LociChromosomalMeiosisGenomeFourth chromosome of Drosophila melanogasterScaffoldsIdentify homologousRole of chromosomesBovineSpeciesSpecific chromosomesPairShort arm of chromosomeMeiotic recombinationSyntenyHumansRecombination eventsHumanYeastVariationDeletionMarkersPhenotypicSequencesTranslocationCentromereBreakpointInversionsCrossoversLocus orderPairsPopulationsAllelesGenomicBacterialSusceptibilitySyntenicContigsQuantitativeComparativeSequenceZebra finchClonesMammalianGenes locatedPatternsMutationsRegionRearrangementsMammalsRecessive alleleSitu hybridizationOccursRegionsGenetic mapInteraction
Loci22
- It was revealed that homologous loci kept a constant distance in nuclei of A. thaliana roots in general growth. (nature.com)
- We also found that DNA double-strand breaks (DSBs) induce the approach of the homologous loci with γ-irradiation. (nature.com)
- Furthermore, AtRAD54, which performs an important role in the homologous recombination repair pathway, was involved in the pairing of homologous loci with γ-irradiation. (nature.com)
- These results suggest that homologous loci approach each other to repair DSBs and AtRAD54 mediates these phenomena. (nature.com)
- Here, we examined chromatin dynamics and arrangement in living roots of A. thaliana with DNA damage, focusing our attention on the distance between homologous loci using the lacO /LacI-EGFP system. (nature.com)
- We revealed that the homologous loci kept a constant three-dimensional distance in the nucleus using live-cell imaging with a bacterial operator/repressor system. (nature.com)
- Moreover, the distance between two homologous loci in the interphase nucleus was shortened by γ-irradiation, which induces DNA double-strand breaks (DSBs). (nature.com)
- We found that AtRAD54, which performs an important role in the homologous recombination (HR) repair pathway, was involved in the approach of two homologous loci under γ-irradiation. (nature.com)
- Our results suggest that the transient reduction in inter-allelic distance and increase in pairing frequency of homologous loci after DSB result in partial chromatin reorganisation of interphase nuclei and that AtRAD54 contributes to the subcellular movement of homologous loci in the HR repair pathway. (nature.com)
- Using restriction-site associated DNA sequencing, a genetic map composed of 6,434 loci, including 6,295 single nucleotide polymorphisms and 139 simple sequence repeat loci, was developed from RIL population. (biomedcentral.com)
- The current autosomal version (4.2) of the sheep genetic map comprises 1175 loci and spans ~3540 cM. (gse-journal.org)
- Each chromosome is represented by a single linkage group, with the largest gap between adjacent loci being 19.8 cM. (gse-journal.org)
- In contrast the 1998 goat genetic map (the most recently published) is much less well developed spanning 2737 cM and comprising only 307 loci. (gse-journal.org)
- The two maps share 218 loci, and the maps have been aligned using the shared loci as reference points. (gse-journal.org)
- Overall there is good agreement between the maps in terms of homologous loci mapping to equivalent chromosomes in the two species, with only four markers mapping to non-equivalent chromosomes. (gse-journal.org)
- We have generated high-resolution genome-wide maps of transformation, finding massive variation in rates at different chromosomal loci. (drexel.edu)
- DNA probes from DXS732 and DXS453, identified as the closest flanking marker loci to the EDA locus, were used to identify homologous Yeast Artificial Chromosome (YAC) clones. (ox.ac.uk)
- Five of these lie in the X-chromosome, and a study of their linkage relations was shown to indicate that the sequence of the five loci concerned is the same in both species, and that the percentages of crossing over in comparable regions, while not indentical, is still not very different. (caltech.edu)
- A recent paper in this journal by Detlefsen(1) is introduced as follows: "There is a well intrenched concept of recent genetics that hereditary factors or genes may be given fairly definite loci on chromosome maps and that these maps correspond to or represent, roughly perhaps, the actual conditions in the chromosome. (caltech.edu)
- The overlapping size range of the Xand Y-chromosome alleles indicated a more complex distribution of alleles at these two loci than previously reported. (wayne.edu)
- A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. (nova.edu)
- Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
Chromosomal8
- 26 ) leveraged the CRISPR-Cas9 system to produce other chromosomal rearrangements, generating targeted mitotic recombination events in yeast to enable the fine mapping of trait variants. (life-science-alliance.org)
- Crossovers (CO) shuffle genetic information and physically connect homologous chromosomal pairs, ensuring their balanced segregation during meiosis. (bvsalud.org)
- This is disappointing as mapping information on a chromosomal basis brings the opportunity to address many fundamental biological questions of genome evolution. (ukri.org)
- This information and technique will allow us in the future to locate genes or QTL detected in different mapping populations efficiently and fast on homologous chromosomes or even chromosomal regions. (elsevierpure.com)
- VCMap was designed to fill a gap in the need for genomics viewers to compare QTL and annotations across species at a chromosomal level with multiple map types. (animalgenome.org)
- Chromosomal theory of inheritance states that Mendelian factors have specific locus on chromosomes and they carry information from one generation to the next generation. (brainkart.com)
- Mutational events that take place within individual genes are called gene mutations or point mutation, whereas the changes occur in structure and number of chromosomes is called chromosomal mutation. (brainkart.com)
- [ 1 ] They described a child with midline fusion defects, and subsequent cytogenetic studies revealed a chromosomal deletion of the short arm of chromosome 4. (medscape.com)
Meiosis6
- Nondisjunction in meiosis can lead to an abnormal number of chromosomes in the resulting cells, which is the cause of Down syndrome, Turner's syndrome, and Klinefelter's syndrome. (proprofs.com)
- In 1930, Barbara was the first person to describe the cross-shaped interaction of homologous chromosomes during meiosis. (biologywise.com)
- crossing over, crossover (noun) the interchange of sections between pairing homologous chromosomes during the prophase of meiosis. (penzionmulda.cz)
- It seems probable that the scheme outlined in this paper will apply for the case of inversions that do not include the locus of the spindle attachment and for other chromosome aberrations in which crossing-over gives rise to chromatids with two spindle attachments, and where the conditions of meiosis are such that (a) the meiotic spindles are oriented so that the reduced nuclei lie approximately on a single straight line, and (b) only one of the terminal nuclei functions in further development. (caltech.edu)
- The pairing of two homologous chromosomes that occurs during meiosis. (brainkart.com)
- The movement of transverse bonds between paired chromosomes in meiosis from their points of origin toward the ends of the chromosomes. (brainkart.com)
Genome14
- Here we present an annotated, chromosome-anchored, genome assembly for Lake Trout (Salvelinus namaycush) - a highly diverse salmonid species of notable conservation concern and an excellent model for research on adaptation and speciation. (authorea.com)
- 84.7% of the genome was assigned to 42 chromosome-sized scaffolds and 93.2% of Benchmarking Universal Single Copy Orthologs were recovered, putting this assembly on par with the best currently available salmonid genomes. (authorea.com)
- Israel's genomic company, NRGene, has mapped the rainbow trout genome in cooperation with scientists from the US Department of Agriculture's (USDA) Agricultural Research Service (ARS) and the University of Illinois. (aquaculturenorthamerica.com)
- In a company statement, Dr Gil Ronen, PhD, CEO, NRGene, said: "Mapping a full and reliable reference genome is a critical step toward efficient breeding, and the trout is simply the first of many critical species for the aquaculture industry that must be mapped. (aquaculturenorthamerica.com)
- Current knowledge about the species differences in sex chromosome organization and function is limited, this despite the availability of reference genome assemblies for most domestic species. (pacb.com)
- The Y chromosome, on the other hand, is typically not included in the reference genome and is studied separately, whereas complete sequence assembly of the male-specific portion of the Y is not yet available for any domestic species. (pacb.com)
- Here we present a de novo human genome assembly that surpasses the continuity of GRCh38, along with the first gapless, telomere-to-telomere assembly of a human chromosome. (pacb.com)
- Similar restriction studies extended to other parasite chromosomes will ultimately yield a long-range physical map of the P. falciparum genome. (johnshopkins.edu)
- It is also possible to compare the overall structure of one genome with another, somewhat like comparing the maps of towns with similar layouts. (ukri.org)
- Every genome sequence needs a good map however modern next generation sequencing (NGS) technologies struggle fully to assemble whole genomes de-novo. (ukri.org)
- We have developed a novel method for mapping genes in bacteria, exploiting natural transformation in combination with genome-wide deep sequencing. (drexel.edu)
- VCMap can be used for many tasks such as: comparing QTL across species, viewing evolutionary rearrangements across species, comparing genome builds within species, comparing different map types within species, and so on. (animalgenome.org)
- In this study, 23 HD-Zip genes distributed on 6 chromosomes were identified from the peach ( Prunus persica ) genome, and named PpHDZ01-23 according to their positions on the chromosomes. (biomedcentral.com)
- The results of JEV and HCV genome mapping were highly consistent with those using mNGS and the de novo assembly. (cdc.gov)
Fourth chromosome of Drosophila melanogaster2
- Example: The fourth chromosome of Drosophila melanogaster is a dot and all the genes present over it are completely linked. (cbsetuts.com)
- Under ordinary conditions there is so little crossing over in the fourth chromosome of Drosophila melanogaster that the usual method of constructing a map is not practicable. (caltech.edu)
Scaffolds3
- We leveraged Pacific Biosciences long-read sequencing, paired-end Illumina sequencing, proximity ligation (Hi-C), and a previously published linkage map to produce a highly contiguous assembly composed of 7,378 contigs (contig N50 = 1.8 mb) assigned to 4,120 scaffolds (scaffold N50 = 44.975 mb). (authorea.com)
- Scaffolds are now being ordered by USDA researchers based on a new genetic map produced by the USDA in collaboration with scientists from Norway. (aquaculturenorthamerica.com)
- We will anchor each of the scaffolds physically to chromosomes by FISH. (ukri.org)
Identify homologous1
- Self-vs-self synteny analysis allowed us to identify homeologs resulting from the Salmonid specific autotetraploid event (Ss4R) and alignment with three other salmonid species allowed us to identify homologous chromosomes in other species. (authorea.com)
Role of chromosomes2
- From understanding the role of chromosomes in inheritance to unraveling the secrets of human evolution, chromosome mapping has revolutionized our comprehension of the genetic landscape. (facts.net)
- Modern genomic research generally focuses on the role of individual genes but the role of chromosomes and homologous synteny blocks (HSBs) is often disregarded. (ukri.org)
Bovine2
- A comparative radiation hybrid map of bovine chromosome 18 and homologous chromosomes in human and mice. (fbn-dummerstorf.de)
- River buffalo chromosome 1 (BBU1) is a sub-metacentric chromosome homologous to bovine chromosomes 1 and 27. (geneticsmr.com)
Species12
- When you load multiple maps from different species, all of the off-backbone maps are anchored relative to the single chromosome from the backbone map, often resulting in multiple chromosomes appearing for each off-backbone species. (animalgenome.org)
- By comparing the chromosome maps of different species, scientists can gain insights into evolutionary relationships and understand how organisms have diverged over time. (facts.net)
- Cytogenetically, the species of the genus Melipona show variation in the amount and distribution of heterochromatin along their chromosomes and can be separated into 2 groups: the first with low content of heterochromatin and the second with high content of heterochromatin. (karger.com)
- In general, Melipona species have 2n = 18 chromosomes, and the species of each subgenus share the same characteristics in relation to heterochromatin regions, DAPI/CMA 3 fluorophores, and the number and distribution of 18S rDNA sites. (karger.com)
- However, it is not well understood why apparently similar sex chromosome abnormalities, such as X-monosomy or certain Y chromosome rearrangements, result in different phenotypic effects in different species. (pacb.com)
- It is thought that this is due to species differences in the organization of the Y chromosome, differences in the set of genes escaping X-inactivation, and the presence of species/lineage specific sex-linked genes with functions in development and reproduction. (pacb.com)
- It appears that sequence assembly of the X chromosome in most species is rather patchy containing multiple gaps and possible misassemblies, being the poorest in the pseudoautosomal region and in regions containing putative lineage-specific sequences. (pacb.com)
- Both the maternal (yak) and paternal (cattle) assemblies contain over one third of the acrocentric chromosomes, including the two largest chromosomes, in single haplotigs.Conclusions These haplotigs are the first vertebrate chromosome arms to be assembled gap-free and fully phased, and the first time assemblies for two species have been created from a single individual. (pacb.com)
- 2012). Virtual Comparative Map (VCMap): A comparative genomics tool designed to facilitate cross-species annotation. (animalgenome.org)
- For example, users can view synteny/homologue blocks and homology lines across species for specific regions while hiding other, less interesting portions of the chromosome. (animalgenome.org)
- These sequence-based comparisons from UCSC define the anchors to allow cross-species comparisons across physical maps. (animalgenome.org)
- Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker ( SMCY ) position rearranged between the species. (nova.edu)
Specific chromosomes2
- By examining specific chromosomes, medical professionals can determine the sex of a fetus during pregnancy. (facts.net)
- For the first time we are now able to anchor linkage groups to specific chromosomes. (elsevierpure.com)
Pair5
- These chromosomes are organized into pairs, with each pair consisting of two homologous chromosomes. (proprofs.com)
- In Arabidopsis, an obligate crossover and repression of nearby crossovers on each chromosome pair are abolished in mutants that lack the synaptonemal complex (SC), a conserved protein scaffold. (bvsalud.org)
- The human PRNP gene is located on the short (p) arm of chromosome 20 between the end (terminus) of the arm and position 12, from base pair 4,615,068 to base pair 4,630,233. (wikidoc.org)
- Crossing over is biological a process that produces new combination of genes by inter-changing the corresponding segments between non-sister chromatids of homologous pair of chromosomes. (brainkart.com)
- When any of the three or more allelic forms of a gene occupy the same locus in a given pair of homologous chromosomes, they are said to be multiple alleles. (brainkart.com)
Short arm of chromosome2
- The Waxy gene ( Wx ) located on the short arm of chromosome 7H is a key gene responsible for amylose synthesis, and also acts as a favorable gene in breeding of hulless barley. (chinacrops.org)
- Wolf-Hirschhorn syndrome results from the deletion of the distal short arm of chromosome 4. (medscape.com)
Meiotic recombination2
- These results are consistent with the hypothesis that minimum efficient processing segments, which have been characterized in Escherichia coli, yeast, and cultured mammalian cells, may be required for efficient homologous meiotic recombination in humans. (nih.gov)
- A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination. (ox.ac.uk)
Synteny2
- All comparitive maps are based on the UCSC synteny for genomic maps. (animalgenome.org)
- Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. (nova.edu)
Humans3
- In humans, there are 23 pairs of chromosomes, for a total of 46 chromosomes. (proprofs.com)
- The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)
- We compared the global pattern of variation at two homologous microsatellites mapping to the long arm of the X chromosome (DXYS156X) and to the short arm of the Y chromosome (DXYS156Y) in humans. (wayne.edu)
Recombination events1
- The HNPP (hereditary neuropathy with liability to pressure palsies) deletion and CMT1A (Charcot-Marie-Tooth disease type 1A) duplication are the reciprocal products of homologous recombination events between misaligned flanking CMT1A-REP repeats on chromosome 17p11. (nih.gov)
Human15
- What is the number of chromosomes in a normal human karyotype? (proprofs.com)
- A normal human karyotype consists of 46 chromosomes. (proprofs.com)
- This is the correct answer because it accurately represents the number of chromosomes in a normal human karyotype. (proprofs.com)
- Breakpoint analysis of the pericentric inversion distinguishing human chromosome 4 from the homologous chromosome in the chimpanzee (Pan troglodytes). (anthropogeny.org)
- The breakpoints of the inversion that distinguishes human chromosome 4 (HSA4) from its chimpanzee counterpart were identified by fluorescence in situ hybridization (FISH) and comparative sequence analysis. (anthropogeny.org)
- At 30 kb proximal to the breakpoint in 4q21.3, we identified an as yet unannotated gene, C4orf12, that lacks an homologous counterpart in rodents and is expressed at a 33-fold higher level in human fibroblasts as compared to chimpanzee. (anthropogeny.org)
- Homologous chromosomes from the human malaria parasite Plasmodium falciparum exhibit striking size polymorphism from isolate to isolate. (johnshopkins.edu)
- Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. (taconic.com)
- A gene expression map of human chromosome 21 orthologues in the mouse. (taconic.com)
- Newer work is using the same approach to map the genes responsible for natural variation in other pathogenesis traits, including resistance to human complement-mediated killing, as well as investigating the possibility of identifying genes involved in in vivo pathogenesis in an animal model of otitis media. (drexel.edu)
- Börjeson-Forssman-Lehmann syndrome (BFLS) is a syndromal X-linked mental retardation, which maps by linkage to the q26 region of the human X chromosome. (edu.au)
- These two YACs were also screened against the ICRF human X chromosome cosmid library and identified 36 cosmid clones. (ox.ac.uk)
- Interestingly, comparative mapping revealed that the Athsq1 congenic interval contains the mouse region homologous to a widely-replicated CHD locus on human chromosome 9p21. (scite.ai)
- Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY-DBY-UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production. (nova.edu)
- Coverage of Crimean-Congo hemorrhagic fever virus reached an average of 15.6%, but the concentrated regions were highly homologous to human-sorting nexin 10. (cdc.gov)
Yeast2
- The authors deliberately induced a single DSB in one of the homologous chromosomes in a diploid yeast strain and achieved homologous recombination-based "loss of heterozygosity" events within 20 kb of the target site. (life-science-alliance.org)
- Fluorescence in situ hybridisation using yeast artificial chromosome clones from Xq26 localised the duplication breakpoint to an ∼400-kb interval in the Xq26.3 region between DXS155 and DXS294/DXS730. (edu.au)
Variation5
- Sinnis, P & Wellems, TE 1988, ' Long-range restriction maps of Plasmodium falciparum chromosomes: Crossingover and size variation among geographically distant isolates ', Genomics , vol. 3, no. 4, pp. 287-295. (johnshopkins.edu)
- We are now using advanced optical mapping technology to reproduce these maps in the absence of genetic variation, in order to disentangle the role of chromosome structure from the potential for genetic incompatibilities ("speciation genes") skewing our results. (drexel.edu)
- Key Words: atherosclerosis Ⅲ congenic strain Ⅲ genetics Ⅲ extracellular matrix Ⅲ mapping S usceptibility to atherosclerosis is influenced by both genetic and environmental factors, with approximately 40% to 60% of interindividual variation attributed to genetic factors. (scite.ai)
- Contrasting patterns of X-chromosome-linked and Y-chromosome-linked variation were reflected in statistically significant differences in genetic diversity values among geographic regions and between X and Y chromosomes. (wayne.edu)
- However, similar genetic rearrangements in this syndrome may determine variable phenotypic effects, most likely as a consequence of allelic variation in the homologous 4p region. (medscape.com)
Deletion4
- By comparing the sequences across recombinant CMT1A-REPs to that of the proximal and distal CMT1A-REPs, the exchange was mapped to a 557-bp region within the previously identified 1.7-kb hotspot in 21 of 23 unrelated HNPP deletion patients. (nih.gov)
- A large deletion several megabases (Mb) in length, easily detected using conventional chromosome analysis, is usually associated with severe phenotypic expression, including multiple malformations. (medscape.com)
- Factors involved in prediction of prognosis include the extent of the deletion, the occurrence of complex chromosome anomalies, and the severity of seizures. (medscape.com)
- As a result of the deletion of part of chromosome 7, some people with this condition are missing one copy of the NCF1 gene in each cell. (medlineplus.gov)
Markers12
- By analyzing specific markers on the chromosomes, we can trace our genetic lineage back to our ancestors and discover our genetic heritage. (facts.net)
- By analyzing the genetic markers on chromosomes, scientists can reconstruct ancient migration routes and understand the movements of different populations. (facts.net)
- To better understand the karyotype organization in Melipona and the relationship among the subgenera, we mapped repetitive sequences and analyzed previously reported cytogenetic data with the aim to identify cytogenetic markers to be used for investigating the phylogenetic relationships and chromosome evolution in the genus. (karger.com)
- This map spanned 4,071.98 cM, with an average distance of 0.63 cM between adjacent markers. (biomedcentral.com)
- Because anonymous marker-based maps are becoming saturated, a genetic map based on conventional markers cannot achieve the resolution required for fine QTL mapping or positional cloning. (biomedcentral.com)
- Only one of the goat chromosomes appears to have complete coverage (chromosome 27), and 16 of the chromosomes are comprised of two or more linkage groups, or a linkage group and one or more unlinked markers. (gse-journal.org)
- In this study, we constructed a new framework radiation hybrid (RH) map from BBU1 using BBURH 5000 panel adding nine new genes ( ADRB3 , ATP2C1 , COPB2 , CRYGS , P2RY1 , SLC5A3 , SLC20A2 , SST , and ZDHHC2 ) and one microsatellite (CSSM043) to the set of markers previously mapped on BBU1. (geneticsmr.com)
- Nasonia vitripennis is a small parasitic hymenopteran with a 50-year history of genetic work including linkage mapping with mutant and molecular markers. (elsevierpure.com)
- Two linkage maps based on a hybrid cross (N. vitripennis x N. longicornis) were constructed using STS, RAPD and microsatellite markers, where 17 of the linked STS markers were developed from single microdissected banded chromosomes. (elsevierpure.com)
- Linkage and physical maps are connected based on positions of markers sequences (STS) as recorded at UniSTS at NCBI. (animalgenome.org)
- The RH maps are mapped to genomic assemblies based on the alignment of STS markers on both maps. (animalgenome.org)
- Linkage and RH maps are only linked to other maps if they contain STS markers that also exist on those maps. (animalgenome.org)
Phenotypic2
- This is despite the ubiquity of HSBs and the phenotypic consequences/evolutionary implications of chromosome rearrangement. (ukri.org)
- Most phenotypic manifestations in this syndrome reflect a contiguous gene syndrome, leading to a phenotypic map of chromosome arm 4p. (medscape.com)
Sequences1
- Comparative mapping of five coding DNA sequences on cattle chromosomes 7 and 25. (fbn-dummerstorf.de)
Translocation2
- Here, we report the breakpoints on chromosome 1 translocation and the clinical features presented in carriers, to enable informed genetic counseling of these patients. (geneticsmr.com)
- Other changes in chromosome 4 can involve a ring structure or translocation. (medscape.com)
Centromere1
- One QTL with a major effect was found to map to the centromere region of chromosome 3 in both crosses. (elsevierpure.com)
Breakpoint2
- Seven out of 11 genes that mapped to the breakpoint regions have been previously analyzed using oligonucleotide-microarrays. (anthropogeny.org)
- Database searches and analysis of available genomic DNA sequence from the region revealed the presence of the fibroblast growth factor homologous factor gene, FHF2, within the duplication breakpoint interval. (edu.au)
Inversions2
- However, there are lots of inversions in locus order between the sheep and goat chromosomes. (gse-journal.org)
- The salivary gland chromosome technique has made it possible to demonstrate not only that these are inverted sections, but also that there are many different inversions present in wild populations inhabiting different geographical regions. (caltech.edu)
Crossovers3
- We find that both crossovers and non-crossovers are strongly depleted at DSB hotspots where the DSB-positioning protein PRDM9 fails to bind to the unbroken homologous chromosome, revealing that PRDM9 also functions to promote homologue-templated repair. (ox.ac.uk)
- It has been shown above that crossovers between X chromosome segments inverted with respect to one another influence the orientation of the meiotic tetrads in such a way as to eliminate the single crossover chromatids, leaving a normal non-crossover one in the reduced egg nucleus. (caltech.edu)
- If the distance which gives one per cent of crossovers is used as an arbitrary unit of measurement, then it follows that distances on the chromosome may be calculated in terms of this unit. (caltech.edu)
Locus order1
- Whilst some of these differences in locus order may be genuine, the majority are likely to be a consequence of the paucity of genetic information for the goat map. (gse-journal.org)
Pairs3
- The restriction maps show that, while the overall structure and organization of chromosome 4 from each clone are similar, large-scale variations occur within a few hundred kilobase pairs of the chromosome ends. (johnshopkins.edu)
- The process in which base pairs on homologous strands are consequently exchanged at a Holliday junction, moving the branch up or down the DNA sequence. (brainkart.com)
- The presence of dominant alleles of two or more pairs on one chromosome and the recessive alleles on the homologous chromosome. (brainkart.com)
Populations1
- We observed 11 alleles in a sample of 2290 X chromosomes and 2006 Y chromosomes from 50 populations representing 6 major geographic regions. (wayne.edu)
Alleles1
- Fine-mapping of a 2-Mb region on chromosome D3 associated with five stable QTLs between Marker25958 and Marker25963 revealed that lines containing alleles derived from CCRI36 in this region exhibited smaller phenotypes and earlier maturity. (biomedcentral.com)
Genomic3
- You are able to load genomic, genetic or radiation hybrid maps. (animalgenome.org)
- In the current version of VCMap, if you wish to load genetic or radiation hybrid comparative map, the genomic version of that map must be loaded before the genetic or radiation hybrid comparative map. (animalgenome.org)
- We also generated multiple resources useful for future genomic research on Lake Trout including a repeat library and a sex averaged recombination map. (authorea.com)
Bacterial1
- We have used this method to map an operon involved in intracellular invasion of airway epithelial cells, a trait with implications for chronic infection, bacterial persistence, and trafficking of cells to different body sites. (drexel.edu)
Susceptibility2
- Chromosome mapping allows researchers to identify the genes responsible for complex traits such as intelligence, height, and susceptibility to diseases. (facts.net)
- Methods and Results-We previously identified atherosclerosis susceptibility QTL (Athsq1) on chromosome 4 acting independently of systemic risk factors. (scite.ai)
Syntenic1
- When other comparative maps are loaded on top of that backbone, they will load all chromosomes that have syntenic regions that fall on the single chromosome of the backbone map, usually from more than one chromosome. (animalgenome.org)
Contigs2
- Mapping of anchor clones from each contig, against the mapping panel, localised all these contigs within the Xq12-q13.1 region. (ox.ac.uk)
- As for the other 4 bacteria, we identified almost no homologous contigs by assembly, and the only contig related to Staphylococcus aureus in sample 10 was completely consistent with the origin sequence of Homo sapiens isolate CHM13 chromosome 21. (cdc.gov)
Quantitative2
- To enhance understanding of the genetic basis of cotton earliness, we constructed an intra-specific recombinant inbred line population (RIL) containing 137 lines, and performed linkage map construction and quantitative trait locus (QTL) mapping. (biomedcentral.com)
- Through QTL analyses we identified one major Quantitative trait chromosome (QTC) underlying differentiation in circadian timing of mating activity. (biomedcentral.com)
Comparative2
- A backbone map is the primary map that will serve as the anchor off of which all comparative maps loaded will locate their sequence. (animalgenome.org)
- In this talk I will discuss comparative organization and function of animal sex chromosomes and related phenotypes proceeding from our research in horses. (pacb.com)
Sequence2
- The P4 primer was designed according to the sequence of Wx gene on chromosome 7H of barley. (chinacrops.org)
- A 1.7-kb hotspot for homologous recombination was previously identified wherein the relative risk of an exchange event is 50 times higher than in the surrounding 98.7% identical sequence shared by the CMT1A-REPs. To refine the region of exchange further, we designed a PCR strategy to amplify the recombinant CMT1A-REP from HNPP patients as well as the proximal and distal CMT1A-REPs from control individuals. (nih.gov)
Zebra finch1
- The remaining OR genes mapped to six homologous chromosomes plus three to four additional chromosomes in the zebra finch and chicken. (biomedcentral.com)
Clones1
- To examine the structural basis for these variations, we have determined full-length restriction maps of chromosome 4 from three P. falciparum clones. (johnshopkins.edu)
Mammalian1
- This is explained by relatively low gene density in both the X and the Y chromosome and by random X chromosome inactivation in mammalian females buffering the effect of X-aneuploidies. (pacb.com)
Genes located3
- This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. (wikipedia.org)
- Genes located closer over the chromosome show strong linkage force and genes located distantly over the chromosome show weak linkage force. (cbsetuts.com)
- Genes located close together on the same chromosome and inherited together are called linked genes the phenomenon is called Linkage. (brainkart.com)
Patterns2
- These heterochromatin patterns and the number of chromosomes are characteristics exclusive to Melipona karyotypes that distinguish them from the other genera of the Meliponini. (karger.com)
- We measure recombination along the chromosome arms in lines differing in patterns of heterozygosity and observe a MSH2-dependent crossover increase at the boundaries between heterozygous and homozygous regions. (bvsalud.org)
Mutations2
- Chromosome mapping has played a crucial role in understanding the genetic mutations that drive cancer development, leading to the development of targeted therapies. (facts.net)
- It is a common knowledge that sex chromosome mutations are better tolerated and more viable compared to changes in autosomes. (pacb.com)
Region6
- The FHF2 gene localisation and tissue-specific expression pattern suggest it to be a candidate gene for familial cases of the BFLS syndrome and other syndromal and non-specific forms of X-linked mental retardation mapping to the region. (edu.au)
- A panel of somatic cell hybrids and X-linked hypohidrotic ectodermal dysplasia (EDA) patient-derived cell lines, containing different rearranged X chromosomes, have been used to refine the physical map of the Xq12-q13.1 region. (ox.ac.uk)
- This map subdivides the region into at least 6 mapping-intervals. (ox.ac.uk)
- The small chromosome, made up of the left end of X attached to the spindle-fibre region of 4, may be obtained in individuals (of either sex) that are otherwise normal diploids. (caltech.edu)
- The core phenotype maps within the terminal 1.9 Mb region of chromosome 4p. (medscape.com)
- The NCF1 gene is located in a region of chromosome 7 that is often deleted in people with Williams syndrome. (medlineplus.gov)
Rearrangements1
- The study of breakpoints that occurred during primate evolution promises to yield valuable insights into the mechanisms underlying chromosome rearrangements in both evolution and pathology. (anthropogeny.org)
Mammals1
- Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. (wikipedia.org)
Recessive allele2
- This means that males, who have only one X chromosome, are more likely to express the recessive allele if they inherit it. (proprofs.com)
- Females, on the other hand, have two X chromosomes, so they are more likely to be carriers of the recessive allele without showing the trait themselves. (proprofs.com)
Situ hybridization1
- Assignment of the protein-tyrosine phosphatase beta gene (PTPRB) to cattle chromosome 5q23→q24 by in situ hybridization and somatic cell panel analysis. (fbn-dummerstorf.de)
Occurs1
- This integration occurs as a result of homologous recombination. (bvsalud.org)
Regions2
- In addition, 55 QTL coincidence regions representing more than 60 % of total QTLs were found on 22 chromosomes, which indicated that several earliness-related traits might be simultaneously improved. (biomedcentral.com)
- Cotton earliness-related QTLs and QTL coincidence regions will provide useful materials for QTL fine mapping, gene positional cloning and MAS. (biomedcentral.com)
Genetic map2
- We developed an SNP-based genetic map, and this map is the first high-density genetic map for short-season cotton and has the potential to provide deeper insights into earliness. (biomedcentral.com)
- She published the first genetic map for corn in 1931, showing the order of three genes on chromosome 9. (biologywise.com)
Interaction1
- Before fertilization, the cytoplasm of the eggs deposited by race B females is so influenced by the chromosomes present in it, that an interaction between this cytoplasm and the autosomes of race A (introduced by the spermatozoon) results in the development of small testes in males arising from such eggs. (caltech.edu)