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  • disorder
  • DBH has been implicated as correlating factor in conditions associated with decision making and addictive drugs, e.g., alcoholism and smoking, attention deficit hyperactivity disorder, schizophrenia, and Alzheimer's disease. (wikipedia.org)
  • Essential thrombocytosis (ET-Also known as essential thrombocythemia) is a disorder characterized by extremely high numbers of circulating platelets. (wikipedia.org)
  • A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair. (wikipedia.org)
  • XIII
  • Umbilical stump bleeding, hemarthroses, retroperitoneal and soft tissue bleeding, and intracranial hemorrhage tend to occur with higher frequency in patients with afibrinogenemia, or with factor (F) II, X or XIII deficiency. (neurologyadvisor.com)
  • cleavage
  • Factor IXa then catalyzes cleavage of factor X. In normal physiologic clotting, the Xase reaction is facilitated by binding of factor X to the activated platelet surface together with the critical cofactor VIIIa, which is generated in response to thrombin. (mhmedical.com)
  • FVII
  • Clinical manifestations in patients with FVII deficiency vary from one patient to another with a poor correlation between baseline factor level and bleeding symptoms. (neurologyadvisor.com)
  • Conclusions- These data suggest that higher levels of FVII and FVIIa circulate when EPCR shedding is greatest. (ahajournals.org)
  • Recent in vitro analysis by surface plasmon resonance of FVIIa passed over soluble EPCR bound to the surface, 7 and cell surface EPCR binding to both FVII and FVIIa 8 has suggested that EPCR also acts as a cellular receptor for activated factor VII (FVIIa) and FVII on endothelium. (ahajournals.org)
  • 9 These findings suggest, in terms of the FVII/FVIIa binding, that higher levels of endothelial or soluble EPCR may shift hemostatic balance toward anticoagulant activity, although it is difficult to predict the relative effects of these processes in vivo. (ahajournals.org)
  • blood
  • Hepatocytes express blood coagulation factor XII. (wikipedia.org)
  • Characterization of the human blood coagulation factor XII gene. (wikipedia.org)
  • angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. (thefreedictionary.com)
  • When vWD is suspected, blood plasma of a patient must be investigated for quantitative and qualitative deficiencies of vWF. (wikipedia.org)
  • Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis (nosebleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. (wikipedia.org)
  • Prevalence of essential hypertension increases with age, and individuals with relatively high blood pressure at younger ages are at increased risk for the subsequent development of hypertension. (wikipedia.org)
  • Hypovitaminosis D is described as any deficiency of vitamin D. A vitamin D blood concentration standard for diagnosing hypovitaminosis D does not exist. (wikipedia.org)
  • Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. (wikipedia.org)
  • Many disease conditions such as diabetes, high blood pressure, etc., are associated with increased mortality. (wikipedia.org)
  • pathway
  • Within NPHSII, markers of coagulation activity have been measured at several steps along the extrinsic or tissue factor pathway. (ahajournals.org)
  • factor B a complement component that participates in the alternative complement pathway. (thefreedictionary.com)
  • The sequence of intracellular reactions involving SMADS is called the SMAD pathway or the transforming growth factor beta (TGF-β) pathway since the sequence starts with the recognition of TGF-β by cells. (wikipedia.org)
  • mutations
  • Mice with mutations in transforming growth factor-β1 gene introduced into 129/Sv Rag2 mutant mouse accelerates adenocarcinomas with strong local invasion suggesting a role for genetic background in tumor development. (wikipedia.org)
  • Platelet
  • Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug) to secondary hemostasis (fibrin meshwork formation). (wikipedia.org)
  • Thymidine phosphorylase has been determined to be almost identical to the platelet-derived endothelial cell growth factor (PD-ECGF). (wikipedia.org)
  • heparin
  • 7 The first group of complicating factors encompasses those that affect the bioavailability of heparin. (labcorp.com)
  • The second group of complicating factors includes those that alter the aPTT dose response to heparin. (labcorp.com)
  • Lastly, those factors that tend to cause a prolonged aPTT in the absence of heparin therapy should be considered. (labcorp.com)
  • subunits
  • Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. (wikipedia.org)
  • amino
  • Human Factor XII is 596 amino acids long and consists of two chains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. (wikipedia.org)
  • conformational
  • The hairpin is partially flexible in solution and its high degree of conformational flexibility allows recognition of the different 5-bp sequences. (wikipedia.org)
  • levels
  • In general, individuals with factor VII levels between 2-10% have mild bleeding symptoms (easy bruising and mucocutaneous bleeding, including menorrhagia). (neurologyadvisor.com)
  • Low levels of factor XI also occur in many other disease states, including Noonan syndrome. (wikipedia.org)
  • Developmental vitamin D deficient (DVD) rats have decreased levels of neurotrophic factors, increased mitosis, and decreased apoptosis. (wikipedia.org)
  • endothelial
  • Although the mechanism of angiogenesis by thymidine phosphorylase is not yet known, reports show that the enzyme itself is not a growth factor but indirectly causes angiogenesis by stimulating chemotaxis of endothelial and other cells. (wikipedia.org)
  • Experiments have found that 2-deoxyribose is an endothelial-cell chemoattractant and angiogenesis-inducing factor, which supports this explanation. (wikipedia.org)
  • Mice
  • Tyk2−/− mice displayed a lack of responsiveness to a small amount of IFN-α, but they respond normally to a high concentration of IFN-α/β. (wikipedia.org)
  • Further elucidation of molecular mechanisms of LPS signaling, showed that Tyk2 and IFN-β deficiency leads resistance to LPS-induced endotoxin shock, whereas STAT1-deficient mice are susceptible. (wikipedia.org)
  • primarily
  • Tyk2 has broader and profound functions in humans than previously appreciated on the basis of analysis of murine models, which indicate that Tyk2 functions primarily in IL-12 and type I-IFN signaling. (wikipedia.org)
  • assay
  • MBS9301618 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the coagulation factor XII, FXII, ELISA Kit target analytes in biological samples. (mybiosource.com)
  • tumor
  • Our recent study showing reversible regulation of tumor suppressor p53 by Complex I deficiency provides a mechanistic explanation for this (Compton et. (pvlsi.org)
  • 12.M Yang, J-H Shao, Y-J Miao, W Cui, Y-F Qi, J-H Han, X Lin, J Du: Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. (54doctor.net)
  • T-lymphocyte turnover is promoted by the production of interleukin-6, interleukin-1, interleukin-2, and tumor necrosis factor (TNF)- α , all of which promote HIV replication [ 1 ]. (hindawi.com)
  • Pediatric
  • We used human glioma lines containing BRAF V600E (adult high-grade: AM-38, DBTRG, PLGG: BT40), or wild-type BRAF (pediatric high-grade: SF188, SF9427, SF8628) and isogenic systems of KIAA1549:BRAF -expressing NIH/3T3 cells and BRAF V600E -expressing murine brain cells. (aacrjournals.org)
  • acute
  • This model is based on our previous study showing that pathological overactivation of neurons could lead to full use of their spare respiratory capacity (Yadava & Nicholls 2007 This model proposes that even a very minor impairment of the oxidative phosphorylation could be detrimental under conditions of acute high-energy demands. (pvlsi.org)
  • Other risk factors: Lack of sufficient insulin (but enough to prevent ketosis) Poor kidney function Poor fluid intake (dehydration) Older age (50-70 years) Certain medical conditions (cerebral vascular injury, myocardial infarction, sepsis) Some medications (glucocorticoids, beta-blockers, thiazide diuretics, calcium channel blockers, phenytoin) HHS is usually precipitated by an infection, myocardial infarction, stroke or another acute illness. (wikipedia.org)
  • diabetes
  • The long-term objectives of my group are to understand how mitochondrial dysfunction leads to neurodegeneration and diseases such as cancer and diabetes, as well as the molecular, biochemical, and physiological causes of mitochondrial dysfunction. (pvlsi.org)
  • Hyperosmolar hyperglycemic state (HHS) is a complication of diabetes mellitus in which high blood sugar results in high osmolarity without significant ketoacidosis. (wikipedia.org)
  • The main risk factor is a history of diabetes mellitus type 2. (wikipedia.org)
  • Symptoms of HHS include: Altered level of consciousness Neurologic signs including: blurred vision, headaches, focal seizures, myoclonic jerking, reversible paralysis Motor abnormalities including flaccidity, depressed reflexes, tremors or fasiciculations Hyperviscosity and increased risk of blood clot formation Dehydration Weight loss Nausea, vomiting, and abdominal pain Weakness Low blood pressure with standing The main risk factor is a history of diabetes mellitus type 2. (wikipedia.org)
  • incidence
  • English, and Scandinavian origin have a particularly high incidence of whom about 10% are carriers of the C282Y mutation on the HFE gene associated with HLA-A3[which? (wikipedia.org)
  • proteins
  • Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. (jci.org)
  • Of these three proteins, TBG has the highest affinity for T4 and T3 but is present in the lowest concentration. (wikipedia.org)
  • These inorganic phosphates are then bound to carrier proteins which deliver the inorganic phosphates to a specific high-affinity transport system, known as the Pst system, which transports phosphate across the cytoplasmic membrane. (wikipedia.org)
  • lungs
  • Because such blood cells carry oxygen from the lungs to the muscles, a higher concentration in the blood can improve an athlete's aerobic capacity (VO2 max) and endurance. (wikipedia.org)
  • mechanisms
  • Although it is possible that multiple mechanisms could play roles in mitochondrial dysfunction-mediated pathogenesis, our data suggest that the "bioenergetic deficit" could be a major driving factor in diseases of tissues with high bioenergetic demands. (pvlsi.org)
  • Using these models, we are deciphering the mechanisms by which complex I deficiency can confer opposite cell fates in neurodegeneration and cancer. (pvlsi.org)
  • Wolf M, Ferrari M, Quaresima V. Progress of general history New Frontiers in technological factor x regulators of the number reclaimed in website mechanisms and offensive for understanding and aware leftist thoughts. (cdmw.de)
  • enzyme
  • The molecular composition of the human telomerase enzyme complex was determined by Dr Scott Cohen and his team at the Children's Medical Research Institute (Sydney Australia) and consists of two molecules each of human telomerase reverse transcriptase (TERT), telomerase RNA (TR or TERC), and dyskerin (DKC1). (wikipedia.org)
  • The levels of this enzyme in the blood depend on factors such as age, gender, blood type and whether an individual is pregnant or not. (wikipedia.org)
  • sufficient
  • The body undergoes aerobic respiration in order to provide sufficient delivery of O2 to the exercising skeletal muscles and the main determining factors are shown in figure 1. (wikipedia.org)
  • levels
  • If, for example, the TBG level is high, which can occur when estrogen levels are high, the TBG will bind more thyroid hormone, decreasing the free hormone available in the blood, which leads to stimulation of TSH, and the production of more thyroid hormone. (wikipedia.org)
  • In contrast to DKA, serum glucose levels in HHS are extremely high, usually greater than 40-50 mmol/L (600 mg/dL). (wikipedia.org)
  • Management
  • The basic approach was the development of high-yielding varieties of cereal grains, expansion of irrigation infrastructure, modernization of management techniques, distribution of hybridized seeds, synthetic fertilizers, and pesticides to farmers. (wikipedia.org)
  • weight
  • Taking into account the molecular weight of each component and its proportion in the composition of air, it is possible to calculate the mean molecular weight of air as 28.966 (approximately 29). (thefreedictionary.com)
  • Initial treatment generally consists of intravenous fluids to manage dehydration, intravenous insulin in those with significant ketones, low molecular weight heparin to decrease the risk of blood clotting, and antibiotics among those in whom there is concerns of infection. (wikipedia.org)
  • indicate
  • Higher rates of cribia orbitalia among females may indicate lesser health status, or greater survival of young females with cribia orbitalia into adulthood. (wikipedia.org)
  • rare
  • For example, in German ancestry, where enzymopathy due to G6PD deficiency is rare, mutation sites on G6PD have been shown to lie near the NADP+ binding site, the G6P binding site, and near the interface between the two monomers. (wikipedia.org)
  • take
  • Do not take this deficiency for longer than needed as that can build up allergic dat in your doctor. (nextstore.se)
  • Seven of the 116 pregnancies in women taking anti-seizure drugs, or 6 percent, had major birth defects, compared to 12 of 580 pregnancies, or 2 percent, in women who did not take the drug. (blogspot.com)
  • provides
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • certain
  • Due to several virus- and patient-related factors, treatment is even less successful in certain populations, especially in HCV genotype 1 infection. (clinicaltrials.gov)
  • Photosynthesis (forward) and respiration (reverse) is represented by the equation: 106 CO 2 + 16 HNO 3 + H 3 PO 4 + 122 H 2 O ⇋ ( CH 2 O ) 106 ( NH 3 ) 16 ( H 3 PO 4 ) + 136 O 2 {\textstyle {\ce {{106CO_{2}}+{16HNO3}+{H3PO4}+{122H_{2}O}{\displaystyle \leftrightharpoons }{(CH2O)106(NH3)16(H3PO4)}+{136O2}}}} Photosynthesis can be limited by deficiencies of certain macronutrients. (wikipedia.org)
  • cells
  • indicated that the exposure of retinal neurosensory and glial cells to HIV Tat resulted in increased activation and release of proinflammatory mediators, predominantly the chemokine and neurotoxic factor CXCL10 and the cytokine TNF- α [ 5 ]. (hindawi.com)
  • study
  • The study also further illustrates that the deficiency of presenilin 1 disconnects the sequential phosphorylation and thus disrupts the normal wnt signaling pathway. (wikipedia.org)
  • repair
  • As indicated in the article Genome instability, such genome instability may be due to deficiencies in other DNA repair genes present in the cancers. (wikipedia.org)
  • research
  • Based on molecular and morphological research, the cetaceans genetically and morphologically fall firmly within the Artiodactyla (even-toed ungulates). (wikipedia.org)
  • blood
  • Symptoms of high blood sugar including increased thirst (polydipsia), increased volume of urination (polyurea), and increase hunger (polyphagia). (wikipedia.org)
  • Blood doping is defined as the use of illicit products (e.g. erythropoietin (EPO), darbepoetin-alfa, hypoxia-inducible factor (HIF) stabilizers) and methods (e.g. increase aerobic capacity by maximizing the uptake of O2) in order to enhance the O2 transport of the body to the muscles. (wikipedia.org)
  • animal
  • A conditional knockout mouse line, called Myd88tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. (wikipedia.org)
  • especially
  • Systemic maternal viral infections can also affect the pregnancy, and these can be especially dangerous, because pregnant women suffer higher virus-associated morbidity and mortality than do nonpregnant counterparts. (jci.org)
  • new, high-yielding varieties (HYVs) of cereals, especially dwarf wheats and rices, in association with chemical fertilizers and agro-chemicals, and with controlled water-supply (usually involving irrigation) and new methods of cultivation, including mechanization. (wikipedia.org)
  • rates
  • Quinlan C.L., Goncalves R.L.S., Hey-Mogensen M., Yadava N., Bunik V.I., Brand M.D. (2014): The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J. Biol. (pvlsi.org)
  • addition
  • These inventions were a part of a general movement toward industrialization that occurred first in England, including a two-axis scanner and reasonably high NA lens, in addition to the heterodyne interferometer and detection electronics necessary optkon OCT. The bonus that the ad promised them never reaches their hands. (forexsignalhere.com)
  • regions
  • High-nutrient, low-chlorophyll (HNLC) regions are regions of the ocean where the abundance of phytoplankton is low and fairly constant despite the availability of macronutrients. (wikipedia.org)
  • This co-occurrence of low chlorophyll and high macronutrient availability is why these regions are deemed "high-nutrient, low-chlorophyll. (wikipedia.org)
  • Agriculture in Mexico had been a sociopolitical issue, a key factor in some regions' participation in the Mexican Revolution. (wikipedia.org)
  • several
  • In higher plants, several isoforms of G6PDH have been reported, which are localized in the cytosol, the plastidic stroma, and peroxisomes. (wikipedia.org)
  • usually
  • A relative insulin deficiency leads to a serum glucose that is usually higher than 33 mmol/L (600 mg/dL), and a resulting serum osmolarity that is greater than 320 mOsm. (wikipedia.org)
  • Stored RBCs are then reinfused, usually 1 to 7 days before a high-endurance event. (wikipedia.org)
  • known
  • Phocids (earless seals) are known to have existed for at least 15 mya, and molecular evidence supports a divergence of the Monachinae (monk seals) and Phocinae lineages 22 mya. (wikipedia.org)
  • The molecular ratio of 106(Carbon):16(Nitrate):1(Phosphorous) was discovered by Redfield, Ketcham, and Richards (RKR) and is known as the Redfield Ratio. (wikipedia.org)
  • content
  • The curcumin content in turmeric is about 3% which is not high, and it may not be easy reaching a 1 gram daily dosage which you can get from supplements, by simply eating the turmeric spice you add to your food. (adamkempfitness.com)