• promoters
  • Methods: Chromatin immunoprecipitation and microarray hybridization (ChIP-chip) was used to identify promoters enriched for histone H3 trimethylated on lysine 4 (H3K4me3) and lysine 27 (H3K27me3) in paired normal colon mucosa and tumor samples from two CRC patients and for the CRC cell line HT29. (diva-portal.org)
  • genes
  • Consistent with this, we find that the Rph1 mutation and a deletion of the histone H3 methylase Set2 affect the same target genes in opposite directions. (diva-portal.org)
  • cell
  • Histone H3.1 is assembled into chromatin during DNA replication, whereas deposition of histone H3.3 occurs throughout the cell cycle ( Ahmad and Henikoff, 2002 ). (biologists.org)
  • normal
  • In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples. (diva-portal.org)
  • Results: By comparing histone modification patterns in normal mucosa and tumors, we found that alterations predicted to have major functional consequences were quite rare. (diva-portal.org)