• graft
  • The Austin Moore device had a small hole in the stem into which bone graft was placed before implanting the stem. (wikipedia.org)
  • He and his colleagues demonstrated for the first time conclusive histologic evidence that demineralized bone matrix used as a bone graft supports periodontal regeneration in humans. (wikipedia.org)
  • The principles involved in successful bone grafts include osteoconduction (guiding the reparative growth of the natural bone), osteoinduction (encouraging undifferentiated cells to become active osteoblasts), and osteogenesis (living bone cells in the graft material contribute to bone remodeling). (wikipedia.org)
  • As native bone grows, it will generally replace the graft material completely, resulting in a fully integrated region of new bone. (wikipedia.org)
  • Osteoconduction occurs when the bone graft material serves as a scaffold for new bone growth that is perpetuated by the native bone. (wikipedia.org)
  • Osteoblasts from the margin of the defect that is being grafted utilize the bone graft material as a framework upon which to spread and generate new bone. (wikipedia.org)
  • In the very least, a bone graft material should be osteoconductive. (wikipedia.org)
  • A bone graft material that is osteoconductive and osteoinductive will not only serve as a scaffold for currently existing osteoblasts but will also trigger the formation of new osteoblasts, theoretically promoting faster integration of the graft. (wikipedia.org)
  • Osteogenesis occurs when vital osteoblasts originating from the bone graft material contribute to new bone growth along with bone growth generated via the other two mechanisms. (wikipedia.org)
  • Depending on where the bone graft is needed, a different doctor may be requested to do the surgery. (wikipedia.org)
  • Doctors that do bone graft procedures are commonly orthopedic surgeons, otolaryngology head and neck surgeon, neurosurgeons, craniofacial surgeons, oral and maxillofacial surgeons, podiatric surgeons and periodontists, dental surgeons, oral surgeons and implantologists. (wikipedia.org)
  • Autologous (or autogenous) bone grafting involves utilizing bone obtained from the same individual receiving the graft. (wikipedia.org)
  • When a block graft will be performed, autogenous bone is the most preferred because there is less risk of the graft rejection because the graft originated from the patient's own body. (wikipedia.org)
  • This kind of graft is known as a vital bone graft. (wikipedia.org)
  • Exact Defect Repair - A precise size and shape is formed for the specific patient, so an accurate bone graft is made. (wikipedia.org)
  • With the use of technology, EpiBone is able to create a reconstructed bone graft. (wikipedia.org)
  • A 2016 systematic review and meta-analysis of randomized controlled clinical trials for PRP use to augment bone graft found only one study reporting a significant difference in bone augmentation, while four studies found no significant difference. (wikipedia.org)
  • recombinant
  • Recombinant human BMP-2 was dissolved in different hydrogels as a carrier, namely gelatin and alginate cross-linked with CaCl 2 -solution, or a solution of GDL and CaCO 3 . (biomedcentral.com)
  • The clinical use of recombinant human BMP-2 (rhBMP-2) in conjunction with scaffolds has raised recent controversies, based on the mode of presentation and the amount to be delivered. (jove.com)
  • Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by other cells including smooth muscle cells, activated macrophages, and endothelial cells Recombinant PDGF is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry as an alternative to bone autograft to stimulate bone regeneration and repair. (wikipedia.org)
  • Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in Japan as a topical spray for the treatment of skin ulcers. (wikipedia.org)
  • Recombinant human protein (rhBMP-2) is currently available for orthopaedic usage in the United States. (wikipedia.org)
  • calvarial bone
  • Using osteo-lineage cell tracing models and intravital imaging of induced microfractures in calvarial bone, OSPCs can be directly observed during the first few days after injury, in which critical events in the early repair process occur. (jove.com)
  • osteogenesis
  • Thus, cell instructive biomaterials with engineered mechanical and biochemical properties represent potentially powerful tools for directing BMSC differentiation to tendon and bone, however paracrine signals from tenogenic cells may delay osteogenesis at the healing enthesis. (jove.com)
  • The biologic mechanisms that provide a rationale for bone grafting are osteoconduction, osteoinduction and osteogenesis. (wikipedia.org)
  • collagen
  • Use of collagen membranes in particular, with bone mineral as a support and space maintainer, has achieved predictable treatment outcomes. (wikipedia.org)
  • The integrity of resorbable membranes over the healing period has been questioned relative to the ePTFE membranes, but a 2007 study suggested that collagen membranes do allow for bone regeneration, given the correct patient and conditions. (wikipedia.org)
  • fractures
  • Other indications include rheumatoid arthritis, avascular necrosis, traumatic arthritis, protrusio acetabuli, certain hip fractures, benign and malignant bone tumors, arthritis associated with Paget's disease, ankylosing spondylitis and juvenile rheumatoid arthritis. (wikipedia.org)
  • Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly. (wikipedia.org)
  • In the 1960s Becker's research also showed that living bone can piezoelectrically generate electric potentials, which led to work on using electricity in the treatment of ununited fractures. (wikipedia.org)
  • deposition
  • In this study, primary culture of human osteoblasts was conducted in the presence of medium containing either ZrCl4 or Zirconium (IV) oxynitrate (ZrO(NO3)2) at concentrations of 0, 5, 50 and 500 µM, and osteoblast proliferation, differentiation and calcium deposition were assessed. (jove.com)
  • For the remodeling to occur, appropriate cell signaling occurs to trigger osteoclasts to resorb the surface of the bone, followed by deposition of bone by osteoblasts. (wikipedia.org)
  • Upon exposure of the periosteal cells to calcium from the alginate gel, these cells become bone cells and start producing bone matrix through the intra-membranous ossification process, recapitulating all steps of bone matrix deposition. (wikipedia.org)
  • grafts
  • Autologous bone grafts are routinely used, but they have drawbacks such as limited quantity and accessibility [ 1 ] and donor site morbidity. (biomedcentral.com)
  • Most bone grafts are expected to be reabsorbed and replaced as the natural bone heals over a few months' time. (wikipedia.org)
  • this is particularly true for block grafts, in which a small block of bone is placed whole in the area being grafted. (wikipedia.org)
  • For these types of grafts, extraction of the part of the periosteum and accompanying blood vessels along with donor bone is required. (wikipedia.org)
  • These specialized bone grafts can simplify surgery, provide exact repair, and shorten recovery times. (wikipedia.org)
  • In today's surgical repairs, bone grafts or replacement bones are not as precise and accurate because they are not made specifically for the patient's needs. (wikipedia.org)
  • No More Foreign Body Implantation - EpiBone's bone grafts are made from the patient's own stem cells, so foreign body complications are eliminated. (wikipedia.org)
  • Two of the most common types of bone grafts used today are allografts, grafts made from a deceased donor's bone, and autografts, grafts made of bone from another part of the patient's body. (wikipedia.org)
  • Also, EpiBone grafts skip the process of molding to the body because they are made to take over the exact size and shape of the damaged bone. (wikipedia.org)
  • The bioreactor makes EpiBone have the potential to build patient-specific bone grafts for craniofacial and orthopedic reconstructions. (wikipedia.org)
  • biomaterials
  • The assay can be used as a bioreactor for studying the effects of drugs and different biomaterials on bone repair without the use of mouse models, refining the use of bone injury models in research. (nc3rs.org.uk)
  • MSCs
  • Accordingly, it is hard for the aged patients to acquire sufficient numbers of functional MSCs for bone regenerative therapy. (biomedcentral.com)
  • All of these human blood-vessel-derived stem cell (hBVSC) populations not only express classic MSC markers but also possess mesodermal developmental potentials similar to typical MSCs. (jove.com)
  • vivo
  • The in vivo models include injecting the implant within a bone cylinder subcutaneously into mice, to study the immune response and blood vessel growth, among other factors. (nc3rs.org.uk)
  • Here, in vivo imaging techniques to investigate the role of endogenous osteogenic stem/progenitor cells (OSPCs) and their progeny in bone repair are provided. (jove.com)
  • osteoblasts
  • Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts. (jove.com)
  • However, the effects of in vitro culture of human osteoblasts (HOBs) with soluble ionic forms of Zr have not been determined. (jove.com)
  • Incubation of human osteoblast cultures with Zr ions increased the proliferation of human osteoblasts and also gene expression of genetic markers of osteoblast differentiation. (jove.com)
  • Osteoinduction involves the stimulation of osteoprogenitor cells to differentiate into osteoblasts that then begin new bone formation. (wikipedia.org)
  • This occurs with the synchronized action of osteoclasts and osteoblasts, cells that resorb and deposit bone, respectively. (wikipedia.org)
  • vitro
  • Therefore, the aim of this study was to investigate the effect of IFN-γ on the immunomodulatory capacity of C-MSC in vitro and to test the bone regenerative activity of C-MSC or IFN-γ-pretreated C-MSC (C-MSCγ) xenografts in a mice calvarial defect model. (biomedcentral.com)
  • To investigate the differentiation ability of human adipose-derived stem cells (ASCs) towards urothelium-like cells in vitro and the dynamic changes of related cytokines and cytokine receptors in the culture medium. (jove.com)
  • Despite the identification and isolation of glial progenitors from adult human sub-cortical white matter and development of various culture conditions to direct differentiation of fetal neural progenitors into myelin producing oligodendrocytes, acquiring sufficient human oligodendrocytes for in vitro experimentation remains difficult. (jove.com)
  • Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. (nih.gov)
  • attachment
  • Early implant designs had the potential to loosen from their attachment to the bones, typically becoming painful ten to twelve years after placement. (wikipedia.org)
  • His most cited paper, Histologic evaluation of new attachment apparatus formation in humans. (wikipedia.org)
  • matrix
  • The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation. (quintpub.com)
  • cells
  • They were then grafted onto the CAM, which incubated the bone, providing a surrogate blood supply that allowed the cells to remain viable. (nc3rs.org.uk)
  • Recently, using fluorescence-activated cell sorting (FACS), we and other researchers prospectively identified and purified three subpopulations of multipotent precursor cells associated with the vasculature of human skeletal muscle. (jove.com)
  • Pooled human platelet lysate (pHPL) replaced fetal bovine serum in all steps of our protocol to completely avoid contact of the cells to xenogeneic proteins. (jove.com)
  • Over time, bone cells from the patient would grow into these spaces and fix the stem in position. (wikipedia.org)
  • His research aims at the development of stem cell therapies using human adult and embryonic stem cells. (wikipedia.org)
  • Research into human embryonic stem cells is controversial, and regulation varies from country to country, with some countries banning it outright. (wikipedia.org)
  • The following therapies do not rely on autologous cells: A vibration technique developed by Ellen L. Barnard and Myrtile Wilhite claims to promote regeneration in the vaginal cell lining. (wikipedia.org)
  • Bone regeneration and stem cells. (wikipedia.org)
  • A subpopulation of dental pulp stem cells has been described as human immature dental pulp stem cells (IDPSC). (wikipedia.org)
  • Together, the cells in any given particular region of the bone surface that are responsible for bone remodeling are known as the basic multicellular unit (BMU), and it is the average lifespan of the BMU that is referred to as the remodeling period. (wikipedia.org)
  • EpiBone will allow patients to grow bones with the use of their own stem cells in order to create a patient-specific product. (wikipedia.org)
  • physiology
  • In bone physiology, the bone remodeling period describes the temporal duration (i.e. lifespan) of the basic multicellular unit (BMU) that is responsible for bone turnover. (wikipedia.org)
  • resorption
  • The remodeling period consists of the combined duration of the resorption, the osteoclastic reversal (the phase marked by shifting of resorption processes into formative processes) and the formation periods of bone growth and development. (wikipedia.org)
  • autologous
  • Autologous bone is typically harvested from intra-oral sources as the chin or extra-oral sources as the iliac crest, the fibula, the ribs, the mandible and even parts of the skull. (wikipedia.org)
  • An example of the implementation of the IVB approach was in the engineering of autologous bone by injecting calcium alginate in a sub-periosteal location. (wikipedia.org)
  • scaffold
  • Bone generally has the ability to regenerate completely but requires a very small fracture space or some sort of scaffold to do so. (wikipedia.org)
  • procedure
  • 40 patients (25 males and 15 females) planned to receive bone regeneration procedure were included in the study. (minervamedica.it)
  • 15,16 This protocol presents a practicable procedure to generate a pool of human platelet lysate (pHPL) derived from routinely produced platelet rich plasma (PRP) of forty to fifty single blood donations. (jove.com)
  • histologic
  • Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. (quintpub.com)
  • newly formed bone
  • The density of the newly formed bone inside the bone-growing chambers measured 27.84% 24.67% in test and 17.90% 4.28% in control subjects, without a statistically significant difference. (quintpub.com)
  • Compared to ePTFE membranes, resorbable barriers allow for fewer exposures and therefore reduce the effects of infection on newly formed bone. (wikipedia.org)
  • cellular
  • There are rudimentary techniques of promoting cellular division to alter the structure of the penis, often referred to as foreskin restoration, and are not to be confused with regeneration. (wikipedia.org)
  • regrowth
  • In less than one month following surgery, x-ray analysis showed the regrowth of bone while macroscopic observation showed the regrowth of nail and skin. (wikipedia.org)
  • hollow
  • The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. (quintpub.com)
  • subpopulations
  • The current isolation protocol, through modifications to the isolation process and adjustments in the selective cell surface markers, allows us to simultaneously purify all three hBVSC subpopulations by FACS from a single human muscle biopsy. (jove.com)
  • formation
  • The bone formation portion (σf) of the bone remodeling period is calculated as follows: σ f = M W T M f {\displaystyle \sigma _{f}={\frac {MWT}{M_{f}}}} in which MWT refers to the mean wall thickness of the completed bone unit and Mf refers to the prevailing mean effective bone appositional rate. (wikipedia.org)