• Arginine
  • Cangitoxin-III (CGTX-III) contains in addition to the previous substitution, a replacement of the 14th amino acid, arginine (R), into histidine (H). Cangitoxin is to varying degrees homologous to the other sea anemone toxins. (wikipedia.org)
  • synthesis
  • Asparagine, however, is not well transported to the brain via the blood-brain barrier," said senior co-author of the study Dr Jacques Michaud, who found that brain cells depend on the local synthesis of asparagine to function properly. (health24.com)
  • One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis from cholesterol. (wikipedia.org)
  • In this way, a negative feedback pathway is established in which synthesis of bile acids is inhibited when cellular levels are already high. (wikipedia.org)
  • mutation
  • A point accepted mutation - also known as a PAM - is the replacement of a single amino acid in the primary structure of a protein with another single amino acid, which is accepted by the processes of natural selection. (wikipedia.org)
  • If a point mutation occurs within an expressed region of a gene, an exon, then this will change the codon specifying a particular amino acid in the protein produced by that gene. (wikipedia.org)
  • Despite the redundancy in the genetic code, there is a possibility that this mutation will then change the amino acid that is produced during translation, and as a consequence the structure of the protein will be changed. (wikipedia.org)
  • Changing a single amino acid in a protein may reduce its ability to carry out this function, or the mutation may even change the function that the protein carries out. (wikipedia.org)
  • Consequently, acceptance of point mutations depends heavily on the amino acid being replaced in the mutation, and the replacement amino acid. (wikipedia.org)
  • Because the value n {\displaystyle n} in the PAMn matrix represents the number of mutations per 100 amino acids, which can be likened to a percentage of mutations, the term percentage accepted mutation is sometimes used. (wikipedia.org)
  • However, 'PAM matrix' refers to one of a family of matrices which contain scores representing the likelihood of two amino acids being aligned due to a series of mutation events, rather than due to random chance. (wikipedia.org)
  • The 'PAMn matrix' is the PAM matrix corresponding to a time frame long enough for n {\displaystyle n} mutation events to occur per 100 amino acids. (wikipedia.org)
  • foods
  • During heating the amino acid asparagine, naturally present in starchy foods, undergoes a process called the Maillard reaction, which is responsible for giving baked or fried foods their brown color, crust, and toasted flavor. (wikipedia.org)
  • either
  • Asparagine is needed to maintain balance in the central nervous system, it prevents you from being either overly nervous or overly calm. (grandmas-herbal-remedies.com)
  • Cells were grown either in liquid Tris-acetic acid-phosphate (TAP) medium ( Gorman and Levine, 1965 ) or on TAP/agar plates. (rupress.org)
  • levels
  • Asparagine can become acrylamide during the frying of potatoes and is a probable human carcinogen, so reduced levels of it are desirable. (wikipedia.org)
  • nuclear
  • The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans. (wikipedia.org)
  • long
  • DUF4596 on human PRP36 is 47 amino acids long, has an isoelectric point of 3.77, and is almost completely conserved across mammals. (wikipedia.org)
  • known
  • The last conserved domain spans from amino acid 320 to 500 and is known as AKAP7 2'5' RNA ligase-like domain (AKAP7_NLS). (wikipedia.org)
  • chemical
  • The effects of these mutations on permeation properties were correlated with the size of the amino acid side chain substituted, rather than its chemical nature. (wiley.com)
  • The 20 amino acids translated by the genetic code vary greatly by the physical and chemical properties of their side chains. (wikipedia.org)
  • process
  • Amino Acid Analysis is a vital tool at all stages of drug discovery and throughout the manufacturing process, where it is used to ensure consistency between drug batches. (sgs.com)
  • cannot
  • As a result, asparagine cannot take part in the Maillard reaction, and therefore the formation of acrylamide is significantly reduced. (wikipedia.org)