• Histological evaluation revealed extensive diffuse evidence of necrosis in all controls (at 3 hours, cold static preservation) but flaps placed on hyperbaric ex-vivo perfusion support showed decreased histologic evidence of ischemic injury or necrosis ranging from rare to moderate. (sages.org)
  • Reperfusion of ischemic tissues is often associated with microvascular injury, particularly due to increased permeability of capillaries and arterioles that lead to an increase of diffusion and fluid filtration across the tissues. (wikipedia.org)
  • In fact an individual suffering from an ischemic insult continues suffering injuries well after circulation is restored. (wikipedia.org)
  • Symptoms can include hemiplegia, aphasia, and visual field deficit and neglect and range in severity from worsening of deficits caused by the initial ischemic injury to new symptoms localizing to a larger area within the same vascular territory. (medscape.com)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • After the ischemic time is reached after two to three hours, fix the fracture of the external carotid artery using micro forceps and gently pull out the thread bolt with another micro forceps. (jove.com)
  • Primary cortical neurons were subjected to glucose deprivation (GD), oxygen-glucose deprivation (OGD) or simulated ischemia-reperfusion (I/R). Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion. (scienceopen.com)
  • Excessive glutamate release and the overexcitation of glutamate receptors has been identified as a central mediator in the pathophysiology of the neuronal injury associated with ischemic stroke and head trauma ( Choi, 1987 ). (jneurosci.org)
  • Nitric oxide is a nonadrenergic and noncholinergic neurotransmitter in the intestinal smooth muscle and it plays an important role in the process of ischemic-reperfusion injury. (csgh.info)
  • Experimental animals, adult male Wistar rats, were divided into three groups according to the reperfusion period after previous ischemic episode lasting for one hour. (csgh.info)
  • The results were compared to a control group without experimental ischemic-reperfusion injury. (csgh.info)
  • These results indicated that the jejunal ischemic-reperfusion injury affected the neurons of the enteric nervous system and resulted in early decrease in the activity of the nitric oxide neurotransmitter one hourafterthe injury. (csgh.info)
  • Further gradual increase of its activity 24 hours after ischemic-reperfusion injury could be considered a result of the plasticity process. (csgh.info)
  • On day 30 after ischemic-reperfusion injury all the histochemical changes reached control levels. (csgh.info)
  • The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. (biomedcentral.com)
  • The purpose of this study is to establish and validate an animal model for research in the recovery and sequela stages of brain ischemia by testing brain infarction and sensorimotor function after middle cerebral artery occlusion/reperfusion (MCAO/R) after 1-90 days in rats. (jove.com)
  • Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice. (scienceopen.com)
  • In rats it has been shown that neurons often die a full 24 hours after blood flow returns. (wikipedia.org)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
  • The rats were fed by gavage immediately after reperfusion. (biomedcentral.com)
  • The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
  • Approach and Results - Rats underwent 30-minute ischemia per 24-hour reperfusion. (utmb.edu)
  • It has also been shown to be protective against IR injury in rats. (unifesp.br)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • The authors provide an overview on where we are in potentially exploiting this therapy for novel treatments of acute kidney injury (AKI). (ajkdblog.org)
  • DC-mediated NKT cell activation is critical in initiating the immune response following kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI). (jci.org)
  • For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
  • Conclusion: From these results, we deduced that the preventive effect of EP on rat kidney ischemia-reperfusion injury was not due to the decreased expression of HMGB1 but the prevention of HMGB1 release. (elsevierpure.com)
  • A recent article by Decuypere et al in AJKD explores the role of autophagy in kidney ischemia-reperfusion injury and therapy. (ajkdblog.org)
  • Reperfusion injury is distinct from cerebral hyperperfusion syndrome (sometimes called "Reperfusion syndrome"), a state of abnormal cerebral vasodilation. (wikipedia.org)
  • Cerebral reperfusion, or hyperperfusion, syndrome is a rare but serious complication that can occur following rapid revascularization of a partially or completely occluded artery with successful thrombolytic therapy, successful thrombectomy, carotid enterectomy (CEA), or carotid artery stenting (CAS). (medscape.com)
  • The clinical presentation of cerebral reperfusion syndrome varies but generally includes components of the following triad: 1) ipsilateral headache, 2) contralateral focal neurologic deficits, and/or 3) seizures. (medscape.com)
  • Symptom severity is not necessarily proportional to degree of reperfusion - both reperfusion and hyperperfusion can result in cerebral injury with similar clinical presentations. (medscape.com)
  • Cerebral reperfusion syndrome presents with ipsilateral headache, contralateral focal neurologic deficits, and/or seizures, but a complete triad is not required for diagnosis. (medscape.com)
  • Several mechanisms have been proposed for the pathogenesis of cerebral reperfusion injury. (medscape.com)
  • Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
  • To determine whether undergoing 36 versus 72 total hours of device-based fever prevention after an initial 24 hours of targeted temperature management (TTM) in comatose patients who suffered a cardiac arrest results in a lower mortality from all causes or hospital discharge with a Cerebral Performance Category (CPC) of 3 or 4 within 90 days (Table 1). (emra.org)
  • The restoration of cerebral blood flow is thought to potentially increase the risk of hyperperfusion injury, hemorrhagic transformation, and symptomatic intracerebral hemorrhage. (ajnr.org)
  • The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model. (scienceopen.com)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • Activated endothelial cells produce more reactive oxygen species but less nitric oxide following reperfusion, and the imbalance results in a subsequent inflammatory response. (wikipedia.org)
  • It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
  • Ischemia-reperfusion injury occurs when circulation is abruptly restored following prolonged ischemia and it is well-known that high levels of calcium and tissue neutrophil accumulation cause cellular damage and produce reactive oxygen species (ROS) during reperfusion and trigger IR injury [ 1 ]. (hindawi.com)
  • During tourniquet-related ischemia, aerobic respiration stops, and ATP is depleted, and during subsequent reperfusion, there is an increase in reactive oxygen species (ROS) production and other endogenous substances, which leads to acute ischemia-reperfusion (IR) injuries, including tissue necrosis and skeletal muscle contractile dysfunction. (nebraska.edu)
  • Group 2 (experimental, n=2) flaps were perfused with hyper-oxygenated UW for seven hours at 37ºC in a hyperbaric chamber at 3 atm before transplantation. (sages.org)
  • The experimental setup is a platform that can be used to conduct further studies on uterine ischemia- and reperfusion injury that may lead to improved human uterus transplantation protocols. (nih.gov)
  • BACKGROUND: Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. (lu.se)
  • Objective: To investigate the morphological effects of free radical injury on spermatogenic cells in both testes of the rabbit experimental model of testicular torsion. (edu.gh)
  • Klarik Z, Tamas R, Toth E, Kiss F, Kovacs EL, Jäckel M, Furka I, Nemeth N. Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion. (scielo.br)
  • Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)
  • While the role of neutrophil extracellular traps (NETs) in sepsis is well-defined, the impact of the commensal gut flora and related activation of innate immune signaling for NETosis in the mesenteric microcirculation during mesenteric ischemia-reperfusion (MIR) is entirely unresolved. (isth.org)
  • To mitigate obligate reperfusion injury in VCA, we evaluate the efficacy of a novel normothermic hyperbaric oxygen warm ex-vivo perfusion strategy using hyperoxygenated University of Wisconsin (UW) solution in a porcine VCA model. (sages.org)
  • Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia). (wikipedia.org)
  • small artery or anterior spinal artery occlusion, "…microthrombi, and altered perfusion due to internal recoil of the spinal architecture following decompression", "… direct trauma from blood flow itself or by the oxygen free radicals…", or "…lipid peroxidation of the neuronal membrane…as a main cause in the secondary injury-induced degenerative cascade. (surgicalneurologyint.com)
  • The purpose of this study was to examine our hypotheses that BoTA provide protection of musculocutaneous flap from ischemia-reperfusion injury. (hindawi.com)
  • In this study, we found that local BoTA preconditioning yielded significant protection against IR injury in a rat musculocutaneous flap model. (hindawi.com)
  • Since reperfusion is necessary, but hyperperfusion is not required, some authors prefer use of the broader term reperfusion syndrome . (medscape.com)
  • Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. (biomedcentral.com)
  • Following acute cervical spinal cord decompression, a subset of patients may develop acute postoperative paralysis due to Reperfusion Injury (RPI)/White Cord Syndrome (WCS). (surgicalneurologyint.com)
  • Postoperative reperfusion injury (RPI)/white cord syndrome (WCS) causing acute deficits following cervical spine surgery. (surgicalneurologyint.com)
  • Ticagrelor, but not clopidogrel, increased myocardial adenosine levels, increased phosphorylation of Akt, endothelial NO synthase, and extracellular-signal-regulated kinase 1/2 4 hours after reperfusion and decreased apoptosis. (utmb.edu)
  • consequently, this activity gradually increased in the group with 24 hour reperfusion, and finally in the group with 30 days reperfusion there were no changes in the activity of the nitrergic neurons compared to the control group. (csgh.info)
  • We found that 48-72 hours after cardiac arrest, thalamocortical neurons demonstrate significantly elevated firing rates both during spontaneous activity and in response to whisker deflections. (cdc.gov)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine model of ischemia/reperfusion, with serial cardiovascular magnetic resonance (CMR) imaging throughout one week using non-invasive pressure-volume loops. (lu.se)
  • CONCLUSION: Using non-invasive pressure-volume loops by CMR, we observed that mild hypothermia at reperfusion alleviates the heart's work after ischemia/reperfusion injuries during the first week and preserves short-term cardiac performance. (lu.se)
  • Current guidelines recommend 72 hours of active fever prevention in comatose patients who have achieved sustained return of spontaneous circulation (ROSC) after an out-of-hospital cardiac arrest (OHCA). (emra.org)
  • The goal of fever prevention is to mitigate the harmful effects of hypoperfusion during a cardiac arrest and reduce sequelae of reperfusion injury after ROSC. (emra.org)
  • Certain factors may lead to an unfavorable outcome even when treatment is administered rapidly, such as reperfusion injury and hemorrhagic transformation, poor collateral circulation, dehydration, poor cardiac output, hypotension, hyperglycemia, and fever ( 1 - 5 ). (ajnr.org)
  • 3 hours after the onset of symptoms reduce mortality or cardiac arrest. (biomedcentral.com)
  • Glucose-insulin-potassium (GIK) has long been advocated as an adjunctive treatment for patients with cardiac dysfunction during episodes of ischemia and reperfusion. (biomedcentral.com)
  • In addition, in pediatric patients undergoing cardiac surgery, detectable urine levels of CRELD2 within postoperative 6 hours strongly associate with severe AKI after surgery. (jci.org)
  • The role of cardiac proteasome dysfunction during I/R and the perspective to diminish I/R injury by manipulating proteasome function remain unclear. (elsevierpure.com)
  • CK can also be elevated in the absence of neuromuscular diseases or cardiac injury, such as after strenuous exercise, intramuscular injection, and with renal disease. (medscape.com)
  • Because the major source of CK-MB is myocardium, an elevated CK-MB level reflects myocardial injury, including acute myocardial infarction, myocarditis, cardiac trauma, cardiac surgery, and endomyocardial biopsy. (medscape.com)
  • The elevated CK-BB in cerebrospinal fluid is a useful predictor of hypoxic brain injury after cardiac arrest. (medscape.com)
  • If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
  • In the present study, a hepatic I/R‑injury model was successfully established using C57BL/6 mice. (spandidos-publications.com)
  • Furthermore, GP exhibits a therapeutic effect on chronic hepatic injury, fibrosis, as well as fatty liver disease, which were induced by a high fat, high cholesterol diet and alcohol in mice ( 5 , 8 ). (spandidos-publications.com)
  • Therefore, in the present study the protective effects of GP against I/R-induced hepatic injury in mice was studied. (spandidos-publications.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
  • NET formation was significantly increased in GF, ASF and ASF+Abx mice after reperfusion. (isth.org)
  • In this study, we showed that mice with A2AR-deficient DCs are more susceptible to kidney IRI and are not protected from injury by A2AR agonists. (jci.org)
  • A 2A R agonist ATL313 (10 ng/kg/min, osmotic mini-pump, s.c.) was administered to mice 24 hours prior to kidney IRI surgery. (jci.org)
  • Following 26 minutes of kidney ischemia and 24 hours of kidney reperfusion, plasma creatinine levels were measured from vehicle- and ATL313-pretreated CD11c-Cre , CD11c-CreAdora2a fl/WT , and CD11c-CreAdora2a fl/fl mice. (jci.org)
  • Here, we studied the protective effects of HBO pretreatment with 100% oxygen at 2.5 ATA against tourniquet/IR injury in mice. (nebraska.edu)
  • After one hour of HBO therapy with 100% oxygen at 2.5 ATA was administered to C57/BL6 mice, a rubber band was placed at the hip joint of the unilateral hindlimb to induce 3 h of ischemia and then released for 48 h of reperfusion. (nebraska.edu)
  • 1) Ticagrelor (10 or 30 mg/kg) or clopidogrel (12.5 mg/kg) was given via intraperitoneal injection 5 minutes before reperfusion. (utmb.edu)
  • Isolated sheep uteri were perfused with the preservation solution IGL-1 and were then exposed to cold ischemia for either 4 (n = 6) or 48 hours (n = 7). (nih.gov)
  • Quantification of cell density indicated no significant edema in the myometrium or in the endometrium of uteri exposed to 4 hours cold ischemia and then a normothermic ex vivo reperfusion for 48 hours. (nih.gov)
  • However, a much faster and severe reperfusion damage of all uterine layers were evident during the reperfusion experiment following 48 hours of cold ischemia. (nih.gov)
  • In conclusion, we have identified a relevant amount of early genes regulated in the human liver after 7-9 hours of cold ischemia and 2 hours from reperfusion, many of them not having been described before in this process. (unina.it)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
  • Our previous results showed that IR injury impaired renal function, by causing extensive tubular necrosis and increasing MHC class II and ICAM-1 molecule expression by mesangial cells (MC). (unifesp.br)
  • Intravenous administration of FTY720 (1 mg/kg) immediately before IR induction did not improve the short-term (24 hours) outcome of renal function or reduced MHC class II and ICAM-1 surface molecule expression. (unifesp.br)
  • This is a technique where one or two renal arteries are ligated for a period of time (30 min to 1 hour), and then released causing AKI. (ajkdblog.org)
  • Dexmedetomidine is widely used for perioperative anesthesia/analgesia, and may have a more profound renal protection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury. (medscape.com)
  • The inflammatory response is partially responsible for the damage of reperfusion injury. (wikipedia.org)
  • Some theorize that this delayed reaction derives from the various inflammatory immune responses that occur during reperfusion. (wikipedia.org)
  • These inflammatory responses cause intracranial pressure, pressure which leads to cell injury and in some situations cell death. (wikipedia.org)
  • Hypothermia has been shown to help moderate intracranial pressure and therefore to minimize the harmful effect of a patient's inflammatory immune responses during reperfusion. (wikipedia.org)
  • The extent of reperfusion injury likely depends on the extent of initial hypoperfusion, the time to collateral collapse, the volume of irreversible tissue damage, and the degree of autoregulatory and pro-inflammatory responses. (medscape.com)
  • Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
  • In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)
  • Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. (scienceopen.com)
  • [ 27 ] Dexmedetomidine pretreatment attenuated the I/R injury by reducing inflammatory response mediated by toll-like receptor4 expression. (medscape.com)
  • Objective To examine the hypothesis that the presence of HARM on MRI correlates with worse neurological recovery after reperfusion therapy. (bmj.com)
  • Conclusions This preliminary analysis shows that the presence of HARM may be linked to worse neurological recovery 24 hours after thrombectomy. (bmj.com)
  • Their analyses may help us to better understand the pathophysiology of IRI and to characterize potential target genes for the prevention or treatment of the liver injury in order to increase the number of patients that successfully undergo transplantation. (unina.it)
  • Materials and Methods: The left testes of 8 peripubertal NZW rabbits (3-6 months) were subjected to 0, 15, 30, 60, 90, 120, and 180 min of ischemia by applying a clamp to the spermatic cord, followed by reperfusion. (edu.gh)
  • Objective We hypothesized that administration of a homodimer of recombinant annexin V, diannexin, could shield phosphatidylserine on the endothelium, and inhibit leukocyte and platelet adhesion, thereby potentially reducing ischemia reperfusion injury (IRI) in lung transplantation. (elsevierpure.com)
  • 1 - 8 ] In theory, such acute cord decompression, and re-expansion disrupts the blood-spine barrier allowing for "rush-in reperfusion", a "…triggered cascade of reperfusion injuries…", and potentially, "…oxygen-derived free radical damage" [ Table 1 ]. (surgicalneurologyint.com)
  • Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. (scielo.br)
  • We, therefore, aimed to develop an ex vivo sheep uterus reperfusion platform that mimics the reperfusion situation so that initial assessments and comparisons can be performed without the need for costly and labor-intensive in vivo transplantation experiments. (nih.gov)
  • Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)
  • Balkanay enrolled adult patients undergoing CABG found a significant difference between high dose group (8 μg/kg) and low dose group (4 μg/kg) for the 24th postoperative hour in the mean values of neutrophil gelatinase-associated lipocalin (NGAL), [ 17 ] indicating that dexmedetomidine had marked effects on renoprotection in a dose-dependent fashion. (medscape.com)
  • Mitochondrial complex I is thought to be the most vulnerable enzyme to tissue ischemia/reperfusion but the mechanism of damage is different in different tissues. (wikipedia.org)
  • We designed this study to identify changes in HMGB1 expression in rat kidney tissues after ischemia reperfusion injury and effects of EP on the expression of HMGB1. (elsevierpure.com)
  • Early rapid fluid resuscitation (boluses) in African children with severe febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus). (biomedcentral.com)
  • The major indications for replantation in the absence of prolonged ischemia, segmental damage, and diffuse crush or severe avulsion injuries are amputations of the thumb, multiple digits, a digit in a child, and a digit distal to the flexor digitorum superficialis insertion. (medscape.com)
  • Rationale: Both cardiomyocyte-restricted proteasome functional enhancement and pharmacological proteasome inhibition (PSMI) were shown to attenuate myocardial ischemia/reperfusion (I/R) injury. (elsevierpure.com)
  • Reperfusion injury plays a major part in the biochemistry of hypoxic brain injury in stroke. (wikipedia.org)
  • Inclusion criteria for thrombolytic therapy were 18 years of age or older, presenting within 6 hours of stroke symptoms onset with initial National Institute of Health Stroke Scale (NIHSS) of 8 or more, except for aphasia and visual field deficit, and normal initial head CT scan. (ajnr.org)
  • Univariate and binary logistic regression models were performed to assess predictors for improvement of the National Institutes of Health Stroke Scale (NIHSS) score by ≥8 points at 24 hours. (bmj.com)
  • To the best of our knowledge, the role of GP in hepatic I/R injury and the underlying molecular mechanism, have not yet been investigated. (spandidos-publications.com)
  • 8. Eltzschig H, Eckle T. Ischemia and reperfusion - from mechanism to translation. (scielo.br)
  • The important considerations are the level of the injury, the mechanism of the trauma, and the general health of the patient. (medscape.com)
  • This model proved to be able to distinguish reperfusion injury-related differences associated to organ preservation. (nih.gov)
  • These results suggest a protective role of FTY720 in an IR injury model. (unifesp.br)
  • More studies are required to identify the mechanisms involved in the protective activity of FTY720 in the IR injury model. (unifesp.br)
  • Objectives: We sought to determine proteasome adequacy in I/R hearts, create a mouse model of cardiomyocyte-restricted PSMI (CR-PSMI), and test CR-PSMI impact on I/R injury. (elsevierpure.com)
  • [ 1 ] In addition, there was a significantly higher risk of receiving 5 or more units of red blood cells within 24 hours of surgery in the patients receiving N-acetylcysteine compared with the placebo group ( P = 0.005). (medscape.com)
  • At 24 hours of reperfusion, myocardial proteasome activities were significantly lower whereas total ubiquitin conjugates and GFPdgn protein levels were markedly higher in all regions of the I/R hearts than the sham controls, indicative of proteasome functional insufficiency. (elsevierpure.com)
  • A total of 795 genes whose expression is significantly modified by ischemia-reperfusion in human liver transplantation were identified in this study. (unina.it)
  • Uteri were then reperfused for 48 hours under normothermic conditions with an oxygenated recirculating perfusate containing growth factors and synthetic oxygen carriers. (nih.gov)
  • Mean arterial pressure remained stable in Normothermic animals (-3%, p=0.77) but dropped two hours post-reperfusion in hypothermic animals (-18%, p=0.007). (lu.se)
  • Thereafter, the Hypothermia group was rapidly cooled (mean 34.5°C) for 5 minutes before reperfusion. (lu.se)
  • Analysis of covariance at 24 hours indicated that hypothermia has cardioprotective properties incremental to reducing infarct size, such as higher external power (p=0.061) and lower arterial elastance (p=0.015). (lu.se)
  • Time of STEMI onset was divided into four 6-hour periods in phase with circadian rhythms. (bmj.com)
  • This response was greatest immediately after reoxygenation and one hour later was diminishing suggesting at least one of the components involved was labile. (bl.uk)
  • Ischemia-reperfusion (IR) injury is a common early feature that contributes to graft damage by impairing resident cell function. (unifesp.br)
  • Therefore, skeletal muscle injury can sometimes cause elevated CK-MB levels, leading to misinterpretation. (medscape.com)
  • 2 Data for the prevention of fevers beyond 12 to 24 hours is less robust, however, based primarily on animal studies and observational data suggesting there is increased morbidity and mortality associated with fever beyond this period. (emra.org)
  • The goal of this trial was to compare outcomes of 2 different durations (36 hours versus 72 hours) of fever prevention after 24 hours of TTM in comatose patients who have been resuscitated after an OHCA. (emra.org)
  • The discovery of novel genes activated by IRI might lead to the identification of potential target genes for the prevention or treatment of the injury. (unina.it)
  • In view of the definition for AKI using conventional tests such as the blood urea nitrogen, serum creatinine levels, urine output quantity and creatinine clearance rate, it may result in delay in the timely detection of kidney injury and can lead to false-negative results, and dexmedetomidine for the prevention of AKI may be more effective than the current results. (medscape.com)
  • Although the majority of research is directed toward reducing the brain injury that results from intrapartum birth asphyxia, the multi-organ injury observed in surviving neonates is of equal importance. (frontiersin.org)
  • Results: In the 24-hour reperfusion group, apoptotic bodies and giant cells were more prominent in the seminiferous tubules of the left testes compared to the right, and were maximal after 90 min. (edu.gh)
  • We performed a retrospective review of 58 patients with 62 MR imaging studies performed within 72 hours following endovascular treatment of intracranial aneurysms. (ajnr.org)
  • After the 24-hour maintenance period at 36°C, the core temperature was gradually increased by 0.5°C per hour to 37°C for a total duration of 36 hours or 72 hours. (emra.org)
  • These data suggest that one hour of HBO pretreatment with 100% oxygen at 2.5 ATA increases the antioxidant response to lower ROS accumulation but does not increase ATP levels in IR muscles and improve tourniquet/IR-injured muscle morphology and contractile function. (nebraska.edu)
  • All patients in the trial underwent cooling to 36°C in the first 24 hours in accordance with international guidelines at the time of the design and initiation of the trial. (emra.org)
  • Many studies have tried to discover pharmacologic or surgical interventions that may alleviate IR flap injuries [ 2 - 13 ]. (hindawi.com)
  • The toxin appears to not only have a positive effect on muscle circulation and vessels [ 20 - 23 ] but also apparently have the ability to alleviate IR injury in muscle flaps [ 6 , 24 ]. (hindawi.com)
  • Time from injury to reperfusion and salvage depends upon the type of tissue involved and the temperature of the injured part. (medscape.com)