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  • nuclear
  • Degradation of IκBα exposes the nuclear localization sequence on NF-κB, allowing for translocation into the nucleus, where NF-κB can initiate gene transcription ( 17 ). (jimmunol.org)
  • binds
  • It is responsible for most of the cytoplasmic HAT activity in yeast, and it binds strongly to histone H4 by virtue of its association with an additional subunit, Hat2. (wikipedia.org)
  • For example, the viral oncoprotein El A binds to p300 and inhibits its activity, whereas phosphorylation of CBP by cyclin E/Cdk2 kinase activates its HAT activity. (allindianpatents.com)
  • The linker histone H1 binds the nucleosome at the entry and exit sites of the DNA, thus locking the DNA into place and allowing the formation of higher order structure. (wikipedia.org)
  • activators
  • The main object of the present invention is to obtain compounds of structural formula (1) as activators of histone acetyltransferases, containing ring A derived from substituted benzoic acid moiety and ring B is substituted anilide. (allindianpatents.com)
  • We previously identified a family of 3,5-disubstituted isoxazoles (Isx) by screening a chemical library in mouse pluripotent stem cells for activators of the gene encoding the homeodomain transcription factor, NK2 transcription factor-related, locus 5 (Nkx2.5) ( 21 ). (pnas.org)
  • lysine 16
  • Although preferentially cytosolic, SIRT2 transiently shuttles to the nucleus during the G2/M transition of the cell cycle, where it has a strong preference for histone H4 lysine 16 (H4K16Ac), thereby regulating chromosomal condensation during mitosis. (wikipedia.org)
  • canonical
  • All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. (wikipedia.org)
  • Histones are subdivided into canonical replication-dependent histones that are expressed during the S-phase of cell cycle and replication-independent histone variants, expressed during the whole cell cycle. (wikipedia.org)
  • complexes
  • In contrast with the negative cell-cycle regulation, p21 may also serve as an assembly factor for cyclin D-CDK4/6 complexes, thus promoting cyclin D-dependent events, and downstream activation of cyclin E-CDK2 [ 7 , 8 ]. (intechopen.com)
  • Thus, histone acetylation may simply be a by-product of anchoring the multi-functional HAT complexes to the target loci. (sigmaaldrich.com)
  • differentiation
  • The diversity of cell-specific NF-κB-mediated transcriptional programs is established at the chromatin level during cell differentiation by lineage-defining transcription factors. (frontiersin.org)
  • When committed to differentiation, those transcription programs designed for cellular proliferation are repressed, or uncontrolled division and malignancies may occur. (sigmaaldrich.com)
  • this transcription factor functions in neuronal and pancreatic β-cell differentiation and is essential for insulin gene transcription. (pnas.org)
  • Isx increased the expression and secretion of insulin in islets that made little insulin after prolonged ex vivo culture and increased expression of neurogenic differentiation 1 and other regulators of islet differentiation and insulin gene transcription. (pnas.org)
  • Among the most important of these transcription factors are neurogenic differentiation 1 (NeuroD1, also known as BETA2), pancreatic and duodenal homeobox 1 (PDX-1), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which activate the insulin gene promoter synergistically and are essential for glucose-stimulated insulin gene transcription. (pnas.org)
  • Expression of one or more of these factors helps promote differentiation of pancreatic endocrine cells from various stem cell populations ( 6 , 20 ). (pnas.org)
  • regulation
  • chronic myeloid leukemia PATH:ko05220 Histone acetylation plays an important role in the regulation of gene expression. (wikipedia.org)
  • Recent data are accumulating about the roles of diverse histone variants highlighting the functional links between variants and the delicate regulation of organism development. (wikipedia.org)