• thrombin
  • In 1964 a proposal was put forth to organize the growing number of coagulation factors into a cascade, or waterfall, mechanism.9,10 In this scheme each zymogen clotting factor was activated to a protease that subsequently acted on the next zymogen until thrombin was ultimately produced. (wordpress.com)
  • 1 As an integral endothelial membrane protein it captures circulating PC and presents it to an adjacent thrombin-thrombomodulin complex which activates the PC with a consequent inhibition of coagulation factors Va and VIIIa, resulting in reduced thrombin generation. (ahajournals.org)
  • One contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and glycoprotein Ib and the fourth is implicated in forming the factor XI homodimer, including a cysteine residue that creates a disulfide bond. (wikipedia.org)
  • Activation by thrombin or factor XIIa is achieved by cleavage of Arg369-Ile370 peptide bonds on both subunits of the dimer. (wikipedia.org)
  • Written through specialists within the box, Antithrombotic Drug remedy in Cardiovascular Disease conscientiously examines person and numerous mixtures of the to be had antithrombotic regimens together with fibrinolytic brokers, antiplatelet remedies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticogulant cures (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and artificial issue X inhibitors), non-ST-segment elevation (NSTE) ACS and ST-segment elevation myocardial infarction (STEMI). (magomechaya.com)
  • In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and XIII to XIIIa. (wikipedia.org)
  • Factor Xa with factor V as a cofactor leads to cleavage of the Gla and two Kringle domains (forming together a fragment called fragment 1.2) and leave thrombin, consisting solely of the serine protease domain. (wikipedia.org)
  • heparin
  • 7 The first group of complicating factors encompasses those that affect the bioavailability of heparin. (labcorp.com)
  • The second group of complicating factors includes those that alter the aPTT dose response to heparin. (labcorp.com)
  • Lastly, those factors that tend to cause a prolonged aPTT in the absence of heparin therapy should be considered. (labcorp.com)
  • The aPTT should not be used for therapeutic monitoring of low molecular weight heparin or danaparoid. (labcorp.com)
  • The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. (wikipedia.org)
  • PMID
  • doi:10.2337/db09-1291 PMID 19959755 High-efficient FLPo deleter mice in C57BL/6J background. (wikipedia.org)
  • blood
  • Hepatocytes express blood coagulation factor XII. (wikipedia.org)
  • angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. (thefreedictionary.com)
  • coagulation factors factors essential to normal blood clotting , whose absence, diminution, or excess may lead to abnormality of the clotting. (thefreedictionary.com)
  • Factor IV is calcium , required in many stages of blood clotting. (thefreedictionary.com)
  • Von Willebrand factor is mainly active in conditions of high blood flow and shear stress. (wikipedia.org)
  • When vWD is suspected, blood plasma of a patient must be investigated for quantitative and qualitative deficiencies of vWF. (wikipedia.org)
  • Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis (nosebleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. (wikipedia.org)
  • Prevalence of essential hypertension increases with age, and individuals with relatively high blood pressure at younger ages are at increased risk for the subsequent development of hypertension. (wikipedia.org)
  • Hypovitaminosis D is described as any deficiency of vitamin D. A vitamin D blood concentration standard for diagnosing hypovitaminosis D does not exist. (wikipedia.org)
  • Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. (wikipedia.org)
  • Many disease conditions such as diabetes, high blood pressure, etc., are associated with increased mortality. (wikipedia.org)
  • inhibitors
  • However, a major cause of Fe deficiency is poor intake of Fe, due to low bioavailability from plant-based diets containing mineral absorption inhibitors as polyphenols and phytates. (biomedcentral.com)
  • Factor Xa inhibitors generally bind in an L-shaped conformation, where one group of the ligand occupies the anionic S1 pocket lined by residues Asp189, Ser195, and Tyr228, and another group of the ligand occupies the aromatic S4 pocket lined by residues Tyr99, Phe174, and Trp215. (wikipedia.org)
  • enzyme
  • Pauling argued that, due to a non-functional form of L-gulonolactone oxidase, an enzyme required to make vitamin C that is functional in most other mammalian relatives, humans have developed a number of adaptations to cope with the relative deficiency. (wikipedia.org)
  • Although the mechanism of angiogenesis by thymidine phosphorylase is not yet known, reports show that the enzyme itself is not a growth factor but indirectly causes angiogenesis by stimulating chemotaxis of endothelial and other cells. (wikipedia.org)
  • endothelial
  • 9 These findings suggest, in terms of the FVII/FVIIa binding, that higher levels of endothelial or soluble EPCR may shift hemostatic balance toward anticoagulant activity, although it is difficult to predict the relative effects of these processes in vivo. (ahajournals.org)
  • Thymidine phosphorylase has been determined to be almost identical to the platelet-derived endothelial cell growth factor (PD-ECGF). (wikipedia.org)
  • Experiments have found that 2-deoxyribose is an endothelial-cell chemoattractant and angiogenesis-inducing factor, which supports this explanation. (wikipedia.org)
  • subunits
  • Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. (wikipedia.org)
  • amino
  • Human Factor XII is 596 amino acids long and consists of two chains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. (wikipedia.org)
  • conformational
  • The hairpin is partially flexible in solution and its high degree of conformational flexibility allows recognition of the different 5-bp sequences. (wikipedia.org)
  • pathways
  • Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors that regulate cytokine signaling pathways. (suny.edu)
  • vitro
  • Recent in vitro analysis by surface plasmon resonance of FVIIa passed over soluble EPCR bound to the surface, 7 and cell surface EPCR binding to both FVII and FVIIa 8 has suggested that EPCR also acts as a cellular receptor for activated factor VII (FVIIa) and FVII on endothelium. (ahajournals.org)
  • activation
  • Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug) to secondary hemostasis (fibrin meshwork formation). (wikipedia.org)