Amyloid beta-Protein PrecursorAmyloid beta-PeptidesAmyloidMicrogliaAlzheimer DiseaseHippocampusPeptide FragmentsProtein PrecursorsAmyloid Precursor Protein SecretasesSmilacaceaePlaque, AmyloidAspartic Acid EndopeptidasesCerebral Amyloid AngiopathyBrainAmyloid NeuropathiesMoraceaeMolecular Sequence DataEndopeptidasesAmino Acid SequenceNeuronsIridoid GlycosidesMice, TransgenicSerum Amyloid A ProteinCells, CulturedCell LineCell MembraneCerebral CortexDisease Models, AnimalBase SequenceMembranesIntracellular MembranesProtein Processing, Post-TranslationalMembrane LipidsRNA, MessengerAgingAmyloidosisMembrane PotentialsMutationCloning, MolecularIslet Amyloid PolypeptideInterleukin-1betaRecombinant ProteinsMembranes, ArtificialMice, Inbred C57BLRats, Sprague-DawleyProtein BindingBlotting, WesternKineticsPresenilin-1Time FactorsImmunohistochemistryPeptidesElectrophoresis, Polyacrylamide GelMolecular WeightProtein Structure, TertiaryMicroscopy, ElectronTransfectionBinding SitesEscherichia coliGene Expression RegulationNerve Tissue ProteinsAstrocytesInsulysinProtein Structure, SecondaryCongo RedProtein ConformationSignal TransductionModels, MolecularErythrocyte MembraneSerum Amyloid P-ComponentMembrane FluidityRecombinant Fusion ProteinsS100 Calcium Binding Protein beta SubunitGene ExpressionCarrier ProteinsMembrane ProteinsRats, WistarSequence Homology, Amino AcidDNAProtein Transporttau ProteinsCricetinaeMaze LearningMice, KnockoutThiazolesVitellogeninsPlasmidsNeurofibrillary TanglesDNA PrimersCell Membrane PermeabilityDose-Response Relationship, DrugProtein BiosynthesisBasement Membranebeta 2-MicroglobulinEnzyme PrecursorsVitellogenesisAnimals, NewbornPresenilin-2Models, BiologicalMembrane Glycoproteins