• This occurs through the downregulation of methylmalonyl coenzyme A epimerase (MCEE), mediated by an extracellular signal-regulated kinase 2-driven transcription factor Sp1/early growth response protein 1 transcriptional switch driven by metastatic signalling at its promoter level. (biomed.news)
  • The prospero related homeobox-1 (PROX1) transcriptional factor and vascular endothelial growth factor receptor-3 (VEGFR3) are responsible for their differentiation into lymphatic endothelial cells. (basicmedicalkey.com)
  • Our results indicate that reduced levels of proteins associated with foot processes and the glomerular slit diaphragm likely contribute, along with reduced levels of GBM collagens, to the nephropathy associated with NPS. (nih.gov)
  • Podoplanin is a Mr 38000 membrane mucoprotein that was originally detected on the surface of rat glomerular epithelial cells (podocytes) and was found to be linked to fl attening of foot processes that occur in glomerular diseases. (listarfish.it)
  • LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. (omicsdi.org)
  • Glomerular LOXL2 was localized to the cytoplasm of podocytes, as determined by double immunofluorescence microscopy using a podocyte marker (synaptopodin). (omicsdi.org)
  • Using antibodies to podocyte proteins important for podocyte function, we found that Lmx1b(-/-) podocytes express near-normal levels of nephrin, synaptopodin, ZO-1, alpha3 integrin, and GBM laminins. (nih.gov)
  • However, mRNA and protein levels for CD2AP and podocin were greatly reduced, suggesting a cooperative role for these molecules in foot process and slit diaphragm formation. (nih.gov)
  • In addition, the mRNA and protein expression levels of LOXL2 were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice. (omicsdi.org)
  • It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)
  • Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
  • Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene. (wikipedia.org)
  • This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. (wikipedia.org)
  • Here, we review mechanisms of mitochondrial gene expression with a focus on the recent findings in the field of mammalian mtDNA transcription and disease phenotypes caused by defects in proteins involved in this process. (biomed.news)
  • The homeobox gene PROX-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. (listarfish.it)
  • Human PROX-1 gene has been mapped to chromosome 1q32.2 - q32.3, and its product shows 94% similarity to the chicken protein. (listarfish.it)
  • The anterior intermediate mesoderm, which expresses LIM homeobox 1 ( Lhx1 ) and paired box gene 2 ( Pax2 ), develops into the ureteric bud lineage, which forms the ureteric epithelium through branching and growth. (j-organoid.org)
  • The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
  • PTEN also dephosphorylates Src homology 2-containing protein (Shc) directly, and inhibits the activation of Shc/Raf/ERK1/2 (extracellular signal-regulated kinase) signaling cascade. (biomedcentral.com)
  • Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • Viroporins compose a group of small hydrophobic transmembrane proteins that can form hydrophilic pores through lipid bilayers. (adenosine-receptor.com)
  • Thus, LMX1B regulates the expression of multiple podocyte genes critical for podocyte differentiation and function. (nih.gov)
  • This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK?2 human proximal tubular cells. (omicsdi.org)
  • Virus release from BSR cells is solely dependent on NS3 expression, whereas virus release from KC cells is strongly reduced by either lack of NS3, NS3a or both proteins. (adenosine-receptor.com)
  • The PDZ-binding domain (post-synaptic density protein (PSD95), Drosophila discs large (Dlg) and the tight junction protein zonula occludens-1 (ZO-1)) associates with the phosphatase activity, membrane association and stability of PTEN. (biomedcentral.com)
  • Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). (thermofisher.com)
  • Viroporins have been implicated in promoting virus release and in affecting cellular functions including protein trafficking and membrane per.S like BTV and AHSV. (adenosine-receptor.com)
  • Here, we show that Lmx1b(-/-) podocytes have reduced numbers of foot processes, are dysplastic, and lack typical slit diaphragms, indicating an arrest in development. (nih.gov)
  • did not observe CPE of BSR cells infected with BTVM14, which is similar to our mutAUG1 virus, and these authors have suggested a blockade in BTV replication late in infection, since all other viral processes were accomplished like protein translation, genome replication and assembly of viral cores. (adenosine-receptor.com)
  • Since virus release from insect cells occurs by budding, these results suggest that both proteins are FCCP site involved in budding, and thus also suggests a specific role for NS3a. (adenosine-receptor.com)
  • The standard vascular markers used in pathologic differential diagnosis of vascular conditions include von Willebrand factor (vWF), factor VIII-associated protein, platelet endothelial cell adhesion molecule-1 (CD31), human hematopoietic progenitor cell antigen (CD34), v- ets avian erythroblastosis virus E26 oncogene homolog (ERG), human herpes virus 8 (HHV-8), latency-associated nuclear antigen (LANA1), podoplanin (D2-40), and PROX1. (basicmedicalkey.com)
  • Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. (thermofisher.com)
  • In conclusion, mutAUG1+2 virus can still cause CPE, and we assume that CPE is the main mechanism of egress to the BTV NS3/NS3a Not Essential for Replication medium of BTV lacking NS3/NS3a protein. (adenosine-receptor.com)
  • This Mouse TGFB1 ELISA Kit was designed for the quantitative measurement of Mouse TGFB1 protein in serum, plasma, cell culture supernates. (cusabio.com)
  • Further research is needed to unravel the specific role of each of these non-structural proteins in virus release from insect cells. (adenosine-receptor.com)
  • Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
  • This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. (nih.gov)
  • The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. (nih.gov)
  • Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation. (nih.gov)
  • Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma. (nih.gov)
  • Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene. (wikipedia.org)
  • However, up-regulation of PTPN12 and miR-146b-3p mimic suppressed ERBB2 protein expression but induced its gene expression. (degruyter.com)
  • In a variety of organisms, SIRT1 regulates gene expression through the deacetylation of histone, transcription factors, and lysine residues of other modified proteins including several metabolic and endocrine signal transcription factors, thereby enhancing the therapeutic effects of endocrine and metabolic diseases. (ijbs.com)
  • In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. (nih.gov)
  • Although LMX1B is a developmental LIM-homeodomain transcription factor, it is expressed in post-natal life in the glomerular podocyte, suggesting a regulatory role in that cell. (nih.gov)
  • 1995 . Truncated WT1 mutants alter the subnuclear localization of the wild-type protein. (nih.gov)
  • GSK3β inhibition differentiates spheroids into segmented, nephron-like kidney organoids containing cell populations with characteristics of proximal tubules, podocytes and endothelium. (nature.com)