• high histamine
  • At this point, my only known triggers for MCAS are high histamine foods and foods that are histamine-releasing, including fermented foods and foods/drinks that have added sulfites. (thepatientceliac.com)
  • Please see my previous post " Celiac Disease and Multiple Food Intolerances " from July 2013 for more details on food triggers and high histamine foods. (thepatientceliac.com)
  • Common triggers include: specific foods and drinks (especially alcohol, and high-histamine content foods) temperature extremes airborne smells including perfumes or smoke exercise or exertion emotional stress hormonal changes, particularly during adolescence, pregnancy and women's menstrual cycles There are no known causes, but the condition appears to be inherited in some patients. (wikipedia.org)
  • eosinophils
  • In normal individuals, eosinophils make up about 1-3% of white blood cells, and are about 12-17 micrometres in size with bilobed nuclei. (wikipedia.org)
  • When eosinophils are activated, they undergo cytolysis, where the breaking of the cell releases eosinophilic granules found in extracellular DNA traps. (wikipedia.org)
  • C3a is also able to play a role in chemotaxis for mast cells and eosinophils, but C5a is a more potent chemoattractant. (wikipedia.org)
  • In both eosinophils and mast cells, Siglec-8 is expressed late in development. (wikipedia.org)
  • In addition, baboon eosinophils as well as monocytes, a subset of lymphocytes, and neutrophils express on their cell surface a protein or proteins that are recognized by polyclonal human Siglec-8-specific antibody, consistent with genetic analyses indicating the existence of a Siglec-8 ortholog in this species. (wikipedia.org)
  • allergy
  • Seneviratne has also been appointed as the Director of Centre for Mast Cell Disorders and as the President of the UK-Sri Lanka Immunology Foundation, an organisation that contributes towards the Immunology and Allergy education in Sri Lanka. (wikipedia.org)
  • chronic
  • I tried a basic low histamine diet, based on information from the International Chronic Urticaria Society and written by histamine researcher Dr Janice Joneja because I was having anaphylactic reactions every time I ate. (wordpress.com)
  • The mechanism of chronic mast cell activation in asthma is unclear. (le.ac.uk)
  • PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. (wikipedia.org)
  • In chronic granulomatous pain and inflammation model, PEA could prevent nerve formation and sprouting, mechanical allodynia, and PEA inhibited dorsal root ganglia activation, which is a hallmark for winding up in neuropathic pain. (wikipedia.org)
  • gastric
  • Another possible mechanism for the development for peptic ulcer is increased histamine release and gastric hyperacidity related with polycythemia vera. (wikipedia.org)
  • release
  • In this study it was investigated whether monomeric IgE induces Ca2+ influx and mediator release from human lung mast cells (HLMC). (le.ac.uk)
  • At concentrations experienced in vivo, monomeric IgE induced dose-dependent histamine release, LTC4 production and IL-8 synthesis. (le.ac.uk)
  • Enhanced histamine release was still evident 1 week after initial exposure to IgE suggesting that continued exposure maintains enhanced secretion. (le.ac.uk)
  • A classic symptom of polycythemia vera is pruritus or itching, particularly after exposure to warm water (such as when taking a bath), which may be due to abnormal histamine release or prostaglandin production. (wikipedia.org)
  • The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF. (wikipedia.org)
  • precursors
  • In mast cells generated from CD34+ precursors, Siglec-8 expression peaks at 4 weeks of differentiation, in parallel with FcεRIα surface expression. (wikipedia.org)
  • induces
  • In addition, there is evidence that MSH induces mast-cell apoptosis (cell death). (jillcarnahan.com)
  • This activation induces a conformational change in the thioester domain of C3(H2O) that allows it to bind to a plasma protein called Factor B. This complex is then cleaved by Factor D, a serine protease, to form C3b(H2O)Bb, or fluid-phase C3-convertase. (wikipedia.org)
  • surrounding blood vessels
  • Mast cells are present in most tissues characteristically surrounding blood vessels and nerves, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose. (wikipedia.org)
  • hematopoietic
  • The "clone" in clonal mast cell disorders refers to the progeny of the hematopoietic progenitor carrying the D816V c-kit mutation. (endocrinologyadvisor.com)
  • SCF may serve as guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in which a stem cell resides), and it plays an important role in HSC maintenance. (wikipedia.org)
  • SCF also increases the survival of various hematopoietic progenitor cells, such as megakaryocyte progenitors, in vitro. (wikipedia.org)
  • Hematopoietic progenitor cells have also been shown to migrate towards a higher concentration gradient of SCF in vitro, which suggests that SCF is involved in chemotaxis for these cells. (wikipedia.org)
  • tissues
  • Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the liver, spleen and lymph nodes, and organs which have normal populations but numbers are increased. (wikipedia.org)
  • activate
  • Significant increases can be seen in people with a severe allergic reaction and in those with a disorder in which the number of mast cells increase (proliferate) and/or activate without apparent allergies. (labtestsonline.org)
  • It appears that binding of two or more IgE molecules (cross-linking) is required to activate the mast cell. (wikipedia.org)
  • In consequence, complexes dissociate into Gαi, Gα12, Gs and Gβγ components which proceed to activate cell signaling pathways that lead functional responses viz. (wikipedia.org)
  • pathways that activate phospholipase C to convert cellular phospholipids to diacylglycerol which promotes the activation of certain isoforms of protein kinase C, pathways that elevated cellular cytosolic Ca2+ which thereby regulate Ca2+-sensitive cell signaling molecules, and pathways that inhibit adenyl cyclase which thereby lowers cellular levels of cyclic adenosine monophosphate (cAMP) to reduce the activity of cAMP-dependent signaling molecules. (wikipedia.org)