AntioxidantProteinsSusceptible to peroxidationOxidation20021999ReactiveSupplementationEnzymesDysfunctionalMalondialdehydeAntioxidantsInhibitMetabolismSerumVitaminRadicalsSuperoxide1992TurmericMiceAccumulationZincOxidative stressStructuralGlutathioneDamageCellConcentrationSignificantlyErythrocytes exposedSubstancesSpermCholesterolIncreaseDifferentiationBloodProductCellsClarifyBodyActivityVitroEffectsSubjectsDepartment of HealtPrimarilyCompounds
Antioxidant9
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- Therefore, in this report the above compounds were evaluated with respect to their role in human nutrition, without limiting the investigation to antioxidant properties. (nationalacademies.org)
- Lipid peroxidation damage on pyrethroid exposure and alternations in antioxidant status in rat erythrocytes: A possible involvement of reactive Oxygen species. (scialert.net)
- The membrane lipid changes and the associated production of signalling metabolites clearly have a pivotal function to modify the heat stress response [27].In addition, dietary protein level is also known to have profound influence on antioxidant system and membrane composition and stability[28]. (ijcrr.com)
- f. on the 2-thiobarbituric acid reactive substances (TBARS) as lipid peroxidation biomarker, aldehydic and ketonic derivatives of oxidatively modified proteins, and total antioxidant capacity (TAC) in the muscle tissue of the rainbow trout (Oncorhynchus mykiss Walbaum). (org.ua)
- The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)
- Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. (ijbs.com)
- GPx, a selenium-containing antioxidative enzyme scavenging system, act directly as an antioxidant and an inhibitor of lipid peroxidation. (ijbs.com)
- Vitamin E is the main lipidsoluble, chain-breaking antioxidant ( Ji 1996 ) which accumulates in the phospholipid bilayer of cell membranes and helps attenuate lipid peroxidation ( Sjodin 1990 ) within the cell membrane acting as an important scavenger of superoxide and lipid radicals ( Powers 2000 ). (ukessays.com)
Proteins4
- 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
- It is known that the increased internal lipid damages proteins and cells as well as DNA by converting reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, and hydroxyl radical into malondialdehyde (MDA) [ 2 ]. (e-pan.org)
- Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
- 10] This is the most toxic component due to high reduction-oxidation (redox) potential that generates oxygen-free radicals such as superoxide anion in the cells, which damages DNA, proteins, and membrane lipids in the cell. (medscape.com)
Susceptible to peroxidation2
- Red cells are always under high oxygen pressure and extremely susceptible to peroxidation and the conditions that favour peroxidation, are seemingly optimal in red cells [1]. (ijcrr.com)
- Polyunsaturated fatty acid in the phospholipids of the human spermatozooa is highly susceptible to peroxidation. (ijbs.com)
Oxidation3
- Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. (vitalraadet.dk)
- 6,7 The oxidation of lipids is a main cause of meat quality deterioration and possibly functional, sensory and nutritive values reductions of meat products. (iranjournals.ir)
- Buege, J.A. and Aust, S.D. (1978) Microsomal lipid per- oxidation. (scirp.org)
20021
- Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
19992
- Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
- Measurement of MDA has become the most commonly used indicator of lipid peroxidation ( Mc Bride 1999 ).Thus, the ingestion of exogenous antioxidants has been proposed to attenuate this increase in ROS. (ukessays.com)
Reactive3
- In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
- Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. (ijbs.com)
- Reactive oxygen species (ROS) play an important role in the human reproduction. (ijbs.com)
Supplementation3
- In the case of the Malaysian study, the rodents either received a dose of tocotrienols commensurate with normal human supplementation or a diet stripped of tocotrienols. (vitanetonline.com)
- Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty PTCA. (vitalraadet.dk)
- Two hundred and fifty male 1-day-old broiler chicks (Ross 308) were used to investigate the effects of dietary supplementation of turmeric and cinnamon powders on meat quality and lipid peroxidation of broilers under heat stress condition. (iranjournals.ir)
Enzymes2
- Human spermatozoa possess these defense enzymes, which might be useful in the prediction of sperm fertilizing potentials [ 5 ]. (ijbs.com)
- Priscilla DH and Prince PS: Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. (spandidos-publications.com)
Dysfunctional2
- 2016. Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. . (oregonstate.edu)
- Spermatozoa are rendered dysfunctional by lipid peroxidation and altered membrane function, together with impaired metabolism, morphology, and motility [ 2 ]. (ijbs.com)
Malondialdehyde1
- ROS have been shown to impair protein synthesis by preventing mRNA translation [14, 15, 16, 17,18].Acute heat-stressed broiler chickens had a 2-fold increase in malondialdehyde, a marker of lipid peroxidation, in skeletal muscle [19]. (ijcrr.com)
Antioxidants3
- 4 Hence, the concentrations of dietary pro-oxidants and antioxidants can affect lipid peroxidation of poultry products. (iranjournals.ir)
- 10 The effective prevention of lipid peroxidation in poultry meat has been indicated by consumption of antioxidants. (iranjournals.ir)
- Evans (1990) noted that several antioxidants, including vitamin C and especially vitamin E, have been shown to decrease the exercise-induced increase in the rate of lipid peroxidation, which could help prevent muscle tissue damage. (ukessays.com)
Inhibit1
- 13 Curcumin has the ability to inhibit the lipid peroxidation and can scavenge the harmful free radicals. (iranjournals.ir)
Metabolism2
- Quantification evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. (cdc.gov)
- Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
Serum1
- Relationship between serum lipid peroxidation products in hypercholesterolemic subjects and vitamin E status. (vitalraadet.dk)
Vitamin3
- The active form of vitamin D, calcitriol , is one of the most powerful hormones in the human body, endowed with the ability to activate over 2,000 genes (roughly 10% of the human genome). (lifeextension.com)
- Lipid peroxidation and changes in vitamin E levels during coronary artery bypass grafting. (vitalraadet.dk)
- 2004. Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma. . (oregonstate.edu)
Radicals5
- The human skin, as the boundary organ between the human body and the environment, is under the constant influence of free radicals (FR), both from the outside in and from the inside out. (mdpi.com)
- 1 The high levels of free radicals production in the body can induce lipid peroxidation and affect the meat quality indices. (iranjournals.ir)
- The mechanism of exercise-induced myopathy could be the cell membrane damage by lipid peroxidation and DNA fragmentation in the working muscle cells by free radicals generation. (scielo.org.ar)
- Zinc stabilizes cell membranes by reducing free radicals and preventing lipid peroxidation. (medscape.com)
- GR and GST- and the lipid peroxidation hydroperoxides and free radicals. (who.int)
Superoxide1
- Tanaka M, Mokhtari GK, Terry RD, et al: Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. (spandidos-publications.com)
19922
- Biochem Int 28:57-66, 1992. (vitalraadet.dk)
- Peroxidation of muscle fibre lipids causes disturbance in cellular homeostasis which may result in muscle fatigue or injury, possibly implicating free radical formation as a major cause of delayed-onset muscle soreness ( Byrd 1992 ). (ukessays.com)
Turmeric1
- 11 Turmeric is the rhizome of Curcuma longa L . and has beneficial effects on human health. (iranjournals.ir)
Mice1
- Effects of deltamethrin on lipid peroxidation in mice. (scialert.net)
Accumulation2
- The in silico prediction was confirmed by the lack of PTHrP(12-48)-stimulated cAMP accumulation in PTHR1-expressing human SaOS2 cells. (phoenixpeptide.com)
- However, due to the abnormal pigments' synthesis, being responsible for skin color in accumulation of melanin, the formation of pigment humans. (bvsalud.org)
Zinc1
- More recently, the gene SLC39A4 was found to encode a solute carrier protein called human zinc/iron-regulated transporterlike protein (hZIP4). (medscape.com)
Oxidative stress1
- Glutathione plays a key role in maintaining proper function and preventing oxidative stress in human cells. (wikipedia.org)
Structural2
- Given this somewhat minor structural difference between family members and the fact that all species are regularly consumed in the average diet, it is noteworthy that α-tocopherol is only one of eight variants actively maintained by the human body. (fusabil.org)
- Lipid peroxidation triggers the loss of membrane integrity, causing increased cell permeability, enzyme inactivation, structural damage to DNA, and cell death [ 3 ]. (ijbs.com)
Glutathione2
- Glutathione reductase (GR) also known as glutathione-disulfide reductase (GSR) is an enzyme that in humans is encoded by the GSR gene. (wikipedia.org)
- Glutathione reductase from human erythrocytes is a homodimer consisting of 52Kd monomers, each containing 3 domains. (wikipedia.org)
Damage2
- Biomarkers of free radical damage: Applications in experimental animals and in humans. (scialert.net)
- Halder, J. and Bhaduri, A.N. (1998) Protective role of bla- ck tea against oxidative damage of human red blood cells. (scirp.org)
Cell2
- miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. (edu.pl)
- Mol.Cell Biochem. (fairpeel.com)
Concentration1
- High fat and high cholesterol diets increase weight, blood lipid and cholesterol concentration [ 1 ]. (e-pan.org)
Significantly1
- Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)
Erythrocytes exposed1
- Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. (scirp.org)
Substances1
- Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
Sperm2
- High lipid peroxidation as represented by MDA levels may cause changes in the sperm and diminish fertility [ 5 ]. (ijbs.com)
- The CDs of mature non-human mammalian sperm are found at the distal end of the midpiece. (biomedcentral.com)
Cholesterol1
- DHEA is the acronym for dehydroepiandrosterone, an androgen occurring naturally in humans and synthesized from cholesterol. (afpafitness.com)
Increase1
- An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
Differentiation1
- PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan. (phoenixpeptide.com)
Blood2
- The development of the human blood-CSF-brain barrier. (cdc.gov)
- In humans, DHEA in its original form is quickly metabolized in the adrenal cortex to its sulphated derivative, DHEA-S, before it is exported out into the blood. (afpafitness.com)
Product2
- End-product of lipid peroxidation, acts as a heat shock protein (hsp) inducer [20]. (ijcrr.com)
- MDA, an end product of lipid peroxidation, represented the level of lipid peroxidation. (ijbs.com)
Cells6
- 2009. Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. . (oregonstate.edu)
- Human primary explant-derived TM cells were cultured in fibroblast medium and then treated with different concentrations of H2O2 for 2 h. (edu.pl)
- Li A, Chi TL, Peterson-Yantorno K, Stamer WD, Mitchell CH, Civan MM. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. (edu.pl)
- Probable impact of age and hypoxia on proliferation and microRNA expression profile of bone marrow-derived human mesenchymal stem cells. (edu.pl)
- Using a specific human PTHrP(12-48) antibody that we developed, PTHrP(12-48) was immunolocalized in primary and bone metastatic human breast cancer cells, as well as within human osteoclasts (OCL) in bone metastasis biopsies, with little or no localization in other resident bone or bone marrow cells. (phoenixpeptide.com)
- Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
Clarify1
- The purpose of this review is to compare CDs to ERC, to describe ERC's relevance to human reproduction, and to clarify its assessment and clinical importance. (biomedcentral.com)
Body2
- It is the most abundant steroid in the human body and is secreted primarily from the adrenal cortex, but is also synthesized by the skin, testes and brain. (afpafitness.com)
- The human body has no active mechanism for the excretion of iron. (medscape.com)
Activity1
- Ascenzi P, Tundo GR, Coletta M. (2018) The nitrite reductase activity of ferrous human hemoglobin:haptoglobin 1-1 and 2-2 complexes . (uniroma2.it)
Vitro1
- In vitro, PTHrP(12-48) was internalized into cultured primary human OCLs and their precursors within 60 minutes. (phoenixpeptide.com)
Effects1
- Recent studies have indicated that exposures to methyl based pharmacokinetic (PBPK) modeling, and evaluat- iodide (MeI) produce a number of effects in laboratory ani- ing the relevance of the observations in animals to human mals, including fetal toxicity, neurotoxicity, and degenera- health. (cdc.gov)
Subjects2
- A third study, also in Malaysia, used human subjects with type 2 diabetes. (vitanetonline.com)
- Markers for the human subjects were also improved for the subjects that consumed tocotrienols. (vitanetonline.com)
Department of Healt1
- U.S. Department of Health and Human Services, Public Health Service. (cdc.gov)
Primarily1
- It is a familiar element of mammalian spermatozoa, though many studies in the past have focused primarily on CDs in non-human species. (biomedcentral.com)
Compounds1
- Resolution of any impact of these compounds on chronic disease will require evaluation of the many human intervention trials that are still under way ( Table 2-1 ). (nationalacademies.org)