Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
PimozidePenfluridolThioridazineMibefradilApomorphineCyproheptadineReceptors, DopamineFluoxetineAntidepressive Agents, Second-GenerationSerotonin Uptake InhibitorsSerotoninDrug InteractionsProduct LabelingDrug Labeling
ThioridazineQuinidineAntipsychoticsAntipsychoticPhenytoinSertralineTourette'sOxiperomideMolindoneHypersensitivityAzithromycinDosageDosesUnborn babySchizophreniaMental illnessMedicationDopamineExtrapyramidalDoseChlorpromazineDrugsHarmfulAvoidPrescriptionKetoconazoleSymptomsBloodSide EffectsIncidenceTreatmentOralIrregularCholesterolPatientsDrugRiskBrand nameConditionsDoctor
Thioridazine1
Quinidine1
  • According to the company, Noxafil should not be given to persons allergic to posaconazole, any ingredients of Noxafil, or other azole antifungal medicines, as well as the administration of the drug with sirolimus, pimozide, quinidine, atorvastatin, lovastatin, simvastatin and ergot alkaloids should be avoided. (pharmaceutical-technology.com)
Antipsychotics3
  • A 2013 systematic review compared pimozide with other antipsychotics for schizophrenia or related psychoses: It is contraindicated in individuals with either acquired, congenital or a family history of QT interval prolongation. (wikipedia.org)
  • Similarly to other typical antipsychotics pimozide has a high affinity for the dopamine D2 receptor and this likely results in its sexual (due to prolactin hypersecretion) and extrapyramidal side effects as well as its therapeutic efficacy against the positive symptoms of schizophrenia. (wikipedia.org)
  • Pimozide belongs to the class of medications called antipsychotics. (pocketpills.com)
Antipsychotic3
  • Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. (wikipedia.org)
  • Pimozide is an antipsychotic medication. (health32.com)
  • Which of the following has the lowest incidence of extrapyramidal reactions, but has the highest incidence of agranulocytosis among antipsychotic agents? (kupdf.net)
Phenytoin1
  • The kinetics characteristic of elimination of ethanol and high doses of phenytoin and aspirin is known as A. Distribution B. Excretion C. First-pass effect D. First-order elimination E. Zero-order elimination 13. (kupdf.net)
Sertraline2
  • In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkylation to 1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one (DHPBI), by four SSRIs (fluoxetine, sertraline, paroxetine, and fluvoxamine) and azithromycin was tested. (nih.gov)
  • At 10 microM paroxetine, sertraline, fluoxetine, or fluvoxamine, the formation of DHPBI from pimozide (10 microM) in HLMs was inhibited by an average (three HLMs) of 7%, 7.7%, 8%, and 16%, respectively, whereas this inhibition did not exceed 55% at the maximum concentrations (100 microM) of the SSRIs tested. (nih.gov)
Tourette's3
  • In 1985 pimozide was approved by the FDA for marketing as an orphan drug for the treatment of Tourette's syndrome. (wikipedia.org)
  • Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette's syndrome. (nih.gov)
  • Pimozide is used to suppress the motor and phonic tics associated with Tourette's disorder. (health32.com)
Oxiperomide1
  • Pimozide & Bezitramide (& Oxiperomide & Neflumozide) are also made from 4-(1-Benzimidazolinone)piperidine precursor Droperidol is similar, but has a tetrahydropyridine ring. (wikipedia.org)
Molindone1
Hypersensitivity1
  • It is also contraindicated in individuals being cotreated with selective serotonin reuptake inhibitors (SSRI) or in those with a known hypersensitivity to pimozide or other diphenylbutyl-piperidine derivatives. (wikipedia.org)
Azithromycin2
  • Azithromycin had negligible effect on pimozide (10 microM) N-dealkylation (19% at 100 microM azithromycin). (nih.gov)
  • These values are least 100-fold higher than the expected plasma concentrations after the usual daily doses of the SSRIs and azithromycin, suggesting that coadministration of SSRIs and azithromycin are unlikely to markedly diminish the elimination of pimozide in patients. (nih.gov)
Dosage1
  • You may not be able to take pimozide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. (health32.com)
Doses3
  • In high doses, it has antihistaminergic and alpha-adrenergic properties. (wikipedia.org)
  • In vivo displacement of 3H-spiperone by pipamperone and LSD occurred at low doses (both 0.63 mg/kg) in the frontal cortex but not in brain dopaminergic areas, while labeling in these fatter regions was reduced by high doses of LSD (10 mg/kg) but only significantly after 2 hr. (erowid.org)
  • Do not take higher doses of this medication than those prescribed by your doctor. (medbroadcast.com)
Unborn baby1
  • Pimozide is in the FDA pregnancy category C. This means that it is not known whether pimozide will be harmful to an unborn baby. (health32.com)
Schizophrenia1
  • Pimozide is used in its oral preparation in schizophrenia and chronic psychosis (on-label indications in Europe only), Tourette syndrome, and resistant tics (Europe, United States and Canada). (wikipedia.org)
Mental illness1
  • People with chronic pain who were on prescription painkillers were at 49% higher risk of mental illness and 82% higher risk of developing substance abuse. (medicaldaily.com)
Medication4
  • Pimozide may also be used for purposes other than those listed in this medication guide. (health32.com)
  • It can also exacerbate the medication induced shortness of breath and puts you at high risk of developing such side effects in the first place. (optimistminds.com)
  • reduce high blood pressure alone or with other medication. (imedi.co.uk)
  • Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working. (medbroadcast.com)
Dopamine1
  • Pimozide, which selectively blocks dopamine type-2 receptors, was the drug first reported to be useful in the condition, and several series indicated a good response in most patients who accepted it. (cdc.gov)
Extrapyramidal1
  • Very common (>10% frequency) side effects include: Akinesia Constipation Dizziness Dry mouth Hyperhidrosis Nocturia Somnolence Speech disorder Pimozide overdose presents with severe extrapyramidal symptoms, hypotension, sedation, QT interval prolongation and ventricular arrhythmias including torsades de pointes. (wikipedia.org)
Dose5
  • If you need a higher or lower dose, your doctor may prescribe the regular tablets instead. (medlineplus.gov)
  • It is a highly potent butyrophenone derivative and is the most potent neuroleptic in the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% the potency per dose of haloperidol). (wikipedia.org)
  • Overdosing on low strength mirtazapine would not produce as dangerous effects as a high dose would produce. (optimistminds.com)
  • The recommended starting dose of pimozide ranges from 2 mg to 4 mg once daily, taken in the morning. (pocketpills.com)
  • Note: may need higher dose in patients with central nervous system disease. (cdc.gov)
Chlorpromazine1
  • It has a high potency compared to chlorpromazine (ratio 50-70:1). (wikipedia.org)
Drugs2
  • In addition, the possibility that these drugs could alter pimozide disposition through effects on transport proteins or via promoter repression cannot be ruled out. (nih.gov)
  • Pharmacists are usually very willingto discuss drugs with patients, and some high-street chemists havespace set aside where you can talk privately. (findmedarticle.com)
Harmful1
Avoid1
  • This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. (qualitydrugstorenow24.com)
Prescription1
  • You could get Pimozide delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. (pocketpills.com)
Ketoconazole1
  • At 0.1 microM and 0.5 microM ketoconazole, the formation of DHPBI from 10 microM pimozide was inhibited by 32% and 62%, respectively. (nih.gov)
Symptoms3
  • Of those patients receiving pimozide, 61% (11/18) experienced improvement in or full remission of symptoms. (wikipedia.org)
  • Get medical help right away if you have any of these symptoms: High fever, uncontrolled Paroxetine pill Buy spasms, stiff muscles, rapid changes in heart rate or blood pressure, confusion, loss of consciousness pass out. (tlccmiracle.org)
  • Do not give Pimozide to anyone else, even if they have the same symptoms as you do. (pocketpills.com)
Blood4
  • This puts pressure on your heart and lungs to supply blood and oxygen to every single cell of your body, resulting in shortness of breath and high blood pressure. (optimistminds.com)
  • It is used to treat adult patients with endogenous Cushing syndrome who have diabetes mellitus or glucose intolerance and have high blood sugars that are a result of elevated cortisol levels. (emedz.net)
  • Also tell your doctor if you are taking certain medicines for high blood pressure , as such medicines can also change the levels of sodium in your blood. (zeepedia.com)
  • If you are older, because you may be at higher risk of getting low sodium levels in your blood (see above). (zeepedia.com)
Side Effects3
  • However, patients who experience negative side-effects with the first line medications are typically given pimozide. (wikipedia.org)
  • The side effects listed below are not experienced by everyone who takes Pimozide. (pocketpills.com)
  • If you are concerned about side effects, discuss the risks and benefits of Pimozide with your doctor. (pocketpills.com)
Incidence1
  • Distal nerve blocks or ablative procedures generally are not recommended owing to a high incidence of early recurrence. (physiotherapy-treatment.com)
Treatment4
  • The use of pimozide for the treatment of delusional parasitosis is based primarily on data from case series/reports that demonstrate some efficacy in the majority of patients. (wikipedia.org)
  • Pimozide has been used in the treatment of delusional disorder and paranoid personality disorder. (wikipedia.org)
  • Gastric lavage, establishment of a patent airway and, if necessary, mechanically assisted respiration is the recommended treatment for pimozide overdose. (wikipedia.org)
  • Do not consume grapefruit or grapefruit juice during treatment with pimozide. (health32.com)
Oral1
  • Both tablets and oral suspension are indicated for the prophylaxis of invasive Aspergillus and Candida infections in patients, aged 13 and older, who are at high-risk of developing these infections due to being severely immunocompromised. (pharmaceutical-technology.com)
Irregular1
  • A dangerous interaction, possibly resulting in irregular heartbeats and/or death may occur if pimozide is taken with any of the medicines listed above. (health32.com)
Cholesterol2
  • Tell your doctor if you have liver disease, kidney disease, diabetes, a bleeding disorder, or high cholesterol or triglycerides. (doctorsolve.com)
  • Shortness of breath is a symptom of high cholesterol levels itself. (optimistminds.com)
Patients2
  • In one case a series of 33 patients with delusional parasitosis (median age, 60 years), pimozide was prescribed for 24 patients, 18 of whom took the drug. (wikipedia.org)
  • University of Michigan Comprehensive Cancer Center professor of internal medicine Daniel Couriel said prophylaxis against invasive Aspergillus and Candida infections play a major role in the management of severely immunocompromised patients with haematologic malignancies or hematopoietic stem cell transplant recipients at high-risk for these life-threatening fungal infections. (pharmaceutical-technology.com)
Drug4
  • There have been numerous studies showing pimozide can be used successfully to treat delusional parasitosis and traditionally was the drug of choice. (wikipedia.org)
  • www.drugguide.com/ddo/view/Davis-Drug-Guide/51612/all/pimozide. (drugguide.com)
  • Your doctor may have suggested Pimozide for conditions other than those listed in these drug information articles. (pocketpills.com)
  • With modern advances in robotics and data processing, high-throughput screening (HTS) is playing an increasingly growing role in the drug discovery process. (oncotarget.com)
Risk3
  • Pimozide increases the risk of heat stroke. (health32.com)
  • It puts people at high risk of chronic obstructive pulmonary disease (COPD), emphysema and lung cancer. (optimistminds.com)
  • When such a person takes mirtazapine, he or she is at high risk of developing shortness of breath. (optimistminds.com)
Brand name1
  • Any specific brand name of Pimozide may not be available in all of the forms or approved for all of the conditions discussed here. (pocketpills.com)
Conditions1
Doctor2