Expression patterns and correlations between LINE-1 ORF1 and c-Met proto-oncogene proteins were analyzed by immunofluorescence staining using both LINE-1 ORF1 and c-Met antibodies. (kosinmedj.org)
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. (unipg.it)
Proto-oncogene changes to oncogene mainly by somatic point mutations, gene amplifications, or chromosomal translocations that bring proto-oncogene under control of differentially expressed protein. (wikilectures.eu)
MEN2 results from germline mutations in the RET proto-oncogene and is transmitted in an autosomal dominant fashion. (medscape.com)
Mutations in RET , a transmembrane proto-oncogene, have been localized to 10q11.2 and are responsible for MEN 2. (medscape.com)
The patient underwent endocrine workup for MEN2B and genetic testing for the RET-proto oncogene mutations, all of which were negative. (jefferson.edu)
Encodes3
Scholars@Duke publication: The proto-oncogene bcl-3 encodes an I kappa B protein. (duke.edu)
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. (wikipedia.org)
The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by chromosomal translocations in approximately 40\% of diffuse large B-cell lymphomas (DLBCLs). (unipg.it)
Kinase4
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II. (guidetopharmacology.org)
Overexpression of the proto-oncogenes in these cells was blocked by superoxide dismutase, catalase and BAPTA/AM confirming that the overexpression of the proto-oncogenes in the tumor cells required elevated levels of ROS and Ca. Inhibitors specific for transcription, PKC and MAP kinase also blocked the overexpression of the proto-oncogenes in the tumor cells. (cdc.gov)
we conclude that the Cd-induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide and Ca. Further, the Cd-induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving PKC and MAP kinase. (cdc.gov)
The cellular sarcoma gene (SRC) is a proto-oncogene encoding for a tyrosine kinase. (jcancer.org)
Transcriptional1
Cadmium -induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. (cdc.gov)
Cellular1
Many oncogenes derived from cellular proto-oncogenes have been found in different retroviruses, implying that the normal vertebrate genome contains many potential cancer-causing genes. (wikilectures.eu)
Oncogenes are product of interaction between organisms and environment and cannot be inherited as syndromes known in tumor suppressor genes defects. (wikilectures.eu)
Cancers2
PBF is a multifunctional proto-oncogene which is overexpressed in thyroid, pituitary and breast cancers, with roles in cell transformation, invasion and transporter regulation. (unife.it)
Oncogenes were primarily identified in viruses causing cancers in chicken (1911, by Peyton Rous). (wikilectures.eu)
Tumor1
As in the case of the tumor cells, treating the non-transformed cells with the various modulators prior to their exposure to CdCl2 resulted in inhibition in the expression of the proto-oncogenes. (cdc.gov)
Receptors1
Typical products of proto-oncogenes are signaling molecules, growth factors or growth factor receptors. (wikilectures.eu)
Human6
LINE-1 hypomethylation induces the activation of proto-oncogenes in human colorectal cancer metastasis. (kosinmedj.org)
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. (edu.au)
Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and human. (oncotarget.com)
Purpose: Hepatocyte growth factor (HGF), a ligand of the c-met proto-oncogene, exhibits activating effects on human lung cancer both in vitro and in vivo. (go.jp)
To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)
The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
Metastasis2
According to recent studies, the long interspersed element-1 (LINE-1) retrotransposon open reading frame (ORF) is located in the intron of the c-Met proto-oncogene, which is involved in cancer progression and metastasis, and regulates its expression. (kosinmedj.org)
Specifically, the activation of proto-oncogene c-Met is involved in liver metastasis of colorectal cancer patients [ 7 ]. (kosinmedj.org)
Expression2
Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. (mdc-berlin.de)
In the present study, we have evaluated this reciprocal relationship by examining the impact of c-Ha-ras(EJ) oncogene transfection on α-smooth muscle (SM) actin and α 18 -adrenoceptor (ADR) gene expression in vascular (aortic) smooth muscle cells (SMCs). (houstonmethodist.org)
10.10161
The published version is available at https://doi.org/10.1016/j.ajoc.2023.101828 . (jefferson.edu)
Methods: We looked at the coding region of all 21 exons of the RET proto-oncogene, including the flanking intronic sequences, by direct DNA sequencing in 76 caucasians from Germany with Hirschsprung's disease. (uni-luebeck.de)
Cells2
When mutated, oncogenes have the potential to cause normal cells to become cancerous. (medlineplus.gov)
Oncogenes have a strong potential to lead the cells into cancer. (wikilectures.eu)
Primary2
pubMedId':'37983791','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/37983791','publicationId':'894814','title':'Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism. (stanford.edu)
The c-myc proto-oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was found to be amplified, usually at moderately increased copy number (2-5 copies). (lu.se)
Long1
C-kit is a proto-oncogene located on the long arm of chromosome 4. (hindawi.com)