• binds
  • It is responsible for most of the cytoplasmic HAT activity in yeast, and it binds strongly to histone H4 by virtue of its association with an additional subunit, Hat2. (wikipedia.org)
  • For example, the viral oncoprotein El A binds to p300 and inhibits its activity, whereas phosphorylation of CBP by cyclin E/Cdk2 kinase activates its HAT activity. (allindianpatents.com)
  • The linker histone H1 binds the nucleosome at the entry and exit sites of the DNA, thus locking the DNA into place and allowing the formation of higher order structure. (wikipedia.org)
  • nuclear
  • Degradation of IκBα exposes the nuclear localization sequence on NF-κB, allowing for translocation into the nucleus, where NF-κB can initiate gene transcription ( 17 ). (jimmunol.org)
  • protein
  • Among the many factors involved in these defense processes against DNA damage, p21 CDKN1A protein - known also as p21 (WAF1/CIP1/SDI1) - plays a key role in several fundamental biological processes, such as cell cycle control, DNA replication/repair, gene transcription, apoptosis, and cell motility [ 3 - 6 ]. (intechopen.com)
  • Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation. (proteopedia.org)
  • The mammalian FOXO family of forkhead transcription factors, Foxo1 (also known as FKHR), Foxo3a (also known as FKHRL1), and Foxo4 (also known as AFX) plays a key role in transmitting insulin signaling downstream of protein kinase B (also called Akt). (pnas.org)
  • p3×IRS-MLP-luc was generated by inserting three copies of the insulin-response sequence derived from the insulin-like growth factor-binding protein 1 promoter into the luciferase reporter gene vector containing an adenovirus major late promoter. (pnas.org)
  • lysine 16
  • Although preferentially cytosolic, SIRT2 transiently shuttles to the nucleus during the G2/M transition of the cell cycle, where it has a strong preference for histone H4 lysine 16 (H4K16Ac), thereby regulating chromosomal condensation during mitosis. (wikipedia.org)
  • ubiquitination
  • These findings demonstrated that acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 and established acetylation as a novel regulatory mechanism that functions in concert with Keap1-mediated ubiquitination in modulating the Nrf2-dependent antioxidant response. (pubmedcentralcanada.ca)
  • canonical
  • All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. (wikipedia.org)
  • Histones are subdivided into canonical replication-dependent histones that are expressed during the S-phase of cell cycle and replication-independent histone variants, expressed during the whole cell cycle. (wikipedia.org)