• heterozygotes
  • Strategy used by Gantz and Bier (2015) to create homozygous lines of Drosophila melanogaster involving the introduction of a Cas9-, gRNA-expressing construct flanked by sequences homologous to the target gene leading to the conversion of heterozygotes to homozygotes. (igtrcn.org)
  • protein
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • Whereas l7Rn6 mRNA levels were indistinguishable from wild type, l7Rn6 4234SB homozygotes exhibited decreased expression of the truncated protein, suggesting protein instability. (genetics.org)
  • activity
  • Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. (jci.org)
  • Laboratory revealed she was homozygote for FII G20210A, with a normal activity of ATIII, PC and PS, the absence of the Factor V Leiden (FVL) and methylenetetrahydrofolate reductase (MTHFR) C677T variant and the absence of antiphospholipid syndrome. (biomedcentral.com)