High organ specificity. Medical search. Frequent questions

Standardization Program (DASP, 2000, 2002, 2003), organized by WHO, the data were: 76-100% sensitivity, 90-100% specificity (100% specificity 3 times), and 100% validity for GAD65 autoantibodies (3). (cdc.gov)
Many studies indicate a high sensitivity and specificity for US in the diagnosis of appendicitis. (springer.com)
High magnetic field strength offers great benefits for magnetic resonance imaging, providing improved spatial and temporal resolution, greater sensitivity to physiological changes and access to new contrasts. (nottingham.ac.uk)
High magnetic field strength offers great benefits for MRI, providing improved spatial and temporal resolution, greater sensitivity to physiological changes - particularly for functional brain imaging - and access to new contrasts, such as those based on chemical exchange saturation transfer and magnetic susceptibility. (nottingham.ac.uk)
High field also delivers greater spectral dispersion and enhanced sensitivity for MRS based on measurement of signals from 1H nuclei in metabolites. (nottingham.ac.uk)
PURPOSE Hypertension is the most common diagnosis in ambulatory care, yet little evidence exists regarding recommended screening intervals or the sensitivity and specificity of a routine office-based blood pressure measurement, the most common screening test. (annfammed.org)
We hypothesize that a more limited annual screening strategy may increase specificity while maintaining sensitivity. (annfammed.org)
CONCLUSION A limited annual screening strategy for hypertension can improve specificity without sacrificing sensitivity when compared with routine screening at every visit in previously normotensive adults. (annfammed.org)
1 Yet there is little evidence to recommend a screening interval 2 or to define the sensitivity and specificity of the most common screening test, a routine office-based blood pressure measurement performed by manual sphygmomanometry. (annfammed.org)
The biosensor offered a highly sensitive glucose sensing platform with nearly 10-fold higher sensitivity compared to previous glucose biosensors. (techbriefs.com)
The sensitivity, specificity, positive and negative predictive values for each test and combination of tests for predicting systemic infection were also determined. (bmj.com)
IL-6 had the highest sensitivity (89%) and negative predictive value (91%) for detecting late onset infection on day 0. (bmj.com)
However, between 24 and 48 hours of onset, C-reactive protein was the best single marker, with an overall sensitivity and specificity of 84% and 96%, respectively. (bmj.com)
The use of serial and multiple markers in the first 48 hours further enhanced the sensitivity and specificity of these tests. (bmj.com)
Performing IL-6 and C-reactive protein on day 0, together with either TNFα on day 1 or C-reactive protein on day 2, showed the best overall sensitivity (98%) and specificity (91%) for the diagnosis of late onset infection. (bmj.com)
The sensitivity and specificity of T 2 -weighted imaging for PCa vary widely due to differences in imaging techniques, reference standards, criteria for defining disease involvement on MRI, and interobserver variability [ 6 ]. (hindawi.com)
T 2 -weighted imaging showed a maximum joint sensitivity and specificity rate of 74% for the staging of PCa [ 7 ]. (hindawi.com)
In this study, a single lactate level of 4.0 mmol per L or greater at the time of sepsis diagnosis had a sensitivity of 0.51, a specificity of 0.75, a positive likelihood ratio of 2.0, and a negative likelihood ratio of 0.65 for predicting 28-day mortality. (aafp.org)
A retrospective cohort study of 1,865 adults with sepsis found that average lactate scores within the first 24 hours of hospital admission had a higher sensitivity, similar specificity, and greater area under the receiver operating characteristic curve (AUROC) than qSOFA for predicting 30-day mortality. (aafp.org)
8 Lactate clearance demonstrated a sensitivity of 0.67, specificity of 0.73, positive likelihood ratio of 2.52, and negative likelihood ratio of 0.45 for predicting mortality. (aafp.org)
11 The sensitivity and specificity of the qPCR test and virus isolation is high during the acute phase of disease. (veterinaryirelandjournal.com)
05) with sensitivity and specificity 80.6% and 75.2%, respectively. (researchsquare.com)
Overall, a CT value of 36 allowed differentiation between PCP and colonization with sensitivity and specificity of 71.3% and 77.1%, respectively. (ntnu.no)
In SOT recipients, a CT cutoff value of 36 resulted in sensitivity and specificity of 95.0% and 83.3%, respectively. (ntnu.no)
The sensitivity, specificity and positive and negative predictive values of the dipstick test for detection of protein were 80.0%, 95.0%, 22.2% and 99.6% and for glucose were 100%, 98.5%, 87.0% and 100% respectively. (who.int)
related clinical problems, the objective of A dipstick test for proteinuria is also this study was to determine the reliabil- widely available, but no information on its ity of the dipstick method as a screening sensitivity or specificity is available when procedure for the detection of haematuria, implementing current guidelines [ 9 ]. (who.int)
of its low sensitivity, the standard urinary dipstick test cannot be recommended as the The study sample was 300 people (185 sole method of screening for renal target male and 115 female) aged over 50 years organ damage [ 10-12 ]. (who.int)
Scintigraphy with indium-111 diethylenetriamine pentaacetic acid (DTPA) octreotide (In-111 DTPA Octr), or OctreoScan, localizes the primary carcinoid and eventual recurrences, as well as other neuroendocrine tumors, with high sensitivity and specificity. (medscape.com)

Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
We generated LCL-stimulated T cell lines from 21 donors according to clinical protocols, and analyzed the antigen specificity of the CD4+ component in EBV-specific T cell preparations using a genetically engineered EBV mutant that is unable to enter the lytic cycle, and recombinantly expressed and purified EBV proteins. (uni-muenchen.de)

Select organ toxicity potentially results from compound accumulation in a particular tissue, cell types within organs, metabolism, and off-target effects. (nih.gov)
Comparing phospholipid profiles of mitochondria and whole tissue: Higher PUFA content in mitochondria is driven by increased phosphatidylcholine unsaturation. (oregonstate.edu)
Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
The majority of those studies focused on liver and white adipose tissue (WAT), which is not surprising given the fact that these are considered the main target organs in a dietary intervention with fatty acids. (biomedcentral.com)

These guidelines address the use of tests for the hepatitis B and C viruses to screen donations of blood and plasma collected for transfusion or further manufacture into injectable products, as well as to screen donors of organs, tissues, and semen. (cdc.gov)
In vivo, 68 Ga-BMS-986192 uptake was high at 1 h after injection in PD-L1-positive tumors (9.0 ± 2.1 percentage injected dose [%ID]/g) and kidneys (56.9 ± 9.2 %ID/g), with negligible uptake in other tissues. (snmjournals.org)
MRI utilizes magnetic properties of ions in the body along with computer-generated radio waves to create detailed images of the body's organs and tissues 4 . (tufts.edu)
The altered signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of cardiofaciocutaneous syndrome. (medlineplus.gov)
The increased signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of Noonan syndrome with multiple lentigines. (medlineplus.gov)

Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin- dependent diabetes mellitus. (cdc.gov)
This microorganism can cause severe pneumonia in susceptible hosts, including patients with cancer and autoimmune diseases and people undergoing solid organ transplantation. (ntnu.no)

Little is known of the molecular response to DHA and EPA of the small intestine, and the potential contribution of this organ to the beneficial effects of these fatty acids. (biomedcentral.com)

We show high predictive performance per organism and in generalization across species. (frontiersin.org)

It lacks ionising radiation, allows dynamic visualisation of the abdominal organs and is of lower cost compared with computed tomography (CT). (springer.com)
DPL is invasive and risks iatrogenic damage to abdominal organs during the procedure. (msdmanuals.com)

Immucor products enable us to accurately assign HLA antibody specificities for better transplant outcomes! (immucor.com)

Expressed at lower levels in lymphoid organs, kidney, colon and liver. (abcam.com)
Liver cirrhosis is a high risk factor for COVID-19 mortality. (researchsquare.com)

The exact prevalence of pelvic organ prolapse is difficult to determine. (medscape.com)
The prevalence in males and inexpensive and adjacent organs can also females was 4.2% (95% CI: 1.7-8.5) and be assessed. (who.int)
However, recent studies indicate a much higher prevalence among patients with hypertension. (aacc.org)
After counseling and testing are effectively implemented in settings of high and moderate prevalence, consideration should be given to establishing programs in settings of lower prevalence. (cdc.gov)

Computed tomography (CT) has been shown to have high accuracy and low operator dependence in the diagnosis of appendicitis. (springer.com)
1. Disease diagnosis requires a high index of suspicion in the presence of specific clinical manifestations. (medscape.com)
The elevation of cancer antigen 125 (CA125) levels in the serum of asymptomatic patients precedes the radiologic detection of high-grade serous ovarian cancer by at least 2 mo and the final clinical diagnosis by 5 mo. (snmjournals.org)
Routine diagnostic testing, although essential for evaluation of other organ systems, often provides little assistance in the diagnosis of pancreatitis. (vin.com)

Pelvic organ prolapse is the abnormal descent or herniation of the pelvic organs from their normal attachment sites or their normal position in the pelvis. (medscape.com)
Although signs of pelvic organ prolapse are frequently observed, the condition seldom causes symptoms. (medscape.com)
Nonsurgical (conservative) management of pelvic organ prolapse should be attempted before surgery is contemplated. (medscape.com)
The recommended management strategy for severe symptomatic pelvic organ prolapse for patients who failed or refused a trial of pessary management is surgery. (medscape.com)
Pelvic organ prolapse (POP) and urinary incontinence (UI) are common conditions affecting many adult women today. (medscape.com)
Pelvic organ prolapse and its consequences have been reported since 2000 BC. (medscape.com)
Hippocrates described numerous nonsurgical treatments for pelvic organ prolapse. (medscape.com)
From the early 1800s through the turn of the century, various surgical approaches have been described to correct pelvic organ prolapse. (medscape.com)
Pelvic organ prolapse is a defect of a specific vaginal segment characterized by descent of the vagina and associated pelvic organ. (medscape.com)
In the most severe case (complete pelvic organ prolapse), the pelvic organ protrudes completely through the genital hiatus. (medscape.com)
A study by Handa et al suggests that vaginal birth and operative vaginal birth increase an individual's risk for urinary incontinence and pelvic organ prolapse 5-10 years after delivery when compared with cesarean delivery without labor. (medscape.com)
Rarely, DPL is indicated when imaging is available, such as in hypotension plus an unclear E-FAST examination result or imaging that shows free pelvic fluid but no apparent solid organ injury (eg, ascites). (msdmanuals.com)
Introduction and hypothesis The aim of the study was to determine whether successful incontinence pessary fitting or pessary size can be predicted by specific POPQ measurements in women without advanced pelvic organ prolapse. (researchgate.net)
vaginal pessary has been used for centuries as a conservative treatment of pelvic organ prolapse [1] and more recently for stress urinary incontinence [2 - 4]. (researchgate.net)
The primary aim of this study was to determine, in a group of women without advanced pelvic organ prolapse and with or without a uterus, (1) whether successful incontinence pessary fitting can be predicted by specific pelvic organ prolapse quantification (POPQ) measurements [8] and (2) whether POPQ measures predict pessary size. (researchgate.net)
Therefore, multiparous women are at particular risk for pelvic organ prolapse. (medscape.com)
[ 5 ] A thorough evaluation and definition of all support defects is of critical importance because most women with pelvic organ prolapse have multiple defects. (medscape.com)
In a 1999 study of Swedish women aged 20-59 years, Samuelsson and colleagues found that, although signs of pelvic organ prolapse are frequently observed, the condition seldom causes symptoms. (medscape.com)

The open design of these systems is an additional benefit for patients with claustrophobia as well as obese patients that have difficulty in high-field MRI systems. (tufts.edu)
Prospective data from nearly 20,000 patients in the Surviving Sepsis Campaign demonstrated that a single serum lactate level greater than 4.0 mmol per L in the presence of hypotension is associated with higher in-hospital mortality (odds ratio = 1.64) compared with either a serum lactate level of 4.0 mmol per L or less or the absence of hypotension. (aafp.org)
https://www.mdcalc.com/qsofa-quick-sofa-score-sepsis ) scores are routinely used for screening and identifying patients at higher risk of sepsis mortality. (aafp.org)
An initial lactate level of greater than 4.0 mmol per L can be used to identify patients with sepsis who are at higher risk of mortality. (aafp.org)
Although a lactate level greater than 4.0 mmol per L clearly correlates with higher mortality in patients with sepsis, lactate levels between 2.0 and 4.0 mmol per L are often incorrectly used to identify septic shock, which could lead to overdiagnosis and the unnecessary initiation of aggressive treatment. (aafp.org)
Although patients receiving T cell preparations with a higher CD4+ T cell proportion show better clinical responses, the specificity of the infused CD4+ component has remained completely unknown. (uni-muenchen.de)
The systemic inflammation and concurrent diseases, such as hepatic lipidosis, diabetes, biliary duct obstruction, can result in organ dysfunction and failure that can be fatal in some patients. (vin.com)
Patients with De Ritis ratio ≥ 1.218 were significantly associated with mortality, severity, higher AST and IL-6, however with lower ALT. (researchsquare.com)
solid organ transplant (SOT) recipients had significantly higher fungal loads than patients with hematological malignancies. (ntnu.no)
Specifically, low loads of microorganisms are sufficient to cause infection in patients with blood cancer compared to those in solid organ recipients. (ntnu.no)
For example, programs that offer counseling and testing to homosexual men, IV-drug abusers, persons with hemophilia, sexual and/or needle-sharing partners of these persons, and patients of sexually transmitted disease clinics may be most effective since persons in these groups are at high risk for infection. (cdc.gov)
Thus, it is important for individuals to receive an annual influenza vaccine and for health-care providers to provide early antiviral treatment for patients with suspected influenza who are at increased risk of severe outcomes, not only when there is high influenza A H3N2 virus circulation but also when influenza A H1N1pdm09 and influenza B viruses are circulating. (cdc.gov)

with newly diagnosed hypertension may indicate the presence of microalbuminuria with high specificity. (who.int)

Here, we investigated the utility of hepatic-, cardiac-, and kidney-derived cell lines to (1) accurately predict cytotoxicity and (2) to accurately predict specific organ toxicities. (nih.gov)
At the functional level, time-of-day-dependent high fat meal feeding tended to influence cardiac function to a greater extent in WT versus CCM mice. (nih.gov)

Staining reveals anatomical organization that is representative of chordotonal organs in most crustaceans. (jove.com)

Only approximately 5% of compounds showed differential toxicity responses in the cell lines with no obvious correlation to the known in vivo organ toxicity. (nih.gov)
High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)

A mismatch between fatty acid availability and utilization leads to cellular/organ dysfunction during cardiometabolic disease states (e.g., obesity, diabetes mellitus). (nih.gov)
After an increase in serum levels of the free chains, the protein deposits in organs, causing significant dysfunction . (medscape.com)
Exhaustion of these protective mechanisms can lead to systemic inflammation and secondary organ dysfunction. (vin.com)
Depending on the organ system affected, the systemic sequelae of pancreatitis may include diabetes/DKA, renal failure, disseminated intravascular coagulation, hepatic dysfunction, bile duct obstruction, acute respiratory distress syndrome, myocardial dysfunction, sepsis or death. (vin.com)

DPL has low specificity, identifying many lesions that cause bleeding but do not require operative repair, and results in a high negative laparotomy rate. (msdmanuals.com)
The primary outcome measure was the TBR, which was obtained by normalizing to the omentum (in 106 lesions) or other solid organs (27 lesions). (cancernetwork.com)

Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)

This is a function of high dose transmission (large populations that contain all possible single nucleotide substitutions) that can be experimentally achieved by serial passage in mice where high dose transmissions generates highly virulent variants. (scitizen.com)

Our offerings include solutions for high accuracy needed for research, short turnaround times when providing clinical results and workflows that meet high throughput needs in a registry lab setting. (immucor.com)

In insects and crustaceans, chordotonal organs are the structures that provide that information to the CNS 1 . (jove.com)
Not all chordotonal organs span a joint but they can still monitor joint movements due to their attachment on the apodemes (tendon like structures) which span the joint and move in association with the skeletal muscle and joint articulation. (jove.com)
The proximity of the electrodes to these structures assured organ specificity. (umn.edu)

Indeed, among epithelial ovarian cancers, the frequency of CA125 positivity is higher in serous histotypes than in mucinous or clear cell disease ( 4 ). (snmjournals.org)
MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)

INTERPRETATION: Despite a higher burden of hospitalisations with influenza A H3N2, we found an increased likelihood of in-hospital severe outcomes in individuals hospitalised with influenza A H1N1pdm09 or influenza B virus. (cdc.gov)

Since this organ contributes significantly to whole organism energy use, this effect on the small intestine may well contribute to the beneficial physiological effects of marine PUFAs under conditions that will normally lead to development of obesity, insulin resistance and diabetes. (biomedcentral.com)

In addition, recipients of blood from paid donors were at higher risk of developing post-transfusion hepatitis than were recipients of blood from non-paid donors (10,11). (cdc.gov)
EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer of polyclonal EBV-specific T cell lines containing CD4+ and CD8+ T cell components. (uni-muenchen.de)

Typically a chordotonal organ has 60-100 or more sensory neurons embedded within an elastic strand, neurons that signal static joint position, direction and speed of movement 3-6 . (jove.com)
Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules' loading and spatial arrangement. (mdpi.com)

The more abnormal the physiological parameters recorded, the higher the PAWS score obtained. (bmj.com)

Establishing the structure-function relationship between the proprioceptive organs, muscles and the nervous system will further help define these roles. (jove.com)

From a virus stand point, a life cycle always begins with receptor binding to susceptible the cell, the specificity of the virus receptor interactions are a component of host range, and so it s known that human influenza viruses bind to receptors that are slightly different from those sialic acid containing receptors that are in birds. (scitizen.com)

The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)

Late onset nosocomial bacterial infection and septic shock in preterm very low birthweight (VLBW) infants carry a high risk of morbidity and mortality. (bmj.com)
Average life span was shorter in those times, but because infant and early childhood mortality was high, not because there were hardly any old people. (nautil.us)

Our results suggest that from a general screening perspective, different cell lines have relatively equal value in assessing general cytotoxicity and that specific organ toxicity cannot be accurately predicted using such a simple approach. (nih.gov)

We found that the majority of compounds, regardless of their designated organ toxicities, had similar effects in all three cell lines. (nih.gov)
We anticipate that these MPL-compatible OS composite resins will pave the path towards production of soft, bioactive, and conductive microstructures for various applications in the emerging fields of flexible bioelectronics, biosensors, nanoelectronics, organ-on-chips, and immune cell therapies. (techbriefs.com)
Many cell fate decisions in higher animals are based on intercellular communication governed by the Notch signaling pathway. (sdbonline.org)

The five-level structure of this terminology provides options for retrieving data by specific or broad groupings, according to the level of specificity required. (wikipedia.org)
Several publications have aimed to predict specific organ toxicities. (nih.gov)
Fatty acid availability was increased in cardiomyocyte-specific CLOCK mutant (CCM) and wild-type (WT) littermate mice for 9weeks in time-of-day-independent (streptozotocin (STZ) induced diabetes) and dependent (high fat diet meal feeding) manners. (nih.gov)
High and specific binding of 68 Ga-BMS-986192 to human PD-L1-expressing cancer cells was confirmed, which closely correlates with the respective PD-L1 expression level determined by flow cytometry and immunohistochemistry staining. (snmjournals.org)

Indices of myocardial metabolic adaptation (e.g., substrate reliance perturbations) to STZ-induced diabetes and high fat meal feeding were found to be dependent on genotype. (nih.gov)

Pneumonia isolates carried higher proportions of virulence genes sfa/foc , papGIII , hlyC , cnf1 , and iroN compared with bacteremia isolates. (cdc.gov)
Virulence factor gene content and antimicrobial drug resistance were higher in pneumonia than in commensal isolates. (cdc.gov)
This virus is very unusual in its high virulence for a broad spectrum of animals that occasionally includes humans? (scitizen.com)

Priorities for public health counseling and testing should be based upon providing ready access to persons who are most likely to be infected or who practice high-risk behaviors, thereby helping to reduce further spread of infection. (cdc.gov)

To further increase the specificity of the testing process, laboratories must use a supplemental test--most often the Western blot test--to validate repeatedly reactive EIA results. (cdc.gov)

Chou, Shelley N. / Innervation of the urinary bladder in higher primates . (umn.edu)

To obtain high-quality, functional exosomes for nucleic acid drug delivery, we can offer scalable exosome production and isolation services, as well as efficient exosome purification and characterization services. (alfaoncology.com)

Symptoms vary with the organ infected. (msdmanuals.com)

Immuno-PET with 89 Zr-labeled mAb-B43.13 is a potential strategy for the noninvasive delineation of extent of disease and may add value in treatment planning and treatment monitoring of high-grade serous ovarian cancer. (snmjournals.org)
High-grade serous ovarian cancer (HGSOC) comprises the major malignant histotype (70%) of epithelial ovarian cancers and bears a molecular signature in the overexpression of MUC16/cancer antigen 125 (CA125), a serum biomarker for ovarian cancer ( 3 ). (snmjournals.org)

Since the intestine contributes to a significant extend to the resting metabolic rate and daily energy expenditure [ 17 ], it is of relevance to also understand the effects on this organ. (biomedcentral.com)

Anatomy2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Health Care1

Sensitivity28

Antigen specificity2

Tissue4

Tissues5

Autoimmune diseases2

Fatty Acids1

Predictive1

Abdominal organs2

Antibody1

Liver2

Prevalence4

Diagnosis4

Pelvic18

Patients12

Hypertension1

Cardiac2

Anatomical1

Responses2

Dysfunction4

Lesions2

Transplantation1

Large populations1

Clinical1

Structures3

Mucinous2

Outcomes1

Significantly1

Recipients2

Typically2

Physiological1

Define1

Interactions1

Solid1

Mortality2

Accurately1

Cell3

Specific4

Diabetes1

Virulence3

Risk1

Increase1

Urinary1

Functional1

Symptoms1

Cancer2

Effects1