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  • CD36
  • 3 6 We demonstrate that ES Mø exhibit properties typical of arterial lesion Mø, including the expression of modified LDL receptors (scavenger receptor [SR]-A, CD36, and CD68), capacity for foam cell formation, secretion of MMPs, and expression of inflammatory cytokines. (ahajournals.org)
  • CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. (wikipedia.org)
  • murine
  • Stoep M. van der, Li Z., Sluis R.J. van der, Berkel T.J.C. van, Eck M. van, Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) activation influences murine platelet count only under normolipidemic conditions, Journal of Thrombosis and Haemostasis 11: 910-910. (universiteitleiden.nl)
  • atherosclerotic lesions
  • Van der Stoep M., Li Z., Calpe-Berdiel L., Van der Sluis R. J., McKinnon H. J., Smit M. J., Van Berkel T. J. C., Van Eck M., Hoekstra M. & Korporaal S. J. A. (2013), Liver X receptor (LXR) agonist T0901317 induces regression of early and advanced atherosclerotic lesions under normolipidemic conditions in mice Journal of Thrombosis and Haemostasis. (universiteitleiden.nl)
  • selective
  • Apomorphine (brand names Apokyn, Ixense, Spontane, Uprima) is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. (wikipedia.org)
  • regulation
  • After chemokine engagement, ACKR2 activate a G-protein-independent and β-arrestin-dependent Rac1-PAK1-LIMK1 signalling cascade to finely regulate the actin cytoskeletal and the microtubules network reorganization, to promote receptor up-regulation and scavenging function. (unimi.it)
  • The activation of Trk receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells. (wikipedia.org)
  • intracellular
  • The binding of BDNF to TrkB receptor causes many intracellular cascades to be activated, which regulate neuronal development and plasticity, long-term potentiation, and apoptosis. (wikipedia.org)
  • inflammatory
  • However, in presence of other factors such as positive energy balance, excessive intake of carbohydrates (in particular mono and disaccharides), and a sedentary lifestyle, the mechanisms to maintain a steady state of PA concentration may be disrupted leading to an over accumulation of tissue PA resulting in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4. (frontiersin.org)
  • genes
  • These genes also exhibit unusually high levels of segregating nonsynonymous polymorphism in D. melanogaster and D . simulans populations. (genetics.org)
  • nervous system
  • Sulfatide is a major component in the nervous system and is found in high levels in the myelin sheath in both the peripheral nervous system and the central nervous system. (wikipedia.org)
  • synthase
  • The present data suggest that ATP synthase β -chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C. (hindawi.com)
  • facilitates
  • To combat infection, the phagocytes of the innate immune system facilitates many pattern recognition receptors (PRR) to help recognize pathogen-associated molecular patterns (PAMPs) on the surface of pathogenic microorganisms. (wikipedia.org)
  • cell
  • Beyond conventional chemokine receptors, which directly induce cell migration through heterotrimeric Gαi-mediated signalling events, a set of atypical chemokine receptors (ACKRs) have been described. (unimi.it)
  • On T cells and B cells, trogocytosis is triggered when the T cell receptor (TCR) on T cells or B cell receptor (BCR) on B cells interacts with the antigen recognized on antigen-presenting cells. (wikipedia.org)
  • compound
  • Similar to other chromium(III) compounds, it is relatively inert and unreactive, meaning that this complex is stable at ambient conditions and high temperatures are required to decompose the compound. (wikipedia.org)
  • functional
  • However, the activation of these receptors also has significant effects on functional properties of neurons. (wikipedia.org)
  • Each monomer of human alpha-2-macroglobulin is composed of several functional domains, including macroglobulin domains, a thiol ester-containing domain and a receptor-binding domain. (wikipedia.org)
  • activation
  • Chemokines promote leukocyte migration through the activation of dedicated G-protein coupled receptors. (unimi.it)
  • This pain arises from activation of the pain receptor, TRPA1, found on sensory nerves and can be mitigated by pretreatment with lidocaine. (wikipedia.org)
  • Many of its biological effects in animals are produced through activation of melatonin receptors, while others are due to its role as an antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA. (wikipedia.org)
  • molecules
  • The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. (wikipedia.org)
  • therefore
  • Therefore, the data suggest that the presence of p75NTR affects the conformation of TrkA, preferentially the state with high-affinity binding site for NGF. (wikipedia.org)
  • expression
  • The authors used bone marrow transplantation to selectively eliminate SR-BI expression in bone marrow-derived cells in a hyperlipidemic mouse model: the LDL receptor-deficient mice. (ahajournals.org)
  • The SV40 promoter was conventionally used until research showed that vectors driven by the Rous Sarcoma Virus (RSV) promoter had much higher expression rates. (wikipedia.org)
  • family
  • The family of Trk receptors is named for the oncogene trk, whose identification led to the discovery of its first member, TrkA. (wikipedia.org)
  • activity
  • Key to the use of apomorphine as a behavioural modifier was the research of Erich Harnack, whose experiments in rabbits (which do not vomit) demonstrated that apomorphine had powerful effects on the activity of rabbits, inducing licking, gnawing and in very high doses convulsions and death. (wikipedia.org)
  • Activity of the alveolar macrophage is relatively high, because they are located at one of the major boundaries between the body and the outside world. (wikipedia.org)
  • Research has generally shown that it improves insulin sensitivity by either prolonging its activity or up-regulating the production of mRNA to produce more insulin receptors. (wikipedia.org)
  • domain
  • Two additional events occur as a consequence of bait region cleavage, namely (i) the h-cysteinyl-g-glutamyl thiol ester becomes highly reactive and (ii) a major conformational change exposes a conserved COOH-terminal receptor binding domain (RBD). (wikipedia.org)
  • directly
  • Even worse, the Hb may be converted to higher oxidation states such as ferrylHb which have potent proinflammatory and prooxidant effects, either directly or via the release of heme which itself is highly prooxidant. (hindawi.com)
  • highly
  • High-sensitivity C-reactive protein (CRP) in the normal range (1 to 10 mg/L) measured by highly sensitive assays, is a strong risk factor for future cardiovascular events. (ahajournals.org)