• PRC2
  • This transcriptionally repressive state is thought to be due to PRC2/EZH2-EED-mediated H3K27 methylation and subsequent recruitment of PRC1 which facilitates condensation of chromatin and formation of heterochromatin. (wikipedia.org)
  • the PcG repressive complex 1 (PRC1) and the PcG repressive complex 2-4 (PRC2/3/4). (wikipedia.org)
  • mitosis
  • The primary functions of chromatin are 1) to package DNA into a more compact, denser shape, 2) to reinforce the DNA macromolecule to allow mitosis, 3) to prevent DNA damage, and 4) to control gene expression and DNA replication. (wikipedia.org)
  • typically
  • Complex multicellular organisms typically have a higher number of histone variants providing a variety of different functions. (wikipedia.org)
  • chromosomes
  • Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA). (wikipedia.org)
  • regulation
  • Recent data are accumulating about the roles of diverse histone variants highlighting the functional links between variants and the delicate regulation of organism development. (wikipedia.org)
  • organisms
  • Histone variants from different organisms, their classification and variant specific features can be found in "HistoneDB 2.0 - Variants" database. (wikipedia.org)
  • Histone variants from different organisms, their classification and variant specific features can be found in "HistoneDB - with Variants" database. (wikipedia.org)
  • enzyme
  • A key verified target gene encodes the enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (PTEN). (wikipedia.org)