• calcium
  • BMS-204352 (BMS) was developed as a neuroprotective drug for disease conditions such as ischemic stroke and it has been shown to have a protective effect, due to activation of big-conductance calcium-activating potassium (BKCa) channels (Gribkoff et al. (epfl.ch)
  • Various pharmaceutical companies developed synthetic molecules activating these channels in order to prevent excessive neurotoxic calcium entry in neurons . (epfl.ch)
  • regulate
  • There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. (wikipedia.org)
  • Adrenal glucocorticoids Adrenal glucocorticoids regulate adaptation mechanisms to environmental challenges ( ) and can modify the electrical excitability of BK channels in human embryonic kidney cells. (epfl.ch)
  • Study
  • 12-16 Identification of the mechanism(s) of 4-AP block has been advanced through the study of recombinant Kv channels. (ahajournals.org)