• These treatments induced exceptionally high mRNA up-regulations in one cytosolic group with a low basal expression, indicative for the major heat inducible hsp70 s. (biomedcentral.com)
  • Our analyses suggest an independent evolution of the heat-inducible cytosol-type hsp70 s in Paramecium and in its close relative Tetrahymena , as well as within higher eukaryotes. (biomedcentral.com)
  • Due to this high conservation, Hsp70 has been widely used as a suitable phylogenetic marker in molecular evolution. (biomedcentral.com)
  • The high conservation of Hsp70 gives its functional properties across the species. (springeropen.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis / trans isomerisation of a prolyl bond. (biomedcentral.com)
  • Heat-shock proteins of the 70 kDa family (Hsp70s) are essential chaperones required for key cellular functions. (biomedcentral.com)
  • Prokaryotic Hsp70 (DnaK) proteins share about 50% amino acid identity with eukaryotic Hsp70s. (biomedcentral.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
  • Despite their shared conservation throughout nature, the three traditional PPIase families do not share a conserved role in cell viability. (biomedcentral.com)
  • Therefore, we have characterised the Hsp70 gene family of Paramecium caudatum to gain insight into the evolution and differential heat stress response of the distinct family members in protists and to investigate the diversification of eukaryotic hsp70 s focusing on the evolution of heat-inducibility. (biomedcentral.com)
  • Phylogenetic analyses revealed five evolutionarily distinct Hsp70-groups, each with a closer relationship to orthologous sequences of Paramecium tetraurelia than to another P. caudatum Hsp70-group. (biomedcentral.com)
  • Information about the hsp70 copy number and diversity in microbial eukaryotes is, however, scarce, and detailed knowledge about the differential gene expression in most protists is lacking. (biomedcentral.com)
  • Comparative EST analyses for P. tetraurelia hsp70 s unveiled a corresponding expression pattern, which supports a functionally conserved evolution of the Hsp70 gene family in Paramecium . (biomedcentral.com)
  • 2. Hui-hui Liu ,Jian-yu He,Chang-feng Chi,Jianzhong Shao.Differential HSP70 expression inMytilus coruscusunder various stressors. (zjou.edu.cn)
  • 11.Jianyu He, Hui-hui Liu ,JingwenYang,XiangliDong,Changwen Wu.Abundant members of Scavenger receptors family and their identification, characterization and expression againstVibrio alginolyticusinfection in juvenileLarimichthys crocea.Fish & Shellfish Immunology , 2016, 50: 297-309. (zjou.edu.cn)
  • Thus, these two isoforms demonstrate differences in expression and function: eEF1A1 is expressed in most cells while eEF1A2 is only expressed in adult neuronal and muscle cells, and only eEF1A1 induces HSP70 during heat shock. (wikipedia.org)
  • Mutations with hsp70 deletions reduced thermotolerance in these organisms, and the thermotolerance defect could be complemented by expression hsp70 genes. (springeropen.com)
  • This result indicates convergent evolution during hsp70 subfunctionalization and implies that heat-inducibility evolved several times during the course of eukaryotic evolution. (biomedcentral.com)
  • Some of the most important and well investigated Hsps are the members of the 70 kDa heat-shock protein family (Hsp70s). (biomedcentral.com)
  • and induction of HSP70 during heat shock. (wikipedia.org)
  • however, almost all the WT tobaccos died after treated at 50 °C and no WT tobacco survived after heat shock at 52 °C. This study firstly showed the function of a hsp70 gene from H. marmoreus . (springeropen.com)
  • Of all HSPs, Hsp70 appears to correlate best with heat resistance either permanent or transient (Li and Mak 2009 ). (springeropen.com)
  • These studies proved that Hsp70 is essential for organisms to survive a severe heat shock. (springeropen.com)
  • Twenty-five SNPs were detected across the three HSP70 genes. (nih.gov)
  • 2003 . Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression. (nih.gov)
  • HNPCC families in which mutations in hMLH1 and hMSH2 are not identified may harbor pathogenic mutations in other mismatch repair genes, such as hMSH6 and hPMS2 . (cdc.gov)
  • One of the standard ideas quoted above is that of neofunctionalization where one copy of the duplicated genes acquires a new function that is subsequently selected giving rise to two members of a gene family that are both under negative selection. (blogspot.com)
  • The genotyping strategy involved identification of common and rare single nucleotide polymorphisms (SNPs) within the HSP70 gene cluster by sequencing, estimation of linkage disequilibrium (LD) and haplotype structure, and thereafter, analysis of SNP/haplotype frequencies in the cases and controls. (nih.gov)