• estradiol
  • Following the results of such studies, the investigators conducted a study (Kulkarni et al 1996) in which a group of premenopausal women with schizophrenia were given 0.02mg oral estradiol as an adjunct to antipsychotic drug treatment for eight weeks, and compared their progress with a similar group who received antipsychotic drugs only. (clinicaltrials.gov)
  • This test measures the change in serum estradiol levels between cycle day two and three after administration of one mg of subcutaneous leuprolide acetate, a gonadatropin releasing hormone agonist. (wikipedia.org)
  • When at least one follicle reached 18mm in diameter and serum estradiol was greater or equal to 150 pg/ML ovulation was induced with an intramuscular injection of 10,000 IU of hCG (human chorionic gonadotropin hormone). (wikipedia.org)
  • Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body. (wikipedia.org)
  • Since the incidence of cardiovascular disease in women has shown a rise that matches the increase in the number of post menopausal women, recent studies have examined the benefits and side effects of oral versus transdermal application of different estrogens and found that transdermal applications of estradiol may give the vascular benefits lowering the incidences of cardiovascular events with less adverse side effects than oral preparations. (wikipedia.org)
  • SERMs
  • Toremifene and fulvestrant are SERMs with little or no agonist activity, and are used for treatment of metastatic breast cancer. (wikipedia.org)
  • Different tissues have different degrees of sensitivity to and activity of endogenous estrogens, so SERMs produce estrogenic or antiestrogenic effects depending on the specific tissue in question as well as the percentage of intrinsic activity (IA) of the SERM. (wikipedia.org)
  • SERMs are used for various estrogen-related diseases. (wikipedia.org)
  • symptoms
  • The group receiving estrogen made a significantly more rapid recovery from acute psychotic symptoms and also reported improvement in their general health status. (clinicaltrials.gov)
  • Does the use of oestrogen inserted vaginally with an applicator, help with the symptoms of faecal (bowel) incontinence in women who are past the age of menopause? (clinicaltrials.gov)
  • METHODS: The medical records of 187 women treated laparoscopically for intestinal endometriosis were reviewed retrospectively for presenting symptoms, methods of surgical treatment, complications, and efficacy of treating pain and infertility. (biomedsearch.com)
  • However, treatment can prolong life, delay the progression of the cancer, relieve cancer-related symptoms, and improve quality of life. (uptodate.com)
  • In addition to the goal of prolonging survival, treatment may help relieve cancer-associated symptoms, leading to an improvement or stability in quality of life. (uptodate.com)
  • Symptomatic metastases - Treatment to a specific lesion may be required if symptoms are present or there is a threat of complications (ie, spinal cord compression or fracture, brain metastases at risk for herniation, or a pending fracture due to a lesion in the hip). (uptodate.com)
  • Hormonal therapy may also be used in the treatment of paraneoplastic syndromes or to ameliorate certain cancer- and chemotherapy-associated symptoms, such as anorexia. (wikipedia.org)
  • Hormone replacement therapy (HRT) Menopausal hormone therapy (MHT) for women are suffering from menopausal symptoms Androgen replacement therapy (ART) in males with low levels of testosterone due to disease or aging Transgender hormone therapy for transgender people Feminizing hormone therapy in sex reassignment therapy for transgender women Masculinizing hormone therapy in sex reassignment therapy for transgender men Hormone replacement therapy for people with intersex conditions (e.g. (wikipedia.org)
  • Some symptoms, however, may be improved with treatment. (wikipedia.org)
  • Hormone replacement therapy may relieve many of the symptoms of menopause. (wikipedia.org)
  • If a woman chooses hormones, they suggest she take the lowest dose that alleviates her symptoms for as short a time as possible. (wikipedia.org)
  • Combined therapy with conjugated estrogens and the SERM bazedoxifene, was approved on October 3, 2013, for the treatment of vasomotor symptoms linked with menopause. (wikipedia.org)
  • SERM is also used in combination with conjugated estrogens indicated for the treatment of estrogen deficiency symptoms, and vasomotor symptoms associated with menopause. (wikipedia.org)
  • The reasoning behind partial suppression for these conditions is to reduce the incidence and severity of menopausal symptoms such as hot flushes and to avoid bone mineral density changes caused by estrogen deficiency that can eventually lead to osteoporosis. (wikipedia.org)
  • antigonadotropins
  • Aromatase inhibitors and antigonadotropins reduce the production of estrogen, while the term "antiestrogen" is often reserved for agents reducing the response to estrogen. (wikipedia.org)
  • Antigonadotropins are used for a variety of purposes, including for the treatment hormonally-sensitive cancers, to delay precocious puberty and puberty in transgender youth, as a form of chemical castration to reduce the sex drives of individuals with hypersexuality or pedophilia, and to treat estrogen-associated conditions in women such as menorrhagia and endometriosis. (wikipedia.org)
  • These include AR antagonists, androgen synthesis inhibitors, and antigonadotropins. (wikipedia.org)
  • hypothalamic-pitu
  • This would seem to be independent of their actions on the hypothalamic-pituitary-gonadal axis and hence on sex hormone production. (wikipedia.org)
  • It is the target of various regulatory mechanisms of the hypothalamic-pituitary-gonadal axis, such as being inhibited by increased estrogen levels in the body. (wikipedia.org)
  • suppress
  • A single oral administration of relugolix at a dose of 3 mg/kg has been found to suppress luteinizing hormone levels for more than 24 hours in castrated cynomolgus monkeys, indicating a long duration of action. (wikipedia.org)
  • pituitary
  • This results in an inhibition of the hypothalamic-pituitary-gonadal (HPG) axis, and thus a decrease in the levels of the androgen, estrogen, and progestogen sex steroids in the body. (wikipedia.org)
  • This is due to a negative feedback effect of continuous stimulation of the pituitary gland by these hormones. (wikipedia.org)
  • When our body detects a low level of testosterone, the hypothalamus starts to produce LHRH, a hormone which, once is received by the pituitary gland activates the synthesis of LH (Luteinizing hormone). (wikipedia.org)
  • therapy
  • Other hormone therapy and Hormonal replacement therapy given within the previous 4 weeks, except for Estring, Vagifem, Estrogen Cream. (clinicaltrials.gov)
  • This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall. (clinicaltrials.gov)
  • The investigators will measure the thickness of the vaginal muscularis, elastic fiber number and morphology, and analyze if elastic fiber synthesis or degradation is affected by estrogen therapy. (clinicaltrials.gov)
  • The results will provide important data to support a larger clinical trial to determine if preoperative and maintenance estrogen therapy alter long-term success rates of pelvic reconstructive surgery for pelvic organ prolapse. (clinicaltrials.gov)
  • The objective of the study is to assess and compare the preliminary efficacy, safety and tolerability of fispemifene 300 mg and placebo given once daily for 4 weeks in the treatment of hypogonadal men with chronic obstructive pulmonary disease (COPD) that are on oral glucocorticoid therapy. (clinicaltrials.gov)
  • The effectiveness of therapy with GH-RH antagonist JV-1-38 and its mechanisms of action were investigated in NCI-H838 non-small cell lung carcinoma (NSCLC) xenografted s.c. into nude mice and in vitro . (aacrjournals.org)
  • If surgery is not an option, radiation therapy (RT) may be an alternative treatment. (uptodate.com)
  • Hormone-receptor positive patients are candidates for antiestrogen therapy, but hormone-receptor negative patients are not. (uptodate.com)
  • Antiestrogen treatment - Antiestrogen treatment is also known as endocrine therapy. (uptodate.com)
  • They are also used to treat infertility, male hypogonadism, and gynecomastia (breast development in men) and are used as a component of hormone replacement therapy for transgender men. (wikipedia.org)
  • Hormonal therapy in oncology is hormone therapy for cancer and is one of the major modalities of medical oncology (pharmacotherapy for cancer), others being cytotoxic chemotherapy and targeted therapy (biotherapeutics). (wikipedia.org)
  • Hormone therapy or hormonal therapy is the use of hormones in medical treatment. (wikipedia.org)
  • Treatment with hormone antagonists may also be referred to as hormonal therapy or antihormone therapy. (wikipedia.org)
  • The most general classes of hormone therapy are oncologic hormone therapy and hormone replacement therapy, of which there are various kinds (e.g., for menopause, for andropause, or for gender transition). (wikipedia.org)
  • The following medications may help: menopausal hormone therapy (MHT), clonidine, gabapentin, or selective serotonin reuptake inhibitors. (wikipedia.org)
  • Antihormone therapy is a type of hormone therapy that suppresses selected hormones or their effects, in contrast with hormone replacement therapy, which encourages hormone activity. (wikipedia.org)
  • In patients under long-term therapy, small amounts of estrogens could be given back ("add-back regimen") to combat such side effects and to prevent bone wastage. (wikipedia.org)
  • Menopause
  • WO9920223A2 ] A pharmaceutical composition comprising an LH antagonist or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier is useful for deferring the onset of menopause. (epo.org)
  • If a correlation is found between the onset of menopause and the development of faecal incontinence, further investigation of effective treatment will be indicated. (clinicaltrials.gov)
  • While typically not needed, a diagnosis of menopause can be confirmed by measuring hormone levels in the blood or urine. (wikipedia.org)
  • Hot flashes are a symptom which may have several other causes, but which is often caused by the changing hormone levels that are characteristic of menopause. (wikipedia.org)
  • Including treatment of ovulatory dysfunction in the management of infertility, treatment and prevention of postmenopausal osteoporosis, treatment and reduction in risk of breast cancer and treatment of dyspareunia due to menopause. (wikipedia.org)
  • orally
  • Subjects took their medications orally or by rubbing it onto the skin (depending on the treatment assignment) once daily for up to 6 months. (clinicaltrials.gov)
  • cyproterone
  • An example is the steroidal antiandrogen cyproterone acetate, which is a potent AR antagonist, a potent progestogen and hence antigonadotropin, and a weak androgen synthesis inhibitor. (wikipedia.org)
  • ovarian
  • 1 , - , 3 Traditional definitive treatment has consisted of suppression or removal of ovarian function, either medically or surgically, and ablation of major pelvic endometriotic lesions without resection of deep lesions in the colon or rectum for fear of complications. (biomedsearch.com)
  • When used in fertility treatment they can also be associated with abdominal pain and ovarian hyperstimulation. (wikipedia.org)
  • Anastrozole
  • While similar in composition to Anastrozole it should be used in a similar context for the reduction of estrogen in men suffering from gynecomastia or for women wanting pre-treatment for breast cancer. (weightloss3x.com)
  • cancers
  • HER2 expression - With the availability of treatment targeted against the human epidermal growth factor 2 (HER2) receptor, a protein that is sometimes made by certain types of aggressive breast cancers, HER2 overexpression in breast cancer cells predicts who should receive HER2-targeted treatment. (uptodate.com)
  • The suppression of certain hormones can be beneficial to patients with certain cancers, because certain hormones prompt or help the growth of a tumor. (wikipedia.org)
  • Treatment of cancers that are hormonally sensitive and where a hypogonadal state decreases the chances of a recurrence. (wikipedia.org)
  • Clomiphene
  • To test whether adding small doses of HP urinary FSH to standard regimen of clomiphene citrate in clomiphene resistant PCOS well yield better results in terms of better ovulation rate,lower follicle number, less consumption of HP urinary FSH,lower treatment cost , better pregnancy rate, lower multiple pregnancy rates compared with the exclusive use of HP urinary FSH in these cases. (clinicaltrials.gov)
  • Clomiphene (trademarked as Clomid) is a selective estrogen receptor modulator (SERM). (wikipedia.org)
  • tumor
  • Using ligand competition assays with 125 I-labeled GH-RH antagonist JV-1-42, specific high-affinity binding sites for GH-RH were found on tumor membranes. (aacrjournals.org)
  • The growth of tumor cells in vitro was stimulated by IGF-I and inhibited by GH-RH antagonist JV-1-38 and a GH-RH antiserum. (aacrjournals.org)
  • The approach to treatment will depend on the tumor size and location, as well as whether or not prior radiation was administered. (uptodate.com)