• disorder
  • Essential thrombocytosis (ET-Also known as essential thrombocythemia) is a disorder characterized by extremely high numbers of circulating platelets. (wikipedia.org)
  • A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair. (wikipedia.org)
  • FVII
  • Conclusions- These data suggest that higher levels of FVII and FVIIa circulate when EPCR shedding is greatest. (ahajournals.org)
  • Recent in vitro analysis by surface plasmon resonance of FVIIa passed over soluble EPCR bound to the surface, 7 and cell surface EPCR binding to both FVII and FVIIa 8 has suggested that EPCR also acts as a cellular receptor for activated factor VII (FVIIa) and FVII on endothelium. (ahajournals.org)
  • 9 These findings suggest, in terms of the FVII/FVIIa binding, that higher levels of endothelial or soluble EPCR may shift hemostatic balance toward anticoagulant activity, although it is difficult to predict the relative effects of these processes in vivo. (ahajournals.org)
  • Clinical manifestations in patients with FVII deficiency vary from one patient to another with a poor correlation between baseline factor level and bleeding symptoms. (cancertherapyadvisor.com)
  • It was demonstrated in several cross-sectional studies that levels of triglycerides are associated with levels of factor VII (FVII) as measured in a clotting assay (FVII-c). 7 8 Furthermore, the Northwick Park Heart Study demonstrated that high levels of FVII-c constitute an independent risk factor for acute coronary events. (ahajournals.org)
  • 9 Others have suggested that these high levels of FVII-c represent enhanced levels of activated FVII (FVIIa). (ahajournals.org)
  • PMID
  • doi:10.2337/db09-1291 PMID 19959755 High-efficient FLPo deleter mice in C57BL/6J background. (wikipedia.org)
  • mutations
  • Mice with mutations in transforming growth factor-β1 gene introduced into 129/Sv Rag2 mutant mouse accelerates adenocarcinomas with strong local invasion suggesting a role for genetic background in tumor development. (wikipedia.org)
  • pathway
  • Within NPHSII, markers of coagulation activity have been measured at several steps along the extrinsic or tissue factor pathway. (ahajournals.org)
  • factor B a complement component that participates in the alternative complement pathway. (thefreedictionary.com)
  • The sequence of intracellular reactions involving SMADS is called the SMAD pathway or the transforming growth factor beta (TGF-β) pathway since the sequence starts with the recognition of TGF-β by cells. (wikipedia.org)
  • blood
  • Hepatocytes express blood coagulation factor XII. (wikipedia.org)
  • Characterization of the human blood coagulation factor XII gene. (wikipedia.org)
  • angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. (thefreedictionary.com)
  • coagulation factors factors essential to normal blood clotting , whose absence, diminution, or excess may lead to abnormality of the clotting. (thefreedictionary.com)
  • Factor IV is calcium , required in many stages of blood clotting. (thefreedictionary.com)
  • Von Willebrand factor is mainly active in conditions of high blood flow and shear stress. (wikipedia.org)
  • When vWD is suspected, blood plasma of a patient must be investigated for quantitative and qualitative deficiencies of vWF. (wikipedia.org)
  • Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis (nosebleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. (wikipedia.org)
  • Prevalence of essential hypertension increases with age, and individuals with relatively high blood pressure at younger ages are at increased risk for the subsequent development of hypertension. (wikipedia.org)
  • Hypovitaminosis D is described as any deficiency of vitamin D. A vitamin D blood concentration standard for diagnosing hypovitaminosis D does not exist. (wikipedia.org)
  • Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. (wikipedia.org)
  • Many disease conditions such as diabetes, high blood pressure, etc., are associated with increased mortality. (wikipedia.org)
  • anticoagulants
  • Lupus anticoagulants or deficiency in contact factors can produce an extended baseline aPTT. (labcorp.com)
  • The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. (wikipedia.org)
  • fibrin
  • These studies showed that fibrin was associated with these cells and led them to conclude that platelets supplied a factor that was required for coagulation. (ahajournals.org)
  • Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug) to secondary hemostasis (fibrin meshwork formation). (wikipedia.org)
  • Poor wound healing due to abnormal fibrin crosslinking and increased sensitivity to fibrinolysis is typical of FXIII deficiency. (cancertherapyadvisor.com)
  • Factor XIIIa is a transglutaminase that catalyzes the formation of covalent bonds between lysine and glutamine residues in fibrin. (wikipedia.org)
  • enzyme
  • MBS9301618 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the coagulation factor XII, FXII, ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Pauling argued that, due to a non-functional form of L-gulonolactone oxidase, an enzyme required to make vitamin C that is functional in most other mammalian relatives, humans have developed a number of adaptations to cope with the relative deficiency. (wikipedia.org)
  • Although the mechanism of angiogenesis by thymidine phosphorylase is not yet known, reports show that the enzyme itself is not a growth factor but indirectly causes angiogenesis by stimulating chemotaxis of endothelial and other cells. (wikipedia.org)
  • heparin
  • 7 The first group of complicating factors encompasses those that affect the bioavailability of heparin. (labcorp.com)
  • The second group of complicating factors includes those that alter the aPTT dose response to heparin. (labcorp.com)
  • Lastly, those factors that tend to cause a prolonged aPTT in the absence of heparin therapy should be considered. (labcorp.com)
  • endothelial
  • Thymidine phosphorylase has been determined to be almost identical to the platelet-derived endothelial cell growth factor (PD-ECGF). (wikipedia.org)
  • Experiments have found that 2-deoxyribose is an endothelial-cell chemoattractant and angiogenesis-inducing factor, which supports this explanation. (wikipedia.org)
  • subunits
  • Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. (wikipedia.org)
  • amino
  • Human Factor XII is 596 amino acids long and consists of two chains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. (wikipedia.org)
  • conformational
  • The hairpin is partially flexible in solution and its high degree of conformational flexibility allows recognition of the different 5-bp sequences. (wikipedia.org)