Germ-Line MutationMutationMutation, MissenseLi-Fraumeni SyndromeMutation RatePoint MutationDNA Mutational AnalysisPedigreePolymerase Chain ReactionHeterozygoteBase SequenceGenes, p53Molecular Sequence DataMicrosatellite RepeatsGenetic Predisposition to DiseaseGenotypeFrameshift MutationCell LineBreast NeoplasmsSelection, GeneticMutagenesisEvolution, MolecularAllelesSequence Analysis, DNAGerm CellsModels, GeneticAmino Acid SequencePhenotypeGenetic VariationExonsDNA, MitochondrialAmino Acid SubstitutionBiological EvolutionGenome SizeNeoplasms, Germ Cell and EmbryonalPhylogenyCell Line, TumorRecombination, GeneticPolymorphism, Single-Stranded ConformationalHomozygoteMutagenesis, Site-DirectedEscherichia coliDNA RepairCodon, NonsenseDNA PrimersSpermatogenesisPolymorphism, GeneticRNA VirusesSequence DeletionDNA-Binding ProteinsChromosome MappingRNA, MessengerTestisGenes, RecessiveProtein Structure, TertiaryTranscription FactorsGenome, ViralDNACloning, MolecularGenetics, PopulationSequence Homology, Amino AcidGenetic TestingGenes, DominantTranscription, GeneticModels, BiologicalGene DeletionCaenorhabditis elegansGonadsBinding SitesDrosophila melanogasterVirus ReplicationModels, MolecularCodonSuppression, GeneticTransfectionGenomeNuclear ProteinsSequence AlignmentProtein BindingPromoter Regions, GeneticGenetic Complementation TestWheat Germ AgglutininsCrosses, GeneticMembrane ProteinsSpermatozoaGene Expression Regulation, DevelopmentalCell Line, TransformedPlasmidsOogenesisCaenorhabditis elegans ProteinsDrosophila ProteinsGenes, LethalSignal TransductionGenesDrosophilaGerm LayersGenetic LinkageRNA, ViralSex Determination AnalysisMice, Transgenic