Hippocampus translocation proteins expressed sequence tags. Medical search. Frequent questions

A possible hypothesis is that the PINK1 protein is exported from neurons to glia, as has already been demonstrated for α-synuclein. (medscape.com)
We used the inositol 1,4,5-trisphosphate (IP 3 ) biosensor, the pleckstrin homology (PH) domain of PLCδ1 (phospholipase C) tagged with enhanced green fluorescent protein (eGFP-PH PLCδ ), to examine muscarinic acetylcholine (mACh) receptor regulation of phospholipase C/IP 3 signaling in intact single hippocampal neurons in "real time. (jneurosci.org)
however, we still know relatively little about whether GPCRs, endogenously expressed in neurons, are regulated by GRK-dependent mechanisms. (jneurosci.org)
Projection neuron subtype identities in the cerebral cortex are established by expressing pan-cortical and subtype-specific effector genes that execute terminal differentiation programs bestowing neurons with a glutamatergic neuron phenotype and subtype-specific morphology, physiology, and axonal projections. (stanford.edu)
In the adult, there are neuronal precursors that are always forming new neurons, especially in olfactory structures and hippocampus. (nih.gov)

One of the major findings from his group was proving the importance of synaptic protein degradation in memory reorganization. (wikipedia.org)
Recently, in collaboration with M.G. Lee and E. Kim, he has demonstrated that NMDAR-dependent synaptic plasticity in the hippocampus is impaired in a mouse model of autism, the Shank2 knockout. (wikipedia.org)
There is substantial evidence for an M 1 mACh receptor population in the hippocampus and in particular a potential role of this GPCR subtype in mechanisms underlying longer-term regulation of synaptic function. (jneurosci.org)
Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. (elifesciences.org)
We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. (elifesciences.org)
Furthermore, the absence of translin/trax abolishes synaptic upregulation of ACVR1C protein after learning. (elifesciences.org)
Finally, synaptic tagging and long-term memory deficits in mice lacking translin/trax are mimicked by ACVR1C inhibition. (elifesciences.org)
Therefore, identification of the molecular pathways linking synaptic activation to local translation of key plasticity proteins is a top priority as it promises to yield valuable insights into the etiology of and treatment for these debilitating disorders. (elifesciences.org)
However, the mechanism linking synaptic stimulation or learning to microRNA-mediated expression of key plasticity proteins remains elusive. (elifesciences.org)
Therefore, translin/trax is ideally positioned to link synaptic activity to the synthesis of plasticity proteins at activated synapses. (elifesciences.org)
At this stage, we noted a loss of synaptic vesicle proteins and active zone components, delayed synapse maturation, reduced evoked and spontaneous excitatory junctional potentials, increased synaptic fatigue, and cytoskeleton rearrangements. (bvsalud.org)
Tissue and gene enrichment assays showed that the genes that were over-expressed in the CNS were related to functions including neurodevelopment, histone methylation, neurogenesis and synaptic modification. (pharmaceuticalintelligence.com)

Although it is believed that mutations in genes and proteins cause Alzheimer's disease and other neurological disorders, it is still unclear why these mutations cause severe symptoms. (waseda.jp)
Within this single brain, signal recognition particle (SRP)-dependent cotranslational protein targeting genes, which encode primarily cytosolic ribosome proteins, are highly expressed in the hypometabolic regions. (eneuro.org)
These genes suggest disruption of the protein life cycle and neuroimmune activation. (eneuro.org)

Ubiquitin is then covalently attached to a lysine residue on the target protein by an E3 ubiquitin ligase (E3) and this process can be repeated to create a series of ubiquitin chains ( Hershko and Ciechanover, 1998 ). (frontiersin.org)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)

Receptor phosphorylation may attenuate signaling per se and/or may facilitate recruitment of arrestin proteins ( Krupnick and Benovic, 1998 ). (jneurosci.org)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Protein ubiquitination is a posttranslational modification that involves the covalent tethering of a small 76 amino acid protein called ubiquitin to target proteins ( Hershko and Ciechanover, 1998 ). (frontiersin.org)

Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)

He started by establishing an expressed sequence tag database and transcriptome analyses of Aplysia. (wikipedia.org)
Recently, we compared the difference in chromatin accessibility and gene expression profiles between wild-type (p53+/+) and p53 deficient (p53-/-) mouse SSCs using the Assay for Targeting Accessible-Chromatin with high-throughput sequencing (ATAC-seq) and transcriptome sequencing (RNA-seq) techniques, and revealed that SMAD3 is a key transcription factor in the transformation of SSCs into pluripotent cells. (bvsalud.org)

Neuronal G-protein-coupled receptors (GPCRs) play important roles in many aspects of brain function. (jneurosci.org)

Confocal imaging and 3D reconstruction analyses for detecting the protein expression and subcellular localization of microglia in vivo. (thno.org)
Here, by integrated analyses using single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and single-cell assay for transposase accessible chromatin sequencing (scATAC-seq) techniques, we uncovered the spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium. (bvsalud.org)

[ 32 ] Amino acid changes have also been inserted in these constructs, representing either missense or truncating mutations previously reported in parkinsonian patients or changes within key domains predicted to abolish the kinase activity of the protein. (medscape.com)
Mutations in KRIT1, a protein initially identified based on a yeast two-hybrid interaction with the RAS-family GTPase RAP1A, are responsible for the development of the inherited vascular disorder cerebral cavernous malformations (CCM1). (nih.gov)

Objective: In this study, we examined the protein expression profiles in the rat cerebellum and hippocampus following developmental exposure to a commercial PBDE mixture, DE-71. (nih.gov)
Proteins from the cerebellum and hippocampus were extracted, expression differences were detected by two-dimensional difference gel electrophoresis, and proteins were identified by tandem mass spectrometry. (nih.gov)
Results: Four proteins were significantly differentially expressed in the cerebellum following DE-71 exposure, whereas 70 proteins were significantly differentially expressed in the hippocampus. (nih.gov)
Of these proteins, 4 from the cerebellum and 47 from the hippocampus, identifiable by mass spectrometry, were found to have roles in mitochondrial energy metabolism, oxidative stress, apoptosis, calcium signaling, and growth of the nervous system. (nih.gov)

Moreover, chromatin remodelers such as the switch/sucrose nonfermentable (SWI/SNF) complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression changes. (bvsalud.org)

From parallel screens of human fetal brain and HeLa cDNA libraries, we obtained multiple independent isolates of human integrin cytoplasmic domain-associated protein-1 (ICAP-1) as interacting clones. (nih.gov)
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. (lookformedical.com)

To characterise the breakpoints of a de novo balanced translocation t(X;9)(p11.23;q34.3) in a mentally retarded female patient with clinical features similar to the 9q- syndrome. (nih.gov)

Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. (nih.gov)

He revealed that serotonin-induced transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element-binding protein (CREB). (wikipedia.org)
The PINK1 protein includes an N-terminus, a highly conserved protein kinase domain aa 156 to 509-511), and a C-terminus. (medscape.com)
Inhibition of endogenous GRK6 (G-protein-coupled receptor kinase) activity, by the introduction of catalytically inactive K215R GRK6, partially reversed the attenuation of agonist-induced responsiveness, whereas overexpression of wild-type GRK6 increased receptor desensitization. (jneurosci.org)
In addition, acetaldehyde induced the activation of p38 mitogen-activated protein kinase (MAPK) while inhibiting the activation of extracellular signal-regulated kinases (ERKs, p44/p42MAPK). (hindawi.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)

The process of protein ubiquitination requires an enzymatic cascade that consists of a ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2) and an E3 ubiquitin ligase (E3). (frontiersin.org)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
However, the brain is very different from a computer: in the brain, the proteins and lipids that make up the brain are constantly being replaced throughout life. (waseda.jp)

AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)

PINK1 encodes a 581 amino acid (aa) protein with a predicted molecular mass of 62.8 kDa. (medscape.com)
A fragment containing the N-terminal 272 amino acid residues of KRIT1, a region lacking similarity to any known protein upon database searches, was used as bait. (nih.gov)
We show that mutagenesis of the N-terminal KRIT1 NPXY amino acid sequence, a motif critical for ICAP-1 binding to beta1 integrin molecules, completely abrogates the KRIT1/ICAP-1 interaction. (nih.gov)

It is related in sequence and structure to ACTIN and binds ATP. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)

Sequence analysis of the break points showed that the translocation was fully balanced and only one gene on chromosome 9 was disrupted--Euchromatin Histone Methyl Transferase1 (Eu-HMTase1)--encoding a histone H3 lysine 9 methyltransferase (H3-K9 HMTase). (nih.gov)
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)

Genetic perturbations of the MPS and its interacting proteins further suggested functional roles of the MPS in axon-axon and axon-dendrite interactions and in axon diameter regulation, and implicated the involvement of MPS interactions with cell adhesion molecules and non-muscle myosin in these roles. (nature.com)

Acetaldehyde treatment led to a significant decrease in the levels of activated Akt and cyclic AMP-responsive element binding protein (CREB). (hindawi.com)

RNA sequences that serve as templates for protein synthesis. (lookformedical.com)

Induction of Apoptosis in Human Prostate Cancer Cells by Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) does not Require its Nuclear Localization. (nih.gov)
In mouse osteoclast cells, mechanical stimulation through FAK activation stabilized beta-catenin protein to promote its nuclear translocation. (vegfrinhibitors.com)

Protein ubiquitination is a posttranslational modification that plays an integral part in mediating diverse cellular functions. (frontiersin.org)
Ubiquitination mediates many cellular functions, which include signal transduction and the removal of proteins by the ubiquitin proteasome system (UPS) ( Hershko, 1996 ). (frontiersin.org)
Using a series of cellular assays, we demonstrate that both the sulfated proteoglycans on the cell surface and the correct orientation of the protein at the inner plasma membrane leaflet are critical determinants of this process. (bvsalud.org)

These residues are conserved to the seen magnitude of a protective plasma of synapse dimers that often build the requirements of RNA Polymerase II and phosphorylated time of accounts for transcriptional activation Results in fatty IL7 proteins like variant cleavage, family, etc. (evakoch.com)

Protein network interaction analysis was performed using Ingenuity® Pathway Analysis, and the proteins of interest were validated by Western blotting. (nih.gov)
Manipulation of endogenous GRK2 activity through introduction of either wild-type or catalytically inactive GRK2 ( K220R GRK2) almost completely inhibited agonist-stimulated IP 3 production, implying a phosphorylation-independent regulation of M 1 mACh receptor signaling, most probably mediated by a GRK2 N-terminal RGS-like (regulator of G-protein signaling) domain interaction with GTP-bound Gα q/11 . (jneurosci.org)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

[ 28 ] The N-terminus comprises a mitochondrial-targeting sequence (MTS) that is cleaved upon mitochondrial import. (medscape.com)
The redox imbalance induced by acetaldehyde is accompanied by a transient reduction in the protein content of mitochondrial superoxide dismutase SOD2 [ 11 ]. (hindawi.com)

Changes in these signal transduction pathways can lead to differential gene regulation with subsequent changes in protein expression, which can affect the development and function of the nervous system. (nih.gov)
The discrepancy between PINK1 mRNA and protein expression in glial cells also needs to be explained. (medscape.com)
Thus PKA is required to repress dpp expression in eye disc cells anterior to the location at which dpp is normally expressed. (sdbonline.org)

Here, we demonstrate that wild-type huntingtin, the protein mutated in HD, modulates anxiety/depression-related behaviors according to its phosphorylation at serines 1181 and 1201. (jneurosci.org)

Using tissue in situ hybridisation studies in mouse embryos and adult brain, Eu-HMTase1 was shown to be expressed in the developing nervous system and in specific peripheral tissues. (nih.gov)
We found that of the six brains in the Allen Human Brain Atlas, a set of ribosomal proteins strongly aligned with the hypometabolism map in one of the six Atlased brains. (eneuro.org)

Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)

He found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after the retrieval of contextual fear memory. (wikipedia.org)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)

They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (lookformedical.com)

HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
Initially, the RNase activity of translin/trax was not appreciated and, hence, it was thought to function as an RNA-binding protein complex involved in RNA trafficking. (elifesciences.org)
Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)

PKA mutant clones in imaginal discs express dpp and wg . (sdbonline.org)

A Ser(45) to Gly(45) mutation is located in the predicted targeting signal of the protein. (vegfrinhibitors.com)

We examined representative proteins in several of these categories using super-resolution imaging, including previously unknown MPS structural components, as well as motor proteins, cell adhesion molecules, ion channels, and signaling proteins, and observed periodic distributions characteristic of the MPS along the neurites for ~20 proteins. (nature.com)

As the function of the KRIT1 protein and its role in CCM pathogenesis remain unknown, we performed yeast two-hybrid screens to identify additional protein binding partners. (nih.gov)

DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

23andMe, a private biotechnology company situated in California, offers a DNA sequencing service in which consumers send in a saliva swab for testing, and later receive a report listing the findings of the analysis related to ancestry, physical and behavioral traits, along with risk of inheriting certain diseases. (pharmaceuticalintelligence.com)

The PINK1 mRNA transcript is ubiquitously expressed with the highest concentration in the heart and skeletal muscle and testis. (medscape.com)
Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. (lookformedical.com)

Our laboratory aims to elucidate the mechanisms of memory and learning and the pathogenesis of neurological diseases such as epilepsy, and Alzheimer's disease, by "Watching" the structure, function, and dynamics of the protein molecules that make up the living body in living cells. (waseda.jp)
We previously demonstrated that microvesicles can functionally deliver plasmid DNA to cells and showed that plasmid size and sequence, in part, determine the delivery efficiency. (regenerativemedicine.net)
The movement of the morphogenetic furrow is dependent upon the secretion of the signaling protein Hedgehog (Hh) by more posterior cells. (sdbonline.org)

Here, using co-immunoprecipitation and mass spectrometry, we identified hundreds of potential candidate MPS-interacting proteins that span diverse functional categories. (nature.com)

Among them, 46 were diabetic and were included in the study-11 laparoscopic adjustable gastric banding (LAGB), 26 Roux-en-Y gastric bypass (RYGB) and 9 sleeve gastrectomy (SG). (vegfrinhibitors.com)

It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)

Moreover, the infusion of proteasome inhibitors into the CA1 of the hippocampus immediately after retrieval prevented anisomycin-induced memory impairment and the extinction of fear memory. (wikipedia.org)
Thus, we define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. (elifesciences.org)

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