• Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
  • However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
  • 1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)
  • yobo佌肰 's EpiCorneal tissue model consists of normal human corneal epithelial cells cultured to form a stratified, squamous epithelium which closely parallels normal human corneal tissue. (wasfahokhaltah.com)
  • The corneal cells, cultured on specially prepared cell culture inserts with serum-free medium, differentiate to form a multi-layered structure. (wasfahokhaltah.com)
  • Transepithelial Electrical Resistance (TEER) of EpiCorneal (COR-100, comprised of corneal epithelial cells) and EpiOcular (OCL-200, comprised of keratinocytes) tissue models. (wasfahokhaltah.com)
  • MUC4 - Mucin 4 is found predominantly in the most superficial cell layers in stratified corneal epithelium. (wasfahokhaltah.com)
  • Epidermal growth factor, insulin, hydrocortisone and other proprietary stimulators of corneal epithelial differentiation. (wasfahokhaltah.com)
  • This study evaluated the antiangiogenic effects of ATN-161, a small peptide inhibitor of integrin α5β1, in human choroidal endothelial cells (hCECs) and in laser-induced CNV in rats. (arvojournals.org)
  • Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Human cerebral endothelial cells are a potential source for bioactive BDNF. (2medicalcare.com)
  • 2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
  • Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
  • Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
  • Adenosine triphosphate (ATP) is a direct energy source in cells and the core of the biochemical system, and is closely related to various metabolic activities in living organisms. (bvsalud.org)
  • Master molds with inverted DLT were produced by 2-photon lithography (2-PL). To measure the mechanotransductive potential of DLT, mesenchymal stem cells were cultivated on silicone or collagen imprints with DLT. (lww.com)
  • Artificial reproduction of Descemet membrane with respect to topography and similar stiffness offers a potential innovative way to bioengineer a functional CEC monolayer from autologous stem cells. (lww.com)
  • In a recent study under review at the journal Molecular Medicine and currently available on the Research Square * preprint server, researchers in China investigate the role of phosphatidylinositol 3 kinase (PI3K)/ protein kinase B (AKT) pathway in causing metabolic disruptions and tissue injury among human corneal epithelial cells (hCECs) and corneal tissues of mice. (worldmedicinefoundation.com)
  • To investigate the combined anti- Acanthamoeba effects of nitric oxide (NO) donors and hypochlorite to maximize amoebicidal outcomes while minimizing damage to human corneal epithelial cells (HCECs). (arvojournals.org)
  • Here, we showed that hAdMSC-CM suppressed Benzalkonium Chloride (BAC)-induced cytotoxicity and inflammation in human corneal epithelial cells (hCECs). (bvsalud.org)
  • Stem cells or progenitor cells are defined by a capacity for self-renewal and the ability to generate different types of cells (multipotentiality) that are involved in the formation of mature tissues. (intechopen.com)
  • Despite the successful isolation and characterization of stem cells from various tissues, relatively few animal studies have been done to investigate the efficacy of stem cell transplantation. (intechopen.com)
  • Dry eye syndrome (DES) is a chronic ocular disease that induces epithelial damage to the cornea by decreasing tear production and quality. (bvsalud.org)
  • Exposure to blue light followed by LY294002 treatment showed synergistic effects in lowering hCEC viability in the two groups. (worldmedicinefoundation.com)
  • Cyclin A2 and cyclin-dependent kinase 2 (CDK 2) levels, both of which are PI3K/AKT pathway substrates, were significantly reduced among the zero-hour LY294002, two-day DMSO, and two-day LY294002 treatment groups as compared to the zero-hour DMSO group. (worldmedicinefoundation.com)