Filter...

AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care

Select a category...

OligosaccharidesLysosomesGlycoproteinsCarbohydratesCarbohydrate SequenceLysosome-Associated Membrane GlycoproteinsMembrane GlycoproteinsCarbohydrate ConformationPlatelet Membrane GlycoproteinsCarbohydrate MetabolismCell MembraneMannoseGlycosylationFucoseDietary CarbohydratesGlycopeptidesMolecular Sequence DataLectinsPolysaccharidesGlucosamineIntracellular MembranesMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseGlycoside HydrolasesElectrophoresis, Polyacrylamide GelCell LineSialic AcidsMembranesMolecular WeightMembrane ProteinsAsparagineGalactoseAmino Acid SequenceMembrane LipidsGolgi ApparatusAmino SugarsHormonesAcetylgalactosamineMannosidasesNeuraminidaseN-Acetylneuraminic AcidChromatography, AffinityPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseErythrocyte MembraneHexosaminidasesGalactose OxidaseViral Envelope ProteinsCricetinaeTunicamycinMembrane PotentialsKineticsMicroscopy, ElectronMembranes, ArtificialProtein Processing, Post-TranslationalBlood PlateletsChromatography, Gelalpha-MannosidasePeriodic AcidThyroid HormonesCells, CulturedEndoplasmic ReticulumOligosaccharides, Branched-ChainSwainsonineAntibodies, MonoclonalAcetylglucosamineGlycolipidsWheat Germ AgglutininsFollicle Stimulating HormoneProtein BindingPolyisoprenyl Phosphate OligosaccharidesReceptors, Concanavalin AMonosaccharidesCattleLuteinizing HormoneLiverHydrogen-Ion ConcentrationMutationViral ProteinsDisaccharidesSialoglycoproteinsCell FractionationChromatography, High Pressure LiquidBase SequenceImmunoelectrophoresis, Two-DimensionalAcetylglucosaminidaseMembrane FluidityGlycoconjugatesGalactosyltransferasesMagnetic Resonance SpectroscopyFluorescent Antibody TechniqueAmino AcidsPlant LectinsBlood Platelet DisordersBiological TransportMucinsCell Membrane PermeabilityBinding SitesSubcellular FractionsCHO CellsConcanavalin AIndolizines

ProteinsReceptorsSialic acidGlycolipidsMonosaccharidesPlasma membraneProteinBasement membraneAminoPolysaccharidesGlucoseMetabolismOrganismsGenesMoleculeFunctionalGlycosylationRecognitionCellGroupGolgiLipidsEmbedded in the plasma membraneSialic acidsEukaryoticBacterialCytoplasmORGANELLESSurroundsDerivativeSemipermeableSystemCell wallPhysicalUnitsDomain

Proteins5

• O-linked found in mucous fluids, but can also be present in membrane and secretory proteins, 3 or more sugars linked by N-acetylglalactosamine (GalNAc)--connected to serine, theronine. (freezingblue.com)
• Biosynthesis and intracellular trafficking of secretory and lysosomal/vacuolar proteins, glycosylation and other post-translational protein modifications as determinants of protein structure and function, catalytic properties and physiological functions of proteases and glycosylation enzymes, proteolysis and its pathological and biotechnological relevance, recombinant expression of biotherapeutics in plants, plant membrane protein biochemistry. (boku.ac.at)
• At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
• The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
• A metabolic disorder is any disease or disorder that negatively affects the biochemical reactions through which individual animal cells process nutrient molecules (such as the components of carbohydrates , proteins , and fats ) to yield energy or perform the functions necessary to sustain life (such as building complex molecules and creating cellular structure). (newworldencyclopedia.org)

Receptors3

• These carbohydrate head groups also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin. (wikipedia.org)
• These results establish that CREG is a lysosomal protein that undergoes proteolytic maturation in the course of its biosynthesis, carries the M6P recognition marker and depends on the interaction with M6P receptors for efficient delivery to lysosomes. (boku.ac.at)
• Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. (lookformedical.com)

Sialic acid1

• NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides. (wikipedia.org)

Glycolipids1

• Fucose is a monosaccharide that is commonly found in the cell walls of bacteria and is involved in the formation of glycoproteins and glycolipids. (lookformedical.com)

Monosaccharides1

• Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. (lookformedical.com)

Plasma membrane5

• It is a component of the cell plasma membrane that modulates cell signal transduction events, and appears to concentrate in lipid rafts[citation needed]. (wikipedia.org)
• Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. (wikipedia.org)
• The results showed that with increasing ketoprofen concentration, root vitality, respiration rate, ATP content, and H+-ATPase activity decreased and plasma membrane permeability increased. (bvsalud.org)
• Results of biochemical assays showed that cyclopaldic acid induced leaf chlorosis, ion leakage, membrane-lipid peroxidation, hydrogen peroxide production, inhibited root proton extrusion in vivo and plasma membrane H+-ATPase activity in vitro. (bvsalud.org)
• Cyclopaldic acid targeted the plasma membrane H+-ATPase, inducing depolarization of the transmembrane potential, mitochondria, disrupting the mitochondrial network and eliciting overproduction of reactive oxygen species, and vacuole, determining tonoplast disgregation and induction of vacuole-mediated programmed cell death and autophagy. (bvsalud.org)

Protein1

• The mutations lead to misfolding of the translated Atp13a2 protein and its premature degradation in the endoplasmic reticulum, never reaching the lysosome where the protein is thought to function. (bvsalud.org)

Basement membrane1

• It consists of the cellular epithelium, that has an outer extracellular matrix - the cuticula - and an inner extracellular matrix - the basement membrane. (collembola.org)

Amino1

• Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

Polysaccharides1

• Polysaccharides are complex carbohydrates composed of long chains of monosaccharide units, with important functions in the body including energy storage, structural support, and immune response. (lookformedical.com)

Glucose1

• α-Glucosidase (α-D-Glucosidase), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. (medchemexpress.com)

Metabolism1

• Carbohydrate metabolism, inborn errors refer to genetic disorders that affect the body's ability to properly process carbohydrates, leading to various metabolic disorders. (lookformedical.com)

Organisms1

• We have investigated its subcellular localization in mammalian cells, Drosophila melanogaster and Arabidopsis thaliana and found that intracellular CREG resides in all these organisms within lysosomes or its functional equivalents. (boku.ac.at)

Genes2

• Mutations in genes coding for these enzymes leads to the accumulation of partially broken down gangliosides in lysosomes, which results in a group of diseases called gangliosidosis. (wikipedia.org)
• qRT-PCR experiments demonstrated that the toxin elicited the transcription of key regulators of the immune response to necrotrophic fungi, of hormone biosynthesis, as well as of genes involved in senescence and programmed cell death. (bvsalud.org)

Molecule2

• A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. (wikipedia.org)
• Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. (lookformedical.com)

Functional1

• For example, the fatal Tay-Sachs disease arises as a genetic defect which leads to no functional hexosaminidase A produced, causing GM2 to accumulate in lysosomes. (wikipedia.org)

Glycosylation1

• Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. (nature.com)

Recognition1

• The oligosaccharide groups on gangliosides extend well beyond the surfaces of the cell membranes, and act as distinguishing surface markers that can serve as specific determinants in cellular recognition and cell-to-cell communication. (wikipedia.org)

Cell1

• CREG is a glycoprotein expressed in most mammalian tissues and cell types. (boku.ac.at)

Group2

• They are degraded to ceramides by sequential removal of sugar units in the oligosaccharide group, catalyzed by a set of highly specific lysosomal enzymes. (wikipedia.org)
• download climate change forests with ChucK membrane-spanning group to Programming for Musicians and Digital Artists( Kadenze ChucK tyrosine for Musicians and Digital Artists( ChucK hydroquinone, Kadenze Discount cis-acting in Course Resources when car situation proteasome: Mac OS X, Windows, or Linux( Planet CCRMA phosphorylated: family with cholesterol. (evakoch.com)

Golgi2

• Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
• The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). (nih.gov)

Lipids6

• Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. (lookformedical.com)
• These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. (lookformedical.com)
• Membrane lipids are required for active transport, several enzymatic activities and membrane formation. (lookformedical.com)
• It is used as a tool in the study of membrane lipids. (lookformedical.com)
• They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. (lookformedical.com)
• The proteins and lipids allow cell communication, and carbohydrates (sugars and sugar chains), which decorate both the proteins and lipids and help cells recognize each other. (microbenotes.com)

Embedded in the plasma membrane1

• Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. (wikipedia.org)

Sialic acids3

• A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. (wikipedia.org)
• This kit has been developed for the quantitative analysis of sialic acids and contains all the reagents necessary for the release of sialic acids from glycoproteins and their conjugation with DMB dye by an amination-cyclization reaction. (ludger.com)
• The strategy involves orthogonal techniques: total N-glycan profiling and quantitative analysis of neutral monosaccharides and sialic acids, where a mAb is used as a model glycoprotein and this workflow can be applied throughout a biopharmaceutical's product life cycle. (ludger.com)

Eukaryotic2

• The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. (lookformedical.com)
• As noted earlier, animal cells are eukaryotic cells with a membrane-bound nucleus. (microbenotes.com)

Bacterial1

• These carbohydrate head groups also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin. (wikipedia.org)

Cytoplasm1

• This is a spherical structured organelle found majorly at the center of a cell surrounded by a double-layered nuclear membrane separating it from the cytoplasm. (microbenotes.com)

ORGANELLES1

• They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. (lookformedical.com)

Surrounds1

• It is a thin semipermeable protein-membrane layer that surrounds an animal cell. (microbenotes.com)

Derivative1

• NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides. (wikipedia.org)

Semipermeable1

• Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. (lookformedical.com)

System1

• Ludger V-Tag system is designed for the analysis of glycopeptides generated from the digestion of therapeutic glycoproteins such as monoclonal antibodies (mAb) . (ludger.com)

Cell wall1

• Most cells are covered by a protective membrane known as the cell wall which gives the cells their shape and rigidity. (microbenotes.com)

Physical2

• The intestinal mucus layer is principally comprised of a subset of high molecular weight glycoproteins called mucins, which play a crucial role in physical protection as well as in regulating the concentration and passage of water, ions, and other immune mediators such as antimicrobial peptides (AMPs) and immunoglobulin-A (IgA) within the gut ( 2 , 3 , 7 ). (frontiersin.org)
• Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization). (lookformedical.com)

Units1

• They are degraded to ceramides by sequential removal of sugar units in the oligosaccharide group, catalyzed by a set of highly specific lysosomal enzymes. (wikipedia.org)

Domain1

• Most characterized GH92 α-mannosidases consist of a single catalytic domain, while a few have extra domains including putative carbohydrate-binding modules (CBMs). (bvsalud.org)