• Although it has not been approved for these uses, MGA has been studied and/or used off-label for a variety of indications including menopausal hormone therapy and the treatment of hot flashes, gynecological/menstrual disorders, endometriosis, endometrial hyperplasia, ovarian cancer, prostate cancer, benign prostatic hyperplasia, male breast cancer, and precocious puberty. (wikipedia.org)
  • The clinical experience relating to the detection of prostate cancer in patients participating in 2 large multicenter clinical trials of finasteride in the treatment of benign prostatic hyperplasia is reviewed. (ox.ac.uk)
  • A total of 1,645 patients 40 to 83 years old with benign prostatic hyperplasia was randomized to receive 1 or 5 mg finasteride or placebo once a day for 12 months in a double-blind fashion followed by an open extension study in which all patients were treated with 5 mg finasteride daily. (ox.ac.uk)
  • Recognition of the human vulvar tumor line A431. (who.int)
  • Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
  • The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
  • SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
  • Screening for prostate-specific antigen (PSA) has led to earlier detection of prostate cancer 3 , but elevated serum PSA levels may be present in non-malignant conditions such as benign prostatic hyperlasia (BPH). (nature.com)
  • However, deaths from malignant neoplasms were greater than expected and mostly consisted of respiratory cancers. (cdc.gov)
  • In this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent LNCaP human prostate cancer cells. (nih.gov)
  • Antiproliferative activity and cytotoxicity of Solanum jamesii tuber extracts on human colon and prostate cancer cells in vitro. (psu.edu)
  • The objective of this study was to investigate antiproliferative activity and cytotoxicity of tuber extracts from 15 Solanum jamesii accessions on human HT-29 colon and LNCaP prostate cancer cell lines in vitro. (psu.edu)
  • Dive into the research topics of 'Antiproliferative activity and cytotoxicity of Solanum jamesii tuber extracts on human colon and prostate cancer cells in vitro. (psu.edu)
  • The small portion of human chromosome 11 (i.e., 11p13cen) was reintroduced into highly metastatic rat prostate cancer cells by using microcell-mediated chromosome transfer. (johnshopkins.edu)
  • The present study was performed to further locate the region of the KAI1 gene on the short arm of chromosome 11, and to examine whether loss of this region is significant during progression of human prostate cancer. (johnshopkins.edu)
  • Loss of heterozygosity (LOH) at polymorphic microsatellite loci on the human chromosome 11 was examined in human prostate cancer tissues. (johnshopkins.edu)
  • Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer. (nature.com)
  • Liotta, L. & Petricoin, E. Molecular profiling of human cancer. (nature.com)
  • Cadherin switching in human prostate cancer progression. (nature.com)
  • Prostatic cancer risk was greater than expected, peaking 20 years after initial exposure. (cdc.gov)
  • Molecular portraits of human breast tumours. (nature.com)
  • Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)
  • The minimum region of human chromosome 11 that contained the KAI1 gene was located on the proximal region of 11p11.2 divided by the D11S554 locus. (johnshopkins.edu)
  • Exposure science studies the interactions and outcomes between environmental stressors and human or ecological receptors. (nih.gov)
  • Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (nih.gov)
  • Here we sought definitive evidence for the existence of polyclonal seeding in human malignancy and to establish the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer. (ox.ac.uk)
  • It was initially identified as an androgen-induced growth factor and plays a role in regulating growth of human BREAST NEOPLASMS and PROSTATIC NEOPLASMS . (bvsalud.org)
  • Human Chorionic Gonadotropin Injection are contraindicated in patients with Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. (etalaze.biz)
  • Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
  • The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
  • The effect of hyperthermia on established human prostate carcinoma cell lines (PC-3, DU-145) and related sublines (1-LN, 125-1L) was investigated in vitro. (tau.ac.il)
  • Kaver, I , Ware, JL & Koontz, WW 1989, ' The effect of hyperthermia on human prostatic carcinoma cell lines: Evaluation in vitro ', Journal of Urology , vol. 141, no. 4 I, pp. 1025-1027. (tau.ac.il)
  • that is, precursor lesions to prostatic carcinoma . (medscape.com)
  • The Agency's Committee for Medicinal Products for Human Use ( CHMP ) considered that the ability of Jevtana to prolong overall survival in castration-resistant metastatic prostate cancer patients was clinically important. (europa.eu)
  • 8. Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistry. (nih.gov)
  • 17. Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence. (nih.gov)
  • BACKGROUND Drug repurposing of phentolamine, an α-adrenoceptor antagonist, as an anticancer agent has been studied in human castration-resistant prostate cancer (CRPC). (tmu.edu.tw)
  • HGPIN is characterized by architecturally benign prostatic acini and ducts lined with atypical cells whose morphologic, histochemical, immunohistochemical, and genetic changes are similar to those of prostate cancer. (medscape.com)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Polymorphism of vitamin D receptor gene FokI and susceptibility of prostatic cancer: a meta-analysis]. (cdc.gov)
  • When a non-metastatic subline from the Dunning rat prostatic cancer was transfected with the v-Ha-ras oncogene, some transfectants acquired metastatic potential. (johnshopkins.edu)
  • Molecular analysis demonstrated that there was no simple dose-response relationship between v-Ha-ras expression and metastatic potential in this prostatic cancer system. (johnshopkins.edu)
  • To test this possibility, non-metastatic and highly metastatic Dunning rat prostatic cancer cells were fused. (johnshopkins.edu)
  • These in vitro results indicate that hyperthermia may become a potentially useful form of adjunctive therapy for local control of prostatic cancer. (tau.ac.il)
  • Measured by the ability of the immobilized protein to support the adhesion of the MCF‑7 human breast cancer cells. (novusbio.com)
  • It explains how the Committee for Medicinal Products for Human Use ( CHMP ) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Jevtana. (europa.eu)
  • Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. (nih.gov)
  • HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for menotropins. (nih.gov)
  • Human Chorionic Gonadotropin Injection (HCG Shots) is used for induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. (etalaze.biz)
  • The dose for induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is sec ondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins is 5,000 to 10,000 USP units one day following the last dose of menotropins. (etalaze.biz)
  • When 5 x10 4 cells/well are added to recombinant human IBSP-coated plates (3 µg/mL with 100 µL/well), approximately 60‑80% will adhere after 30 minutes at 37° C. (novusbio.com)
  • PIN refers to the precancerous end of a morphologic spectrum involving cellular proliferation within prostatic ducts, ductules, and acini. (medscape.com)
  • Chorionic Gonadotropin is a water soluble glycoprotein derived from human pregnancy urine. (nih.gov)
  • Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta subunit. (nih.gov)
  • The active ingredient present in HCG injections is Human Chorionic Gonadotropin. (etalaze.biz)
  • Each vial of HCG injection contains 1500 iu, 2000 iu, 5000 iu or 10000 iu of purified Human Chorionic Gonadotropin. (etalaze.biz)
  • Each vial of Human Chorionic Gonadotropin Injection (HCG Shot) is sold along with a vial of sterile diluent containing 30 mL of bacteriostatic water for Injection USP, containing 0.9% benzyl alcohol. (etalaze.biz)
  • To augment its role in understanding human health and the exposome, we aimed to centralize and integrate exposure science data into the broader biological framework of the Comparative Toxicogenomics Database (CTD), a public resource that promotes understanding of environmental chemicals and their effects on human health. (nih.gov)
  • We have described our curation process, demonstrated how exposure data can be accessed and analyzed in the CTD, and shown how this integration provides a broad biological context for exposure data to promote mechanistic understanding of environmental influences on human health. (nih.gov)
  • Curation and integration of exposure data within the CTD provides researchers with new opportunities to correlate exposures with human health outcomes, to identify underlying potential molecular mechanisms, and to improve understanding about the exposome. (nih.gov)
  • Exposure science plays a critical role in the translation and assessment of experimental toxicity data, prioritizing research, aiding risk analysis for human health, and informing public health decisions ( Hubal 2009 ). (nih.gov)
  • The exposome complements the human genome by providing a measure of environmental exposure history in the three broad domains of internal, specific external, and general external exposures ( Wild 2012 ). (nih.gov)
  • The alpha subunit is essentially identical to the alpha subunits of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha subunit of human thyroid-stimulating hormone (TSH). (nih.gov)
  • A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. (nih.gov)
  • Immunohistochemical studies have shown that PSA is found predominately in the cytoplasm of prostatic acinar cells and ductal epithelium. (cdc.gov)