• Culex mosquito species have between 27 and 83 CSP genes [44]. (wikipedia.org)
  • More than hundreds of protein variants can be produced from CSP genes through or mediated via post-translational modifications and/or RNA-peptide editing as in the case of Dscam and cochlear sensory genes [9-14]. (wikipedia.org)
  • Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
  • Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
  • The PDZ and LIM domain-containing protein family is encoded by a diverse group of genes whose phylogeny has currently not been analyzed. (princeton.edu)
  • As conventional alignment and phylogenetic procedures of full-length sequences fell short of elucidating the evolutionary history of these genes, we started to analyze the PDZ and LIM domain sequences themselves. (princeton.edu)
  • The blocks of A. oryzae -specific sequence are enriched for genes involved in metabolism, particularly those for the synthesis of secondary metabolites. (nature.com)
  • The 37-Mb genome was predicted to contain a total of 12,074 genes encoding proteins with a length greater than 100 amino acid residues (see Methods). (nature.com)
  • By sequencing the fire moss genome, researchers hope to identify genes that provide tolerance to high levels of heavy metal contamination. (oosteinde.info)
  • Preliminary analyses using 454 transcriptome and Bacterial Artificial Chromosome (BAC) sequences from three Heliconius species highlighted a cluster of genes within each region showing relatively higher rates of sequence evolution. (biomedcentral.com)
  • Other genes within the region appear to be highly constrained, and no ω estimates exceeded one. (biomedcentral.com)
  • Three genes from each locus with the highest average pairwise ω values were amplified from additional Heliconius species and races. (biomedcentral.com)
  • Two selected genes, fizzy-like ( HmYb ) and DALR ( HmB ), were too divergent for amplification across species and were excluded from further analysis. (biomedcentral.com)
  • Transcriptional analysis of ACBP-deficient parasites revealed differentially expressed genes involved in a wide range of biological processes such as lipid metabolism, posttranslational modification, and membrane biogenesis. (biomedcentral.com)
  • Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
  • pqbp1 and wbp11 genes are similarly expressed in mesoderm and neural tissues during Xenopus development. (xenbase.org)
  • 10,200 protein-encoding genes were predicted based on the genome sequence. (springeropen.com)
  • The genes and proteins were predicted and annotated based on the genome sequence. (springeropen.com)
  • Each RBH couple consists of two genes, one from each of the two genome sequences (or genomes) to compare, which display the highest scoring hit in the other data set in a reciprocal manner [ 36 ]. (biomedcentral.com)
  • Potential C. elegans orthologs for II of the 12 protein-coding genes predicted in the B. malayi sequence were identified. (biomedcentral.com)
  • All genomes encode conserved genes. (biomedcentral.com)
  • Kent and Zahler [ 9 ] compared 8.1 megabases (Mb) of fragmentary C. briggsae sequence derived from sequenced cosmid clones to C. elegans and derived a mean syntenic fragment length of 8.6 klobases (kb), or approximately 1.8 genes (there is one gene per 5 kb in C. elegans ) [ 13 ]. (biomedcentral.com)
  • As orthologous genes are commonly mutated in canine models of human blinding disorders, canine ABCA4 appears to be an ideal candidate gene to identify and study sequence changes in dogs affected by various forms of inherited retinal degeneration. (upenn.edu)
  • Gene expression analyses using microarrays have further revealed that some of the down-regulated genes in seeds of the wri1 mutant are involved in glycolysis and FA synthesis, rather than in TAG assembly [ 7 ]. (biomedcentral.com)
  • Additionally, the 10 genes of the L. infantum PUF family were cloned and used to express the Leishmania PUFs in bacteria as recombinant proteins. (biomedcentral.com)
  • The genome sequence of Barbarea vulgaris facilitates the study of ecological biochemistry. (pacb.com)
  • Here we report a draft genome sequence of the G-type, and re-sequencing of the P-type for comparison. (pacb.com)
  • Draft genome sequence of Micromonospora sp. (pacb.com)
  • Complete genome sequence of Kosakonia oryzae type strain Ola 51(T). (pacb.com)
  • Here we summarize the features of the strain Ola 51(T) and describe its complete genome sequence. (pacb.com)
  • ud \ud Methods and Results: We aligned expressed sequence tags (ESTs) from Ceratodon purpureus to the Physcomitrella patens genome sequence, and designed primers that are homologous to … Here we examine the genetic and genome size diversity in Mediterranean populations of the moss Ceratodon purpureus s.l. (oosteinde.info)
  • The Arabidopsis thaliana Niederzenz-1 genome sequence was recently published with an ab initio gene prediction. (biomedcentral.com)
  • Since non-canonical splice sites are difficult to predict ab initio, we checked for options to improve the annotation by transferring annotation information from the recently released Columbia-0 reference genome sequence annotation Araport11. (biomedcentral.com)
  • The improved gene set of the Nd-1 genome assembly (GeneSet_Nd-1_v1.1) was evaluated via comparison to the initial gene prediction (GeneSet_Nd-1_v1.0) as well as against Araport11 for the Col-0 reference genome sequence. (biomedcentral.com)
  • RNA-Seq data ("external hints") does not support the detection and annotation of non-canonical splice sites on genome sequence assemblies at a satisfying level [ 26 , 27 , 28 ]. (biomedcentral.com)
  • This thematic series of companion papers constitutes the initial exploration of the genome biology of the waterflea (Daphnia) building on the first complete crustacean genome sequence. (biomedcentral.com)
  • To assess whether this pattern is true of nematodes in general, we have used genome sequence to compare two nematode species that last shared a common ancestor approximately 300 million years ago: the model C. elegans and the filarial parasite Brugia malayi . (biomedcentral.com)
  • NDK isozymes have been sequenced from prokaryotic and eukaryotic sources. (embl.de)
  • Using information from most sequenced eukaryotic lineages, our phylogenetic analysis is based on full-length cDNA-, EST-derived-and genomic- PDZ and LIM domain sequences of over 25 species, ranging from yeast to humans. (princeton.edu)
  • Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. (signalchem.com)
  • It phosphorylates eukaryotic elongation factor 2 (EEF2), an abundant cytoplasmic protein that catalyzes the movement of the ribosome along mRNA during translation in eukaryotic cells, and inhibits the EEF2 function (1). (signalchem.com)
  • The eukaryotic proteins are more complicated than the bacterial enzyme complexes. (tcdb.org)
  • The addition of glycine near cysteine at specific location, amino acid inversion and motif insertion in protein sequence strongly argue for the existence of recoding at the level of protein synthesis in the CSP family [9-14]. (wikipedia.org)
  • the WD motif is responsible for a protein-protein interaction. (embl.de)
  • Our analysis identified a novel methylation motif associated with a DNA methylase that is conserved in all complete Ralstonia spp. (pacb.com)
  • Further, we describe the separation of the ALP and Enigma subfamilies in lower vertebrates and identify a novel consensus motif, which we call 'ALP-like motif' (AM). This motif is highly-conserved between ALP subfamily proteins of diverse organisms. (princeton.edu)
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • Furthermore, based on sequence analysis it is proposed that Hjc_15-6 has a three-part catalytic motif corresponding to E-SD-EVK, and this motif may be common among other Hj-resolving enzymes originating from thermophilic bacteriophages. (iucr.org)
  • NM23 belongs to a large family of structurally and functionally conserved proteins consisting of 4-6 identically folded subunits of approximately 16-20 kDa. (embl.de)
  • Interestingly, functionally redundant SNIPER1 and SNIPER2 can control the protein levels of diverse sNLRs and the interactions between SNIPER1 and sNLRs appear to be through the common nucleotide-binding (NB) domains of sNLRs. (ubc.ca)
  • The fact that NUDF and LIS1 interact with the same protein domain strengthens the notion that these two proteins are functionally related. (xenbase.org)
  • While the M. smegmatis enzyme could be functionally expressed, the M. tuberculosis homologue was insoluble and inactive under a large variety of expression conditions. (biomedcentral.com)
  • Helper NLRs (hNLRs) with their characteristic RPW8 domain function downstream of diverse sNLRs and are evolutionarily conserved. (ubc.ca)
  • The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
  • Members of the evolutionarily conserved Nanos gene family are preferentially expressed in the ovaries and are known to play an important role in germ cell development, maintenance, and survival [ 24 - 30 ]. (hindawi.com)
  • The GnRH1 gene and amino acid sequences were subjected to bioinformatic analyses. (geneticsmr.com)
  • Strains were transformed with nudE variants in pAid vector and grown at 43°C. Numbers refer to amino acid residues of NUDE protein expressed by the constructs (see Fig. 3 for detailed amino acid sequences). (xenbase.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • When a cell needs to make a particular protein, it first copies the instructions from the matching gene into a molecule known as a messenger RNA (or an mRNA for short). (elifesciences.org)
  • The more mRNA copies it makes, the more protein it can produce. (elifesciences.org)
  • A simple way to control protein production is to raise or lower the number of these mRNA messages, and living cells have lots of ways to make this happen. (elifesciences.org)
  • The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)
  • Translation of WT mRNA, but not mut mRNA for lim1, otx2, or HA-tagged otx5 was inhibited by the corresponding MO. (xenbase.org)
  • Western blotting was performed using lysates from X. laevis embryos, which were first injected with MO (5 pmol/embryo), followed by a second injection of lim1, otx2 or HA-tagged otx5 mRNA (200 pg/embryo) to avoid interactions between MO and mRNA prior to injection. (xenbase.org)
  • In addition, NUDF coprecipitates with an epitope-tagged NUDE. (xenbase.org)
  • Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
  • IC1 has a unique primary structure, the N-terminal part is homologous to the sequence of thioredoxin, the middle part consists of three repetitive sequences homologous to the sequence of nucleoside diphosphate kinase, and the C-terminal part contains a high proportion of negatively charged glutamic acid residues. (embl.de)
  • We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
  • The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
  • Transcriptome sequencing revealed that all homologs induced the same general patterns with a drastic shift in gene expression profiles of leaves from that of a typical source tissue to a source-limited sink-like tissue: Transcripts encoding enzymes for plastid uptake and metabolism of phosphoenolpyruvate, fatty acid and oil biosynthesis were up-regulated, as were also transcripts encoding starch degradation. (biomedcentral.com)
  • More than a quarter of a million species of land plants serve as primary producers in terrestrial biomes, but most of the genomic data about land plants has so far focused on a few flowering plants. (oosteinde.info)
  • He thanked CDC and KTL for their support in providing accurate genomic sequencing results of polioviruses in a timely manner, as this greatly facilitated planning and targeting the polio eradication activities. (who.int)
  • Head specification by the head -selector gene, orthodenticle (otx), is highly conserved among bilaterian lineages. (xenbase.org)
  • Sequence analysis of the Daphnia pulex genome holds some surprises that could not have been anticipated from what was learned so far from other arthropod genomes. (biomedcentral.com)
  • Simple sequence repeats (SSRs) are highly variable features of all genomes. (biomedcentral.com)
  • Reviewed-Annotation score: -Protein inferred from homology i. (oosteinde.info)
  • The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)
  • Deep cDNA sequencing demonstrated that both wild-type and mutant alleles were expressed . (massgenomics.org)
  • Canine ortholog cDNA sequence was cloned and verified using RPE/choroid 5′- and 3′-RACE. (upenn.edu)
  • Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)
  • Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. (cdc.gov)
  • In contrast to ancestral clade 2.3.4 H5 proteins, novel clade 2.3.4.4 H5 proteins bind to fucosylated sialosides because of substitutions K222Q and S227R, which are unique for highly pathogenic influenza virus H5 proteins. (cdc.gov)
  • Highly pathogenic avian influenza A(H5N1) viruses have caused major economic losses in the poultry industry and might cause zoonotic infections. (cdc.gov)
  • Whereas highly pathogenic avian influenza A(H5N1) viruses previously detected in poultry in the Americas are believed to have descended from low pathogenicity viruses in this region ( 5 ), clade 2.3.4.4 viruses were the first highly pathogenic avian influenza virus of the A/goose/Guangdong/1/1996 lineage to appear in North America ( 2 - 4 ) during the winter of 2014-2015. (cdc.gov)
  • Viruses with H5 or H7 subtypes occasionally acquire a multibasic cleavage site in their HA ( 8 ), which results in a highly pathogenic phenotype. (cdc.gov)
  • In general, highly pathogenic H5 viruses have the N1 subtype (H5N1). (cdc.gov)
  • In contrast, the novel highly pathogenic H5 clade 2.3.4.4 viruses have reassorted with different NA subtypes, including N1, N2, N3, N5, N6, and N8 ( 1 , 9 - 17 ). (cdc.gov)
  • Although a recent study ( 22 ) reported enhanced avidity of H5N6 viruses for human-type receptors, recombinant clade 2.3.4.4 highly pathogenic influenza A virus H5 proteins from virus isolates in North America show a strict avian receptor-binding preference ( 23 ). (cdc.gov)
  • Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
  • A single unified hypothesis of RNA editing and retrotransposition-driven evolution of CSPs, i.e. initial production of new CSP protein motifs via DNA and RNA -dependent RNA polymerization before retro- transposition of edited CSP-RNA variants, has been proposed in moths [11]. (wikipedia.org)
  • Recent studies have reported the occurrence of GnRH molecular variants in numerous species. (geneticsmr.com)
  • The process is catalyzed by a RNA protein complex called a spliceosome, which exists in several variants. (biomedcentral.com)
  • In this report, we conducted mass spectrometric analysis of the N-glycosylation profiles of recombinant spike proteins derived from four common SARS-CoV-2 variants classified as Variant of Concern, including Alpha, Beta, Gamma, and Delta along with D614G variant spike as a control. (cdc.gov)
  • Our data reveal that the amino acid substitutions and deletions between variants impact the abundance and type of glycans on glycosylation sites of the spike protein. (cdc.gov)
  • In comparison with our previously reported site-specific glycan analysis on the S-D614G and its ancestral protein, glycan types on later variants showed high similarity on the site-specific glycan content to S-D614G. (cdc.gov)
  • Detailed site-specific glycan analysis of a wide variety of SARS-CoV-2 variants provides useful information toward the understanding of the role of protein glycosylation on viral protein structure and function and development of effective vaccines and therapeutics. (cdc.gov)
  • claiming that two homologous chromosomes paired between complementary sequences lead to the formation of a cross-stranded structure that physically links the two component helices. (iucr.org)
  • G) Translation of C-terminal myc -tagged Xenopus PQBP1 (PQ- myc ) was blocked by co-injection of pqbp1 MO1 but not control MO (CT). (xenbase.org)
  • NUDF protein interacts with the Aspergillus NUDE coiled-coil in a yeast two-hybrid system, while human LIS1 interacts with the human homologue of the NUDE/RO11 coiled-coil and also the Xenopus MP43 coiled-coil. (xenbase.org)
  • Loss of function analysis using Xenopus tropicalis embryos (A) Sequence alignment of MOs and mRNAs. (xenbase.org)
  • MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
  • Genome sequencing of multiple R. solanacearum strains has identified both unique and shared genetic traits influencing their evolution and ability to colonize plant hosts. (pacb.com)
  • Sequencing of R. solanacearum strains GMI1000 and UY031 using Single Molecule Real-Time technology allowed us to perform a comparative analysis of R. solanacearum methylomes. (pacb.com)
  • Chemosensory proteins (CSPs) are small soluble proteins which mediate olfactory recognition at the periphery of sensory receptors in insects, similarly to odorant-binding proteins. (wikipedia.org)
  • The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
  • The pore-forming BCL-2 family proteins mediate mitochondrial poration to initiate apoptosis through protei-protein and protein-lipid interactions. (portlandpress.com)
  • Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
  • The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
  • RNA-binding proteins of the PUF family share a conserved domain consisting of tandemly repeated 36-40 amino acid motifs (typically eight) known as Puf repeats. (biomedcentral.com)
  • They are also expressed in many various organisms such as crustacean, shrimp and many other arthropod species [23]. (wikipedia.org)
  • They are also expressed at the level of the bacterial superkingdom, demonstrating their existence not only in eukaryotes, but also in prokaryote organisms [23-24]. (wikipedia.org)
  • The heterodimeric glycoprotein hormones have only been identified in vertebrates and are highly conserved in organisms from primitive rayfin fish (Chondrostei) to human in both primary sequences and functional characteristics. (biovendor.com)
  • This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic tractability compared with many model organisms. (portlandpress.com)
  • Following recognition of TLR ligands, TLRs elicit innate immunity by activating multiple intracellular signaling cascades including variable adaptor proteins and transcriptional factors. (frontiersin.org)
  • Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
  • The particular role of CSP proteins in lipid transport in relation with insecticide resistance has been brought up by Liu et al. (wikipedia.org)
  • showed insecticide-mediated up regulation and interaction of the protein with C18-lipid (linoleic acid), suggesting a metabolic role of CSP in insect defense rather than olfaction or chemical communication [34]. (wikipedia.org)
  • They provide NTPs for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerisation. (embl.de)
  • Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
  • Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
  • First, Tim Graubert and colleagues describe the whole-genome sequencing of an MDS-derived secondary AML tumor and a matched normal (skin) sample. (massgenomics.org)
  • Sequencing of the A. oryzae genome was accomplished using the whole-genome shotgun (WGS) approach. (nature.com)
  • Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses. (cdc.gov)
  • RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood. (elifesciences.org)
  • In this study, we discover a previously unknown type of SBD and identify its causal gene, TMEM53 , which encodes nuclear envelope transmembrane (NET) protein 53 (TMEM53, also known as NET4). (nature.com)
  • SUSA2 encodes an F-box protein Actin-Related Protein 8 (ARP8) and SUSA3 encodes the chaperone protein HSP90.3. (ubc.ca)
  • To overcome the host plant defense response, M. phaseolina encodes a significant number of P450s, MFS type membrane transporters, glycosidases, transposases, and secondary metabolites in comparison to all sequenced ascomycete species. (biomedcentral.com)
  • The transcript is predominantly expressed in RPE/choroid and encodes bestrophin, a 580-amino acid protein of 66 kDa. (upenn.edu)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • The mRNAs can carry short sequences of genetic letters that can trigger their own destruction. (elifesciences.org)
  • Together these proteins shorten the end of the mRNAs, preparing the molecules for degradation. (elifesciences.org)
  • The test-tube system confirmed previous suggestions that a protein called Puf3 forms a bridge between Ccr4-Not and mRNAs. (elifesciences.org)
  • Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
  • The balance between activities of HA and NA proteins has a critical role in optimal viral fitness, tropism, and transmission ( 21 ). (cdc.gov)
  • Phylogenetic analysis of 18S rRNA gene sequences placed the Chadian Brugia sp. (bvsalud.org)
  • NDK are proteins of 17 Kd that act via a ping-pong mechanism in which a histidine residue is phosphorylated, by transfer of the terminal phosphate group from ATP. (embl.de)
  • BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
  • The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
  • Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • EEF2K is involved in the regulation of protein synthesis. (signalchem.com)
  • This basic two-step process has been confirmed in most mammalian cells, although its regulation and the repertoire of specific accessory proteins are likely to be highly context dependent. (centrodinoferrari.com)
  • FSH, LH, and TSH, mainly expressed in the anterior pituitary, are essential for coordinated endocrine regulation in the hypothalamus- pituitary axis and show to activate specific G protein-coupled receptors in the thyroid (TSH receptor) and gonads (LH and FSH receptors), respectively. (biovendor.com)
  • In anterior neuroectoderm, otx2 is weakly expressed, while otx5 is more strongly expressed. (xenbase.org)
  • Also very weakly expressed in brain, spinal cord and placenta. (creativebiomart.net)
  • Vertebrate chromosomes are mosaic structures containing large conserved segments that can reside in different linkage groups in different species. (biomedcentral.com)
  • We found high levels of sequence similarity to B. malayi and B. pahangi based on amplification of 18S rRNA, 5.8S rRNA, and ITS-2 regions. (bvsalud.org)
  • An 83 kb region flanking the gene for Bm-mif-1 (macrophage migration inhibitory factor, a B. malayi homolog of a human cytokine) was sequenced. (biomedcentral.com)
  • Comparison of B. malayi BAC-end genome survey sequence to C. elegans also revealed a bias towards intrachromosome rearrangements. (biomedcentral.com)
  • RT-qPCR analysis of leaves expressing Arabidopsis WRI1 showed the temporal trends of transcripts selected as 'markers' for key metabolic pathways one to five days after agroinfiltration. (biomedcentral.com)
  • Chlorophyll fluorescence measurements of leaves expressing Arabidopsis WRI1 showed a significant decrease in photosynthesis, even though effect on starch content could not be observed. (biomedcentral.com)
  • We find that the fission yeast homologues of Tristetraprolin/TTP and Pumilio/Puf (Zfs1 and Puf3) interact with Ccr4-Not via multiple regions within low-complexity sequences, suggestive of a multipartite interface that extends beyond previously defined interactions. (elifesciences.org)
  • The protein was then subjected to molecular characterization using bioinformatic methods, and the tissue expression pattern was further assayed by semi-quantitative reverse-transcription polymerase chain reaction. (geneticsmr.com)
  • Herein, we document the first reported case of a Brugia species infection in a dog from North America and the first molecular characterization of the species in question. (bvsalud.org)
  • Further characterization showed that susa2-2 only suppresses the autoimmunity mediated by either CHS1-SOC3 or TN2-SOC3 paired NLR proteins, indicating that SUSA2 is specifically involved in NLR protein SOC3-mediated immunity. (ubc.ca)
  • A) Homology between A. nidulans NUDE protein and N. crassa RO11 protein. (xenbase.org)
  • This study set a baseline for the marine microbial diversity in Icelandic marine waters and identified three photosynthetic microorganisms - the cyanobacteria Synechococcus and two members of the Chlorophyta clade - as valuable indicator species for future monitoring, as well as for application in ecosystem modeling in context with research on climate change. (matis.is)
  • The aim of this study was to sequence Acinetobacter baumannii phage AB3 and conduct bioinformatic analysis to lay a foundation for genome remodeling and phage therapy. (geneticsmr.com)
  • Analysis of Hha I sequences showed the greatest similarity with B. patei, a parasite previously reported from dogs, cats, and wildlife hosts in Kenya. (bvsalud.org)
  • Syntenic analysis of the three aspergilli revealed the presence of syntenic blocks and A. oryzae -specific blocks of sequence (lacking synteny with the two other aspergilli) in a mosaic manner throughout the A. oryzae genome ( Fig. 1 ). (nature.com)
  • In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
  • This protein migrates in several bands by Western blot analysis (WB). (mdpi.com)
  • Our sequence analysis of the complete canine ABCA4 coding region will clearly provide a baseline and tools for future association studies and comparative genomics to further delineate the role of ABCA4 in canine blinding disorders. (upenn.edu)
  • in domestic dogs in Chad and additional research is needed to definitively identify the species present, elucidate transmission, and understand potential risks to canine and human health. (bvsalud.org)
  • See how the University of Washington used HiFi sequencing to uncover a key finding about ALS and the human genome. (pacb.com)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • Recombinant full-length human EEF2K was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. (signalchem.com)
  • NUDF protein, the product of the nudF gene, displays 42% sequence identity with the human protein LIS1 required for neuronal migration. (xenbase.org)
  • A similar coiled-coil domain is present in several putative human proteins and in the mitotic phosphoprotein 43 ( MP43 ) of X. laevis. (xenbase.org)
  • B) Complementation of the nudE deletion and the nudF7 mutant by extra copies of nudE, the nudE NH2-terminal domain, and nudE chimeras carrying coiled-coil regions from human and frog proteins, respectively. (xenbase.org)
  • The regions between arrowheads were used in sequence exchange experiments to test if human or X. laevis coiled-coil regions can substitute for the NUDE coiled-coil. (xenbase.org)
  • The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. (hindawi.com)
  • The immunization antigen (13.34 kDa) is a protein containing 120 AA of recombinant Human Thyrostimulin beta subunit. (biovendor.com)
  • Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
  • Recombinant fragment of Human PDE8B with N-terminal proprietary tag, 115kDa. (creativebiomart.net)
  • The reactivity of hamster sera against recombinant LiPUF1 and LiPUF2 was particularly prominent, and these proteins were subsequently assayed against sera from human patients. (biomedcentral.com)
  • AN - check the tag INFANT HN - 2008 FX - Child Nutrition FX - Infant Nutrition Physiology FX - Milk FX - Milk, Human DH - Adolescent Nutrition DI - 052508 MN - SP6.021.067 MS - Nutrition of persons 10 through 19 years of age. (bvsalud.org)
  • Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
  • To be available for TAG synthesis, carbons from sucrose must first be converted to pyruvate through cytosolic or plastidic glycolytic pathways and at some point be imported into the plastid to yield acetyl-coenzyme A (CoA) which feeds fatty acid (FA) synthesis with carbon backbones. (biomedcentral.com)
  • Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
  • Furthermore, the adaptation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-Associated protein 9 (CRISPR/Cas9) technology has dramatically improved gene editing efficiency at the single gene level. (portlandpress.com)
  • Proteins containing tandem repeats are often dominant targets of humoral responses during infectious diseases. (biomedcentral.com)
  • DEAF-1 is maternally expressed, and the encoded protein is broadly distributed throughout the early embryo. (sdbonline.org)
  • Kappe didn't find the homologs (those were identified later by another group), but he uncovered something else: a paralog of the Duffy protein that his group named MAEBL, for membrane antigen-1-erythrocyte binding-like protein. (the-scientist.com)
  • All WRI1 homologs induced oil accumulation when expressed in leaf tissue. (biomedcentral.com)
  • The authors undertook systematic sequencing of U2AF1 exons in 150 MDS cases, and found that 8.7% had mutations at Ser34. (massgenomics.org)
  • In addition, they are capable of breathing or specific conformational changes upon ligand binding, which may represent another key feature of the ancestral primitive multifunctional soluble binding protein [15]. (wikipedia.org)
  • Using 16S ribosomal RNA gene amplicon sequencing and metagenomics, we resolved the microbial community composition on the North and South Shelves of Iceland, analyzed its evolution from 2011 to 2018, identified frequently occurring taxa, and predicted their potential metabolism. (matis.is)
  • MAEBL is a chimera between two previously known molecules: AMA-1 (apical membrane antigen-1) and EBL (erythrocyte binding-like) protein. (the-scientist.com)
  • N-Glycosylation plays an important role in the structure and function of membrane and secreted proteins. (cdc.gov)
  • Sequencing the genome of the moss Ceratodon purpureus, a well-established developmental model with abundant natural genetic variation in morphological and developmental traits, to advance gene discovery and phylogenomic comparisons. (oosteinde.info)
  • Protein-coding change is one possible genetic mechanism underlying the evolution of adaptive wing colour pattern variation in Heliconius butterflies. (biomedcentral.com)
  • These mimetic, aposematic butterflies are highly phenotypically varied and complex, yet patterns are under simple genetic control. (biomedcentral.com)
  • They have been reported from bacterial species such as coccobacillus Acinetobacter baumannii, Macrococcus/Staphylococcus caseolyticus, the filamentous actinomycete Kitasatospora griseola, an Actinobacteria genus in the family Streptomycetaceae, and Escherichia coli (E. coli) which are known as common bacteria from the digestive tract, main prokaryotic secondary metabolites, opportunistic multi-drug resistant pathogens, high positive cytochrome c oxidase reactions, and symbionts of multiple insect species [24]. (wikipedia.org)
  • However, they neither markedly altered the core gut microbiome, which was dominated by three bacterial species, nor detectably colonized the gut environment after the 4-week probiotic treatment. (matis.is)
  • Taxonomic distribution of proteins containing NDK domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with NDK domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing NDK domain in the selected taxonomic class. (embl.de)
  • The LIS1 -related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. (xenbase.org)
  • The highly conserved NH(2)-terminal coiled-coil domain of the NUDE protein suffices for protein function when overexpressed. (xenbase.org)
  • As information was limited on canine filaria species in Sri Lanka, we studied the filaria parasites among dog populations in lymphatic filariasis (LF) endemic and non-endemic regions by microscopy and molecular methods. (bvsalud.org)
  • Fibroblast growth factor 5 (FGF5) is a secreted signaling protein that belongs to the FGF family, and was found to be associated with hair growth in humans and other animals. (geneticsmr.com)
  • Amino-acid sequence and structure comparison suggested that the enzyme belongs to a group of enzymes classified as archaeal Holliday junction-resolving enzymes, which are typically divalent metal ion-binding dimers that are able to cleave X-shaped dsDNA-Holliday junctions (Hjs). (iucr.org)
  • In order to clarify the biological and pharmacological mechanisms of O. sinensis , we carried out the genome sequencing of H. sinensis, anamorph of O. sinensis , for the first time, described the annotation and gene expression, and analyzed the complete sequencing data (Li et al. (springeropen.com)
  • Daphnia magna is a well-established model species in ecotoxicology, ecology and evolution. (biomedcentral.com)