• Adrenal cancer is the presence of malignant adrenal tumors, and includes neuroblastoma, adrenocortical carcinoma and some adrenal pheochromocytomas. (wikipedia.org)
  • Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby tissues, but may cause significant health problems by unbalancing hormones. (wikipedia.org)
  • Both benign and malignant tumors of the adrenal cortex may produce steroid hormones, with important clinical consequences. (wikipedia.org)
  • citation needed] Adrenocortical adenomas are benign tumors of the adrenal cortex that are extremely common (present in 1-10% of persons at autopsy). (wikipedia.org)
  • However, size and weight of the adrenal cortical tumors are no longer considered to be a reliable sign of benignity or malignancy. (wikipedia.org)
  • Neuroblastoma and pheochromocytoma are the two most important tumors which arise from the adrenal medulla. (wikipedia.org)
  • Both tumors may also arise from extra-adrenal sites, specifically, in the paraganglia of the sympathetic chain. (wikipedia.org)
  • Adrenal Pheochromocytoma is a condition in which tumors are formed on the adrenal gland. (targetwoman.com)
  • These tumors occur predominantly on one adrenal gland as an unilateral condition. (targetwoman.com)
  • Adrenal tumors are generally categorized into functional and nonfunctional depending upon their type. (targetwoman.com)
  • Tumors associated with the adrenal cortex fall into the functional category whereas the remaining part of the adrenal gland secreting mixed hormones such as sex hormones and aldosterone fall under the nonfunctional category. (targetwoman.com)
  • Adrenal tumors of the benign non-functional origin are also caused by other conditions such as amyloidosis and granuloma. (targetwoman.com)
  • Adrenal tumors are identified by a careful examination of the patient history followed by biochemical and radiological investigations. (targetwoman.com)
  • Surgical procedures such as laparoscopic adrenalectomy have produced good results in the removal of adrenal tumors. (targetwoman.com)
  • Methods of analysis of tumors of the DNS are also presented because some of these techniques are indispensable for the diagnosis of many neuroendocrine neoplasms. (basicmedicalkey.com)
  • Tumors or cancers of the ADRENAL CORTEX. (ucdenver.edu)
  • Adrenocortical adenoma  encapsulated, expansile, yellow tumors, lipid-rich cells, adjacent adrenal cortex and contralateral adrenal glands are atrophic b/c of suppression of endogenous ACTH by high cortisol levels. (docsbay.net)
  • 2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors. (roche.com)
  • Cushing's is a disease of middle-aged to older cats (7-12 years), and may be caused by a pituitary tumor (90% are adenomas), pituitary hyperplasia, adrenal tumors, adrenal hyperplasia, by non-endocrine tumors (usually lung) or it may be iatrogenic. (dvm360.com)
  • Thus, we can't use it to discriminate between adrenal tumors and PDHA in cats. (dvm360.com)
  • Rather, the feline 'High-dose dexamethasone test', i.e. administering 1.0mg/kg dexamethasone IV and sampling at times 0,2, 4, 6 and 8 hours will differentiate PDHA from adrenal tumors in most cases. (dvm360.com)
  • Morning levels of plasma cortisol in patients with adrenal carcinoma and ectopic ACTH producing tumors were reduced on the average to about one half of the pretreatment levels, and in patients with adrenal hyperplasia to about two thirds of the pretreatment levels, during 1-3 months of therapy with Aminoglutethimide. (wikidoc.org)
  • Metastasis to one or both adrenal glands is the most common form of malignant adrenal lesion, and the second most common adrenal tumor after benign adenomas. (wikipedia.org)
  • The adrenal glands are located at the top of each kidney and produce hormones that help regulate metabolism, blood sodium and potassium levels, blood pressure, response to stressors, immune function, and other essential functions. (health.mil)
  • 1 The adrenal glands produce cortisol, aldosterone, catecholamines (epinephrine, norepinephrine, and dopamine), and small amounts of androgens (hormones with testosterone-like function). (health.mil)
  • The hypothalamus and pituitary gland are regulators of the thyroid gland functioning, which is carried out with the help of two kinds of hormones - thyreotropic hormone( TSH) and thyrotropin-stimulating hormone( TRH).All three glands form a single chain, which regulates the work of the entire human body. (womensecr.com)
  • This is because even with disruption of the connections between the individual glands of internal secretion, the thyroid gland, remaining without proper regulation, continues to produce other hormones. (womensecr.com)
  • Once excited, the PVN produces the neuropeptide corticotropin-releasing factor (CRF), which travels through the hypophyseal portal system and stimulates the adrenal and pituitary glands to produce many neurotransmitters. (bvsalud.org)
  • Infections of the adrenal glands , particularly with cytomegalovirus, are found in nearly half of patients with untreated HIV at autopsy. (difusireview.com)
  • A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. (edu.au)
  • citation needed] The adrenal medulla is located anatomically at the center of each adrenal gland, and is composed of neuroendocrine (chromaffin) cells which produce and release epinephrine (adrenaline) into the bloodstream in response to activation of the sympathetic nervous system. (wikipedia.org)
  • Glucocorticoid synthesis and release is strictly regulated by the pituitary and hypothalamus by negative feedback and, to a lesser extent, by catecholamines from the adrenal medulla and neural inputs from the autonomic system. (medscape.com)
  • The adrenal gland comprises two distinctive regions cortex and medulla respectively. (targetwoman.com)
  • The most relevant hormones for the neuroendocrine axis are the adrenocorticotropic hormone (ACTH) and ß-endorphins, which stimulate the secretion of various endogenous substances, such as glucocorticoids, produced in the adrenal cortex, and noradrenaline and adrenaline, produced in the adrenal medulla and nerve endings 5-7 . (bvsalud.org)
  • Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) can be associated with abnormal responses of aberrantly expressed adrenocortical receptors. (hal.science)
  • DHEA and DHEAS (an active, sulfated form of DHEA), are endogenous hormones secreted by the adrenal cortex in primates and a few non-primate species in response to ACTH. (medilabcompounding.com)
  • citation needed] Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer of adrenal cortical cells, which may occur in children or adults. (wikipedia.org)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • Some of the significant hormones produced by the adrenal gland include aldosterone, cortisol, sex hormones and adrenaline. (targetwoman.com)
  • Normal cats and cats with non-adrenal illnesses will consistently show cortisol suppression at this dose. (dvm360.com)
  • Acute adrenal (Addisonian) crisis is an emergency caused by insufficient cortisol. (difusireview.com)
  • Data available from the few patients with adrenal adenoma suggest similar reductions in plasma cortisol levels. (wikidoc.org)
  • ACCs may be "functional", producing steroid hormones and consequent endocrine dysfunction similar to that seen in many adrenocortical adenomas, but many are not. (wikipedia.org)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Although the term carcinoid tumor has been broadly used to refer to many neoplasms derived from the DNS ( 9 ), this term is being replaced by neuroendocrine neoplasms. (basicmedicalkey.com)
  • However, to communicate effectively with clinicians, the term carcinoid tumor can still be used in parenthesis for neoplasms of the gastrointestinal tract and lungs. (basicmedicalkey.com)
  • Cellular and molecular abnormalities of a macronodular adrenal hyperplasia causing beta-blocker-sensitive Cushing's syndrome. (hal.science)
  • Altogether, the demonstration of aberrant responses to hormonal receptors and autocrine hormone production in the same tissue supports the assumption of multiple molecular alterations in adrenal macronodular hyperplasia. (hal.science)
  • the former is most often the result of autoimmune destruction of the adrenal cortex and the latter is generally the result of pituitary disease. (health.mil)
  • Patients with destruction of the adrenal cortices or with classic 21-hydroxylase deficiency also have mineralocorticoid deficiency, typically with hyponatremia, volume depletion, and hyperkalemia. (difusireview.com)
  • With a lack of hormones T3 and T4, produced by the thyroid gland, the level of thyrotropic hormone immediately increases and, conversely, when they increase, the secretion of TSH by the pituitary gland decreases. (womensecr.com)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. (roche.com)
  • Although distinguishing endogenous from exogenous Cushing syndrome is usually straightforward, the investigation and differentiation of Cushing syndrome from other causes of hypercortisolism require a sound understanding of the physiology of the hypothalamic-pituitary-adrenal (HPA) axis. (medscape.com)
  • The hypothalamic-pituitary-adrenal (HPA) axis is responsible for many body functions in mammals. (bvsalud.org)
  • Although the APUD concept provided a unifying theory for explaining some endocrine diseases and ectopic hormone productions, the hypothesis that the cells were all of neural crest origin, as postulated by Pearse, was later disproved by the experiments of LeDouarin ( 5 ) and others. (basicmedicalkey.com)
  • Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. (roche.com)
  • The adrenal cortex is composed of three distinct layers of endocrine cells which produce critical steroid hormones. (wikipedia.org)
  • Table 1 summarizes the relative potencies and half-lives of main steroid hormones. (medscape.com)
  • The steroid-producing endocrine cells of the adrenal cortex, ovary, and testis, as well as the thyroid hormone-producing follicular cells in the thyroid gland, do not form part of the DNS. (basicmedicalkey.com)
  • cancer of the adrenal cortex - A rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions). (academic.ru)
  • Although autoimmune disorders play a major role in the adrenal insufficiencies, other causes such as infectious diseases, vascular impairments, congenital disorders and also iatrogenic causes lead to adrenal insufficiencies. (targetwoman.com)
  • Pituitary stalk interruption syndrome (PSIS) is a congenital di se a se with isolated growth hormone deficiency (GHD) or multiple anterior pituitary hormone deficiencies (MPHD). (nel.edu)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
  • Endogenous DHEA Capsules are a complex hormone, and researchers still have much to discover in regards to its physiologic effects in males and females. (medilabcompounding.com)
  • After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. (nih.gov)
  • Abnormally accelerated (rapid) regression or, conversely, excessively lengthy persistence of the X-zone can be effects of treatment with various chemicals and exogenous hormones. (nih.gov)
  • Functional morphologic changes in female sex organs induced by exogenous hormones / edited by Gisela Dallenbach-Hellweg. (who.int)
  • The hypothalamus controls the pituitary gland by means of thyrotropin-releasing hormone( TRH), and the pituitary gland, in turn, regulates the thyroid gland with the help of thyroid-stimulating hormone. (womensecr.com)
  • Since the hypothalamus and pituitary gland secrete many other hormones that control the work of other organs, secondary hypothyroidism shows signs of pathology from the lungs, heart, kidneys and other organs. (womensecr.com)
  • This is the first MSMR report of the incidence of adrenal disorders in the U.S. Armed Forces. (health.mil)
  • A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
  • Studies imply that autoimmune diseases such as Addison's disease are the predominant cause for the adrenal sufficiency. (targetwoman.com)
  • It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer. (lookformedical.com)
  • Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner. (ucdenver.edu)
  • Adrenal neuroblastoma typically presents with a rapidly enlarging abdominal mass. (wikipedia.org)
  • The intensity of this disorder can be represented as primary or secondary depending upon the impaired adrenal cortex and its functionality. (targetwoman.com)
  • In the secondary condition of this disorder, the production of adrenocortico tropic hormone is reduced to a greater extent. (targetwoman.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • Thymus, thymic hormones and T lymphocytes / edited by F. Aiuti, H. Wigzell. (who.int)
  • The hormone replacement therapy helped to rai se the sodium concentration to a normal level and in the termination of se izures. (nel.edu)
  • In order to get the adrenals to suppress in the cat, the 'Low-dose dexamethasone test' requires 0.1mg/kg dexamethasone sodium phosphate IV and sample plasma at times 0,2,4,6 and 8 hours after injection. (dvm360.com)
  • Aminoglutethimide is an aromatase inhibitor that is FDA approved for the treatment of suppression of adrenal function in selected patients with Cushing's syndrome . (wikidoc.org)
  • Aminoglutethimide is indicated for the suppression of adrenal function in selected patients with Cushing's syndrome . (wikidoc.org)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)