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  • tumor
  • However, in a more recent series of 4,212 consecutive lung cancer cases, only one (0.024%) lesion was determined to be a "pure" giant-cell carcinoma after complete sectioning of all available tumor tissue. (wikipedia.org)
  • malignant
  • RESULTS: WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hypersecreting matrix metalloproteinase-9. (thefreelibrary.com)
  • lung
  • These recent reports also highlight the potential use of drugs such as crizotinib that target ALK rearrangement with proven efficiency in non-small cell lung carcinomas [ 12 ] for highly aggressive types of thyroid cancer . (omicsonline.org)
  • Like nearly all lung carcinomas, however, GCCs are exceedingly rare in very young people: in the US SEER program, only 2 cases were recorded to occur in persons younger than 30 years of age between 1983 and 1987. (wikipedia.org)
  • tissue
  • Transgenic mice expressing elevated levels of cyclin E in the mammary epithelium during pregnancy and lactation suffer from a higher incidence of mammary adenocarcinoma ( 8 ), suggesting that cyclin E might act as an oncogene in this tissue ( 9 ). (aacrjournals.org)
  • BRD4-NUT
  • Expression profiling of NMCs show that the set of genes whose expression is maintained by BRD4-NUT is highly enriched for MYC upregulated genes, and MYC and BRD4-NUT protein expression is strongly correlated in primary NMCs. (aacrjournals.org)
  • abnormal
  • 2 Therefore, a method to determine and differentiate types of fusion genes in patient samples is required to understand the function of abnormal genes in cancer. (dovepress.com)
  • cells
  • Bisulfite genomic sequencing analysis indicated that the methylation levels of the DEK promoter in normal hepatic cells and tissues were higher than those in hepatocellular carcinoma (HCC) cells. (cancerindex.org)
  • diagnostic
  • Ability to identify multiple fusion genes in a single sample has become important for diagnostic and clinical purposes. (dovepress.com)
  • human
  • Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. (wikipedia.org)
  • consists
  • The DEK-NUP214 fusion protein (cloned by von Lindern et al,1992) consists of almost the whole of the DEK protein fused to the C-terminal two-thirds of the NUP214 protein. (cancerindex.org)
  • The highly conserved PD consists of a 128 amino acid region that binds to DNA sequences related to the TCACGC/G motif. (wikipedia.org)
  • growth
  • Bcl-2 is specifically considered an important anti-apoptotic protein but it is NOT considered a proto-oncogene because it is not a growth signal transducer. (wikipedia.org)
  • distinct
  • Epimorphin/syntaxin-2 (EPM) is a plasma membrane-anchored protein that has at least two distinct functions depending on its membrane topology: vesicle fusion when localized to the cytoplasmic surface and morphogenic signaling when localized to the extracellular surface. (aacrjournals.org)
  • However
  • Like nearly all lung carcinomas, however, GCCs are exceedingly rare in very young people: in the US SEER program, only 2 cases were recorded to occur in persons younger than 30 years of age between 1983 and 1987. (wikipedia.org)
  • often
  • Furthermore, the aggressive nature of current therapies often leads to severe, long-term side effects such as cerebellar mutism, cognitive and endocrine impairments, hearing loss, infertility, and neuropathies. (pubmedcentralcanada.ca)