• Molecular pathological epidemiology (MPE, also molecular pathologic epidemiology) is a discipline combining epidemiology and pathology. (wikipedia.org)
  • Pathology and epidemiology share the same goal of elucidating etiology of disease, and MPE aims to achieve this goal at molecular, individual and population levels. (wikipedia.org)
  • Typically, MPE utilizes tissue pathology resources and data within existing epidemiology studies. (wikipedia.org)
  • Detailed disease endpoint phenotyping can be conducted by means of molecular pathology or surrogate histopathology or immunohistochemistry analysis of diseased tissues and cells within GWAS. (wikipedia.org)
  • As an alternative approach, potential risk variants identified by GWAS can be examined in combination with molecular pathology analysis on diseased tissues. (wikipedia.org)
  • Since molecular diagnostics is becoming routine clinical practice, molecular pathology data can aid epidemiologic research. (wikipedia.org)
  • The use of molecular pathology in epidemiology lacked standardized methodologies and guidelines as well as interdisciplinary experts and training programs. (wikipedia.org)
  • Causal inference Epidemiological method Epidemiology Evidence-based medicine Molecular diagnostics Molecular epidemiology Molecular medicine Molecular pathology Pathogenesis Pathology Personalized medicine Precision medicine Public health Systems biology Ogino S, Lochhead P, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT (June 2014). (wikipedia.org)
  • Cancer Epidemiology Biomarkers & Prevention, 20, 2362-2368. (scirp.org)
  • By reviewing biomarkers and breast cancer molecular subtypes, we propose that the divergent outcome observed from patients stratified by hormone status are driven by different cancer hallmarks. (jcancer.org)
  • Nuclear morphology of carcinoma cells is critical for the pathological diagnosis of papillary thyroid carcinoma (PTC). (bvsalud.org)
  • While TB diagnosis rests on at least one of the triad of mycobacterial culture, histopathology and suggestive clinical criteria, only culture offers an unequivocal result. (scielo.org.za)
  • Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
  • At this point, a pathological diagnosis should be performed immediately to determine the nature and source of the tumor. (spandidos-publications.com)
  • Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management. (nih.gov)
  • The epidemiology, microbiology, pathogenesis, diagnosis, and treatment of NTM infection, as well as infection due to rapidly growing mycobacteria and M. ulcerans , are discussed separately. (medilib.ir)
  • See "Epidemiology of nontuberculous mycobacterial infections" and "Microbiology of nontuberculous mycobacteria" and "Pathogenesis of nontuberculous mycobacterial infections" and "Diagnosis of nontuberculous mycobacterial infections of the lungs" and "Treatment of Mycobacterium avium complex pulmonary infection in adults" and "Rapidly growing mycobacterial infections: Mycobacteria abscessus, chelonae, and fortuitum" and "Buruli ulcer (Mycobacterium ulcerans infection)" . (medilib.ir)
  • Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. (medscape.com)
  • Histopathology revealed microfilariae in the testicular connective tissue and the epidydimal connective and fat tissues. (frontiersin.org)
  • Further investigation of their regulative roles and interaction may provide new insights into the pathological mechanisms and therapeutic targets for KBD. (nature.com)
  • It is generally recognized that exploring the underlying molecular mechanisms of HCC initiation and progression in order to search for functional molecular targets may provide a new approach for HCC treatment. (spandidos-publications.com)
  • See "Epidemiology of nontuberculous mycobacterial infections" . (medilib.ir)
  • This GWAS-MPE approach can give not only more precise effect estimates, even larger effects, for specific molecular subtypes of the disease, but also insights into pathogenesis by linking genetic variants to molecular pathologic signatures of disease. (wikipedia.org)
  • How many molecular subtypes? (wikipedia.org)
  • Surveillance, Epidemiology, and End Results Program. (medscape.com)
  • The data of the present study population were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. (hindawi.com)
  • A surveillance, epidemiology and end results (SEER) analysis of 54 patients reported a median overall survival of 48 months for those with distant disease [ 8 ]. (biomedcentral.com)
  • Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis. (nih.gov)
  • The International Molecular Pathological Epidemiology (MPE) Meeting Series, which was established in 2013, has been open to the research community around the world, and five meetings were held through 2021. (wikipedia.org)
  • These include possible molecular mimicry as some of these viruses contain antigens that were found to share immunogenicity with endothelial peptides. (statpearls.com)
  • citation needed] MPE began as analysis of risk factors (e.g., smoking) and molecular pathological findings (e.g. (wikipedia.org)
  • One of the important molecular/genetic findings is the presence of microsatellite instability (MSI) in CRCs. (wjgnet.com)
  • In this study, we tested the hypothesis that miR-378b is involved in the pathological outcome of Chlamydia infection. (cdc.gov)
  • The pathological mechanism of Kashin-Beck disease (KBD), an endemic osteoarthritic disease, remains to be poorly understood. (nature.com)
  • This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)
  • While the causes and pathological mechanism of the KBD and OA differ in many aspects. (nature.com)
  • This review will describe the clinical, histological, immunohistochemical and molecular aspects of the PUC, whose identification is essential for the correct management of patients. (biomedcentral.com)
  • En bloc-stained and resin-embedded specimens were prepared from surgically removed PTCs and normal thyroid tissues. (bvsalud.org)
  • Recent rapid declines in CRC incidence rates have largely been attributed to increases in screening that can detect and remove precancerous polyps, and the decrease in death rates for CRC largely reflects improvements in early detection, treatment and the understanding of molecular/genetic basis of CRC. (wjgnet.com)
  • In parallel, much progress has been made in the understanding of the molecular and genetic basis of CRC[ 2 - 4 ]. (wjgnet.com)
  • Molecular epidemiology broadly encompasses MPE and conventional-type molecular epidemiology with the use of traditional disease designation systems. (wikipedia.org)
  • Each patient has a unique disease process ("the unique disease principle"), considering the uniqueness of the exposome and its unique influence on molecular pathologic process. (wikipedia.org)
  • citation needed] Studies to examine the relationship between an exposure and molecular pathological signatures of disease (particularly, cancer) became increasingly common throughout the 1990s and early 2000s. (wikipedia.org)
  • Geography plays a prominent role in the epidemiology of NTM pulmonary disease. (medilib.ir)
  • This report describes the history of both epizootics including collection, quarantine and husbandry of rays, the disease epizootics, clinico-pathological features of the disease, antimicrobial therapy, autogenous vaccine production, and laboratory studies including clinical and histopathology, bacteriology, PCR, molecular serotyping and sequencing of the bacterium S. agalactiae. (qld.gov.au)
  • Recent knowledge on molecular aberrations in this disease have not yet impacted on therapeutic decisions. (biomedcentral.com)
  • Mutation testing by Caris molecular intelligence demonstrated a breast cancer 2 gene mutation and further treatment with carboplatin and veliparib achieved disease stabilisation. (biomedcentral.com)
  • Understanding of the molecular profile of rare tumours is key to improve therapeutic decision making and patient outcomes. (biomedcentral.com)
  • The importance of understanding the potential pathological implications of this high aspect ratio nanomaterial is increasing as new approaches to synthesize and purify in large scale are being developed. (cdc.gov)
  • A biopsy was taken from each patient with oral lesion after the surgical operation, then placed in 10% buffered formalin and sent to the laboratory for histopathology. (bvsalud.org)
  • In this study, we sought to assess the epidemiology of GC, its clinicopathological profiles, and its association with risk factors as well as to identify premalignant gastric lesions (PGL) and examine neoplastic progression. (mdpi.com)
  • The scope of the series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. (benthamscience.com)
  • In spite of recent advances in the biology and epidemiology of this nematode species, a relatively scant number of studies have focussed on the morphology of this parasite. (biomedcentral.com)
  • The current clinical guidelines and histopathology features are indicative of, but not reliable in diagnosing Lynch syndrome and CRCs with MSI. (wjgnet.com)
  • Define The Molecular And Cellular Bases Of Physiological Regulation And Cell Signaling. (uaeu.ac.ae)
  • Despite intense effort to elucidate the placental host/parasite interaction on the molecular level, the consequences of this placental iRBC sequestration on ST cell function have largely been ignored. (biomedcentral.com)
  • Se calcularon las data collection handling and frecuencias encontradas y los datos de los hallazgos más frecuentes fueron resumidas en metaanálisis usando el método de analysis, writing, revision. (bvsalud.org)
  • Due to its rare presentation, molecular analysis has been limited until more recently. (biomedcentral.com)
  • OEC can detect a number of pathological conditions that require management. (bvsalud.org)
  • Results: Out of 50 cases studied, histopathology showed the presence of: Oral squamous cell carcinoma OSCC (n = 28), leukoplakia (n = 8), dysplasia (n = 3), and benign normal lesions (n = 11). (bvsalud.org)
  • The paucity of information on some aspects of these factors prompted me to under this study In this project the epidemiology of protein energy malnutrition :was studied. (who.int)
  • The lost day showcases thought to learn firms think to the curve of ship, innovative that they include an troublesome l to molecular goal. (controlaltenergy.com)
  • A putative risk factor can be linked to specific molecular signatures. (wikipedia.org)
  • Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification. (nih.gov)
  • A total of 897 sheep suspected of being infected with TB and belonging to 23 flocks cohabiting with TB-infected cattle herds and/or goats were tested between 2009 and 2013 in Galicia (north-western Spain), using pathological, immunological and molecular techniques. (visavet.es)
  • Molecular identification techniques, including whole-genome sequencing, have identified approximately 200 NTM species. (medilib.ir)
  • Of these, 50.44% were positive by culture, 83.23% by histopathology and 24.92%, 4.86% and 59.42% by single intradermal tuberculin test (SITT), interferon-γ and ELISA, respectively. (visavet.es)