
Intracellular antigens must be processed before presentation to CD8 + T cells by major histocompatibility complex (MHC) class I molecules. (johnshopkins.edu)
HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
classical HLA Class I antigens are not expressed on these cells. (ox.ac.uk)
The E049 antibody reacts with a variety of human epithelial cells. (histoprime.com)
Immunoprecipitation of [35S]methionine-labeled cell extracts and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that cells from two human choriocarcinomas JaR and BeWo contained beta 2-microglobulin. (ox.ac.uk)
The JaR cells, and one subline of BeWo, did not express surface HLA-A, -B, and -C (HLA-ABC) antigens, nor did JaR contain the antigens when cell-free extracts were measured in a sensitive radioimmunoassay. (ox.ac.uk)
Introduction: In spondyloarthritis (SpA), an increased type 3 immune response, including T helper cells (Th) 17 excess, is observed in both human and SpA animal models, such as the HLA-B27/human ß2-microglobulin transgenic rat (B27-rat). (bvsalud.org)

The striking observation from two phase I clinical trials, in patients with prostate cancer immunized with prostate-specific antigen mRNA-transfected DCs and patients with renal cancer immunized with autologous tumor RNA-transfected DCs, was that the majority of patients exhibited a vaccine-induced T-cell response. (nova.edu)
PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging. (regionh.dk)
abstract = "PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging.METHODS: In total, 130 men from our database had index lesions with PI-RADS scores of 3. (regionh.dk)
Patients with a prostate specific antigen level of 40 ng/ml or more, or any finding suggestive of prostate cancer were excluded. (ox.ac.uk)
Why men with prostate cancer want wider access to prostate specific antigen testing: qualitative study. (ox.ac.uk)
OBJECTIVES: To explore the attitudes of men with confirmed or suspected prostate cancer to testing for prostate specific antigen. (ox.ac.uk)

Epithelial membrane antigen belongs to a group of homomolecular glycoproteins isolated from the membrane of human milk fat globules. (histoprime.com)

Who is who among urothelial neoplasms? (mesotheliomadr.com)

Viral coinfections were identified in four patients, Persons experiencing homelessness are often at increased risk for including both SARS-CoV-2 and rhinovirus (one patient), invasive pneumococcal disease (IPD)* due to underlying health respiratory syncytial virus (one), human metapneumovirus conditions or risk factors (risk conditions) ( 1 , 2 ). (cdc.gov)
Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
From these results we conclude that finasteride-treated patients should be evaluated periodically by digital rectal examination, careful monitoring of prostate specific antigen levels and appropriate investigation of any suspicious findings. (ox.ac.uk)
Furthermore, anti-BP180 autoantibodies from patients affected with BP are capable of inducing dermal-epidermal separation in cryosections of normal human skin, further supporting the pathogenic role of BP180. (medscape.com)
Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
[ 4 ] With the abundance of cats and dogs in US households and the commensal nature of the bacteria, the risk of acquiring Pasteurella infections is increasing, particularly in patients who have predisposing factors such as prosthetic joints, malignant neoplasms, and immunosuppression. (medscape.com)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. (ox.ac.uk)
Immunohistochemical analysis that demonstrates the endothelial nature of the neoplasm is frequently positive for specific vascular markers (CD31, CD34, factor VIII), and keratin 1,2,5,6 . (bvsalud.org)

For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
These in vitro, and their expression in these human tumour virus. (who.int)

Anatomy1

Diseases6

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Disciplines and Occupations1

Pancreatic Neoplasms1

Middle Aged1

Antibodies7

Tumors10

Carcinoma6

Carcinoembryonic2

Dendritic Cells5

Surface Antigens1

Immunotherapy1

Proteins4

Serum2

Therapeutic2

Melanoma4

Monoclonal antibody5

Hematologic Neoplasms1

Endothelial Cells1

Flow Cytometry1

Receptors1

Lymph nodes1

Protein2

Germ cell1

Tumor cells3

Mice3

Specificity1

Lung3

Choriocarcinoma cell2

Cancers4

Gene2

Stem Cells1

Carcinomas1

Vaccines3

Cells11

Prostate cancer6

Glycoproteins1

Urothelial1

Patients6

Induce1

CD342

Tumour4