Human genetic therapy. Medical search. Frequent questions

The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC) is an expert-curated description of the genes driving human cancer that is used as a standard in cancer genetics across basic research, medical reporting and pharmaceutical development. (nih.gov)
Structural equation modeling was used to evaluate the genetic and environmental correlations and gene-environment interactions between the career-goal appraisals and depressive symptoms. (cambridge.org)
A decade before stem cells began to reach the front page, the next big thing in medical applications of genetic technologies was supposed to be gene therapy. (wordsontheweb.com)
Scientifically and socially, gene therapy still has more questions than answers. (wordsontheweb.com)
Things are not nearly so simple (see Chapter 2) but that's the principle behind the hope of what is called 'gene therapy' and the perhaps more imminent hazard of 'gene doping' in sports (see Chapter 7). (wordsontheweb.com)
Gene therapy' is really a misnomer: So far, there have been hundreds of experiments but very little success and no therapies. (wordsontheweb.com)
The very failure of gene therapy ironically increased the pressure from some quarters to attempt the fully-fledged human genetic engineering of children, as discussed in more detail below. (wordsontheweb.com)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
Theodore Friedmann (born June 16, 1935) is an American researcher most noted for his work in human gene therapy. (wikipedia.org)
He is a past president of the American Society for Gene Therapy (now the American Society for Gene and Cell Therapy). (wikipedia.org)
He also served as the first chair of WADA's Gene Doping Expert Group, from its establishment in 2004 to 2019 He was awarded the Japan Prize in 2015 'for the proposal of the concept of gene therapy and its clinical applications. (wikipedia.org)
Gene therapy for human genetic disease? (wikipedia.org)
Progress toward human gene therapy. (wikipedia.org)
A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. (news-medical.net)
This study describes the findings from the targeted delivery of gene therapy to midbrain to treat a rare deadly neurodevelopmental disorder in children with a neurogenetic disease, aromatic L-amino acid decarboxylase (AADC) deficiency characterized by deficient synthesis of dopamine and serotonin. (news-medical.net)
Remarkably, these episodes are the first symptom to disappear after gene therapy surgery, and they never return," said study co-author Dr. Krystof Bankiewicz, professor of neurological surgery at Ohio State College of Medicine who leads the Bankiewicz Lab. (news-medical.net)
The directed gene therapy in seven children ages 4 to 9 who were infused with the viral vector resulted in dramatic improvement of symptoms, motor function and quality of life. (news-medical.net)
During the gene therapy surgery, physicians infuse a benign virus programmed with specific DNA into precisely targeted areas of the brain. (news-medical.net)
Researchers believe this same method of gene therapy can be used to treat other genetic disorders as well as common neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. (news-medical.net)
The directed gene therapy, in these patients, resulted in dramatic improvement of symptoms, motor function and quality of life. (news-medical.net)
It's our hope that this will be first of many ultra-rare and other neurologic disorders that will be treated with gene therapy in a similar manner," Bankiewicz said. (news-medical.net)
2021) Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. (news-medical.net)
They studied the cancer type-specific prevalence of KRAS , NRAS and HRAS mutant alleles (alternative forms of a gene) at codons (units of genetic code) 12, 13 and 61 in the overall population and stratified their results by patient age, race and gender. (hopkinsmedicine.org)
We are using state-of-the-art next generation sequencing combined with bioinformatic strategies, and developing stem cell-based approaches for gene therapy and drug discovery. (nih.gov)
How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)
Find basic explanations of how genes work and how mutations cause disorders, as well as current information about genetic testing, gene therapy, genetics research, and precision medicine. (medlineplus.gov)
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury. (medindia.net)
Rather than targeting a genetic mutation , we essentially modified a normal gene to make sure it wouldn't become harmfully overactive. (progress.org.uk)
if this new gene therapy works, it would be a game changer. (progress.org.uk)
Is Gene Therapy Delivering on Its Promises? (geneticsandsociety.org)
The internationally recognized program that she leads at Baylor has generated hundreds of new mouse models of human disease, which have enabled discoveries of gene functions in diverse areas, including cancer, reproduction, neurobiology, obesity, and blood, heart and bone development. (biologists.com)
Scientists from Sun Yat-sen University in Guangzhou, China, led by Canquan Zhou and Junjiu Huang, used the CRISPR/Cas9 genome editing system in non-viable human zygotes to modify the gene that causes the hereditary blood disease beta-thalassemia. (genomeweb.com)
The scientists directed the CRISPR/Cas9 editing system to the human beta-globin gene HBB, part of the beta-globin gene cluster and the gene that is mutated in beta-thalassemia, a blood disease that can be fatal, depending on the specific mutation. (genomeweb.com)
This high rate of repair using endogenous sequences presents obvious obstacles to gene therapy strategies using CRISPR/Cas9, as pseudogenes and paralogs may effectively compete with exogenous templates (or endogenous wild-type sequences) during [homology directed repair], leading to unwanted mutations," the authors said. (genomeweb.com)
We discovered that long term culture of human ESCs and iPSCs often results in selection for cells in which the TP53 gene is deleted. (ca.gov)
It underlies the concept of transgenics, in which an organism is modified to incorporate new genes that lead to new characteristics, such as the production of proteins for human health, or the expression of a gene for herbicide resistance in plants, to name just two applications. (sciencemediacentre.co.nz)
It is the insertion of a gene into an organism, altering the genetic makeup. (sciencemediacentre.co.nz)
A gene has been identified that will strengthen muscles but has not yet been inserted into humans. (sciencemediacentre.co.nz)
Inserting this gene into zebrafish will elucidate the function of this gene and will facilitate potentially live-saving gene therapy in humans. (sciencemediacentre.co.nz)
Gene therapy is a technique where a 'normal' gene is inserted into a patient to replace an 'abnormal' gene that causes disease. (sciencemediacentre.co.nz)
At present, no gene therapy has been approved for use however recent clinical trials, such as those looking at inherited forms of blindness, have shown promise. (sciencemediacentre.co.nz)
Scientists have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia, a rare form of lymphoma that has eluded all previous efforts to find a genetic cause. (sciencedaily.com)
While it is clear that Jiankui egregiously violated university regulations and ethical standards, his announcement has since ignited a heated international dialogue about the permissibility of human embryonic gene editing. (harvard.edu)
First of all, it is key to realize that most scientists are not opposed to editing somatic cells for gene therapy. (harvard.edu)
Certain genetic defects that cause severe diseases could be cured with embryonic gene editing. (harvard.edu)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
In untreated HIV infection, associations between HLA genetic polymorphism and disease progression were identified in several studies, using both candidate gene (reviewed in Carrington and O'Brien, 2003 ), and genome-wide strategies ( The International HIV Controllers Study, 2010 ). (frontiersin.org)
Although gene therapy is defined as any treatment that changes gene function, it is often thought of as the insertion of normal genes into the cells of a person who lacks such normal genes because of a specific genetic disorder. (msdmanuals.com)
This technique is called gene insertion therapy or insertion gene therapy. (msdmanuals.com)
Currently, such gene insertion therapy is most likely to be effective in the prevention or cure of single-gene defects, such as cystic fibrosis. (msdmanuals.com)
A different method of gene therapy uses antisense technology. (msdmanuals.com)
It seems to have the potential to be more effective and safer than gene insertion therapy. (msdmanuals.com)
Another approach to gene therapy is to increase or decrease the activities of certain genes by using chemicals to modify chemical reactions in the cell that control gene expression. (msdmanuals.com)
The Director-General designated two rapporteurs, Professor A.S. Daar (Oman) and Professor J.-F. Mattei (France), to assess the current and potential applications of cloning, considering not just cloning techniques but the overall area of gene manipulation and its implications for human health. (who.int)
Somatic gene therapy holds promise for improving human health, but possible risks for health must be balanced against possible benefits. (who.int)
Results of search for 'ccl=su:{Gene therapy. (who.int)
Molecular genetic abnormalities preceding, or occurring during, BC include overexpression of the BCR/ABL transcript, upregulation of the EVI1 gene, increased telomerase activity, and mutations of the tumor suppressor genes RB1, TP53, and CDKN2A. (lu.se)
For example, our sickle cell disease initiative is taking advantage of gene therapy and gene editing. (medlineplus.gov)

Subsequently, she was a postdoctoral fellow in the Mammalian Genetics Laboratory at the National Cancer Institute (NCI), the laboratory that created the mouse-human comparative molecular map, with Drs Neal Copeland and Nancy Jenkins. (biologists.com)
Her overall research goal is to merge mouse modeling with clinical genetics to understand the basis of and develop treatments for human diseases. (biologists.com)
Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)
In addition to her academic work, Dr. Mathews has spent time at the Genetics and Public Policy Center, the US Department of Health and Human Services, the Presidential Commission for the Study of Bioethical Issues, and the National Academy of Medicine working in various capacities on science policy. (hopkinsmedicine.org)
The aim has been to ensure that these values can be faithfully incorporated in WHO's policies and cooperation work in areas of genetics related to human health. (who.int)
Negative perceptions of science can detract from the beneficial applications of genetics to human health. (who.int)

Researchers at the Johns Hopkins Kimmel Cancer Center , three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers. (hopkinsmedicine.org)
Their four-year study of the RAS family - including the KRAS , NRAS and HRAS genes that are mutated in approximately one-third of all human cancers - found that the frequency of mutant RAS genes differs among various tumor types, age, sex and racial groups, and co-mutation patterns among RAS genes and other genes potentially can result in different clinical outcomes or identify new areas for therapeutic intervention. (hopkinsmedicine.org)
MedlinePlus has easy-to-understand information about genetic conditions and genes, all of the human chromosomes, and mitochondrial DNA (mtDNA). (medlineplus.gov)
Now based at the Baylor College of Medicine, Monica's research exploits the remarkable conservation in genes and whole chromosome regions between the mouse and human. (biologists.com)
At the same time, this means that any associated risks with these genetic modifications (e.g. off-target effects where other genes are mistakenly edited leading to negative health outcomes or other unintended consequences) would also be inherited down this family tree as well, potentially forever. (ipscell.com)
When the genetic material within the living cells, i.e. genes are working properly, the human body can develop and function smoothly. (faqs.org)
Pro-GM campaigners argue that humans have been 'genetically modifying' organisms for thousands of years, albeit without knowledge that the favourable traits they were selecting for were determined by genes. (sciencemediacentre.co.nz)
Polymerase chain reaction (PCR) Genetic diagnostic technologies are scientific methods that are used to understand and evaluate an organism's genes. (msdmanuals.com)

De Forni, D., Stevens, MR., and Lori, F. Strategies to improve efficacy and safety of a novel class of antiviral hyper-activation-limiting therapeutic agents: the VS411 model in human immunodeficiency virus/acquired immunodeficiency syndrome. (rightinstitute.net)
Human Immunodeficiency Virus (HIV) Genetic Diversity Informs Stage of HIV-1 Infection Among Patients Receiving Antiretroviral Therapy in Botswana. (bvsalud.org)
Human immunodeficiency virus ( HIV )-1 genetic diversity increases during infection and can help infer the time elapsed since infection . (bvsalud.org)
Pharmacological reactivation of human immunodeficiency virus (HIV) expression from latent proviruses coupled with fully suppressive antiretroviral therapy (ART) has been suggested as a strategy to eradicate HIV infection. (frontiersin.org)

Almost 7 years after their first derivation from human embryos, a pressing urgency to deliver the promises of therapies based on human embryonic stem cells (hESC) has arisen. (johnshopkins.edu)
Particularly, human embryonic stem cells (hES cells), which can give rise to all tissues of an organism (Figure A), are used to generate mature cells of the heart (Figure B) allowing us to study radiation/microgravity-induced cardiovascular alterations, which may occur during long-term space missions. (gsi.de)
A) Colonies of human embryonic stem cells, bright field microscopy, scale bar: 100µm. (gsi.de)
Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. (ca.gov)
We have performed a combinatorial study on both hESCs and hiPSCs to compare the effects of enzymatic vs. mechanical passaging, and feeder-free vs. mouse embryonic fibroblast feeder substrate, on the genetic and epigenetic stability and the phenotypic characteristics of hPSCs. (ca.gov)

Our study shows that you need to consider who the host is and what the genetic makeup is of the tumor, because RAS-mutant tumors with different co-mutations have completely different profiles and clinical behavior. (hopkinsmedicine.org)
Why do some mutations manifest later in life even though the genetic change was present at birth? (nih.gov)
Can we find common cellular pathways associated with photoreceptor cell death caused by distinct genetic mutations? (nih.gov)
Genome editing is most often discussed in relation to correcting genetic mutations that cause disease. (progress.org.uk)
However, this potential cardioprotective strategy is proposed to treat cardiovascular disease which is not caused by genetic mutations. (progress.org.uk)
The scientists then used human induced pluripotent stem cells to generate specialized retinal cells that contained one of the MacTel-associated PHGDH mutations. (scripps.edu)

The study, led by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine, offers new hope to those living with incurable genetic and neurodegenerative diseases. (news-medical.net)
This work provides a framework for the treatment of other human nervous system genetic diseases. (news-medical.net)
I was convinced that my future path should be directed towards improving human health, primarily in the field of childhood diseases, and I planned to go to medical school. (biologists.com)
Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. (biologists.com)
Animals are also genetically modified to give them human diseases in order to test new drugs or to study the biology of disease, or to make them more 'environmentally friendly' [2]. (sciencemediacentre.co.nz)
Or should scientists like Egli be encouraged to continue their work, which might provide life-saving treatments for severe genetic diseases? (harvard.edu)
Attention must focus not just on the genetic component of diseases but also on the importance of acting on lifestyles and environmental factors to help prevent diseases such as cancer and to reduce their severity. (who.int)
Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)

Scientists from the Netherlands say that a compound, which they have identified in human saliva, greatly speeds wound healing, according to their report published in The Journal of Federation of American Societies for Experimental Biology (FASEB). (medindia.net)
Publishing their results in Science , the scientists used base-editing to remove the oxidative activation sites of CaMKIIδ in human heart cells grown in the lab. (progress.org.uk)
The study comes less than a month after Science published an editorial on the topic of human germline engineering, co-authored by some of the leading scientists working with CRISPR/Cas9, including Jennifer Doudna of the University of California, Berkeley and George Church of Harvard Medical School. (genomeweb.com)
Join the New York Academy of Sciences and Johnson & Johnson for a series of engaging and insightful webinars with extraordinary scientists whose discoveries have made a profound impact on human health. (nyas.org)
The National Human Genome Research Institute (NHGRI) wants to ensure that all populations are knowledgeable about the science underpinning the Human Genome Project and genomics research, and have the opportunity to participate in various ways, such as becoming research scientists, research participants and policy makers. (genome.gov)
In the 1950s, largely as the result of the pioneering work of James Watson (1928-) and Francis Crick (1916-), scientists discovered the structure of deoxyribonucleic acid (DNA) molecules and how DNA stores and transmit genetic information. (faqs.org)
An organization of scientists is recommending that limitations on several experimental and controversial research procedures - including heritable genome editing, artificial gametes, and growing human embryos in the lab - be loosened or rolled back. (geneticsandsociety.org)
Under these guidelines an oversight committee can deliberate behind closed doors and quietly give its blessing to scientists to impregnate a monkey with a partly human embryo, or to see how far into human development scientists can grow artificially constructed synthetic human embryos in bottles. (geneticsandsociety.org)
Currently, there are scientists in the United States working in university laboratories, experimenting with genetic editing of human embryos. (harvard.edu)
Genetic changes to these can be passed down to many future generations, allowing scientists to direct evolution. (harvard.edu)

Safety, Tolerability, and Immunogenicity of Repeated Doses of DermaVir, a Candidate Therapeutic HIV Vaccine, in HIV-Infected Patients Receiving Combination Antiretroviral Therapy: Results of the ACTG 5176 Trial. (rightinstitute.net)
HIV genetic diversity informs stage of HIV-1 infection among patients receiving antiretroviral therapy in Botswana. (ox.ac.uk)
Do HIV-specific CTL continue to have an antiviral function during antiretroviral therapy? (frontiersin.org)

Interview with Kelly Hills on human genetic modification. (ipscell.com)
Part of the possible power of some forms of human genetic modification procedures being considered for potential future use is that they are heritable. (ipscell.com)
And so we need to very seriously discuss how we define these terms and the others that frame the debate around germline modification-because no matter how hard we try, some genetic variation, including some genetic disease, crops up spontaneously. (ipscell.com)
Genetic modification (GM) is the alteration of the genome of a plant or animal by the addition of new genetic material. (sciencemediacentre.co.nz)
What is genetic modification? (sciencemediacentre.co.nz)
Selective breeding is a form of genetic modification which doesn't involve the addition of any foreign genetic material (DNA) into the organism. (sciencemediacentre.co.nz)

This research holds great potential for elucidating how genetic variation and regulatory elements lead to diverse visual phenotypes. (nih.gov)
Because genetic variation contributes substantially to ICH, genomic analyses constitute a powerful tool to identify new biological mechanisms involved in its occurrence. (nih.gov)

We then applied this model to evaluation set subjects (n = 12,115) and tested the association of RBA with tobacco smoking, alcohol consumption, and genetic variants. (nature.com)
Although we've known that MacTel has a genetic component, the precise variants had remained elusive. (scripps.edu)
Many more variants likely exist but haven't been found yet-a challenge considering the small patient population with diverse genetic causes. (scripps.edu)
Increasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommodate data sparsity, which arises from unbalanced case-control ratios and/or rare genetic variants. (karger.com)

Intentional Human GE would of course be done in the lab, using very early embryos and IVF techniques, not the germ cells of adults. (wordsontheweb.com)
Most widely noted is the lifting of the "14-day rule," the longstanding prohibition against culturing human embryos in the lab for longer than two weeks. (geneticsandsociety.org)
G]iven the public scrutiny of studies of human embryos, the ISSCR should have engaged the public while considering changes to the guidelines. (geneticsandsociety.org)
For instance, Columbia University professor Dieter Egli is currently working on trying to edit embryos to fix the genetic defects that cause retinitis pigmentosa (RP), an inherited form of blindness. (harvard.edu)

NEW YORK (GenomeWeb) - No longer a rumor, human germline editing with CRISPR/Cas9 is now the subject of a study published today in Protein & Cell . (genomeweb.com)
From the surface, it certainly seems like everything has been okay, but I think it would be an excellent idea to actually do longitudinal studies once we do get to the point of human use of CRISPR/Cas9. (ipscell.com)

Our investigations utilize in vivo mouse retina and human retinal organoids derived from pluripotent stem cells as study systems. (nih.gov)

An electron microscopy image of human retinal cells analyzed in a new study on a rare eye disease known as MacTel. (scripps.edu)
Through genetic analyses and experiments in human-derived retinal tissue, we were able confirm that even a partial loss of PHGDH function can have a damaging effect on the retina. (scripps.edu)

Genetic manipulation from the beginning. (projectavalon.net)

Germline genetic engineering does affect the eggs or sperm and is therefore passed on to future generations, who will carry the alterations in every cell of their bodies. (wordsontheweb.com)
Emerging data suggest that drug efficacies depend on disease aetiology and genetic alterations. (uhi.ac.uk)
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells. (medindia.net)
However, the large numbers of cells necessary for many of these applications require extensive expansion of hPSC cultures, a process that has been associated with genetic and epigenetic alterations. (ca.gov)

With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
This large collection of genetic mutants, still used to this day, was crucial to understand fundamental mechanisms of vertebrate development as well as human Mendelian genetic disease. (biologists.com)
hES cells also serve as a basis for cerebral organoid models (Figure C) to better understand e.g. the mechanisms of cognitive impairment and radiation necrosis as severe side effects of radiation therapies. (gsi.de)

All research areas are substantiated by analyses (Figure D) monitoring the acute radiation-induced cytogenetic damage and the long-term genetic stability of cells. (gsi.de)
Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. (lu.se)
However, the clinical impact of additional cytogenetic and molecular genetic aberrations is most likely modified by the treatment modalities used. (lu.se)

Genetic interventions on non-human species may contribute significantly to the improvement of human health and well-being. (who.int)
Although genetic interventions hold great promise for the betterment of human health, vigilance should be exercised lest they contribute to racism, stigmatization, discrimination or the development of ruthless social policy. (who.int)

Professor Lorna Harries, of the University of Exeter Medical School, who led the research, said: "We're really excited by the discovery that disrupting targeted genetic processes can bring about at least a partial reversal of key elements of the ageing process in human cells. (neurosciencenews.com)

The current therapeutic landscape for HAE is discussed with a focus on treatment for acute angioedema attacks, short- and long-term HAE prophylaxis, and home-based therapy. (ajmc.com)
The results indicate that any therapeutic use of the technology in humans remains distant. (genomeweb.com)
Improved understanding of the underlying cancer biology of this subpopulation of cancer stem cells, thought to drive tumor formation and therapeutic resistance, could potentially lead to improved targeted therapies that prolong patient survival. (cns.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs) make them a promising source of material for cell transplantation therapy, drug development, and studies of cellular differentiation and development. (ca.gov)

Disrupting these genetic processes, researchers say, could reverse signs of aging in human cells. (neurosciencenews.com)
In a blog post titled Risks rise as ISSCR drops strict 14-day rule on human embryo growth in the lab , UC Davis stem cell researcher Paul Knoepfler also expressed concern: "[W]ithout a clear limit, I think it's likely that some researchers are going to go too far utilizing new embryo culture technologies. (geneticsandsociety.org)

There is a crucial distinction between somatic and germline genetic engineering, or 'therapies' as advocates of Human GE like to call them. (wordsontheweb.com)
Somatic genetic engineering affects some of the cells in a single body but is not passed on to future generations because it does not change the eggs or sperm. (wordsontheweb.com)
Somatic cells, such as heart cells or kidney cells, are cells where the genetic changes remain confined to that individual. (harvard.edu)

Debra JH Mathews, Ph.D., M.A., is the Assistant Director for Science Programs for the Johns Hopkins Berman Institute of Bioethics , and an Associate Professor in the Department of Genetic Medicine, Johns Hopkins School of Medicine . (hopkinsmedicine.org)
Human dignity in bioethics and biolaw / Deryck Beyleveld, Roger Brownsword. (who.int)

The field took a leap forward in the 1980s, led in part by the work of George Streisinger and others who recognized that zebrafish could be a useful model for genetic screens ( Walker and Streisinger, 1983 ), paving the way to large-scale phenotypic screens in embryogenesis. (biologists.com)

The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
Targeted molecular therapy can also act as a complement to other existing cancer therapies. (medscape.com)
Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)

The editorial recommended that the research community "strongly discourage" attempts to engineer the human germline for clinical applications, a sentiment that is likely to be echoed given the results of the new study. (genomeweb.com)

The announcement of a new major US Precision Medicine initiative comes more than a decade after the completion of the Human Genome Project, the ambitious project that culminated in sequencing all 3 billion base pairs of our genome. (cdc.gov)
The Human Genome Project, perhaps the greatest scientific endeavor of the 21st century, has changed the way medicine is practiced and how research is conducted in the future. (genome.gov)

Exploring subtypes in preclinical models with human relevance will therefore be essential to advance precision medicine in HCC. (uhi.ac.uk)

Harmful genetic defects could be 'edited-out' of families and, eventually, human populations. (harvard.edu)

The use of the technique of nuclear transfer for reproduction of human beings is surrounded by strong ethical concerns and controversies and is considered a threat to human dignity. (who.int)
General Assembly the adoption of a declaration on human cloning by which Member States were called upon to prohibit all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life. (who.int)
This technique is surrounded by strong ethical concerns and is considered a threat to human dignity. (who.int)
The draft guiding principles are based on fundamental values such as dignity, human rights and freedom, as invoked by the United Nations Charter and other international instruments. (who.int)

They also introduce the Platform for Accelerating Genetic Discovery for Cerebrovascular Disease, a newly created resource that aims to create a common workspace for genetic analyses that will bring together 100,000 stroke cases and suitable controls from numerous institutions in several countries. (nih.gov)

Is it ethical to exploit animals for human benefit? (sciencemediacentre.co.nz)

Here, the authors summarize the most recent genetic discoveries for ICH. (nih.gov)

It is also being tried for cancer therapy and some neurologic disorders, but it is still very experimental. (msdmanuals.com)

Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age. (neurosciencenews.com)
In May 2001, the National Advisory Council for Human Genome Research approved the Action Plan which outlines clear goals for the inclusion of underrepresented minority groups in research training, research collaborations, and education and outreach activities supported by all components of the institute. (genome.gov)
The research, presented at the American Society of Hematology's 2011 annual meeting on Dec. 12, points to an error in a single digit of DNA -- one of three billion letters in the human genetic code -- as the leading culprit in Waldenström's, and a prime target for new therapies against the disease. (sciencedaily.com)
On May 26, the International Society of Stem Cell Research released its newly revised guidelines on human embryo research. (geneticsandsociety.org)
5. Most countries in the African Region have no specific regulations and policies governing genetic manipulations for assisted conception, treatment and research. (who.int)

The stage has almost been set for the next step: transplantation in animal models of human disease. (johnshopkins.edu)
IVDs for clinical decisions on diagnosis and treatment, as does screening of blood/blood products for transfusion and human organs/tissues for transplantation. (who.int)
For example, +8 is more common after busulfan than hydroxyurea therapy, and the secondary changes seen after interferon-alpha treatment or bone marrow transplantation are often unusual, seemingly random, and occasionally transient. (lu.se)

To shed light on the underlying factors, this study investigated possible genetic and environmental factors that are common to negative career-goal appraisals and depressive symptoms among young adults. (cambridge.org)

3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)

In order to further understand why depressive symptoms are associated with negative goal appraisals, the present study examined the genetic and environmental correlations and interactions between depressive symptoms and career-related goal appraisals. (cambridge.org)
The study, published in the FASEB Journal, was conducted in human cells in laboratories. (neurosciencenews.com)
This study provides a step toward precision therapeutics for PTSD by demonstrating that comorbid MDD and genetic markers may help guide treatment selection. (nature.com)
In the new study, Rando Allikmets, PhD, of Columbia University, used an alternative approach to find genetic drivers of disease. (scripps.edu)

Brain tumor-initiating cells (BTICs), self-renewing multi-potent cells critical for tumor maintenance and growth, are attractive targets of glioblastoma therapy. (cns.org)
Fresh human glioblastoma tumors obtained directly from neurosurgical resections were immediately dissociated and passaged in neural stem cell media to enrich the subpopulation of tumor cells with stem-like properties. (cns.org)

these features can serve as targets for molecularly-driven therapies. (hopkinsmedicine.org)

Somogyi E, Lisziewicz J. HIV vaccine to induce cytotoxic T cells recognizing conserved HIV-1/2-epitopes derived from the most frequent HLA types of the human population. (rightinstitute.net)
Significantly, the team found that disrupting these genetic processes could reverse signs of ageing in cells. (neurosciencenews.com)
It's still early days and we need to understand far more about the complex relationships of how our cells and genetic processes influence ageing, yet it's an exciting contribution to how we may one day be able to influence healthier ageing. (neurosciencenews.com)
cbtabs][cbtab title="MLA"]University of Exeter"Disrupting Genetic Processes Reverses Aging in Human Cells. (neurosciencenews.com)
Retrieved September 13, 2018 from https://neurosciencenews.com/aging-genetic-disruption-9858/[/cbtab][cbtab title="Chicago"]University of Exeter"Disrupting Genetic Processes Reverses Aging in Human Cells. (neurosciencenews.com)
In the other dish, cells were bathed in human saliva. (medindia.net)
This proved that human saliva contains a factor, which accelerates wound closure of oral cells. (medindia.net)
Depicts human cells, showing the stages of cell division. (progress.org.uk)
For this purpose, we use human stem cells that play a pivotal role in tissue development, maintenance and function. (gsi.de)
In extensive experiments involving over 100 continuous passages, we observed that both enzymatic passaging and feeder-free culture were associated with genetic instability, higher rates of cell proliferation, and persistence of OCT4/POU5F1-positive cells in teratomas, with enzymatic passaging having the stronger effect. (ca.gov)
Our results highlight the need for careful assessment of the effects of culture conditions on cells intended for clinical therapies. (ca.gov)
Genetic engineering is the altering of the genetic material of living cells in order to make them capable of producing new substances or performing new functions. (faqs.org)
Another concern is that the new, normal DNA may become "lost" or may fail to be incorporated into new cells after some period of time, leading to the reappearance of the genetic disorder. (msdmanuals.com)

A clone is an organism that is a genetic copy of an existing one. (who.int)

https://neurosciencenews.com/aging-genetic-disruption-9858/ (accessed September 13, 2018). (neurosciencenews.com)

These include the creation of certain kinds of human-animal chimeras (for example, as NPR put it, "allow[ing] a human-monkey embryo to develop inside a monkey's womb"), creating and culturing "embryo-like entities," and so-called mitochondrial replacement techniques. (geneticsandsociety.org)

The management of advanced HNSCC consists of multiple-modality therapy with surgery, radiation, and chemotherapy. (medscape.com)

It also sheds light on fundamental aspects of metabolism in the retina, a tissue with one of the highest energy demands in the human body. (scripps.edu)

One method is to use a virus because certain viruses have the ability to insert their genetic material into human DNA. (msdmanuals.com)
Individuals have the right to retain control over their genetic material and the information derived from it. (who.int)

Anatomy1

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Disciplines and Occupations2

Information Science1

Publication Characteristics1

Gene60

Genetics6

Genes8

Immunodeficiency virus4

Embryonic5

Mutations6

Diseases8

Scientists10

Antiretroviral Therapy3

Modification6

Variation2

Variants4

Embryos4

CRISPR-Cas92

Organoids1

Retinal2

Manipulation1

Alterations4

Mechanisms3

Cytogenetic3

Interventions2

Disrupting targeted1

Therapeutic4

Pluripotent1

Researchers2

Somatic3

Bioethics2

Zebrafish1

Molecular4

Germline1

Genome Project2

Subtypes1

Defects1

Dignity4

Analyses1

Ethical1

Discoveries1

Neurologic disorders1

Research5

Transplantation3

Environmental factors1

Implications1

Study4

Tumor2

Targets1

Cells13

Organism1

20181

Mitochondrial1

Chemotherapy1

Tissue1

Material2