• tumor
  • However, in a more recent series of 4,212 consecutive lung cancer cases, only one (0.024%) lesion was determined to be a "pure" giant-cell carcinoma after complete sectioning of all available tumor tissue. (wikipedia.org)
  • genes
  • Expression profiling of NMCs show that the set of genes whose expression is maintained by BRD4-NUT is highly enriched for MYC upregulated genes, and MYC and BRD4-NUT protein expression is strongly correlated in primary NMCs. (aacrjournals.org)
  • Ability to identify multiple fusion genes in a single sample has become important for diagnostic and clinical purposes. (dovepress.com)
  • 2 Therefore, a method to determine and differentiate types of fusion genes in patient samples is required to understand the function of abnormal genes in cancer. (dovepress.com)
  • Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. (wikipedia.org)
  • One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 genes. (wikipedia.org)
  • lethal
  • The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large cells, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from cell fusion. (wikipedia.org)
  • malignant
  • RESULTS: WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hypersecreting matrix metalloproteinase-9. (thefreelibrary.com)
  • gene
  • We found that our assay was able to identify three different types of fusion gene with a wide detection range and detection limit of 1 fmol (almost the same level of the RT-PCR result reported). (dovepress.com)
  • This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. (wikipedia.org)
  • tissue
  • Transgenic mice expressing elevated levels of cyclin E in the mammary epithelium during pregnancy and lactation suffer from a higher incidence of mammary adenocarcinoma ( 8 ), suggesting that cyclin E might act as an oncogene in this tissue ( 9 ). (aacrjournals.org)
  • cancer
  • ATC is the most aggressive form of thyroid carcinoma especially when metastatic - accounting for 14-50% of all thyroid cancer related deaths [ 2 ]. (omicsonline.org)
  • Papillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. (scielo.br)
  • Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is. (wikipedia.org)
  • protein
  • The DEK-NUP214 fusion protein (cloned by von Lindern et al,1992) consists of almost the whole of the DEK protein fused to the C-terminal two-thirds of the NUP214 protein. (cancerindex.org)
  • Bcl-2 is specifically considered an important anti-apoptotic protein but it is NOT considered a proto-oncogene because it is not a growth signal transducer. (wikipedia.org)
  • survival
  • In contrast, mutated FAT1 is overexpressed in some acute myeloid leukaemia, pre-B acute lymphocytic leukaemia (ALL) and T-ALL, and is associated with shorter survival suggesting FAT1 may also act as an oncogene in some cellular contexts. (sanger.ac.uk)
  • consists
  • The highly conserved PD consists of a 128 amino acid region that binds to DNA sequences related to the TCACGC/G motif. (wikipedia.org)