• gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
  • At their best, they usually rely on some mysterious things called ionic pumps, that perform active transport, powered by little motors, under instructions from molecules that act on their specific receptors. (raypeat.com)
  • More basic and clinical studies are needed to address the effects of drugs on specific receptors and improve the treatment of postoperative pruritus. (asahq.org)
  • This effect was blocked by coinjection of 1 μg (hr)IL-1β receptor antagonist or 0.1 ng of 3-((+)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate, selective antagonists of IL-1β and NMDA receptors, respectively. (jneurosci.org)
  • Moreover, this variant is a natural antagonist for the wild-type IL-17F. (hindawi.com)
  • 1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
  • These results suggest that IL-6 stimulated PA activity through an enhancement of tPA gene expression and may be involved in extracellular matrix degradation through the stimulation of the PA-plasmin system of human dental pulp (HDP) cells ( 7 ). (ispub.com)
  • Flow cytometric analysis of Stat5 (PY694) expression in human CD4+ T lymphocytes. (bdbiosciences.com)
  • Static magnetic fields generated by a 0.5 T MRI unit affects in vitro expression of activation markers and interleukin release in human peripheral blood mononuclear cells (PBMC) [med. (emf-portal.org)
  • Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects [med. (emf-portal.org)
  • It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
  • In this study, we examined whether AdipoR mRNA expression in human myotubes correlates with in vivo measures of insulin sensitivity. (diabetesjournals.org)
  • We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
  • and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
  • In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
  • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. (sagepub.com)
  • bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
  • Recently, cytokines and their receptors have been located in many other tissues, including the peripheral and central nervous systems ( Hopkins and Rothwell, 1995 ). (jneurosci.org)
  • The immunopathogenesis of many human diseases is characterized at the molecular level. (medscape.com)
  • Recently, two distinct TNF receptors with molecular weights of 55 kDa (TNFR55) and 75 kDa (TNFR75) have been cloned and characterized. (ox.ac.uk)
  • BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)
  • The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. (sagepub.com)
  • 1. NIHR Liverpool Pancreas Biomedical Research Unit and Department of Cellular and Molecular Physiology, University of Liverpool, UK. (pancreapedia.org)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • They recognize microorganisma through their Fc, complement and toll-like receptors (TLR), as well as non-TLR. (medscape.com)
  • Indeed, Toll-like receptors are a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades. (nature.com)
  • Medzhitov, R. Toll-like receptors and innate immunity. (nature.com)
  • She is also focused on TIR8/SIGIRR, a member of the family of IL-1 Receptors and Toll Like Receptors, acting as a negative regulator of inflammatory and immune responses in the context of inflammatory diseases, infections and cancer. (sepsisamsterdam.nl)
  • The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade. (nature.com)
  • Such studies have led to the identification of a new innate lymphoid subset that produces the canonical type 2 cytokines IL-5, IL-9 and IL-13 in response to IL-25 and IL-33. (nature.com)
  • These group 2 or type 2 innate lymphoid cells (ILC2 cells) represent a critical source of type 2 cytokines in vivo and serve an important role in orchestrating the type 2 response to helminths and allergens. (nature.com)
  • [ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
  • Specifically, TNF-α is a potent inhibitor of the clonal growth of primitive and committed murine and human bone marrow progenitors in combination with multiple cytokines, including granulocyte colony-stimulating factor (G-CSF), CSF-1, erythropoietin (Epo), stem cell factor (SCF), and flt3 ligand (FL). (ox.ac.uk)
  • Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)
  • Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
  • Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
  • 3 In CML, several pro-inflammatory cytokines, such as IL-6, 5 4 IL-1β, 6 and TNF-α, 4 have been shown to be up-regulated in patient serum. (haematologica.org)
  • To inves- inflammatory cytokines and the timing of their production support tigate the interplay of proinflammatory and anti-inflammatory cyto- an immunologic response appropriate to the amount of Ag and kines in human granulomatous disease, we evaluated the ability of duration of exposure. (cdc.gov)
  • Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
  • Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
  • Tumor necrosis factor (TNF) and interleukin-(IL)-18 are important mediators of neuroinflammation after closed head injury (CHI). (biomedcentral.com)
  • Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. (nature.com)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
  • The ICH laboratory has a long-standing interest in innate immunity and inflammation, and has made key contributions to the field of the interleukin-1 family, chemokines, pentraxins, and their role in infections, inflammatory responses and cancer-related inflammation, with a focus on negative regulatory processes. (sepsisamsterdam.nl)
  • Current work in the research group is focused on the long pentraxin-3 in innate immunity and as potential biomarker of inflammatory conditions, on negative regulators of inflammation (TIR8/SIGIRR, decoy receptors), and on markers of macrophage polarization (MSF). (sepsisamsterdam.nl)
  • His group cloned PTX3 (cDNA, genome, human, mouse), the first member of the long pentraxin family, and defined its function in innate immunity and inflammation. (sepsisamsterdam.nl)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • Chronic inflammation is connected to neoplastic transformation, and it is known that patients with autoimmune diseases have increased risks for some types of tumors [ 3 , 4 ], with neoplastic transformation often occurring [ 5 - 8 ]. (medsci.org)
  • Eicosanoids play pivotal roles in parturition, inflammation, hemodynamics, and renal function, and our appreciation of their bioimpact and relevance to human diseases is still evolving. (jci.org)
  • LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • Both IL-6R and gp130 also occur in soluble form in biological fluids and has been purified from human serum and urine. (sbhsciences.com)
  • He described the negative regulation circuits of the type II decoy receptor for IL-1 and discovered that pro- and anti-inflammatory signals regulate the level of chemokine production and of receptors. (sepsisamsterdam.nl)
  • C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
  • Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)
  • No. 554611) prior to staining, or 2) pre-block the fixed/permeabilized cells with unlabelled JES3-19F1 antibody (Cat. (bdbiosciences.com)
  • use at comparable concentrations to the antibody of interest (e.g., ≤ 0.5 µg mAb/1 million cells). (bdbiosciences.com)
  • The JES3-19F1 antibody reportedly neutralizes the biological activity of human IL-10 and ebvIL-10. (bdbiosciences.com)
  • The reconstituted cells were then washed and stained with BD Horizon™ BUV395 Mouse Anti-Human CD4 antibody (Cat. (bdbiosciences.com)
  • No. 564724) and BD Horizon™ R718 Mouse Anti-Human Stat1 (pY701) antibody (Cat. (bdbiosciences.com)
  • Examples include: antimalarial agents such as chloroquine and hydroxychloroquine, antivirals such as lopinavir/ritonavir and remdesivir, and tocilizumab as an anti-interleukin 6 (IL-6) receptor antibody ( 21 - 24 ). (frontiersin.org)
  • Suppression of experimental allergic neuritis by an antibody to the intracellular adhesion molecule ICAM-1. (2medicalcare.com)
  • Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. (2medicalcare.com)
  • Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
  • Another study has demonstrated that both serum and synovial fluid from rheumatoid arthritis (RA) could not stimulate chondrocyte proteoglycan synthesis once the IGF-1 function was blocked by a primary antibody [ 6 ]. (biomedcentral.com)
  • hPepT1 transports muramyl dipeptide, activating NF-κB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. (nature.com)
  • Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. (wikipedia.org)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
  • In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (rndsystems.com)
  • Finally, to address the functional role of this cytokine, we measured the effect of human recombinant (hr)IL-1β on seizure activity as one marker of the response to kainate. (jneurosci.org)
  • (1) in a standardized model of CHI in TNF/lymphotoxin-α gene-deficient mice and wild-type (WT) littermates, and (2) by intracerebro-ventricular injection of mouse recombinant TNF in WT C57BL/6 mice. (biomedcentral.com)
  • Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
  • Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. (sagepub.com)
  • The inflammatory cytokine interleukin-6 (IL-6) is a powerful inducer of the hepatic acute-phase response, and it has been proposed to be a central mediator in the pathogenesis of coronary heart disease through a combination of autocrine, paracrine, and endocrine mechanisms ( 8 ). (ispub.com)
  • Her activity has been focused on the functional characterization of original molecules of the immune system, in particular the long pentraxin PTX3 in the context of innate immune responses to pathogens and in the regulation of inflammatory responses in conditions of infections or tissue damage. (sepsisamsterdam.nl)
  • The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin. (diabetesjournals.org)
  • 2. Tissue injury and inflammatory cell recruitment. (pancreapedia.org)
  • In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)
  • genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
  • Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury. (biomedcentral.com)
  • Alberto Mantovani, MD was appointed Professor of General Pathology at the University of Brescia, Italy, in 1994, where he worked within the Department of Medical Biotechnology. (sepsisamsterdam.nl)
  • A particular interest has been devoted to the setting of the process for the purification of a clinical-grade protein and to the validation of PTX3 as diagnostic and prognostic marker in human pathology. (sepsisamsterdam.nl)
  • The sequence of human IL-2 cDNA predicts a 153 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein (3). (abscitech.com)
  • We and other groups discovered the human IL-17F gene from a human EST sequence, a genomic DNA clone, and T-cell cDNA sequences in 2001 [ 3 , 8 , 9 ]. (hindawi.com)
  • Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
  • We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. (hindawi.com)
  • Intrahippocampal application of 0.77 nmol of bicuculline methiodide, which induces EEG seizures but not cell loss, enhanced IL-1β immunoreactivity and microglia, although to a less extent and for a shorter time compared with kainate. (jneurosci.org)
  • and induces the proliferation and differentiation of oligodendrocytes (1, 2). (abscitech.com)
  • When cartilage is damaged, MSCs derived from synovial fluid can partially move to the injured site and differentiate into chondrocytes to repair the defect, and IGF-1 induces chondrogenic differentiation [ 11 , 12 , 13 ]. (biomedcentral.com)
  • Galan JE, Wolf-Watz H: Protein delivery into eukaryotic cells by type III secretion machines. (interleukin-receptor.com)
  • Lindeberg M, Cartinhour S, Myers CR, Schechter LM, Schneider DJ, Collmer A: Closing the circle on the discovery of genes encoding Hrp regulon members and type III secretion system effectors in the genomes of three model Pseudomonas syringae strains. (interleukin-receptor.com)
  • constitutive but well install Hh being not regulates on the synthesis of development effects through the Toll-like activity. (evakoch.com)
  • matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
  • An ex vivo study showed that IGF-1 in fetal bovine serum was responsible for maintaining articular cartilage proteoglycan synthesis. (biomedcentral.com)
  • The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains (7, 8). (abscitech.com)
  • As summarized elsewhere (1), the combination of a declining birth rate and an increased average life span is expected to increase the proportion of the population aged 65 years and older in the United States from 12.4% in 2000 to 19.6% in 2030. (cdc.gov)
  • Globally, the number of older adults (aged 65 years and older) is projected to increase even more dramatically - more than doubling from 420 million in 2000 to 973 million in 2030 (1). (cdc.gov)
  • Figure 2: Innate and adaptive type 2 cell ontogeny. (nature.com)
  • The two recognized types of immunity are innate and adaptive. (medscape.com)
  • Therefore, IGF-1 is the crucial factor in serum and synovial fluid that promotes cartilage matrix anabolism. (biomedcentral.com)
  • and (3) types of outcomes - the primary outcome was total efficacy rate, which was ≥ 50% repigmentation rate, and the secondary outcomes were cure rate (proportion of patients achieving 100% repigmentation of the lesion), serum cytokine levels, and blood ratio of CD4 + /CD8 + T cells. (medscape.com)
  • There are very low levels of free zinc in plasma, since it is mostly bound to proteins such as albumin, alpha-2-macroglobulin (A2M), and transferrin. (frontiersin.org)
  • Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. (nature.com)
  • Structurally, the IL-17 cytokine family members have no sequence similarity to any other known cytokine or other mammalian proteins [ 2 ]. (hindawi.com)
  • Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
  • Gurlebeck D, Thieme Org 27569 F, Bonas U: Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with host plant. (interleukin-receptor.com)
  • Grant SR, Fisher EJ, Chang JH, Mole BM, Dangl JL: Subterfuge and manipulation: Type III effector proteins of phytopathogenic bacteria. (interleukin-receptor.com)
  • IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation. (abscitech.com)
  • Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (wikipedia.org)
  • Thus, the IL-17 cytokine family appears to represent a distinct ligand-receptor signaling system. (hindawi.com)
  • The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
  • Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes (1, 2). (abscitech.com)
  • Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. (sagepub.com)
  • The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)
  • H1N1), measles, parainfluenza type our institute in 1997. (cdc.gov)
  • Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are the central molecules for uPA/uPAR/plasmin-dependent proteolysis, which is thought to play a significant role in the development of pregnancy, as well as its many complications during pregnancy. (ispub.com)
  • The basic biology of this system, including the range of known Jaks and STATs, is discussed, as are the defects in animals and humans lacking some of these signaling molecules. (sagepub.com)
  • IL-17A, the original member of the IL-17 cytokine family, was first identified in 1993 and was initially recognized for its similarity to a sequence belonging to the open reading frame 13 of Herpesvirus saimiri (HVS13) [ 1 , 2 ]. (hindawi.com)
  • it is to be used by all states for AIDS case reporting effective January 1, 1993. (cdc.gov)
  • The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. (wikipedia.org)
  • Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
  • Also, proteolysis is found in pathological conditions such as tumor growth, metastasis, arthritis and autoimmune diseases ( 1 ). (ispub.com)
  • The plasminogen activator (PA)-plasmin proteolytic system has recently received considerable attention because of its participation in a wide variety of biological activities and in pathological conditions involving tissue destruction. (ispub.com)
  • This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
  • REVISED HIV CLASSIFICATION SYSTEM FOR ADOLESCENTS AND ADULTS The etiologic agent of acquired immunodeficiency syndrome (AIDS) is a retrovirus designated human immunodeficiency virus (HIV). (cdc.gov)
  • Users also reported greater testing for sexually transmitted disease, human immunodeficiency virus, and pregnancy. (cdc.gov)
  • The biological effects of IL-2 are mediated by specific cell surface receptor complexes. (abscitech.com)
  • Human apelin was identified and isolated in 1998 as an endogenous ligand of the G-protein-coupled receptor APJ and was named the APJ endogenous ligand. (encyclopedia.pub)
  • Through studies of Nmnat transgenic mice which has axonal protective phenotype after injury, we found that enzymatic activity of Nmnat is essential to delay axonal degeneration both in-vitro and in-vivo. (wustl.edu)
  • details] Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation [med. (emf-portal.org)
  • Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)
  • Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)
  • Acute radiation syndromes can be caused by a sufficient dose of some internally deposited radionuclides that are widely distributed in tissues and organs and have a high specific activity. (msdmanuals.com)
  • Interleukin 25 promotes the initiation of proallergic type 2 responses. (nature.com)
  • Yeasts promotes both the human being and animal health, also they intensify the bioavailability of minerals through hydrolysis of phytate, folate biofortification, detoxification of fungal toxins and xenobiotics. (enmd-2076.com)
  • 6 ) suggest that low-density lipoprotein (LDL) regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the up regulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed protein kinase C (PKC) activation associated with an increased PA inhibitory activity. (ispub.com)
  • The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)
  • Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. (sagepub.com)
  • Insulin-like growth factor-1 (IGF-1), a member of a family of growth factors that are structurally closely related to pro-insulin, has shown profound effects on chondrocyte biological behavior and fundamentally regulates cartilage matrix metabolism during cartilage repair. (biomedcentral.com)
  • Pulendran, B. & Artis, D. New paradigms in type 2 immunity. (nature.com)
  • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. (nature.com)
  • IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. (abscitech.com)
  • 10 8 By contrast, chronic exposure to IL-1 leads to exhaustion of normal HSC. (haematologica.org)
  • Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
  • By tradition, the most commonly used classification of oral candidosis divides the infection into 4 types including (1) acute pseudomembranous candidosis (thrush), (2) acute atrophic (erythematous) candidosis, (3) chronic hyperplastic candidosis, and (4) chronic atrophic (erythematous) candidosis. (medscape.com)
  • Chronic hyperplastic candidosis was further subdivided into 4 groups based on localization patterns and endocrine involvement including (1) chronic oral candidosis (candidal leukoplakia), (2) endocrine candidosis syndrome, (3) chronic localized mucocutaneous candidosis, and (4) chronic diffuse candidosis. (medscape.com)
  • In cases of chronic liver disease, type C hepatic encephalopathy can be episodic or persistent. (medscape.com)
  • The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
  • The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)
  • uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)
  • Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1β in the rat hippocampus after focal application of kainic acid inducing electroencephalographic (EEG) seizures and CA3 neuronal cell loss. (jneurosci.org)
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
  • Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
  • Representative standard curve for IL-2 ELISA. (abscitech.com)
  • Quantification of IL-18 and TNF levels in human CSF samples and in murine brain homogenates was performed by species-specific commercially available ELISA (R&D Systems, Abingdon, UK). (biomedcentral.com)
  • There is little evidence for systemic toxicity following dermal exposure to strontium compounds, which would suggest that they are not readily absorbed across the skin of humans (ATSDR 2001e). (cdc.gov)
  • Type C: Hepatic encephalopathy associated with cirrhosis and portal hypertension or portal-systemic shunts. (medscape.com)
  • Whole-genome sequencing revealed 2 dominant serotypes-emm3 and emm6-with high rates of mucoid phenotype and systemic bacteremia. (cdc.gov)
  • In contrast, TNF-α at low concentrations can synergistically and directly enhance the clonal growth of primitive and more mature human CD34+ bone marrow progenitors when combined with GM-CSF or interleukin (IL)-3. (ox.ac.uk)
  • 2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
  • Because the biological availability and toxicity of strontium are primarily related to the strontium(II) oxidation state, ATSDR (2001e) has focused on that form of strontium. (cdc.gov)
  • The subsequent development of TNF-α mutants with selective activity on either TNFR55 or TNFR75 suggest that such mutants might maintain the therapeutic (anti-tumor) potential of wild type TNF-α, but exhibit reduced toxicity (proinflammatory effects). (ox.ac.uk)
  • Conclusions: We document a significant but transient increase in iGAS disease incidence in 2 months of 2017. (cdc.gov)
  • IL12RB1, is the name of its human gene. (wikipedia.org)
  • The gene for IL-2 has been mapped to human chromosome 4q (6). (abscitech.com)
  • The apelin gene located at chromosome Xq25-26.1, encodes a 77 amino acid preproprotein [ 1 ] [ 2 ] . (encyclopedia.pub)
  • This article has been published as part of BMC Microbiology Volume 9 Supplement 1, 2009: The PAMGO Consortium: Unifying Themes In Microbe-Host selleck Associations Identified Through The Gene Ontology. (interleukin-receptor.com)
  • These secondary neurons immediately cross over to the opposite anterolateral spinothalamic tract 3 to the thalamus and then to the somatosensory cortex of the postcentral gyrus 6 ( fig. 1 ). (asahq.org)