• TMPRSS2-ERG
  • Recent studies have found that prostate cancer expresses abnormal genetic markers including multiple types of TMPRSS2-ERG fusion genes. (dovepress.com)
  • The expression level of different TMPRSS2-ERG fusion genes is correlated to pathologic variables of aggressive prostate cancer and disease progression. (dovepress.com)
  • State-of-the-art methods for detection of TMPRSS2-ERG fusion genes include reverse transcription polymerase chain reaction (RT-PCR) with a detection limit of 1 fmol at urinary condition. (dovepress.com)
  • There is a need for a sensitive diagnostic test to detect multiple TMPRSS2-ERG fusion genes for an early diagnosis and prognosis of prostate cancer. (dovepress.com)
  • Here, we propose to develop an assay for prostate cancer diagnosis using oligonucleotide-functionalized quantum dot and magnetic microparticle for optical detection of rearranged TMPRSS2-ERG fusion genes at a low concentration in urine. (dovepress.com)
  • Here, we show detection of multiple TMPRSS2-ERG fusion genes using color-coded oligonucleotides in cell lysate and urine. (dovepress.com)
  • Fifty percent of patients with positive prostate-specific antigen tests show overexpression of fusion genes of transmembrane protease serine 2 (TMPRSS2) and erythroblastosis virus E26 transformation-specific (ETS) transcription factor family, such as TMPRSS2-ERG (v-ets erythroblastosis virus E26 oncogene homology) 3 , 4 ( Figure 1A ). (dovepress.com)
  • Fusion of TMPRSS2 and ERG loci at the chromosomal level and subsequent overexpression of the TMPRSS2-ERG transcript and truncated ERG protein product are essentially 100% specific for the presence of prostate cancer in tissue-based studies. (dovepress.com)
  • 4 , 5 Recent studies have found that the expression level of different TMPRSS2-ERG fusion genes is correlated to pathologic variables associated with the progression of aggressive prostate cancer. (dovepress.com)
  • Here, we collected blood every month from 89 patients (54 chemotherapy-naive patients and 35 docetaxel-treated patients) treated in phase I/phase II clinical trials of an orally available, highly specific CYP17 inhibitor, abiraterone acetate, that ablates the synthesis of androgens and estrogens that drive TMPRSS2-ERG fusions. (aacrjournals.org)
  • NSCLC
  • and mutations in the tyrosine kinase domain of EGFR1, a marker indicating a patient's non-small-cell lung carcinoma (NSCLC) will likely respond to gefitinib or erlotinib treatment. (wikipedia.org)
  • tumor
  • However, in a more recent series of 4,212 consecutive lung cancer cases, only one (0.024%) lesion was determined to be a "pure" giant-cell carcinoma after complete sectioning of all available tumor tissue. (wikipedia.org)
  • genes
  • Expression profiling of NMCs show that the set of genes whose expression is maintained by BRD4-NUT is highly enriched for MYC upregulated genes, and MYC and BRD4-NUT protein expression is strongly correlated in primary NMCs. (aacrjournals.org)
  • Ability to identify multiple fusion genes in a single sample has become important for diagnostic and clinical purposes. (dovepress.com)
  • 2 Therefore, a method to determine and differentiate types of fusion genes in patient samples is required to understand the function of abnormal genes in cancer. (dovepress.com)
  • Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. (wikipedia.org)
  • One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 genes. (wikipedia.org)
  • lethal
  • The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large cells, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from cell fusion. (wikipedia.org)
  • Gene
  • We found that our assay was able to identify three different types of fusion gene with a wide detection range and detection limit of 1 fmol (almost the same level of the RT-PCR result reported). (dovepress.com)
  • 6 , 7 The isoform of the fusion gene exon 1 of TMPRSS2 combined with exon 4 of ERG is the most common type of fusion gene in prostate cancer. (dovepress.com)
  • This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. (wikipedia.org)
  • malignant
  • RESULTS: WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hypersecreting matrix metalloproteinase-9. (thefreelibrary.com)
  • tissue
  • Transgenic mice expressing elevated levels of cyclin E in the mammary epithelium during pregnancy and lactation suffer from a higher incidence of mammary adenocarcinoma ( 8 ), suggesting that cyclin E might act as an oncogene in this tissue ( 9 ). (aacrjournals.org)
  • protein
  • The DEK-NUP214 fusion protein (cloned by von Lindern et al,1992) consists of almost the whole of the DEK protein fused to the C-terminal two-thirds of the NUP214 protein. (cancerindex.org)
  • Bcl-2 is specifically considered an important anti-apoptotic protein but it is NOT considered a proto-oncogene because it is not a growth signal transducer. (wikipedia.org)
  • survival
  • In contrast, mutated FAT1 is overexpressed in some acute myeloid leukaemia, pre-B acute lymphocytic leukaemia (ALL) and T-ALL, and is associated with shorter survival suggesting FAT1 may also act as an oncogene in some cellular contexts. (sanger.ac.uk)
  • consists
  • The highly conserved PD consists of a 128 amino acid region that binds to DNA sequences related to the TCACGC/G motif. (wikipedia.org)