EosinophilsMacrophagesMyeloperoxidase activityLymphocytesInflammationLamina propriaCellular infiltrationHematoxylin and eosinDendriticTissueBronchoalveolar lavageCytokinesNecrosisRecruitmentMediatorsInflammatory cellTissuesMacrophageSquamousCytologyMiceHepaticCharacteristicMicroenvironmentInnateLesionsNeutrophilicImmuneCellsCountsLeukocytesSignificantlyCellLung injurySmallBrainExpressionDisease
Eosinophils6
- The skin eruptions are often pruritic and accompanied by fever, headache, a high number of neutrophils and eosinophils in the blood, and elevated blood levels of markers for inflammation (i.e. erythrocyte sedimentation rate and C-reactive protein). (wikipedia.org)
- B ) Muzzle skin was digested and analyzed via FACS for Siglec F + eosinophils (left panels), Ly- 6G + neutrophils (middle panels), Ly-6C + MHC-II lo monocytes and Ly-6C + MHC-II hi monocyte-derived dendritic cells (right panels). (elifesciences.org)
- Lungs from the exposed groups were inflamed as indicated by recruitment of neutrophils in all three exposed groups and eosinophils and an increase in numbers of airway epithelial goblet cells in 5- and 20-day exposure groups. (biomedcentral.com)
- For the differential cell counts of macrophages, neutrophils, eosinophils, and lymphocytes, the cells were cytospun onto a glass slide and stained with Diff-Quik, and cell types in a total of 200 cells were identified by morphologic criteria. (estme.org)
- Furthermore, the suppression was associated with a significant decrease in the production of Th2 cytokines, such as IL-4, IL-5, and IL-13, and a reduction in the number of total cells, including eosinophils, macrophages, and neutrophils in the airway. (blogspot.com)
- In particular, the inflammatory response leads to injury of epithelial/endothelial cells and enhances the release of inflammatory mediators, including chemokines, cytokines and inflammatory cells (mainly neutrophils and macrophages , but also eosinophils , basophils, mast cells). (omicsonline.org)
Macrophages2
- Aberrant activation of macrophages and neutrophils has been reported to lead to excessive activation of innate immunological pathways. (life-science-alliance.org)
- As the disease progresses, there is recruitment of leukocytes, including neutrophils and macrophages, which in turn express pro-inflammatory mediators, including the cytokines interleukin (IL)-1β, IL-6, TNFα, and IFN-I, and the chemokine CXCL10 ( Han et al, 2020 ). (life-science-alliance.org)
Myeloperoxidase activity2
- These adjustments correlated with reduces in neutrophil infiltration in the lung, evidenced by reduces in Gr-1-stained cells and myeloperoxidase activity and improved lung histology. (woofahs.com)
- Unlike in WT or TLR2-deficient mice, disruption/absence of TLR4 pathway reduced IRI, as manifested by liver function (serum alanine aminotransferase levels), histology (Suzuki's scores), neutrophil infiltration (myeloperoxidase activity) and local/systemic TNF-α production (mRNA/protein levels). (houstonmethodist.org)
Lymphocytes4
- B) Airway: bronchioles with neutrophils in the lumen, also lymphocytes around the airway and vessel. (cdc.gov)
- The inflammation is caused by the infiltrations of lymphocytes, plasma cells, and in this case neutrophils, into the lamina propria of the stomach and/or small intestine. (clarius.com)
- The disease may become more chronic and the originally pure neutrophilic inflammation may then become a mixed inflammatory cell inflammation with neutrophils, plasma cells and lymphocytes. (vin.com)
- Lymphocytic cholangitis is characterized by infiltration of the portal tracts with small lymphocytes. (vin.com)
Inflammation6
- In a recent study [ 9 ] it was indicated for the first time that among various mediators involved in the inflammation-driven differentiation of fibroblast to an activated myofibroblast, a main architect is the neutrophil, a cell whose role in fibrosis was obscure up to now. (omicsonline.org)
- We assessed selleckchem tissue inflammation by detecting neutrophil infiltration and by measuring proinflammatory mRNA up-regulation. (hormonessignaling.com)
- Histology slides stained with hematoxylin and eosin (H&E) were evaluated for the intensity of inflammation by observing the density of inflammatory cells and graded 1 to 4 (1- light inflammation, 4 - severe inflammation). (pan.pl)
- This is an inflammation of the biliary tree (intra- and extrahepatic bile ducts and the gall bladder) characterized by presence of neutrophils in the bile, but often also within the epithelial cells lining the bile ducts. (vin.com)
- Toluene diisocyanate (TDI) is a chemical that is widely used inflammation was assessed by bronchoalveolar lavage and histology. (cdc.gov)
- 2001 and 2002) used TDI and reported mild inflammation neutrophils. (cdc.gov)
Lamina propria1
- After end of the study, rats were sacrificed and examined for nasal sinuses and lamina propria histology. (ijpsonline.com)
Cellular infiltration2
- Skin histology examination showed cutaneous and subcutaneous fibrinoid necrosis with bleeding, abscess, neutrophil-rich cellular infiltration, and the presence of PAS-, Grocott- and mucin-positive spores. (medihelp.life)
- For general morphology, tissue sections were stained with hematoxylin and eosin (H&E). The extent of cellular infiltration in the bronchovascular bundles was assessed in a blinded manner. (estme.org)
Hematoxylin and eosin1
- Liver injury was assessed by serum transaminase levels (ALT) and liver histology (hematoxylin and eosin). (wjgnet.com)
Dendritic2
- Significant differences across cancer types for GSK-3B-mutated tumors were observed for B cells (p=0.018), monocytes (p=0.002), dendritic cells (p=0.005), neutrophils (p=0.0003), and endothelial cells(p=0.014). (providence.org)
- APOE level was significantly correlated with tumor-infiltrating cells (B cells, CD8+ T cells, neutrophils, and dendritic) and immune biomarkers in PTC. (jcancer.org)
Tissue12
- Studies have clearly shown that tissue neutrophil numbers need to be tightly regulated for optimal CDI outcomes: while excessive colonic neutrophilia is associated with severe CDI, neutrophil depletion also results in worse outcomes. (frontiersin.org)
- C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
- We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
- RR genotype) was associated with higher CXCR2 expression and more tissue neutrophils. (frontiersin.org)
- and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
- In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
- However, despite a key role for neutrophils in disease pathogenesis, the underlying biological mechanisms that regulate systemic and tissue neutrophil numbers after CDI remain poorly defined. (frontiersin.org)
- AGEP therefore differs from the other SCARs disorders in that it involves the tissue-injuring action of inappropriately activated neutrophils and the excessive production of cytokines which stimulate production of, recruit to tissues, and/or activation of neutrophils (Interleukin 8, Interleukin 17, GM-CSF) and promote innate immune and autoimmune responses (Interleukin 22). (wikipedia.org)
- The following indices were evaluated: fluid requirements for resuscitation, liver injury tests, liver tissue myeloperoxidase, and liver histology. (nebraska.edu)
- 0.05) in tests demonstrating hepatic injury, myeloperoxidase in hepatic tissue, and histology studies. (nebraska.edu)
- Pancreas tissue samples were collected at 6, 10, and 14 hours after perfusion and cold preserved for histology and immunohistochemistry examination, P-selection (PS) and ICAM-1 were determined. (gastrores.org)
- Several animal models of allograft rejection exhibit monocyte and macrophage infiltration in allograft tissue [ 13 - 17 ], and these cells have a central role in human chronic allograft damage [ 18 , 19 ]. (hindawi.com)
Bronchoalveolar lavage1
- Measurements and main results: Three days after paraquat injection, every rat was ventilated for 90 min, a static pressure-volume curve and bronchoalveolar lavage were performed and postmortem histology was examined. (tmu.edu.tw)
Cytokines1
- The infiltration of immune cells, such as Th2 cytokines in the lungs, and the lung histology, were assessed in the OVA-challenged mice in the presence and absence of an intratracheal administration of bvPLA2. (blogspot.com)
Necrosis3
- During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. (mdpi.com)
- Small intestine histology assessed 24 hours after 60 minutes hepatic IR in H&E-stained sections demonstrated villous endothelial cell apoptosis (Fig. 6B, magnified insert), villous epithelial cell necrosis, and the development of a necrotic epithelial pannus over the mucosal surface. (hormonessignaling.com)
- Sixty minutes of hepatic ischemia resulted in significant recruitment of neutrophils into the liver, kidney, and intestine in IL-17A wildtype mice (Supporting Fig. Arachidonate 15-lipoxygenase 2A-C). Neutrophil infiltration coincided with areas of liver necrosis. (hormonessignaling.com)
Recruitment1
- Additionally, CB2R-deficiency led to increased neutrophil recruitment, decreased neutrophil activation, and decreased p38 activity at the site of infection. (aai.org)
Mediators1
- Conclusions Administration of C75 after hemorrhage and resuscitation reduced the upsurge in serum FFA, reduced markers of cells damage, downregulated the manifestation of inflammatory mediators, and reduced neutrophil infiltration and lung damage. (woofahs.com)
Inflammatory cell1
- Surfactant with methylprednisolone pretreatment decreases inflammatory cell infiltration, but cannot further improve oxygenation and lung histology. (tmu.edu.tw)
Tissues3
- Histology The lung tissues were excised, and the left lung was fixed and stained as described previously (16). (estme.org)
- Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. (hindawi.com)
- At 6 and 12 months post implantation the prostheses were removed and tissues samples were examined using 2 methods: histology and immunohistochemistry (IHC). (pan.pl)
Macrophage1
- Surfactant with methylprednisolone pretreatment significantly decreased total cell, macrophage and neutrophil counts when compared with the surfactant group. (tmu.edu.tw)
Squamous1
- Uterine endometrioid carcinoma was the most commonly mutated (4%) tumor, and copy number variations (CNVs) were most commonly observed in squamous histologies. (providence.org)
Cytology1
- Cytology reveals the presence of neutrophils, whereas normal bile contains no cells whatsoever. (vin.com)
Mice1
- In mice undergoing moderate-intensity exercise, BAL total cells and neutrophils decreased in response to 45 or 90 min of exercise. (bvsalud.org)
Hepatic1
- Background: Neutrophil infiltration is a characteristic feature of the hepatic injury associated with prolonged hypotension. (nebraska.edu)
Characteristic2
- EBVaGC has characteristic clinicopathological features, including predominance among males, a proximal location in the stomach, lymphoepithelioma-like histology and a favorable prognosis. (spandidos-publications.com)
- In 1990, Burke et al ( 3 ), first reported the association between EBV and gastric carcinoma with characteristic lymphoepithelioma-like histology based on polymerase chain reaction (PCR) techniques. (spandidos-publications.com)
Microenvironment1
- Overall, GSK-3B molecular alterations were detected in approximately 1% of solid tumors, tumors with GSK-3B mutations displayed a microenvironment with increased infiltration of B cells, and GSK-3B mutations were associated with increased PD-L1 expression in selected histologies. (providence.org)
Innate1
- Neutrophils are key first-responders in the innate immune response to C. difficile infection (CDI) and play a central role in disease pathogenesis. (frontiersin.org)
Lesions1
- Patients with vegetating lesions and pemphigus vegetans-like histology are classified as IgA pemphigus vegetans (IgA-PVeg). (medscape.com)
Neutrophilic1
- Histopathologically, epidermal acantholysis and neutrophil infiltration predominate, hence the synonyms intraepidermal neutrophilic (IEN) IgA dermatosis, intraepidermal IgA pustulosis, IgA herpetiform pemphigus, and intercellular IgA vesiculopustular dermatosis have been used to describe this group of diseases. (medscape.com)
Immune1
- APOE is a potential independent biomarker for PTC and APOE expression is positively correlated with immune cell infiltration in PTC. (jcancer.org)
Cells1
- Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). (bvsalud.org)
Counts1
- Treatment with surfactant resulted in a significant decrease in total cell and neutrophil counts relative to the control group. (tmu.edu.tw)
Leukocytes1
- Type 1 interferons (IFNs) have been shown to protect rodents from ischemic stroke brain injury through reducing the infiltration of leukocytes to the ischemic brain. (ashpublications.org)
Significantly2
- The count of neutrophils was reduced significantly in test group compared with control along absence of eosinophil. (ijpsonline.com)
- Neutralization of IL-17A, deficiency in IL-17A receptor or IL-17A significantly reduced neutrophil infiltration in all three organs. (hormonessignaling.com)
Cell2
- Degeneration: degenerative neutrophils and necrotic cell debris. (cdc.gov)
- Previous work has already stressed the important contribution of neutrophil-endothelial cell interactions in the organ injury seen after hemorrhagic shock. (nebraska.edu)
Lung injury1
- Objective: To investigate whether exogenous surfactant would improve gas exchange and lung histology and methylprednisolone pretreatment would enhance the surfactant effect in a rat model of paraquat-induced lung injury. (tmu.edu.tw)
Small1
- Immature neutrophils are small, the care but be trumped by 1 or emotional trauma. (iidmt.com)
Brain1
- G) Brain of gp91/ mouse infected with CSF strain: meningeal thickening and histiocyte infiltration-histiocytic meningitis. (cdc.gov)
Expression1
- Here, we investigated the biological mechanisms that regulate neutrophil CXCR2 expression after CDI, and the influence of host genetics on this process. (frontiersin.org)
Disease1
- Neutrophils in ATBF are a notable component of the host reaction, per- conorii , with respect to the pattern of inflammatory reac- haps because ATBF is a milder disease than the other rick- tion. (cdc.gov)