• kinase
  • Distinct from other classes of protein kinases, HKs are usually parts of a two-component signal transduction mechanisms in which HK transfers a phosphate group from ATP to a histidine residue within the kinase, and then to an aspartate residue on the receiver domain of a response regulator protein (or sometimes on the kinase itself). (wikipedia.org)
  • The mechanism for the reactions catalyzed by histidine kinase have not been completely elucidated, but current evidence suggests that the catalytic domain of one dimeric unit may rotate in such a way that the ATP binding pocket of that unit can come into contact with a particular histidine residue on the opposite unit and a nucleophilic addition results in a phosphorylated histidine. (wikipedia.org)
  • These proteins possess a phosphorylatable histidine residue and are responsible for transferring a phosphoryl group from an aspartate residue on an intermediate "receiver" domain, typically part of a hybrid histidine kinase, to an aspartate on a final response regulator. (wikipedia.org)
  • In orthodox two-component signaling, a histidine kinase protein autophosphorylates on a histidine residue in response to an extracellular signal, and the phosphoryl group is subsequently transferred to an aspartate protein on the receiver domain of a response regulator. (wikipedia.org)
  • In phosphorelays, the "hybrid" histidine kinase contains an internal aspartate-containing receiver domain to which the phosphoryl group is transferred, after which an HPt protein containing a phosphorylatable histidine receives the phosphoryl group and finally transfers it to the response regulator. (wikipedia.org)
  • In some cases, a phosphorelay system is constructed from four separate proteins rather than a hybrid histidine kinase with an internal receiver domain, and in other examples both the receiver and the HPt domains are present in the histidine kinase polypeptide chain. (wikipedia.org)
  • examples include a bifurcated pathway with multiple downstream outputs, as in the case of the Caulobacter crescentus ChpT HPt involved in cell cycle regulation, or, alternatively, pathways in which more than one histidine kinase controls a single response regulator, such as the sporulation pathway in Bacillus subtilis, which can give rise to complex temporal variations. (wikipedia.org)
  • Relative to the number of histidine kinase and response regulators present in a genome, eukaryotes that have more identifiable HPt domains than bacteria. (wikipedia.org)
  • Other names in common use include ATP:protein-L-histidine N-tele-phosphotransferase, histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK3. (wikipedia.org)
  • proteins
  • This turns out to be an important property when histidine is incorporated into proteins , particularly when it becomes a part of the primary structure of some enzymes . (encyclopedia.com)
  • I think if someone is living a strict vegan lifestyle and not consuming complete proteins (or loads of rice, wheat and rye) then l-histidine supplementation may be beneficial when taking beta alanine for performance. (anabolicminds.com)
  • Humans and other animals must ingest histidine or histidine-containing proteins. (wikipedia.org)
  • Histidine kinases (HK) are multifunctional, and in non-animal kingdoms, typically transmembrane, proteins of the transferase class of enzymes that play a role in signal transduction across the cellular membrane. (wikipedia.org)
  • In marked contrast to Ser, Thr and Tyr phosphorylation, the analysis of phosphorylated Histidine using standard biochemical and mass spectrometric approaches is much more challenging, and special procedures and separation techniques are required for their preservation alongside classical Ser, Thr and Tyr phosphorylation on proteins isolated from human cells. (wikipedia.org)
  • The histidine phosphotransfer function can be carried out by proteins with at least two different architectures, both composed of a four-helix bundle but differing in the way the bundle is assembled. (wikipedia.org)
  • peptide
  • In short, I think that the answer to your question has to vary depending on the peptide fragment and one cannot always assume that free histidine binds better. (bio.net)
  • Alanine/Histidine/Lysine Polypeptide Copper HCl is a copper derivative of a peptide derivedfrom alanine, histidine, and lysine. (ewg.org)
  • enzymes
  • Histidine-tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. (wikipedia.org)
  • hydrochloride
  • What is histidine hydrochloride? (answers.com)
  • Histidine hydrochloride carries the IUPAC name of Histidine or His. (answers.com)
  • HTK solution is based on the principle of inactivating organ function by withdrawal of extracellular sodium and calcium, together with intensive buffering of the extracellular space by means of histidine/histidine hydrochloride, so as to prolong the period during which the organs will tolerate interruption of oxygenated blood. (wikipedia.org)
  • supplementation
  • Plasma amino-acid concentration, plasma iron, serum transferrin, packed cell volume, and reticulocyte count were all measured before and after two months of histidine supplementation. (bmj.com)
  • Reticulocyte counts fell after two months of histidine supplementation. (bmj.com)
  • polypeptide
  • The primary structure of human HRG is predicted to be a 507 amino acid multidomain polypeptide consisting of two cystatin-like regions at the N-terminus, a histidine-rich region (HRR) flanked by proline-rich regions (PRR), and a C-terminal domain. (wikipedia.org)
  • catalytic
  • In catalytic triads, the basic nitrogen of histidine is used to abstract a proton from serine, threonine, or cysteine to activate it as a nucleophile. (wikipedia.org)
  • concentration
  • The treatment raised the plasma histidine concentration and at the same time there was a rise in transferrin and iron levels and packed cell volume. (bmj.com)
  • functional
  • As Carnosine is a multi-functional dipeptide made up of Beta-Alanine and L-Histidine, though, I would like to know if you would add L-Histidine to Carnage any time in the future, or if you think Carnage provides adequate intra-muscular Carnosine as-is, without L-Histidine. (anabolicminds.com)
  • D-Fructose-L-histidine (FruHis) is a ketosamine combining the D-isomer of fructose and the L-isomer of histidine into a functional group. (wikipedia.org)
  • Domain
  • Histidine Ammonia-Lyase at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • acid
  • Histidine is an amino acid used for rheumatoid arthritis, ulcers and anemia caused by kidney failure. (answers.com)
  • It has the ability to switch between protonated and unprotonated states, which allows histidine to participate in acid-base catalysis. (wikipedia.org)
  • Histidase converts histidine into ammonia and urocanic acid. (wikipedia.org)
  • The osmolarity of HTK is 310 mOsm/L. Sodium: 15 mmol/L Potassium: 9 mmol/L Magnesium: 4 mmol/L Calcium: 0.015 mmol/L Ketoglutarate/glutamic acid: 1 mmol/L Histidine: 198 mmol/L Mannitol: 30 mmol/L Tryptophan: 2 mmol/L Biostasis Organ transplant 1. (wikipedia.org)
  • HUMAN
  • Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation - a prospective multi-centre observation study. (wikipedia.org)
  • group
  • A group of 28 uraemic patients on dialysis treatment were given daily supplements of histidine by mouth. (bmj.com)