One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w. (shengsci.com)
Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). (mdpi.com)
GPCRs5
Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
Arrestins are best known for their role in homologous desensitization of G protein-coupled receptors (GPCRs). (bvsalud.org)
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)
These pits are the entry route for macromolecules bound by cell surface receptors. (lookformedical.com)
Proteins6
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
BACKGROUND AND PURPOSE: The cannabinoid CB(1) receptor is primarily thought to be functionally coupled to the G(i) form of G proteins, through which it negatively regulates cAMP accumulation. (bvsalud.org)
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. (embl.de)
The characterization of homologous proteins endowed with different quaternary structures is particularly suited to unveil key factors in protein oligomerization [1, 2]. (cancer-pictures.org)
The primary actions that regulate circadian rhythms, although mediated by nonhomologous proteins, are conserved in progression [16] highly. (monossabios.com)
Protein14
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. (wikipedia.org)
This gene encodes the α2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. (wikipedia.org)
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
These include the T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), TIGIT, and B-and T-lymphocyte-associated protein (BTLA) receptors associated with T cell exhaustion and V-domain immunoglobulin suppressor of T cell activation (VISTA), a receptor found on tumor-infiltrating myeloid cells. (biomedcentral.com)
G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions. (bvsalud.org)
The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. (shengsci.com)
Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)
Theencoded protein enhances androgen receptor (AR) transactivation, and this enhancement canbe increased further in the presence of other androgen receptor associated coregulators. (cancer-ecosystem.com)
One version of childhood acute myeloid leukemia is the result of a cryptictranslocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer ofzeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome11. (cancer-ecosystem.com)
Kinases1
The TOR (target of rapamycin) kinases are highly conserved and promote cell growth in response to favorable nutrient conditions and growth-factor signals. (cancer-ecosystem.com)
Arrestin1
Here we demonstrate that arrestin-2 isoform is cleaved by caspases during apoptosis induced via death receptor activation or by DNA damage at evolutionarily conserved sites in the C-terminus. (bvsalud.org)
Sequences2
Polyprotein sequences of infections retrieved from CH1494 following the two homologous rechallenges that led to transient viremia had been identical using the H77C pathogen. (logic2010.org)
On the other hand, the polyprotein sequences of infections recovered from both chimpanzees after homologous rechallenge leading to continual infection had many changes. (logic2010.org)
Chimeric2
Using CB(1)/CB(2) chimeric receptors, the second intracellular loop (ICL2) of the CB(1) receptor was identified as primarily responsible for mediating G(s) and G(i) coupling specificity. (bvsalud.org)
Take action can be performed with unmanipulated cells or designed cells that express chimeric antigen receptors (CAR-T cells). (azd1152.com)
Agonists2
Despite scientific evidence proving that inhaled β 2 -adrenergic receptor (β 2 -AR) agonists can reverse bronchoconstriction in all ages, current guidelines advocate against the use of β 2 -AR bronchodilators in infants with viral bronchiolitis because clinical trials have not demonstrated an overall clinical benefit. (ersjournals.com)
β 2 -Adrenergic receptor (β 2 -AR) agonists are essential for the management of many conditions causing lower airway obstruction in adults and children [ 5 , 6 ]. (ersjournals.com)
Immune4
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. (biomedcentral.com)
Alternative inhibitory receptors have been identified that may also be targeted for anti-tumor immune therapy. (biomedcentral.com)
Nevertheless, anamnestic cellular immune system replies developed through the preliminary homologous rechallenge, specifically in CH96A008, which created a continual infections. (logic2010.org)
Ligand1
Our receptor-ligand interaction analysis reveals a highly complex interactive network of the NB microenvironment from which we highlight several interactions that we suggest for future therapeutic studies. (pklab.org)
Gene3
The human gene encoding this receptor has the symbol ADRA2B. (wikipedia.org)
Its sequence, when compared to those of members of the human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. (shengsci.com)
Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (shengsci.com)
Cellular2
Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. (lookformedical.com)
Apoptosis is programmed cell death triggered by activation of death receptors or cellular stress. (bvsalud.org)
Extracellular1
Conversely, inhibition of PVA neuronal activity using DREADDs (designer receptors exclusively activated by designer drugs) or inactivation of PVA extracellular signal-regulated kinase at the critical time window blunted mechanical hyperalgesia in chronic pain models. (iasp-pain.org)
Activation1
KEY RESULTS: CB(1) receptors could couple to both G(s)-mediated cAMP accumulation and G(i)-induced activation of ERK1/2 and Ca(2+) mobilization, whereas CB(2) receptors selectively coupled to G(i) and inhibited cAMP production. (bvsalud.org)
Structural2
Here, we investigated the dual coupling properties of CB(1) receptors and characterized the structural determinants that mediate selective coupling to G(s) and G(i). (bvsalud.org)
CB(1)/CB(2) receptor chimeras and site-directed mutagenesis combined with functional assays and computer modelling were used to determine the structural determinants mediating selective coupling to G(s) and G(i). (bvsalud.org)
Human2
Here we use single-nucleus RNA sequencing to profile RNA expression in 188,776 individual interneurons across homologous brain regions from three primates (human, macaque and marmoset), a rodent (mouse) and a weasel (ferret). (nature.com)
In this study, we found that GM-CSF is highly expressed in human malignant osteosarcoma. (iasp-pain.org)
Family1
It is a subtype of the adrenergic receptor family. (wikipedia.org)
Infection1
First, MAP infection is highly prevalent in Sardinian T1D patients. (healthweblognews.info)
Disease1
However, in the metastatic setting, ccRCC remains a highly lethal disease. (pklab.org)
Role1
These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (wikipedia.org)
Include1
α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. (wikipedia.org)
Multiple1
Viral isolates from all over the world have been categorized into six main genotypes and multiple subtypes (genotypes 1a, 1b, 2a, etc. (logic2010.org)
Brain1
Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. (jci.org)
Function1
Outcomes Rab27b is certainly portrayed in neutrophils and its own appearance is certainly upregulated in the lack of Rab27a Rab27b is certainly 72% homologous to Rab27a, ((26) and Supplementary Fig. S1) binds to Rab27a effectors and has an important function in the legislation of several secretory systems (28). (cancerdir.com)
Specific1
Only a modest fraction of the genes identified as 'markers' of specific interneuron subtypes in any one species had this property in another species. (nature.com)
Response1
For future years perspective of developing a highly effective vaccine against HCV, it really is stimulating that 20 to 30% of contaminated individuals are in a position to support an defense response that may control this infections. (logic2010.org)
Class1
However, non-formylated peptide ligands have also been found for this receptor class. (lookformedical.com)
Found1
We also found a notable subcortical innovation: an abundant striatal interneuron type in primates that had no molecularly homologous counterpart in mice or ferrets. (nature.com)
Study1
However, in a far more latest study, fast viral clearance was noticed pursuing homologous and heterologous genotype 1 rechallenge in chimpanzees that got recovered off N-Shc their preliminary infections 1.5 to 16 years previous (2). (logic2010.org)
Expression1
Homologous interneuron types-which were readily identified by their RNA-expression patterns-varied in abundance and RNA expression among ferrets, mice and primates, but varied less among primates. (nature.com)