Homophilic cell adhesion. Medical search. Frequent questions

The structure of PTPmu suggests that it can regulate cell adhesion and migration using its extracellular cell adhesion molecule features, while also regulating the level of tyrosine phosphorylation inside of cells using its catalytic tyrosine phosphatase domain. (wikipedia.org)
PTPmu accomplishes this by interacting with another PTPmu molecule on an adjacent cell, known as homophilic binding. (wikipedia.org)
Since cysteines are susceptible to forming disulfide bonds, the single cysteines at the EGF-like repeats of a teneurin molecule can facilitate the homophilic and heterophilic dimerisation of teneurin family molecules. (wikipedia.org)
In humans, mutations in the L1 cell adhesion molecule are associated with a neurological syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation, adducted thumbs, spasticity, and hydrocephalus. (jneurosci.org)
L1 is a transmembrane adhesion molecule with extracellular immunoglobulin and fibronection III-like domains ( Schachner, 1991 ). (jneurosci.org)
CADM1, together with MITF, is essential for development and survival of mast cells in vivo, and it may act as a synaptic cell adhesion molecule that drives synapse assembly. (nih.gov)
Cell Adhesion Molecule 1, also known as CADM1 belongs to the nectin family. (neuromics.com)
CD56 is a single transmembrane glycoprotein also known as NCAM (neural cell adhesion molecule), Leu-19, or NKH1. (biolegend.com)
Protein tyrosine phosphatase receptor delta ( PTPRD ) is an important regulator of axon growth and guidance and is highly expressed in the central nervous system where it functions as a transmembrane homophilic neuronal cell adhesion molecule [ 1 ]. (biomedcentral.com)
Cell adhesion molecule that binds to CD6. (eiaab.com)
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM). (umbc.edu)
Ig3_NCAM-1_like: domain similar to the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM). (umbc.edu)
Kinetics of homophilic binding by embryonic and adult types of the neural cell adhesion molecule. (youngdisciples.org)
Nerve progress factor enhances expression of neuron-glia cell adhesion molecule in PC12 cells. (youngdisciples.org)
During regular growth, the neural cell adhesion molecule N-CAM adjustments on the cell-surface from a sialic acid-rich embryonic, or E type, to several adult, or A forms that have less sialic acid (E-to-A conversion). (youngdisciples.org)
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)
Purification and characterization of a cell adhesion molecule from neural retina. (academicinfluence.com)
Nerve development problem enhances expression of neuron-glia cell adhesion molecule in PC12 cells. (arbanifoods.com)
During normal improvement, the neural cell adhesion molecule N-CAM changes at the cell-surface from a sialic acid-rich embryonic, or E type, to a number of adult, or A forms which have less sialic acid (E-to-A conversion). (arbanifoods.com)
Background E-cadherin is a calcium-dependent intercellular adhesion molecule encoded by the CDH1 gene and present on epithelial cells. (qedbio.com)
Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. (bvsalud.org)
We previously demonstrated that the activated leukocyte cell adhesion molecule ( ALCAM /CD166) can interact with galectin -8 (Gal-8) in endothelial cells . (bvsalud.org)
Importantly, exogenously added Gal-8 provoked ALCAM segregation, probably trapping this adhesion molecule at the surface of breast cancer cells . (bvsalud.org)

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (wikipedia.org)
The structure of type IIb RPTPs classifies them as members of the immunoglobulin superfamily of cell adhesion molecules, in addition to being tyrosine phosphatases. (wikipedia.org)
At high cell density, when PTPmu molecules bind to one another homophilically, phosphotyrosine levels are decreased. (wikipedia.org)
The NECTIN Protein is a family of cell-adhesion molecules that, so far, includes four members. (prospecbio.com)
The family of molecules will primarily regulate adhesion between two cells, although Nectin-like molecules - known as Necl - will perform other tasks at a cellular level. (prospecbio.com)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
Placental Cadherin (P-Cadherin or PCAD) is a member of the cadherin family of cell adhesion molecules, designated CDH3. (rndsystems.com)
Briefly, IgSFs are adhesion molecules that bind to themselves (homophilic) or compatible IgSFs (heterophilic) across cell-cell junctions. (elifesciences.org)
During embryonic morphogenesis, adhesion molecules are required for selective cell-cell interactions. (rupress.org)
These links are used in cell motility as the actin cytoskeleton generates force pulling the integrin and attached matrix molecules towards the cell center. (biologists.com)
These molecules promote cell adhesion via a homophilic mechanism. (bvsalud.org)
These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue. (bvsalud.org)
From a phylogenetic point of view, hemolin function is consistent with the assumption that non-self recognition molecules of the IgSF arose from cell-adhesion molecules with multiple functions. (diva-portal.org)
By this model, Ig1,and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. (umbc.edu)
cadherin 2) are the most prominent members of the cadherin family of cell adhesion molecules. (biomedcentral.com)
Classical cadherins are cell adhesion molecules, which play fundamental roles in the development of multicellular organisms [ 1 ]. (biomedcentral.com)
The mechanism of binding of neural cell adhesion molecules. (youngdisciples.org)
Alterations in neural cell adhesion molecules during growth of various regions of the nervous system. (youngdisciples.org)
Altered expression of neuronal cell adhesion molecules induced by nerve damage and repair. (youngdisciples.org)
Cell adhesion molecules: implications for a molecular histology. (academicinfluence.com)
Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
Cell adhesion molecules in early chicken embryogenesis. (academicinfluence.com)
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
Alterations in neural cell adhesion molecules throughout improvement of assorted areas of the nervous system. (arbanifoods.com)
Here, we analyzed the physical interaction between both molecules in breast cancer cells and the functional relevance of this phenomenon. (bvsalud.org)

It may also mediate heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. (nih.gov)
CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner as well as mediating heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. (neuromics.com)
The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. (utsouthwestern.edu)

ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell - cell interactions . (bvsalud.org)

Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. (embl.de)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
The extracellular domains of cadherins form parallel dimers that possess intrinsic homophilic-binding activity. (embl.de)
Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. (rndsystems.com)
Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. (rndsystems.com)
The classical cadherins mediate homophilic calcium-dependent cell adhesion and are founding members of the large and diverse cadherin superfamily. (rupress.org)
Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. (ecmbio.com)
Cadherins cluster to form foci of homophilic binding units. (ecmbio.com)
A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. (ecmbio.com)
Biological Function Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). (qedbio.com)
cadherins may thus contribute to the sorting of heterogeneous cell types. (qedbio.com)

RPTPs are single pass transmembrane proteins usually with one or two catalytic domains in their intracellular domain (the part of the protein that is inside the cell) and diverse extracellular structures (the part of the protein that is outside the cell). (wikipedia.org)
Dimerization of identical RPTP proteins at the cell surface leaves the PTP domains either in an open active conformation, as in the case of PTPmu and LAR, or in an inhibited conformation that leaves the catalytic domain inaccessible, in the case of CD45, PTPalpha, and PTPzeta/beta. (wikipedia.org)
Substrates of PTPmu (proteins that are dephosphorylated by PTPmu), such as p120catenin, tend to be dephosphorylated at high cell density, supporting the hypothesis that PTPmu is catalytically active when bound homophilically. (wikipedia.org)
These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. (nih.gov)
Nectin proteins have been identified as providing a wide range of functions within the cell. (prospecbio.com)
Finally, nectin proteins perform cell-to-cell adhesion. (prospecbio.com)
Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition phenomena. (rcsb.org)
183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. (rupress.org)
In its GTP-bound form, Cdc42 binds several effectors that help direct polarized cell growth: repolarizing actin and microtubules, directing polarized exocytosis via this reoriented cytoskeleton and by direct contact with exocytic machinery, and recruiting proteins such as septins that form a boundary restricting the region of cell growth. (rupress.org)
Par proteins, like Cdc42, play conserved roles in cell polarity in many contexts, from early embryos to epithelial apical-basal polarity ( Goldstein and Macara, 2007 ). (rupress.org)
mPEG-MAL (Thiol PEGylation of Proteins) - A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells, Cell, Volume 157, Issue 7, 19 June 2014, Pages 1644-1656, Text . (creativepegworks.com)
The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. (utsouthwestern.edu)

L1 has been localized to growth cones and processes of postmitotic developing neurons, where it mediates cell adhesion, neurite outgrowth, and axon bundling. (jneurosci.org)
We found that follower axon navigation depended on the extracellular but not on the intracellular domain, suggesting that FMI-1 mediates primarily adhesion between pioneer and follower axons. (biologists.com)
NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. (umbc.edu)

The Ig domain is also responsible for localizing PTPmu to the plasma membrane surface of the cell. (wikipedia.org)
β1 also recruits ankyrin to the plasma membrane at sites of cell-cell contact in response to homophilic cell adhesion (Malhotra et al. (jneurosci.org)
Located in cell surface and plasma membrane. (dimabio.com)

Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. (nih.gov)
The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
Adhesion among neural cells of the chick embryo. (academicinfluence.com)

In recent reports, there is evidence that heterophilic interactions are more successful than homophilic counterparts. (prospecbio.com)
Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro . (jneurosci.org)
During development, intercellular communication of morphogens is critical for embryonic cells to determine their positional identity, directionality, and interactions in an organized pattern to sculpt tissue. (biorxiv.org)
Understanding how signals might inform cells of their positional identity, directionality, and interactions and organize these functions in diverse tissue-specific patterns is critical to understanding morphogenesis. (biorxiv.org)
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. (creativebiomart.net)
Involved in neurite extension by neurons via heterophilic and homophilic interactions. (eiaab.com)
May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. (eiaab.com)

PTPmu protein expressed on the surface of cells is able to mediate binding between two cells, which results in the clustering of the cells, known as cell-cell aggregation. (wikipedia.org)
We found that Ca 2+ and/or 1,25(OH) 2 D 3 stimulated CaSR promoter activity and CaSR protein expression in the human colon carcinoma CBS cells, which possessed a functional CaSR. (aacrjournals.org)
MOG is a membrane protein expressed on the cell surface of oligodendrocytes and thought to provide structural integrity to the outermost surface of myelin sheaths. (antibodiesinc.com)
CADM1, a single-pass type 1 cell membrane protein, appears to be involved in several biological processes: Apoptosis, Cell adhesion, Differentiation, Immunity and Spermatogenesis. (nih.gov)
Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA. (gzsys.org.cn)
TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
TotalSeq™-D reagents are designed to profile protein expression at single cell level. (biolegend.com)
This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. (nih.gov)
FMI-1 has a unique and strikingly conserved structure with cadherin and C-terminal G-protein coupled receptor domains and could mediate cell-cell adhesion and signaling functions. (biologists.com)
Sequence Location Cell junction, adherens junction, Cell membrane, Single-pass type I membrane protein. (qedbio.com)
Gal-8 is a "tandem-repeat"-type galectin , known as a matricellular protein involved in cell adhesion . (bvsalud.org)

They may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. (embl.de)
Cell adhesion and the molecular processes of morphogenesis. (academicinfluence.com)

Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. (embl.de)
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. (embl.de)
In this paper, we demonstrate a novel mechanism of adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad). (rupress.org)
The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton. (ecmbio.com)
Western blot image of human A431 cells that were probed with rabbit polyclonal anti-E-Cadherin (a.a. 774-786) at 1:250 (lane 1), 1:1000 (lane 2), and 1:4000 (lane 3) or mouse monoclonal anti-E-cadherin (Cytoplasmic) at 1:250 (lane 4) and 1:1000 (lane 5). (ecmbio.com)
In western blots, the antibody detects a 120 kDa band corresponding to E-cadherin in human A431 cells, and does not detect VE-cadherin or N-Cadherin. (ecmbio.com)
N-cadherin (N-cad, Cdh2) is initially expressed at the gastrulation stage when epiblast cells downregulate E-cad and undergo an epithelial-mesenchymal transition (EMT). (biomedcentral.com)
E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. (qedbio.com)

In this report, we demonstrate for the first time that experimental up-regulation of PTPRD in neuroblastoma cell lines significantly decreases cell growth and increases apoptosis. (biomedcentral.com)
We found that the sole presence of N-cad induces constitutively active fibroblast growth factor (Fgf) signaling and a precocious involution resulting in massive apoptosis of alveolar cells. (biomedcentral.com)
Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. (qedbio.com)

The protocadherins are the largest subgroup within this superfamily, yet their participation in calcium-dependent cell adhesion is uncertain. (rupress.org)

Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
Both agents concomitantly induced a series of changes in the CBS cells that influence proliferation and differentiation, but cellular responses to the two agents were not identical. (aacrjournals.org)
Finally, it may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. (nih.gov)

The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. (nih.gov)
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
Does not act as receptor for alpha-herpesvirus entry into cells. (creativebiomart.net)

see Muscle System - GLR Cells ), which are associated only with the somatic nervous system. (wormatlas.org)
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. (bvsalud.org)
Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD , indicating a potential tumor suppressor function for this gene. (biomedcentral.com)
Neuroblastoma is derived from primitive cells of the sympathetic nervous system, and is the most common extracranial solid tumor in children accounting for 15% of all childhood cancer deaths [ 13 ]. (biomedcentral.com)

In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)
Cell bodies of most neurons are clustered in ganglia in the head or tail ( NeuroFIG 1 ). (wormatlas.org)
If the neurons are radially symmetrical, each cell has a three-letter name followed by L (left), R (right), D (dorsal), or V (ventral). (wormatlas.org)
Most of the neurons are components of the various head sensilla with associated sheath and socket cells. (wormatlas.org)

These include cell movement and proliferation. (prospecbio.com)
boi controls follicle stem cell proliferation. (cellimagelibrary.org)
CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). (qedbio.com)

In combination with a conditional gene inactivation approach, we expressed N-cad in the absence of E-cad (referred to as Ncadk.i.) in alveolar epithelial cells of the mammary gland starting in late pregnancy. (biomedcentral.com)
The mammary gland (MG) consists of lobulo-alveolar structures formed by epithelial cells expressing E-cad [ 9 ]. (biomedcentral.com)
Myoepithelial cells surround the alveoli and provide mechanical stimuli to the epithelial cells of the alveoli during the lactation process. (biomedcentral.com)
Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. (qedbio.com)

Annu Rev Cell Dev Biol. (embl.de)
J Cell Biol (2011) 195 (7): 1115-1121. (rupress.org)
J Cell Biol (2008) 183 (6): 971-974. (rupress.org)
Image correlates to Fig 1C in J Cell Biol. (cellimagelibrary.org)

The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. (umbc.edu)

Adhesion by the Pcdh19-Ncad complex was unaffected by mutations that disrupt Ncad homophilic binding but was inhibited by a mutation in Pcdh19. (rupress.org)

Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN. (nih.gov)

The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. (nih.gov)
After homo-dimer formation, they can interact in a heterophilic or homophilic manner. (prospecbio.com)

Our findings indicate that FMI-1 is a cell-type dependent axon guidance factor with different domain requirements for its different functions in pioneers and followers. (biologists.com)

PTPmu is expressed in different organ tissues in the body, including the lung, heart and brain, pancreas, endothelial cells in capillaries and arteries throughout the body, and in retinal and brain cells. (wikipedia.org)

The interaction with CRTAM promotes natural killer (NK) cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro over and above NK cell-mediated rejection of tumors expressing CADM3 in vivo. (neuromics.com)

The MAM, Ig, and the first two FNIII repeats are the minimum extracellular domains required for efficient cell-cell adhesion. (wikipedia.org)

Thus, GPI-anchored FGF organizes both source and recipient cells and self-regulates its cytoneme-mediated tissue-specific dispersion and signaling. (biorxiv.org)
The discrete tissue-specific organization of morphogen signaling is known to be dependent on the ability of signal-receiving cells to selectively sense and respond to a specific signal 3 . (biorxiv.org)

We revealed a number of cell adhesion characteristics of hemolin 1) a membrane associated form, (2) Ca 2+ -dependent homophilic binding, (3) glycosylation (4) importance of Ca 2+ and carbohydrates on the binding to hemocytes. (diva-portal.org)
We showed that recombinant glycosylated ALCAM and endogenous ALCAM from breast carcinoma cells physically interacted with Gal-8 in a glycosylation -dependent fashion displaying a differential behavior compared to non-glycosylated ALCAM . (bvsalud.org)
Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation -dependent mechanisms. (bvsalud.org)

J Cell Sci (2002) 115 (12): 2581-2590. (biologists.com)

Previous studies have shown that small beads coated with FN7-10, a four-domain cell adhesion fragment of fibronectin, bind to cell surfaces and translocate rearward. (biologists.com)

Nearly twenty years ago Cdc42 was recognized as an essential link between polarity cues and the machinery that generates cell polarity ( Bender and Pringle, 1989 ). (rupress.org)

These results suggest that effects of β1 on sodium channel gating are dependent on the genetic background and signal transduction pathways present in the cell type used in heterologous expression and emphasize the importance of analyzing the effects of β1 in vivo . (jneurosci.org)

potent anti-cancer drugs, combretastatin A-4 (CA-4) and docetaxel (DTX), against tumor cells and vasculature. (ajol.info)
Advances in tumor cell biology have led to the ability to subclassify NHL via the World Health Organization (WHO) classification of lymphomas (see below). (medscape.com)
CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. (nih.gov)
It may additionally contribute to the less invasive phenotypes of lepidic growth tumor cells. (nih.gov)

We performed binding assays by surface plasmon resonance to study the interaction between Gal-8 and the recombinant glycosylated ALCAM ectodomain or endogenous ALCAM from MDA-MB-231 breast cancer cells . (bvsalud.org)

These functions include coupling cytoskeletal force generation to strongly adherent sites on the cell surface and the regulation of intracellular signaling events. (embl.de)
Both establish calcium-dependent homophilic cell-cell adhesion with their extracellular domains and are connected with catenins at their intracellular domains [ 4 ]. (biomedcentral.com)

In Drosophila , FGF produced in wing-disc cells regulates the development of the disc-associated air-sac-primordium (ASP). (biorxiv.org)

These findings bring along a paradox - not only do signals instruct cells and organize discrete cellular patterns, but cells also control the patterns of signal presentation and reception by organizing the distribution of cytonemes and cytoneme contacts 6 , 9 . (biorxiv.org)
The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. (rupress.org)

A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells . (bvsalud.org)

The unavailability of this information is demonstrated in previous classification systems, including the Lukes-Collins, Kiel, and Working Formulation systems, which did not identify subclasses of NK/T-cell malignancies. (medscape.com)

We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). (ajol.info)

β1 subunits affect sodium channel gating and cell surface expression when expressed in heterologous cells in vitro . (jneurosci.org)
Here, we show that FGF is Glycosylphosphatidylinositol-anchored to the producing cell surface and that this modification both inhibits free FGF secretion and activates target-specific bidirectional FGF-FGFR signaling through cytonemes. (biorxiv.org)
Fluorescence microscopy showed that the trimer and pentamer bound strongly to the cell surface, and within 5 minutes were prominently localized to actin fiber bundles. (biologists.com)
On the ventral surface this rearward movement of the cytoskeleton contributes to forward motion of the cell relative to the substrate. (biologists.com)
Surface modulation in cell recognition and cell growth. (academicinfluence.com)

These conserved families of secreted morphogens/signals, such as Fibroblast Growth Factor (FGF), Hedgehog (Hh), Wingless (Wg)/Wnt, Epidermal Growth Factor (EGF), and Decapentaplegic (Dpp - a BMP homolog), act away from their sources and, upon binding to receptors, activate gene regulatory pathways to induce functions in recipient cells 1 , 2 . (biorxiv.org)

Although Pcdh19 alone is only weakly adhesive, the Pcdh19-Ncad complex exhibited robust adhesion in bead aggregation assays, and Pcdh19 appeared to play the dominant role. (rupress.org)

In addition, the complex exhibited homophilic specificity, as beads coated with Pcdh19-Ncad did not intermix with Ncad- or Pcdh17-Ncad-coated beads. (rupress.org)

At cell membranes, Cdc42 recruits and stimulates activators of the Arp2/3 complex. (rupress.org)

The aim of the present studies was to characterize the binding of hemolin to insect cells and further investigate the mechanisms behind. (diva-portal.org)

Contact-mediated FGF-FGFR binding induces bidirectional signaling, which, in turn, promotes ASP and source cells to polarize cytonemes toward each other and reinforce signaling contacts. (biorxiv.org)

Anatomy38

Organisms7

Diseases5

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Molecule24

Molecules25

Heterophilic cell-cell adhesion3

Immunoglobulin1

Cadherins11

Proteins12

Mediates3

Plasma membrane3

Neural3

Interactions7

Protein11

Morphogenesis2

Cadherin8

Apoptosis3

Calcium-dependent cell adhesion1

Differentiation4

Receptor4

Nervous system4

Neurons4

Proliferation3

Epithelial cells4

Biol4

NCAM1

Mutations1

Mechanism1

Interact2

Axon1

Endothelial1

CADM31

Repeats1

Tissue2

Glycosylation3

20021

Fibronectin1

19891

Vivo1

Tumor4

Recombinant1

Intracellular2

Regulates1

Cellular2

Interaction1

Classification1

Biology1

Surface5

Gene1

Aggregation1

Beads coated1

Membranes1

Mechanisms1

Promotes1